Tag: M.W=150-200

Javed, Erman; Guthrie, Jacob D.; Neu, Justin; Chirayath, George S.; Huo, Shouquan published the artcile< Introducing an α-Keto Ester Functional Group through Pt-Catalyzed Direct C-H Acylation with Ethyl Chlorooxoacetate>, Recommanded Product: 4-Chloro-2-methoxyphenol, the main research area is aryloxy pyridine chlorooxoacetate platinum catalyst regioselective acylation; aryl oxoacetate preparation.

Platinum-catalyzed selective C-H acylation of 2-aryloxypyridines with Et chlorooxoacetate provided an efficient way of introducing an α-keto ester functional group. The reaction is oxidant-free, additive-free and more significantly free of any decarbonylative side reactions. The reaction tolerated a variety of substituents from strongly electron-donating to strongly electron-withdrawing groups. Double acylation was feasible for 2-phenoxypyridine and its derivatives with only one substituent at the para position. Although the reaction of 2-(2-methylphenoxy)pyridine with Et malonyl chloride did not produce the desired β-keto ester, the reaction with Et succinyl chloride proceeded smoothly to give the γ-keto ester. Et chlorooxoacetate was much more reactive than Et succinyl chloride in this Pt-catalyzed C-H acylation reaction.

ACS Omega published new progress about Acylation catalysts (regioselective). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Recommanded Product: 4-Chloro-2-methoxyphenol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Yongjie; Jiang, Kai; Zhu, Hua; Yin, Biaolin published the artcile< Synthesis of Highly Conjugated Functionalized 2-Pyridones by Palladium-Catalyzed Aerobic Oxidative Dicarbonation Reactions of N-(Furan-2-ylmethyl) Alkyne Amides and Alkenes as Coupling Partners>, COA of Formula: C9H5ClO2, the main research area is furanylmethylpropynamide ethene palladium catalyst diastereoselective aerobic oxidative dicarbonation; oxopropenyl ethenyl pyridinone preparation.

A mild, step-economical method for the synthesis of highly conjugated functionalized 2-pyridones from N-(furan-2-ylmethyl) alkyne amides was reported. This method involved Pd-catalyzed aerobic oxidative dicarbonation reactions of alkynes with carbon nucleophiles of a furan ring and an acrylate or styrene as coupling partners. The UV-vis absorption spectra of some of the 2-pyridones indicated that they absorbed shortwave radiation, suggested their potential utility for filtration of such radiation.

Journal of Organic Chemistry published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, COA of Formula: C9H5ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Farran, Daniel; Bertrand, Philippe published the artcile< Hammett constants effects in microwave cascade etherification-cyclization-Krapcho reaction to access [2,3]-dihydrobenzofuran-3-ones from salicylic derivatives>, Product Details of C8H7ClO3, the main research area is salicylate bromopropionate etherification cyclization Krapcho cascade microwave Hammett constant; hydrobenzofuranone preparation.

Two methods were evaluated for the synthesis of substituted 2,3-dihydro-2-methylbenzofuran-3-ones from the corresponding salicylate esters under microwave irradiation A 2-step sequence via ether intermediates was convenient for various substituted salicylate derivatives, while the 2nd strategy involving a 1-pot procedure was efficient for electron-donating substituted salicylates. Results allowed correlation of the Hammett constants effects in the intramol. cyclization of O-ethoxycarbonyl ethers of salicylic esters.

Synthetic Communications published new progress about Aromatic hydroxycarboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (esters). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Kun; Jelier, Benson; Passera, Alessandro; Jeschke, Gunnar; Katayev, Dmitry published the artcile< Synthetic Diversity from a Versatile and Radical Nitrating Reagent>, Product Details of C8H6ClNO2, the main research area is nitroalkene preparation diastereoselective regioselective chemoselective; alkene nitrosuccinimide nitration ruthenium photocatalyst; nitrohydrin preparation regioselective chemoselective; ketone alkene nitrosuccinimide nitration ruthenium photocatalyst; isoxazoline preparation regioselective chemoselective; nitrosuccinimide ketone alkene dipolar cycloaddition ruthenium photocatalyst; isoxazole preparation regioselective chemoselective; alkyne nitrosuccinimide ketone dipolar cycloaddition ruthenium photocatalyst; C−H nitration; alkenes; photoredox; radicals; reaction mechanisms.

A new methodol. was described for the activation of N-nitrosuccimide for the direct synthesis of β-nitroalkenes, β-nitrohydrins, β-nitroethers, isoxazolines I [R = Me, cyclopropyl; R1 = n-heptyl, Bn, CH2OPh; R2 = H, R1R2 = (CH2)4, (CH2)9, (CH2)10C(O)(CH2)3; R3 = H, Me] and isoxazoles II [R4 = CO2Et, CH2CH2Br, cyclohexyl, etc.]. Detailed mechanistic studies strongly suggested that a mesolytic N-N bond fragmentation liberates a nitryl radical. Using in situ photo-sensitized, ESR spectroscopy, direct evidence of a nitryl radical in solution by nitrone spin-trapping was observed To further exhibit versatility of N-nitrosuccinimide under photoredox conditions, the late-stage diversification of an extensive number of C-H partners to prepare isoxazolines I and isoxazoles II was presented. This approach allowed for the formation of an in situ nitrile oxide from a ketone partner, the presence of which was detected by the formation of the corresponding furoxan when conducted in the absence of a dipolarophile. This 1,3-dipolar cycloaddition with nitrile oxides and alkenes or alkynes proceeded in a single-operational step using a mild, regioselective and general protocol with broad chemoselectivity.

Chemistry – A European Journal published new progress about 1,3-Dipolar cycloaddition catalysts (regioselective). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Product Details of C8H6ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Hong; Di, Shu-Sheng; Huang, Xiao-Bo; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue published the artcile< Direct dilithiation of N-aryl heterocycles for the construction of condensed N-heterocycles>, Electric Literature of 17082-09-6, the main research area is condensed heterocycle preparation; aryl heterocycle direct dilithiation acyl chloride trapping.

A 1,4-dilithio intermediate can be prepared from N-heterocycles by n-BuLi-promoted direct C-H dilithiation. The subsequent trapping of the 1,4-dilithio intermediate with acyl chlorides affords condensed N-heterocycles in high yields in a one-pot fashion. This protocol features a broad substrate scope, good efficiency, and high atom economy. The control experiments support the presence of a 1,4-dilithio intermediate.

Organic Chemistry Frontiers published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Electric Literature of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cheng, Hua; Shen, Yan-Qing; Pan, Xia-Yan; Hou, Yi-Ping; Wu, Qiong-You; Yang, Guang-Fu published the artcile< Discovery of 1,2,4-triazole-1,3-disulfonamides as dual inhibitors of mitochondrial complex II and complex III>, Reference of 35852-58-5, the main research area is triazoledisulfonamide preparation inhibitor mitochondria complex II III; antibacterial activity Xanthomonas.

Respiratory chain succinate-ubiquinone oxidoreductase (SQR or complex II) and ubihydroquinone-cytochrome (cyt) c oxidoreductase (cyt bc1 or complex III) have been demonstrated as the promising targets of numerous antibiotics and fungicides. As a continuation of our research work on the development of new fungicides, a series of 1,2,4-triazole-1,3-disulfonamide derivatives with dual functions targeting both SQR and cyt bc1 were designed and synthesized by coupling diverse di-Ph ether moieties with triazolesulfonamide units. These newly synthesized compounds were characterized by elemental analyses, 1H NMR and ESI-MS spectrometry. The in vitro assay indicated that most of the synthesized compounds displayed good inhibition against porcine succinate-cytochrome reductase (SCR) with IC50 values ranging from 3.2 to 81.8 μM, revealing much higher activity than that of the com. control amisulbrom whose IC50 value is 93.0 μM. Further evaluation against the resp. SQR and cyt bc1 indicated that most compounds exhibited SQR-inhibiting activity as well as cyt bc1-inhibiting activity, but the inhibition potency against SQR is much higher than that against cyt bc1, showing that the SCR inhibition might be contributed greatly by the SQR inhibition. The further antibacterial evaluation against Xanthomonas oryzae pv. oryzae revealed that four compounds showed excellent potency at the concentration of 20 μg mL-1. In particular, compounds (I) and (II) exhibited much better antibacterial activity than the com. control bismerthiazol in terms of their EC50. Impressively, II has an EC90 of 33.62 μg mL-1, more than 10-fold higher than that of bismerthiazol.

New Journal of Chemistry published new progress about Antibacterial agents. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Reference of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Genc, Hayriye Nevin; Ozgun, Ummu; Sirit, Abdulkadir published the artcile< Design, synthesis and application of chiral tetraoxacalix[2]arene[2]triazine-based organocatalysts in asymmetric Michael addition reactions>, Application In Synthesis of 5153-70-8, the main research area is aryl dimethyl nitrobutanal preparation enantioselective; isobutyraldehyde nitrostyrene Michael oxacalixarene triazine organocatalyst; Michael addition; asymmetric synthesis; organocatalysis; stereoselectivity; tetraoxacalix[2]arene[2]triazine.

A novel type of (R,S)/(S,R)-oxacalix[2]arene[2]triazine-based organocatalysts I for asym. Michael reactions is reported for the first time. Chiral subunits were attached to the heteroatom-bridged calixarom. platform by a reaction of (R)- and (S)-1-aminotetraline with tetraoxacalix[2]arene[2]triazine in both enantiomeric forms. To evaluate the catalytic efficiency of the novel organocatalysts , isobutyraldehyde reacted with various substituted and unsubstituted aromatic trans-β-nitrostyrenes (E)-RCH=CHNO2 (R = Ph, 2-bromophenyl, furan-2-yl, etc.) in THF (THF), leading to Michael adducts (S)-HC(O)C(CH3)2CH(R)CH2NO2 in excellent yields and enantioselectivites (up to 97% yield and 99% ee).

Chirality published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Candish, Lisa; Lupton, David W. published the artcile< N-heterocyclic carbene cascade catalysis: Dual Bronsted/Lewis base rearrangement of cyclopropyl enol esters to dihydropyranones>, Formula: C10H9ClO2, the main research area is heterocyclic carbene cascade catalysis Bronsted Lewis base rearrangement; cyclopropyl enol ester dihydropyranone rearrangement.

The first example of Broensted/Lewis base cascade catalysis using an N-heterocyclic carbene was realized through the rearrangement of cyclopropyl esters to dihydropyranones. The scope and mechanism of this transformation was examined implicating a novel NHC-mediated electrocyclic cyclopropane rearrangement followed by an anionic oxy Claisen-rearrangement.

Chemical Science published new progress about Acylation (proton transfer and O-). 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Formula: C10H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Lin; Bu, Ran; Liu, Xiao-Yan; Mu, Peng-Fei; Gao, En-Qing published the artcile< Schiff-base molecules and COFs as metal-free catalysts or silver supports for carboxylation of alkynes with CO2>, Category: chlorides-buliding-blocks, the main research area is alkynoic acid preparation; alkyne terminal carboxylation carbon dioxide organocatalyst; Schiff base covalent organic framework preparation alkyne carboxylation catalyst.

Carboxylation of terminal alkynes with CO2 to produce propiolic acids is an atom economical and high-value route for CO2 fixation and utilization, but the conversion under mild conditions needs transition metal catalysts. In this article, the application of transition-metal-free organocatalysts for the reaction have been demonstrated for the first time. These efficient catalysts are Schiff bases derived from 1,3,5-triformylphloroglucinol, either homogeneous (discrete mols.) or heterogeneous (covalent organic frameworks, COFs). The key catalytic sites are phenoxo and imine groups, which activate CO2 through phenoxo-CO2 complexation and also activate the C(sp)-H bond through bifurcate C-H···Nimine and C-H···Ophenoxo hydrogen bonds. The 2,2′-bipyridyl sites in the COF also contribute to the catalytic performance. The COF catalyst is less active than the mol. one but has the advantages of heterogeneous catalysis. Higher performance was also demonstrated by combining silver nanoparticles with the intrinsically catalytic COF. This work opens up the potential of developing transition-metal-free catalysts for the CO2 conversion reaction and demonstrates the new prospects of COFs as tailorable platforms for heterogeneous catalysis.

Green Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gallagher, Rory T.; Basu, Souradeep; Stuart, David R. published the artcile< Trimethoxyphenyl (TMP) as a Useful Auxiliary for in situ Formation and Reaction of Aryl(TMP)iodonium Salts: Synthesis of Diaryl Ethers>, Synthetic Route of 16766-30-6, the main research area is diaryl ether preparation chemoselective; aryl iodonium salt arylation.

Herein, a synthetic approach for arylation that exploits the in situ formation and reaction of an unsym. diaryliodonium salt is described. In this way, aryl iodides are used as reagents in a metal-free reaction with phenols, and a trimethoxyphenyl (TMP) group is used as a “”dummy”” group to facilitate transfer of a wide range of aryl moieties. The scope of aryl electrophiles and phenol nucleophiles is broad (>30 examples) and the yields are high (52-95%, 80% avg.). One-pot coupling reactions avoid the synthesis of diaryliodonium salts and provide opportunities for sequential reactions and novel chemoselectivity.

Advanced Synthesis & Catalysis published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Synthetic Route of 16766-30-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics