Tag: M.W=150-200

Pawar, Hari R.; Kamble, Narendra R.; Kamble, Vinod T. published the artcile< Chemoselective, room temperature and solvent-free synthesis of thio-esters using effective synergistic catalytic system>, Computed Properties of 17082-09-6, the main research area is thioester preparation chemoselective green chem; acyl chloride thiol acylation silver perchlorate niobium chloride solventless.

A simple and highly efficient room temperature catalytic protocol was developed towards the synthesis of thioesters R1C(O)SR2 (R1 = Me, Ph, 2-phenylethenyl, etc.; R2 = Ph, 4-methylphenyl, Et, propyl) from acyl chlorides R1C(O)Cl and thiols R2SH under solvent-free conditions. Ambient reaction conditions, short reaction time, and excellent product yields are notable features of this methodol.

Rasayan Journal of Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Computed Properties of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bazzi, Sakna; Schulz, Emmanuelle; Mellah, Mohamed published the artcile< Electrogenerated Sm(II)-Catalyzed CO2 Activation for Carboxylation of Benzyl Halides>, Computed Properties of 611-19-8, the main research area is phenylacetic acid preparation; benzyl halide carbon dioxide reductive electrochem carboxylation samarium catalyst.

Sm(II)-catalyzed carboxylation of benzyl halides is reported through the electrochem. reduction of CO2. The transformation proceeds under mild reaction conditions to afford the corresponding phenylacetic acids in good to excellent yields. This user-friendly and operationally simple protocol represents an alternative to traditional strategies, which usually proceeds through the C(sp3)-halide activation pathway.

Organic Letters published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Computed Properties of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Borges-Gonzalez, Jorge; Garcia-Monzon, Irma; Martin, Tomas published the artcile< Conformational Control of Tetrahydropyran-based Hybrid Dipeptide Catalysts Improves Activity and Stereoselectivity>, Category: chlorides-buliding-blocks, the main research area is aldehyde nitrostyrene dipeptide catalyst enantioselective diastereoselective Michael addition; nitro phenyl alkanal preparation.

It was demonstrated as to how carbohydrates can be used as conformational control units of organocatalysts to tune their catalytic properties was introduced. New hybrid dipeptide-like organocatalysts based on ζ-sugar aminoacids and proline were prepared and tested for the asym. Michael addition of aldehydes to β-nitrostyrenes. Taking full advantage of the modular nature of the carbohydrate motif, both reactivity and stereoselectivity were significantly improved. By simple structural changes, such as the elimination of the methoxy group in the C4 position of the tetrahydropyran ring, we obtained two complementary catalysts that allow accessed to both enantiomers of the γ-nitroaldehydes with excellent yields, diastereoselectivity and enantiomeric excesses between 97 and 99%, using a catalytic load even below 1 mol%.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shingdilwar, Shashikant; Dolui, Subrata; Kumar, Devendra; Banerjee, Sanjib published the artcile< Facile access to template-shape-replicated nitrogen-rich mesoporous carbon nanospheres for highly efficient CO2 capture and contaminant removal>, COA of Formula: C9H9Cl, the main research area is nitrogen carbon dioxide capture nanosphere atom transfer radical polymerization.

Rising atm. CO2 levels and water pollution have necessitated new research towards the development of novel CO2 capture materials and innovative methods for wastewater treatment. Herein, we demonstrate a facile fabrication strategy to prepare novel template-shape-replicated nitrogen-rich mesoporous carbon nanospheres (NMCN) with high surface area, pore volume and ordered pore geometry via a combination of in situ co-condensation, surface-confined atom transfer radical polymerization (SC-ATRP) and post-polymerization modification. NMCN exhibited efficient CO2 capture performance and contaminant removal capability from wastewater. This work may open a new direction for the design of novel porous nanomaterials for CO2 capture and other emerging applications.

Materials Advances published new progress about Adsorption (isotherm). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Jinggong; Liu, Weilin; Ge, Hu; Gao, Jinbo; He, Qingqing; Su, Lijuan; Xu, Jun; Gu, Lian-quan; Huang, Zhi-shu; Li, Ding published the artcile< Syntheses and characterization of non-bisphosphonate quinoline derivatives as new FPPS inhibitors>, Computed Properties of 22717-55-1, the main research area is non bisphosphonate quinoline derivative preparation FPPS geranyltransferase inhibitor cancer; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide; Allosteric site; BPs; BSA; Bisphosphonate; Cancer; DL-dithiothreitol; DTT; FPPS; Farnesyl pyrophosphate synthase; HAP; MTT; Quinoline derivative; Tris; bisphosphonates; bovine serum albumin; farnesyl pyrophosphate synthase; hydroxyapatite; tris(hydroxymethyl)aminomethane.

Background: Farnesyl pyrophosphate synthase (FPPS) is a key regulatory enzyme in the biosynthesis of cholesterol and in the post-translational modification of signaling proteins. It has been reported that non-bisphosphonate FPPS inhibitors targeting its allosteric binding pocket are potentially important for the development of promising anti-cancer drugs. Methods: The following methods were used: organic syntheses of non-bisphosphonate quinoline derivatives, enzyme inhibition studies, fluorescence titration assays, synergistic effect studies of quinoline derivatives with zoledronate, ITC studies for the binding of FPPS with quinoline derivatives, NMR-based HAP binding assays, mol. modeling studies, fluorescence imaging assay and MTT assays. Results: We report our syntheses of a series of quinoline derivatives as new FPPS inhibitors possibly targeting the allosteric site of the enzyme. Compound 6b showed potent inhibition to FPPS without significant hydroxyapatite binding affinity. The compound showed synergistic inhibitory effect with active-site inhibitor zoledronate. ITC experiment confirmed the good binding effect of compound 6b to FPPS, and further indicated the binding ratio of 1:1. Mol. modeling studies showed that 6b could possibly bind to the allosteric binding pocket of the enzyme. The fluorescence microscopy indicated that these compounds could get into cancer cells. Conclusions: Our results showed that quinoline derivative 6b could become a new lead compound for further optimization for cancer treatment. General significance: The traditional FPPS active-site inhibitors bisphosphonates show poor membrane permeability to tumor cells, due to their strong polarity. The development of new non-bisphosphonate FPPS inhibitors with good cell membrane permeability is potentially important.

Biochimica et Biophysica Acta, General Subjects published new progress about Antitumor agents. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Computed Properties of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kim, Sou Hyun; Kim, Minwoo; Kwon, Doyoung; Pyo, Jae Sung; Kim, Joo Hyun; Kwak, Jae-Hwan; Jung, Young-Suk published the artcile< N-phenyl cinnamamide derivatives protect hepatocytes against oxidative stress by inducing cellular glutathione synthesis via nuclear factor (erythroid-derived 2)-like 2 activation>, HPLC of Formula: 17082-09-6, the main research area is phenyl cinnamamide preparation antioxidant hepatocyte Nrf2 ARE agonistic activity; N-phenyl cinnamamide; antioxidant response element; glutathione; nuclear factor (erythroid-derived 2)-like 2.

Substituted N-Ph cinnamamide derivatives I (R = OMe, OEt, CN, Cl, N(Me)2) were designed and synthesized to confirm activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway by the electronic effect on beta-position of Michael acceptor according to introducing the R1 and R2 group. Compounds were screened using the Nrf2/antioxidant response element (ARE)-driven luciferase reporter assay. Compound II (R = N(Me)2) showed desirable luciferase activity in HepG2 cells without cell toxicity. MRNA and protein expression of Nrf2/ARE target genes such as NAD(P)H quinone oxidoreductase 1, hemeoxygenase-1, and glutamate-cysteine ligase catalytic subunit (GCLC) were upregulated by compound II (R = N(Me)2) in a concentration-dependent manner. Treatment with compound II (R = N(Me)2) resulted in increased endogenous antioxidant glutathione, showing strong correlation with enhanced GCLC expression for synthesis of glutathione. In addition, tert-Bu hydroperoxide (t-BHP)-generated reactive oxygen species were significantly removed by compound II (R = N(Me)2) , and the results of a cell survival assay in a t-BHP-induced oxidative cell injury model showed a cytoprotective effect of compound II (R = N(Me)2) in a concentration dependent manner. In conclusion, the novel compound II (R = N(Me)2) can be utilized as an Nrf2/ARE activator in antioxidative therapy.

Molecules published new progress about Antioxidants. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Yuanjin; Ma, Yangyang; Li, Liangkui; Jiang, Hao; Li, Zhiping published the artcile< Nitration-Peroxidation of Alkenes: A Selective Approach to β-Peroxyl Nitroalkanes>, Computed Properties of 1592-20-7, the main research area is peroxyl nitroalkane preparation nitration peroxidation alkene Bu nitrite hydroperoxide.

Nitration-peroxidation of alkenes for the synthesis of β-peroxyl nitroalkanes has been developed by using tert-Bu nitrite and tert-Bu hydroperoxide. The method presents a new and selective difunctionalization of alkenes to introduce a nitro group and a peroxyl group across the double bonds of alkenes under mild conditions. A radical reaction pathway is proposed by exptl. and theor. studies. Of note, mixing a metal salt and peroxide can cause an explosion.

Organic Letters published new progress about Alkanes, nitro Role: SPN (Synthetic Preparation), PREP (Preparation) (β-peroxyl). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Computed Properties of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ju, Changha; Park, Chanhyuk; Kim, Taehyung; Kang, Hyo published the artcile< Vertical alignment of liquid crystals on plant-based vanillin derivative-substituted polystyrene films>, Formula: C9H9Cl, the main research area is vanillin polystyrene film liquid crystal thermal optical property.

To investigate the alignment behavior of liquid crystal (LC) mols., we synthesized a series of vanillin derivative-substituted polystyrene films (PVAN#, # = 20, 40, 60, 80, and 100), where # is the substitution ratio (%) of the vanillyl Bu ether (VAN) moiety as one of the bio-renewable vanillin derivatives In general, a vertical LC alignment was observed in the LC cell fabricated using the polymer film having a higher molar content of VAN. Moreover, the surface energies of these polymer films were strongly related to the vertical LC alignment behavior. For example, a uniform vertical alignment was observed when the polar surface energy of the polymer was lower than approx. 2.05 mJ m-2, induced by the nonpolar and long carbon groups in the plant-based vanillin moiety. The LC cell fabricated using PVAN100 had good electrooptical characteristics such as voltage holding ratio and residual direct-current voltage and stable alignment under extreme external conditions.

RSC Advances published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jin, Zai-Su; Wang, Wen-Xi; Hu, Wei-Xiao; Yang, Zhong-Yu; Chen, Hong-Wei; Xuan, Ri-Cheng published the artcile< 5-Chloro-2-benzofuran-1,3-dione>, Application In Synthesis of 118-45-6, the main research area is mol structure chlorobenzofurandione; crystal structure chlorobenzofurandione; hydrogen bonding chlorobenzofurandione.

The asym. unit of the title compound, C8H3ClO3, contains two mols. The mol. packing is controlled by C-H…O H bonding. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application In Synthesis of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Xi; Talley, Samantha J.; Haag, James V.; Spiering, Glenn A.; Liu, Boer; Drummey, Kevin J.; Murayama, Mitsuhiro; Moore, Robert B.; Long, Timothy E. published the artcile< Doubly Charged ABA Triblock Copolymers: Thermomechanically Robust Physical Network and Hierarchical Microstructures>, Safety of 1-(Chloromethyl)-4-vinylbenzene, the main research area is doubly charged triblock copolymer synthesis thermomechanically robust network microstructure.

This manuscript describes the structure-property-morphol. relationships of doubly charged 1,4-diazabicyclo[2.2.2]octane (DABCO) salt-containing ABA triblock ionomers. The triblock copolymers consist a soft poly(Bu acrylate) (PnBA) central block and two external styrenic hard blocks bearing amphiphilic pendant C18-alkyl groups and doubly charged salt units. Surprisingly, the DABCO salt-containing ABA block copolymers preserved the thermomech. integrity until degradation, which indicated the formation of a reinforcing phys. network compared to the corresponding doubly charged random copolymers and singly charged block copolymer analogs. Small-angle X-ray scattering data revealed that the DABCO-based ABA block copolymers self-assembled into highly ordered hierarchical microstructures, in which the soft and hard domain of the block copolymers phase-separated into highly ordered lamellar morphologies. Moreover, a secondary structure that originated from the ordering of the amphiphilic pendant groups formed within the lamellar hard domain. The interesting thermal, thermomech., and morphol. properties of doubly charged ionic block copolymers open promising avenues for the synthesis of novel thermoplastic elastomers.

Macromolecules (Washington, DC, United States) published new progress about Amphiphiles. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Safety of 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics