Tag: M.W=150-200

Gensini, Martina; Altamura, Maria; Dimoulas, Tula; Fedi, Valentina; Giannotti, Danilo; Giuliani, Sandro; Guidi, Antonio; Harmat, Nicholas J. S.; Meini, Stefania; Nannicini, Rossano; Pasqui, Franco; Tramontana, Manuela; Triolo, Antonio; Maggi, Carlo Alberto published the artcile< Modulation on C- and N-Terminal Moieties of a Series of Potent and Selective Linear Tachykinin NK2 Receptor Antagonists>, Name: 4-Chloro-2-methoxybenzaldehyde, the main research area is tachykinin NK2 receptor antagonist preparation structure activity.

Herein we describe the synthesis of a series of new potent tachykinin NK2 receptor antagonists by the modulation of the C- and N-terminal moieties of ibodutant (MEN 15596, 1). The N-terminal benzo[b]thiophene ring was replaced by different substituted naphthalenes and benzofurans, while further modifications were evaluated at the C-terminal tetrahydropyran moiety. Most compounds demonstrated a high affinity for the human NK2 receptor and high in vitro antagonist potency, indicating that a wide range of substituents at both termini can be incorporated in the mol. without detrimental effects on the interactions with the NK2 receptor. Selected compounds were tested in vivo confirming their activity as NK2 antagonists. In particular, after both iv and id administration to guinea pig, compound 61 b was able to antagonize NK2-induced colonic contractions with a potency and duration-of-action fully comparable to the reference compound 1 (MEN 15596, ibodutant).

ChemMedChem published new progress about Colon (contractions). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Name: 4-Chloro-2-methoxybenzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hoffmann, Maxi; Iacob, Ciprian; Kaysan, Gina; Simmler, Mira; Nirschl, Hermann; Guthausen, Gisela; Wilhelm, Manfred published the artcile< Charge Transport and Glassy Dynamics in Blends Based on 1-Butyl-3-vinylbenzylimidazolium Bis(trifluoromethanesulfonyl)imide Ionic Liquid and the Corresponding Polymer>, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene, the main research area is butyl vinylbenzylimidazolium bistrifluoromethanesulfonyl imide ionic liquid polymer glassy dynamic; PFG-NMR; broadband dielectric spectroscopy; charge transport; imidazolium; ionic liquid blends; ionic liquids; rheology.

Charge transport, diffusion properties, and glassy dynamics of blends of imidazolium-based ionic liquid (IL) and the corresponding polymer (polyIL) were examined by Pulsed-Field-Gradient NMR (PFG-NMR) and rheol. coupled with broadband dielec. spectroscopy (rheo-BDS). We found that the mech. storage modulus (G’) increases with an increasing amount of polyIL and G’ is a factor of 10,000 higher for the polyIL compared to the monomer (GIL’ = 7.5 Pa at 100 rad s-1 and 298 K). Furthermore, the ionic conductivity (σ0) of the IL is a factor 1000 higher than its value for the polymerized monomer with 3.4×10-4 S cm-1 at 298 K. Addnl., we found the Haven Ratio (HR) obtained through PFG-NMR and BDS measurements to be constant around a value of 1.4 for the IL and blends with 30 weight% and 70 weight% polyIL. These results show that blending of the components does not have a strong impact on the charge transport compared to the charge transport in the pure IL at room temperature, but blending results in substantial modifications of the mech. properties. Furthermore, it is highlighted that the increase in σ0 might be attributed to the addition of a more mobile phase, which also possibly reduces ion-ion correlations in the polyIL.

Polymers (Basel, Switzerland) published new progress about Dielectric constant. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Klepp, Julian; Podversnik, Harald; Puschnig, Johannes; Wallace, Andrew; Greatrex, Ben W. published the artcile< Diastereoselective sulfa-Michael reactions controlled by a biomass-derived chiral auxiliary>, HPLC of Formula: 17082-09-6, the main research area is dioxabicyclo octanyl phenylpropenoate preparation thiophenol sulfa Michael addition; propanoate dioxabicyclo octanyl diphenyl diastereoselective green preparation.

A family of chiral auxiliaries derived from the lignocellulosic biomass pyrolysis product levoglucosenone (LGO) was screened in the sulfa-Michael reaction. When promoted by inorganic bases with potassium counterions, the auxiliary with geminal benzyl substituents showed diastereoselectivity up to 90:10 for a broad range of α,β-unsaturated esters.

Tetrahedron published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tao, Zhihua; Li, Yuanxun; Peng, Yi Xiao; Su, Hua; Han, Likun; Liu, Guanting published the artcile< Electrochemical studies of prothioconazole as a novel corrosion inhibitor for copper in acidic solutions>, Application In Synthesis of 611-19-8, the main research area is prothioconazole copper corrosion current density electrochem impedance.

Prothioconazole is a fungicide that has a wide number of applications in agriculture, and it can ensure the safety of crops, users, and the environment. Prothioconazole, as a suppressor of copper dissolution in 0.5 M H2SO4 solution, has been evaluated using electrochem. experiments, weight loss tests, quantum chem. calculations, and SEM (SEM). The electrochem. test results showed that prothioconazole was an excellent inhibitor, and the anticorrosion ability increased with the inhibitor concentration The interaction of prothioconazole with copper is a spontaneous adsorption process accompanied by typical chemisorption. The number of water mols. (X) displaced by one prothioconazole mol. was obtained using diverse substitutional adsorption models based on electrochem. impedance spectroscopy (EIS) data. In addition, the Fukui functions indicate that the triazole and benzene rings and the -C=S atoms were the main active sites for the adsorption process.

RSC Advances published new progress about Adsorption. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Application In Synthesis of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shen, Yao-Bin; Zhao, Jian-Qiang; Ge, Zhen-Zhen; Wang, Zhen-Hua; You, Yong; Zhou, Ming-Qiang; Yuan, Wei-Cheng published the artcile< HFIP-promoted intramolecular dearomative annulation of pyridylacetate derivatives to access functionalized 3,4-dihydroquinolizin-2-ones>, Application of C9H7ClO, the main research area is hydroxy nitropyridinylalkadiene hexafluoroisopropanol intramol dearomative annulation; aryl quinolizine preparation.

HFIP-promoted transition metal-free intramol. dearomative annulation reaction of 2-pyridylacetate derivatives was successfully developed under mild conditions, affording structurally diverse substituted 3,4-dihydroquinolizin-2-ones decorated with a range of functional groups in moderate to good yields. The key to the success of this reaction was the existence of the substrates 2-pyridylacetate derivatives in complete enol forms as well as the utilization of HFIP as the solvent.

Tetrahedron published new progress about 1,3-Alkadienes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yi; Shang, Jia-Qi; Wang, Xiang-Xiang; Xia, Wen-Jin; Yang, Tao; Xin, Yangchun; Li, Ya-Min published the artcile< Copper-Catalyzed Decarboxylative Oxyalkylation of Alkynyl Carboxylic Acids: Synthesis of γ-Diketones and γ-Ketonitriles>, Synthetic Route of 3240-10-6, the main research area is arylalkynylcarboxylic acid ketone nitrile decarboxylative oxyalkylation; diketone preparation; ketonitrile preparation; copper decarboxylative oxyalkylation catalyst.

A copper-catalyzed decarboxylative oxyalkylation of alkynylcarboxylic acids with ketones and alkylnitriles via direct C(sp3)-H bond functionalization to construct new C-C bonds and C-O double bonds was developed. This transformation is featured by wide functional group compatibility and the use of readily available reagents, thus affording a general approach to γ-diketones and γ-ketonitriles. A possible mechanism is proposed.

Organic Letters published new progress about Alkylation catalysts (decarboxylative oxy-). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Synthetic Route of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verbicky, John W. Jr.; Williams, Louella published the artcile< Remarkably selective chlorination of phthalic anhydride and its monochlorinated derivatives>, SDS of cas: 118-45-6, the main research area is phthalic anhydride chlorination; chlorophthalic anhydride chlorination.

The vapor-phase chlorination of phthalic anhydride (I), 4-chlorophthalic anhydride (II), and 3-chlorophthalic acid (III) at 390° to 600° is highly selective. Chlorination of I at 390°-450° gave high yields of monochlorinated products accompanied by only small amounts of dichlorination with a high degree of regioselectivity favoring the formation of II. Chlorination of III by this method has provide the first direct synthesis of 3,5-dichlorophthalic anhydride from I via chlorination.

Journal of Organic Chemistry published new progress about Chlorination. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, SDS of cas: 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Hua; Gao, Meng-Qi; Chen, Yan; Wang, Yu-Xia; Zhu, Xiao-Lei; Yang, Guang-Fu published the artcile< Discovery of Pyrazine-Carboxamide-Diphenyl-Ethers as Novel Succinate Dehydrogenase Inhibitors via Fragment Recombination>, Product Details of C7H4ClF3O, the main research area is succinate dehydrogenase inhibitor optimization drug design; diphenyl-ether; fragment; fungicide; molecular docking; succinate dehydrogenase.

The discovery of novel succinate dehydrogenase inhibitors (SDHIs) has attracted great attention worldwide. Herein, a fragment recombination strategy was proposed to design new SDHIs by understanding the ligand-receptor interaction mechanism of SDHIs. Three fragments, pyrazine from pyraziflumid, diphenyl-ether from flubeneteram, and a prolonged amide linker from pydiflumetofen and fluopyram, were identified and recombined to produce a pyrazine-carboxamide-diphenyl-ether scaffold as a new SDHI. After substituent optimization, compound 6y was successfully identified with good inhibitory activity against porcine SDH, which was about 2-fold more potent than pyraziflumid. Furthermore, compound 6y exhibited 95% and 80% inhibitory rates against soybean gray mold and wheat powdery mildew at a dosage of 100 mg/L in vivo assay, resp. The results of the present work showed that the pyrazine-carboxamide-diphenyl-ether scaffold could be used as a new starting point for the discovery of new SDHIs.

Journal of Agricultural and Food Chemistry published new progress about Binding energy. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Product Details of C7H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Akutsu, Hiroshi; Nakashima, Kosuke; Hirashima, Shin-ichi; Matsumoto, Hikari; Koseki, Yuji; Miura, Tsuyoshi published the artcile< Highly efficient asymmetric conjugate addition of 5-benzylfurfurals to nitroalkenes using a thiourea organocatalyst>, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is nitroalkene benzyl furfural thiourea organocatalyst Michael reaction; phenyl nitropropyl furancarbaldehyde enantioselective diastereoselective regioselective preparation.

The asym. direct bisvinylogous conjugate addition of 5-benzylfurfural derivatives to nitroalkenes using a thiourea organocatalyst resulted in a corresponding ε-regioselective addition products in high yields and up to 95% enantiomeric excess.

Tetrahedron published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anderson, Marc O.; Sherrill, John; Madrid, Peter B.; Liou, Ally P.; Weisman, Jennifer L.; DeRisi, Joseph L.; Guy, R. Kiplin published the artcile< Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum>, SDS of cas: 22717-55-1, the main research area is synthesis antimalarial aminoacridine derivative.

A parallel synthetic strategy to the 9-aminoacridine scaffold of the classical antimalarial drug quinacrine is presented. The method features a new route to 9-chloroacridines that utilizes triflates of salicylic acid derivatives, which are com. available in a variety of substitution patterns. The route allows ready variation of the 2 diversity elements present in this class of mols.: the tricyclic aromatic heterocyclic core, and the disubstituted diamine side-chain. In this study, a library of 175 compounds was designed, although only 93 of the final products had purities acceptable for screening. Impurity was generally due to incomplete removal of 9-acridones, a degradation product of the 9-chloroacridine synthetic intermediates. The library was screened against two strains of P. falciparum, including a model of the drug-resistant parasite, and 6 novel compounds were found to have IC50 values in the low nanomolar range.

Bioorganic & Medicinal Chemistry published new progress about Antimalarials. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics