Tag: M.W=150-200

Herbain, Maurice published the artcileA biologic test of antilipemic heparin derivatives, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Clinica Chimica Acta (1960), 204-7, database is CAplus and MEDLINE.

cf. Velluz, et al., CA 53, 10555g, 19898g. Rabbits were fed a diet containing saturated fats and 200 mg./kg./day cholesterol for a period of 30 days. Those animals in which serum total cholesterol levels reached 8 g./l. or more were selected for testing. The ratio of β-lipoprotein lipide/total lipide exceeded 0.70 compared to a control value of 0.35. After removal of cholesterol from the diet for 24 hrs., 5 mg./kg. heparin or other antilipemic agent was injected intravenously and total and β-lipoprotein lipides (the latter were precipitated with dextran) were estimated at 6, 10, and 14 hrs. When the test was carried out with N-dimethylbenzoyl-N-desulfoheparin, its antilipemic activity was found to be slower but more intense than that of heparin.

Clinica Chimica Acta published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ren, Jing-Ling published the artcileLimonoids containing a C₁-O-C₂₉ moiety: isolation, structural modification, and antiviral activity, Quality Control of 6313-54-8, the publication is Marine Drugs (2018), 16(11), 434, database is CAplus and MEDLINE.

Five new limonoids named thaigranatins A-E (1-5), containing a C1-O-C29 moiety, were isolated from seeds of the Thai Xylocarpus granatum, collected at the mangrove swamp of Trang Province, together with the known limonoid, granatumin L (6). The structures of these compounds were established by HR-ESIMS and extensive NMR spectroscopic data. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction anal., conducted with Cu Kα radiation; whereas that of 2 or 6 was established to be the same as that of 1 by the similarity of their electronic CD (ECD) spectra. In view of the marked antiviral activity of 6, its structure was modified via hydrolysis with alk. KOH, esterification with diazomethane and various organic acids, and oximization with hydroxyamine. Finally, 18 derivatives, viz. 7-10, 8a-8i, 9a-9b, and 10a-10c, were obtained. In vitro antiviral activities of these derivatives against human immunodeficiency virus 1 (HIV-1) and influenza A virus (IAV) were evaluated. Most notably, 8i exhibited marked inhibitory activity against HIV-1 with an IC50 value of 15.98 ± 6.87 μM and a CC50 value greater than 100.0 μM; whereas 10b showed significant inhibitory activity against IAV with an IC50 value of 14.02 ± 3.54 μM and a CC50 value greater than 100.0 μM.

Marine Drugs published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ke, Jie published the artcileHexafluoroisopropanol-Enabled Copper-Catalyzed Asymmetric Halogenation of Cyclic Diaryliodoniums for the Synthesis of Axially Chiral 2,2′-Dihalobiaryls, Name: 4-Chloro-2-methylphenylboronic acid, the publication is Organic Letters (2021), 23(2), 329-333, database is CAplus and MEDLINE.

An efficient asym. halogenation of cyclic diaryliodonium salts was demonstrated, which gave access to a wide range of axially chiral 2,2′-dihalobiaryls in good to excellent yields and with excellent enantioselectivities. The use of CuX with chiral bisoxazoline ligand and tetrabutylammonium halides in the unique solvent of hexafluoroisopropanol (HFIP) led to the best results in the process. The axially chiral 2,2′-dihalobiaryls was transformed into a number of enantiopure chiral ligands that was potentially useful in asym. catalysis.

Organic Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Name: 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

de Vasconcelos, Alana published the artcile2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Anti-glioma Activities in C6 and GL261 Cells, Application of 3-Chlorobenzylchloride, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2021), 17(6), 601-610, database is CAplus and MEDLINE.

Thiazolidinediones (TZDs) represent an important class of heterocyclic compounds that have versatile biol. activities, including anticancer activity. Glioma is one of the most common primary brain tumors, and it is responsible for most of the deaths caused by primary brain tumors. In the present work, 2,4-thiazolidinediones were synthesized via a multicomponent microwave one-pot procedure. The cytotoxicity of compounds was analyzed in vitro using rat (C6) and mouse (GL261) glioblastoma cell lines and primary cultures of astrocytes. This study aims to synthesize and characterize 2,4-thiazolidinediones and evaluate their antitumor activity. TZDs were synthesized from three components: 2,4-thiazolidinedione, arene-aldehydes, and aryl chlorides. The reactions were carried out inside a microwave and monitored using thinlayer chromatog. (TLC). Compounds were identified and characterized using gas chromatog. coupled to mass spectrometry (CG-MS) and hydrogen (¹H-NMR) and carbon NMR spectroscopy (¹³C-NMR). The antitumor activity was analyzed using the 3-(4,5- dimethyl)-2,5-diphenyltetrazolium bromide (MTT) reduction test, in which cell viability was verified in the primary cultures of astrocytes and in rat and mouse glioblastoma cells exposed to the synthesized compounds The cytotoxicity of all derivatives was analyzed at the 100 μM concentration, both in astrocytes and in the mouse and rat glioblastoma cell lines. The compounds that showed the best results, 4CI and 4DI, were also tested at concentrations 25, 50, 100, 175, and 250 μM to obtain the IC₅₀. Seventeen TZD derivatives were easily obtained through one-pot reactions in 40 min with yields ranging from 12% to 49%. All compounds were cytotoxic to both glioblastoma cell lines without being toxic to the astrocyte primary cell line at 100 μM, thus demonstrating a selective activity. Compounds 4CI and 4DI showed the best results in the C6 cells: IC₅₀ of 28.51 μM and 54.26 μM, resp. The compounds were not cytotoxic in astrocyte culture, demonstrating selectivity for malignant cells. Changes in both rings are important for anti-glioma activity in the cell lines tested. TZD 4CI had the best anti-glioma activity.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Application of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xiong, Feng published the artcileSynthesis of ortho-Phenolic Sulfilimines via an Intermolecular Sulfur Atom Transfer Cascade Reaction, Application In Synthesis of 209919-30-2, the publication is Organic Letters (2020), 22(10), 3799-3803, database is CAplus and MEDLINE.

A N-H sulfenylation/[2,3]-sigmatropic rearrangement cascade reaction was reported. This mild reaction enabled com. available thiols as the sulfenylation reagent and generated water as the sole byproduct. Moreover, the reaction showed a wide substrate scope and was conducted on a gram scale with excellent reaction efficiency.

Organic Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C10H18O4, Application In Synthesis of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bennett, George Macdonald published the artcileβ,β’-Dichlorodiethyl disulfide, Related Products of chlorides-buliding-blocks, the publication is Journal of the Chemical Society, Transactions (1921), 418-25, database is CAplus.

The behavior of S₂Cl₂ and C₂H₄ has been the subject of some controversy, the issue being whether a monosulfide or a disulfide is formed. Bennett has reinvestigated the reaction at 30-35° and concludes that the liquids are two-phase systems in which the continuous phase is nearly pure S(C₂H₄Cl)₂ and the disperse phase a liquid consisting chiefly of S. The varying behavior on dilution with Et₂O, etc., may be due to different degrees of dispersion. 50 cc. S₂Cl₂ gave 111 g. of a pale amber-colored liquid, d₁₅ 1.373, m. 5-6°; the relative viscosity at 15° was 10.25. which is characteristic of liquid-liquid 2-phase systems. The product b₂₀ 110-20°. The addition of 20 cc. dry Et₂O to 30 cc. of the liquid before distillation produced no separation into 2 phases. 100 cc. Et₂O caused the separation of 4.7 g. of a S-yellow oil, which was impure S. Heating in a stream of dry air for an hr. also caused the separation of S. In each case the m. p. of the sulfide was unaffected. Attempts to prepare the emulsion from the sulfide and S were unsuccessful. SHCH₂CH₂OH (Ann. 124, 257) was prepared by melting 225 g. crystalline Na₂S on the H₂O bath, saturating with H₂S, cooling to 50° and stirring in 70 g. ClCH₂CH₂OH. It b₁₈ 58°, d₄²⁰ 1.1153, n_D²⁰ 1.4443. This was oxidized to β,β’-dichlorodiethyl disulfide C₄H₈Cl₂S₂, by H₂O₂, FeCl₃ or NaBrO, straw-colored oil, b₃₀ 155°, d₄²⁰ 1.3375, (η/η_H2O)₂₀, 6.08. It resembles the monosulfide in many of its properties. Its vesicant action was 1/3 that of the monosulfide. Boiled with PhONa, it yields β,β’-diphenoxydiethyl disulfide, small, silvery plates, m. 96-7°. Na₂S gives S(C₂H₄)₂S. On oxidation it yields C₂H₄O₃ClSNa.H₂O (Ann. 223, 213).

Journal of the Chemical Society, Transactions published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cadogan, J. I. G. published the artcileThe production of 1,4-dialkylpiperazines by the thermal decomposition of 1,1,4,4-tetraalkylpiperazinium salts, COA of Formula: C5H13Cl2N, the publication is Journal of the Chemical Society (1955), 2971-3, database is CAplus.

Several 1,1,4,-4-tetraalkylpiperazinium dihalides were prepared and their pyrolysis products studied. All the dichlorides investigated gave the 1,4-dialkylpiperazine and alkyl chloride in 72-88% yield at atm. pressure. The dibromides under comparable conditions gave lower yields. Et₂NCH₂CH₂Cl.HCl (0.5 mole) added to a vigorously stirred ice-cold mixture of 500 ml. H₂O and 250 ml. Et₂O, treated with solid Na₂CO₃, and the layers separated yielded from the dried (MgSO₄) Et₂O layer a yellow oil which, refluxed with 250 ml. EtOH 3 hrs., gave 80% 1,1,4,4-tetraethylpiperazinium dichloride (I), plates, m. above 300° (from MeOH/acetone). Similarly, MeEtNCH₂CH₂Br.HBr gave 65% 1,4-diethyl-1,4-dimethylpiperazinium dibromide, m. 295° (from aqueous EtOH), and (CH₂Br)₂ with (CH₂NMe₂)₂ in EtOH gave 83% 1,1,4,4-tetramethylpiperazinium dibromide (II), m. above 330° (from aqueous EtOH). Ethylene oxide (40 g.) passed into 101 g. NHPr₂, 20 ml. N H Cl added, and the mixture, which became dark, kept 2 hrs. at 60°, yielded from the organic layer 75% Pr₂NCH₂CH₂OH, b₂₀ 90-2° n_D²⁵ 1.4375, converted into Pr₂NCH₂CH₂Cl.HCl with excess SOCl₂ in dry C₆H₆ at 0°. The free base was isolated and converted as above to 51% 1,1,4,4-tetrapropylpiperazinium dichloride (III), m. 295° (from EtOH/EtOAc). Similarly, ethylene oxide and NHBu₂ gave 68% Bu₂NCH₂CH₂OH, b₁₀ 104°, n_D²⁵ 1.4422, converted to 47% 1,1,4,4-tetrabutylpiperazinium dichloride monohydrate (IV), m. 239° (from aqueous EtOH-EtOAc). Me₂NCH₂CH(OH)Me was converted into Me₂NCH₂CHMeCl.HCl by the method of C.A. 42, 4934i and the latter converted to 65% hexamethylpiperazinium dichloride (V), m. 275° (from EtOH-C₆H₆). The tetraalkylpiperazinium salts were warmed with a free flame until decomposition began, with slight suction maintained to draw the alkyl halides into a cold trap, and the bases collected and fractionated from KOH. In this way were prepared the following 1,4-dialkylpiperazines (alkyl, % yield, b.p./mm., n_D²⁵ and m.p. of: dimethiodide given): Et, 88, 68°/10, 1.4520, 240°; Pr, 80, 84°/10, 1.4514 228°; Bu, 72, 112°/10, 1.4542, 215°; Me, 10., 130°/760, 1.4448, 310°. V gave 87% tetramethylpiperazine, b₁₀ 62, n_D²⁵ 1.4522; monomethiodide, m. 251°.

Journal of the Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, COA of Formula: C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhou, Yan published the artcileRecyclable palladium-catalyzed cyclocarbonylation between benzyl chlorides and salicylic aldehydes towards coumarins, Quality Control of 939-99-1, the publication is Molecular Catalysis (2022), 112404, database is CAplus.

A novel and practical route to coumarin derivatives was developed via the heterogeneous Pd-catalyzed carbonylative reaction and subsequent intramol. condensation process starting from com. easily available benzyl chlorides and salicylic aldehydes. Reactions were performed in the existence of 2 mol% of an SBA-15-immobilized bidentate phosphine palladium complex [SBA-15-P,P-PdCl2] in dioxane at 110°C with Et₃N as base under 10 bar of CO to afford a wide range of coumarin derivatives mostly with good to high yields. Importantly, this new heterogenized palladium complex was easy to recover via filtration of the reaction mixture, and was recyclable up to 8 times without apparent drop in its catalytic performance.

Molecular Catalysis published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C12H17NS2, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yang-hua published the artcileDevelopment of QSAR model for predicting mutagenicity of aromatic compounds, Application of 3-Chloro-4-fluoronitrobenzene, the publication is Chinese Journal of Structural Chemistry (2015), 34(3), 324-334, database is CAplus.

Quant. structure-activity relationship (QSAR) model was developed for predicting the mutagenicity of aromatic compounds The log revertants data of S. typhimurium TA98 strain from Ames test have been collected. 225 Aromatic compounds were randomly divided into the training set with 186 mols. and test set with 39 mols. Multiple linear regression (MLR) anal. was used to select six descriptors from thousands of descriptors calculated by semi-empirical AM1 and E-dragon methods. The final QSAR model with six descriptors was internal and external validated. In addition, to validate the utility of our QSAR model for the chem. evaluation, three aromatic compounds were taken to test the predictive ability and reliability of the model exptl. The compounds selected for testing were not based on the predictions, thus spanning the range of predicted probabilities. The subsequently generated results of the Ames test were in good correspondence with the predictions and confirmed this approach as a useful means of predicting likely mutagenic risk of aromatic compounds

Chinese Journal of Structural Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Xiao-Long published the artcileQSTR studies on acute toxicity and mutagenicity of halogenated benzenes, Computed Properties of 350-30-1, the publication is Asian Journal of Chemistry (2014), 26(9), 2707-2710, database is CAplus.

In this paper, a quant. structure toxicity relationship study was performed for the prediction of the acute toxicity and mutagenicity of halogenated benzenes. The mol. descriptors of halogenated benzenes have been calculated with semi-empirical AM1 and E-dragon methods and both quant. structure toxicity relationship models for mice via the oral LD₅₀ model and the S. typhimurium (TA98 + S9) mutagenic model of halogenated benzenes were developed using multiple linear regression (MLR) anal. The validation results obtained from the test set indicate that the proposed models are robust and satisfactory.

Asian Journal of Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C9H8BNO2, Computed Properties of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics