Tag: M.W=150-200

Carrillo-Arcos, Ulises A.; Porcel, Susana published the artcile< Gold promoted arylative cyclization of alkynoic acids with arenediazonium salts>, SDS of cas: 22717-55-1, the main research area is benzoheterocyclic compound preparation; alkynoic acid arenediazonium salt arylative cyclization.

Alkynoic acids derived from salicylic acid and analogs undergo arylative cyclization with arenediazonium salts promoted by gold in the absence of external ligands. The reaction is thermally induced and proceeds even in the absence of light. A difference in regioselectivity has been found compared with that observed in the cycloisomerization process of the same type of compounds

Organic & Biomolecular Chemistry published new progress about Carboxylic acids, alkynyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ban, Tao; Vu, Huu-Manh; Zhang, Jing; Yong, Jia-Yuan; Liu, Qiong; Li, Xu-Qin published the artcile< Rhodium-Catalyzed Azine-Directed C-H Amidation with N-Methoxyamides>, Category: chlorides-buliding-blocks, the main research area is hydrazinylidene amide preparation; azine methoxyamide amidation rhodium catalyst.

Using N-methoxyamide reagents R1C(O)NHOCH3 (R1 = Ph, cyclohexyl, naphth-1-yl, thiophen-2-yl, etc.) as an amide source, C-H amidation was realized at the ortho position of azine under the action of rhodium and boric acid. The method has mild reaction conditions, high at. utilization, excellent yield, and wide adaptability to amidation reagents (both aromatic amides and fatty amides are applicable). Amide-substituted ketones can be obtained by a simple treatment and further transformed into bioactive substances. This provides a good supplement for the C-H bond amidation of aromatic rings.

Journal of Organic Chemistry published new progress about Amidation. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Montgomery, Justin I.; Toogood, Peter L.; Hutchings, Kim M.; Liu, Jia; Narasimhan, Lakshmi; Braden, Timothy; Dermyer, Michael R.; Kulynych, Angela D.; Smith, Yvonne D.; Warmus, Joseph S.; Taylor, Clarke published the artcile< Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase>, Name: Methyl 3-chloro-4-hydroxybenzoate, the main research area is ether benzyl aryl preparation bacterial phenylalanyl tRNA synthetase inhibitor.

A series of benzyl aryl ethers I (X = CH, N; R1 = 3-Cl, 4-Cl, 3,4-F2, 3,5-F2; R2 = H, Cl, Me; Y = CO2Me, SO2NMeCH2CH2NEt2, CONHCMeCH2OH, 1,3,4-oxadiazol-2-yl, etc.) that displays potent inhibition of bacterial phenylalanyl-tRNA synthetase is described. The synthesis, SAR, and select ADMET data are provided.

Bioorganic & Medicinal Chemistry Letters published new progress about Alkyl aryl ethers Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 3-chloro-4-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Jian-Cheng; Kan, Xuan; Shang, Jin-Yan; Qiao, Hua; Dong, Yu-Bin published the artcile< Catalytic Asymmetric Synthesis of Chiral Covalent Organic Frameworks from Prochiral Monomers for Heterogeneous Asymmetric Catalysis>, Electric Literature of 5153-70-8, the main research area is catalytic asym chiral covalent organic framework prochiral monomer catalysis.

Direct synthesis, postsynthetic modification, and chiral induction have been recognized as three powerful methods to synthesize chiral covalent organic frameworks (CCOFs). However, catalytic asym. methodol., as the most important and effective synthetic approach to access chiral organics, has not been enabled for CCOFs synthesis thus far. Herein we report, for the first time, the construction of CCOFs from prochiral monomers via catalytic asym. polymerization The obtained propargylamine-linked CCOFs can be the highly reusable chiral catalysts to promote asym. Michael addition reactions. The concept of catalytic asym. polymerization might open a new route for constructing the CCOFs that are not possible with the existing CCOF synthetic methods.

Journal of the American Chemical Society published new progress about Asymmetric catalysis. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Electric Literature of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Muliang; Yuan, Xiang-Ai; Zhu, Chengjian; Xie, Jin published the artcile< Deoxygenative Deuteration of Carboxylic Acids with D2O>, Application of C10H9ClO2, the main research area is deuterated aryl alkyl aldehyde chemoselective preparation; chemoselective photochem reduction deuteration aryl alkyl aldehyde iridium photocatalyst; phenylphosphine phenylphosphinite oxygen acceptor chemoselective deuteration reduction aldehyde; aldehydes; carboxylic acids; deoxygenation; deuteration; synergistic catalysis.

C1-Deuterated aryl and alkyl aldehydes such as 4-PhC6H4CDO and PhCH2CH2CDO were prepared chemoselectively with 58-96% deuterium incorporation by reduction of aromatic and aliphatic carboxylic acids using iridium photocatalysts, either Ph3P or Ph2OEt as an oxygen acceptor, 2,4,6-i-Pr3C6H2SH as a hydrogen atom donor, and using D2O as an inexpensive deuterium source. The method was used for the preparation of deuterated derivatives of pharmaceuticals and natural products containing aromatic carboxylic acid moieties. The method was also used for chemoselective reduction of aryl and alkyl carboxylic acids to the corresponding aldehydes using H2O as a hydrogen atom source.

Angewandte Chemie, International Edition published new progress about Acidity. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Application of C10H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bu, Ran; Zhang, Lin; Gao, Lu-Lu; Sun, Weng-Jie; Yang, Shuai-Liang; Gao, En-Qing published the artcile< Copper(I)-modified covalent organic framework for CO2 insertion to terminal alkynes>, Electric Literature of 3240-10-6, the main research area is carbon dioxide insertion alkyne catalyzed copper covalent organic framework.

The carboxylation of terminal alkynes with CO2 is an attractive route for CO2 fixation and conversion, and various homogeneous Cu(I) catalysts were explored for the reaction. However, it is still a challenge to develop efficient heterogeneous catalysts for the conversion under mild conditions. Considering that covalent organic frameworks (COFs) are emerging as versatile platforms for the design of functional materials, the authors developed a TpBpy-supported Cu(I) catalyst, where TpBpy is a stable imine-type porous COF furnished with rich N,N- and N,O-chelating sites for Cu(I) immobilization. The hybrid material can efficiently catalyze the conversion of CO2 and terminal alkynes to propiolic acids under relatively mild conditions (1 atm CO2, 60°). The catalytic activity arises from the synergy between the organic framework of TpBpy and the Cu(I) sites. Not merely serving as a porous support to afford isolated and accessible Cu(I) sites, the organic framework itself has its own catalytic activity through the polar and basic N and O functional sites, which could activate the C-H bond and facilitate CO2 absorption. The framework also serves as a giant ligand to shift the reversible Cu(I)-catalyzed process in favor of carboxylation. The catalyst shows somewhat reduced activity after reused for three cycles owing to the oxidation of Cu(I) to Cu(II), but it can be easily regenerated by treating with KI.

Molecular Catalysis published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Electric Literature of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Profft, Elmar; John, Peter published the artcile< Studies on thiophene. XII>, Recommanded Product: 4,5-Dichlorothiophene-2-carboxylic acid, the main research area is .

The transformation of 2,3-dichloro-5-(chloromethyl)thiophene (I) to 2,3-dichlorothiophene-5-acetonitrile (II) and 2,3-dichlorothiophene-5-acetic acid (III) was studied. As II was not formed from I + KCN in Me2CO, the reaction was carried out in EtOH-H2O. In 1 hr. 67 g. I was added to a boiling solution of 31 g. KCN in 50 cc. H2O and 20 cc. EtOH, and the mixture boiled for 5 hrs. and cooled, and 200 cc. H2O was added. The aqueous phase was separated and extracted twice with Et2O, which was combined with the oily product, dried over Na2SO4, and distilled at 99-104°/1 mm. Washing with cold petr. ether yielded 10.2 g. II, yellow prisms, m. 45°. Saponification of I was best done by acidic hydrolysis in MeOH. A slow current of dry HCl was led through 10 g. II in 30 cc. MeOH. A solid intermediate was formed. After saturation with HCl, 30 cc. H2O was added, whereupon the mixture was kept 3 days. A yellowish oil separated (III Me ester), b16 124-8°, from which III was obtained with 20% aqueous KOH and purified from NaHCO3 solution to give 1.5 g., m. 106° (petr. ether). Hydrogenation of 5 g. II with 1.3 g. LiAlH4 in 20 cc. Et2O yielded 2,3-dichloro-5-(2-aminoethyl)thiophene. As this compound was unstable, it was isolated as 1.8 g. benzoyl derivative, m. 120°. The high reactivity of I was shown by adding 44 g. I to 5 g. Na and 64 g. CH2(CO2Et)2 in 150 cc. EtOH. The Et ester of bis(2,3-dichlorothienyl)malonic acid (IV) (42 g.), m. 121°, was obtained. Even when smaller amounts of CH2(CO2Et)2 were used, no monosubstituted ester was obtained. Saponification of the Et ester yielded the acid (IV), C13H8Cl4O4S2, m. 171°, which was characterized as the dichloride, m. 137°, diamide m. 285°, di(ethylamide), m. 232° and di(butylamide), m. 221°. At 180° IV decarboxylated, to give 82% β,β’-bis(2,3-dichlorothienyl)isobutyric acid, m. 117°, which was characterized by the amide, m. 144°, butylamide, m. 128°, anilide, m. 199° and 2-naphthylamide, m. 183°. I (2 g.) was kept 6 days with 1.05 g. diethanolamine in 15 cc. Et2O. H2O was added and the acidified solution extracted with Et2O, made alk., and extracted again. The Et2O solution was dried with Na2SO4 and 0.8 g. N-(2,3-dichlorothenyl)diethanolamine-HCl precipitated with dry HCl, m. 138°. From the residue N,O-bis(2,3-dichlorothienyl)diethanolamine-HCl was isolated, m. 163°. In the same way N,N-bis(2,3-dichlorothenyl)ethanolamine-HCl, m. 202°, was obtained from 2 g. I and 1 g. ethanolamine in 15 cc. Et2O; in this reaction no O-substituted compounds could be isolated. 2,3-Dichloro-5-thiophenealdehyde was transformed by a Cannizzaro reaction into the alcohol and 2,3-dichlorothiophenecarboxylic acid (V). V was characterized by its amide, m. 165°, butylamide, m. 83°, ethanolamide, m. 153°, anilide m. 181°, 2-naphthylamide, m. 191° as well as the Me ester, m. 60°.

Journal fuer Praktische Chemie (Leipzig) published new progress about 31166-29-7. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, Recommanded Product: 4,5-Dichlorothiophene-2-carboxylic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kuehl, Valerie A.; Duong, Phuoc H. H.; Sadrieva, Deana; Amin, Samrat A.; She, Yuqi; Li-Oakey, Katie D.; Yarger, Jeffery L.; Parkinson, Bruce A.; Hoberg, John O. published the artcile< Synthesis, Postsynthetic Modifications, and Applications of the First Quinoxaline-Based Covalent Organic Framework>, Recommanded Product: 4,5-Dimethoxybenzene-1,2-diamine, the main research area is postsynthetic first quinoxaline covalent organic framework; COF; covalent organic framework; membrane filtration; modifiable materials; nanoporous; quinoxaline.

We report a new synthetic protocol for preparing highly ordered two-dimensional nanoporous covalent organic frameworks (2D-COFs) based on a quinoxaline backbone. The quinoxaline framework represents a new type of COF that enables postsynthetic modification by placing two different chem. functionalities within the nanopores including layer-to-layer crosslinking. We also demonstrate that membranes fabricated using this new 2D-COF perform highly selective separations resulting in dramatic performance enhancement post crosslinking.

ACS Applied Materials & Interfaces published new progress about Covalent organic frameworks. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Recommanded Product: 4,5-Dimethoxybenzene-1,2-diamine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aulakh, Manpreet Kaur; Pal, Bonamali; Vaishnav, Alisha; Prakash, N. Tejo published the artcile< Biosynthesized monodispersed spherical Se co-catalyst nanoparticles impregnated over ZnO for 4-chloroguaiacol degradation under solar irradiations>, Product Details of C7H7ClO2, the main research area is chloroguaiacol selenium zinc oxide cocatalyst nanoparticle degradation solar irradiation.

The present study outlines the importance of biosynthesized selenium (Se) nanoparticles as co-catalyst for enhanced photoactivity of Se@ZnO nanocomposites under solar irradiations. The selenium-rich Bacillus sp. bacteria were isolated and used to synthesize extracellular Se nanoparticles (Se NPs), and structural characterization was carried out using various techniques. Different amounts (0.5-2 wt%) of Se NPs were loaded over ZnO followed by calcination at 200° C for 120 min to form Se@ZnO nanocomposites. The optical absorption of Se@ZnO showed a slight red shift as compared to bare ZnO and a new broadband in 500-700 nm range appeared with increasing the amount of Se. HR-TEM anal. showed spherical shaped, highly monodispersed Se NPs with size less than 100 nm. Further, 1 wt% Se@ZnO nanocomposites exhibited the highest degradation efficiency (93%) of 4-chloroguaiacol (4-CG) as compared to bare ZnO (8%) under natural sunlight. The reaction followed first-order kinetics with an apparent rate constant k = 0.16 min-1. Moreover, the environmental applicability of the synthesized Se@ZnO was also tested for real pharmaceutical industrial effluent degradation It was observed that the COD (COD) level decreased from 1140 mgL-1 to 500 mgL-1 after 240 min of sunlight exposure.

Journal of Environmental Chemical Engineering published new progress about Absorption spectra. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Product Details of C7H7ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sireesha, Reddymasu; Sreenivasulu, Reddymasu; Chandrasekhar, Choragudi; Jadav, Surender Singh; Pavani, Y.; Rao, Mandava Venkata Basaveswara; Subbarao, Mannam published the artcile< Design, synthesis, anti-cancer evaluation and binding mode studies of benzimidazole/benzoxazole linked β-carboline derivatives>, Formula: C8H12N2O2, the main research area is benzazolylthiazolyl carboline preparation antitumor SAR docking.

A new series of benzimidazole/benzoxazole linked β-carbolines I [X = N, O; R = H, 5,6-di-Me, 5,6-di-Br, etc.] were rationally designed and synthesized by combining two different anti-cancer fragments. The new hybrid β-carbolines I were subjected to anti-cancer screening against four different human cancer cell lines such as MCF-7 (breast), A549 (lung), Colo-205 (colon) and A2780 (ovarian) by using standard MTT assay. These hybrid β-carbolines I exhibited significant and high fold anti-cancer activity against MCF-7 cell lines than reference standard They were proved to be effective against A549 and Colo-205 cell lines. Further, compound I [X = N, R = 5,6-di-MeO, 5,6-di-Me; X = O, R = 5,6-di-Me] exhibited maximum anti-cancer activity among these hybrid β-carbolines. Later, all of the hybrid β-carbolines I were subjected to mol. interaction anal. against a few selected kinase targets such as cdc-like kinase (CLK-1 to CLK-4), epidermal growth factor reductase (EGFR) kinase, protein (ATR) kinase along with APC-Asef interface. The violin plot of binding energies of compounds I suggested them as good kinase binders. Result interpretation reported that hybrid β-carbolines I as promising CLK binders. The anti-cancer data of new hybrid β-carbolines I against MCF-7 cell lines were agreement with parent β-carboline skeleton.

Journal of Molecular Structure published new progress about Amino phenols Role: RCT (Reactant), RACT (Reactant or Reagent). 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Formula: C8H12N2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics