Tag: M.W=150-200

Sun, Jingjing; Chen, Yichao; Xu, Jieni; Song, Xiangping; Wan, Zhuoya; Du, Yuqian; Ma, Weina; Li, Xizhen; Zhang, Lin; Li, Song published the artcile< High loading of hydrophobic and hydrophilic agents via small immunostimulatory carrier for enhanced tumor penetration and combinational therapy>, Application of C9H9Cl, the main research area is enhanced tumor penetration combinational therapy small immunostimulatorycarrier hydrophobic hydrophilicagent; T-cell immune response; high loading capacity; patient derived xenograft (PDX); tumor penetration.

Development of small-sized nanoformulations for effective tumor penetration, particularly for those tumors with dense stroma is a major challenge in cancer nanomedicine. It is even more challenging to achieve effective co-loading of both hydrophobic and hydrophilic anticancer agents through a small-sized nanocarrier. In this work, we designed a novel redox-responsive gemcitabine (GEM)-conjugated polymer POEG-co-PVDGEM (PGEM) as a small-sized nanocarrier to co-deliver hydrophilic GEM and hydrophobic paclitaxel (PTX). The in vitro physicochem. and biol. properties of PTX/PGEM NPs were characterized. The efficiency of the PGEM carrier in selective codelivery of GEM and PTX in two murine tumor models as well as a patient derived xenograft model (PDX) was also evaluated. In addition, we investigated the changes in tumor immune microenvironment after treatment with PTX/PGEM nanoparticles. We discovered that GEM conjugation could significantly decrease the nanoparticle size from 160 nm to 13 nm. Moreover, different from most reported GEM-conjugated polymers, PGEM polymer could serve as a prodrug carrier to load a wide variety of hydrophobic agents with high drug loading capacity and excellent stability. More importantly, our strategy could be extended to various nucleotides-based drugs such as azacytidine, decitabine and cytarabine, suggesting a new platform for co-delivery of various first line hydrophilic and hydrophobic anticancer agents. Imaging showed that our small-sized carrier was much more effective in tumor accumulation and penetration compared to the relatively large-sized drug carrier. The PGEM prodrug-based carrier not only well retained the pharmacol. activity of GEM, but also boosted T-cell immune response. Furthermore, delivery of PTX via PGEM led to significantly improved antitumor activity in several murine cancer models and a PDX model of colon cancer. This work not only provided a small-sized carrier platform that was able to load multiple hydrophilic and hydrophobic drugs with high loading capacity, but also provided an effective regimen for enhanced tumor penetration and improved anti-tumor immunity.

Theranostics published new progress about Antitumor agents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application of C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhu, Xiao-Lei; Zhang, Rui; Wu, Qiong-You; Song, Yong-Jun; Wang, Yu-Xia; Yang, Jing-Fang; Yang, Guang-Fu published the artcile< Natural product neopeltolide as a cytochrome bc1 complex inhibitor: Mechanism of action and structural modification>, Application In Synthesis of 35852-58-5, the main research area is neopeltolide cytochrome bc1 inhibitor mechanism structure modification fungicide discovery; bc1 complex; inhibitor; molecular design; natural product; neopeltolide.

The marine natural product neopeltolide was isolated from a deep-water sponge specimen of the family Neopeltidae. Neopeltolide has been proven to be a new type of inhibitor of the cytochrome bc1 complex in the mitochondrial respiration chain. However, its detailed inhibition mechanism has remained unknown. In addition, neopeltolide is difficult to synthesize because of its very complex chem. structure. In the present work, the binding mode of neopeltolide was determined for the first time by integrating mol. docking, mol. dynamics simulations, and mol. mechanics Poisson-Boltzmann surface area calculations, which showed that neopeltolide is a Qo site inhibitor of the bc1 complex. Then, according to guidance via inhibitor-protein interaction anal., structural modification was carried out with the aim to simplify the chem. structure of neopeltolide, leading to the synthesis of a series of new neopeltolide derivatives with much simpler chem. structures. The calculated binding energies (ΔGcal) of the newly synthesized analogs correlated very well (R2 = 0.90) with their exptl. binding free energies (ΔGexp), which confirmed that the computational protocol was reliable. Compound 45, bearing a di-Ph ether fragment, was successfully designed and synthesized as the most potent candidate (IC50 = 12 nM) against porcine succinate cytochrome c reductase. The mol. modeling results indicate that compound 45 formed a π-π interaction with Phe274 and two hydrogen bonds with Glu271 and His161. The present work provides a new starting point for future fungicide discovery to overcome the resistance that the existing bc1 complex inhibitors are facing.

Journal of Agricultural and Food Chemistry published new progress about Free energy of binding. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Application In Synthesis of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sousa-Brito, Hellida Larissa; Arruda-Barbosa, Loeste; Vasconcelos-Silva, Alfredo Augusto; Gonzaga-Costa, Karoline; Duarte, Gloria Pinto; Borges, Rosivaldo Santos; Magalhaes, Pedro Jorge Caldas; Lahlou, Saad published the artcile< Vasorelaxant effect of trans-4-chloro-β-nitrostyrene, a synthetic nitroderivative, in rat thoracic aorta>, Product Details of C8H6ClNO2, the main research area is trans chloro nitrostyrene vasorelaxant thoracic aorta structure activity relationship; IP3 receptors; calcium influx; endothelium-independent vasorelaxation; ryanodine-sensitive Ca2+ channels; trans-4-chloro-β-nitrostyrene.

Previously, we showed that 1-nitro-2-phenylethene, a nitrostyrene derivative of 1-nitro-2-phenylethane, induced vasorelaxant effects in rat aorta preparations Here, we studied mechanisms underlying the vasorelaxant effects of its structural analog, trans-4-chloro-β-nitrostyrene (T4CN), in rat aortic rings. Increasing concentrations of T4CN (0.54-544.69μM) fully and similarly relaxed contractions induced by phenylephrine (PHE, 1μM) or KCl (60 mM) in endothelium-intact aortic rings with IC50 values of 66.74 [59.66-89.04] and 79.41 [39.92-158.01] μM, resp. In both electromech. and pharmacomech. couplings, the vasorelaxant effects of T4CN remained unaltered by endothelium removal, as evidenced by the IC50 values (108.35 [56.49-207.78] and 65.92 [39.72-109.40] μM, resp.). Pretreatment of endothelium-intact preparations with L-NAME, ODQ, glibenclamide, or TEA did not change the vasorelaxant effect of T4CN. Under Ca2+-free conditions, T4CN significantly reduced the phasic contractions induced by caffeine or PHE, as well as the contractions due to exogenous CaCl2 in aortic preparations stimulated with PHE (in the presence of verapamil). These results suggest that in rat aortic rings, T4CN induced vasorelaxation independently from the activation of soluble guanylate cyclase/cGMP pathway, an effect that may be related to the electrophilicity of the substituted chloro-nitrostyrene. This vasorelaxation seems to involve inhibition of both calcium influx from the extracellular milieu and calcium mobilization from intracellular stores mediated by IP3 receptors and by ryanodine-sensitive Ca2+ channels.

Fundamental & Clinical Pharmacology published new progress about Arterial endothelium, thoracic aorta endothelium. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Product Details of C8H6ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shimada, Naoyuki; Nakamura, Yuki; Ochiai, Takayuki; Makino, Kazuishi published the artcile< Catalytic Activation of Cis-Vicinal Diols by Boronic Acids: Site-Selective Acylation of Carbohydrates>, Formula: C9H7ClO, the main research area is carbohydrate site selective acylation boronic acid catalyst.

Site-selective acylation of unprotected carbohydrates by using stable, storable, and easily handled imidazole-containing organoboronic acid catalysts is described. This catalytic process with low catalyst loading enables the introduction of a wide variety of acyl functional groups into the equatorial position of cis-vicinal diols in unprotected hexapyranosides with excellent site selectivity. This is the first example that uses a Lewis base-containing boronic acid to enhance the nucleophilicity of hydroxy groups.

Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fujimori, Ko; Iguchi, Yusuke; Yamashita, Yukiko; Gohda, Keigo; Teno, Naoki published the artcile< Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts>, SDS of cas: 3964-57-6, the main research area is farnesoid receptor agonist mesenchymal stem cell differentiation osteoblast; FXR; agonist; bone; mesenchymal stem cells; osteoblast.

The modulators of farnesoid X receptor (FXR), a bile acid receptor, regulate various biol. processes including bile acid metabolism and are associated with the control of fatty liver and osteoporosis. Thus, the control of FXR activity and development of FXR modulators are critical not only for research, but also for clin. application. In this study, we synthesized novel FXR agonists 1-4 possessing isoxazole and N-substituted benzimidazole moieties, and compared their effects on osteoblast differentiation with the known FXR agonists, chenodeoxycholic acid and a synthetic compound GW4064. Two (3 and 4) of the four novel FXR agonists 1-4 showed high specificities for FXR. Computer-assisted modeling suggested that the binding of the FXR agonist 3 with ligand binding domain of FXR was similar to GW4064. FXR was expressed in mouse bone marrow-derived mesenchymal stem cell (MSC)-like ST2 cells (ST-2 MSCs). The FXR agonists activated the BMP-2-induced differentiation of ST-2 MSCs into osteoblasts and enhanced the expression of RUNX2. Moreover, the potency of the FXR agonist 3 was comparable to GW4064 in promoting osteoblast differentiation of ST-2 MSCs. These results indicate that FXR activation enhanced the BMP-2-induced differentiation of MSCs into osteoblasts through activating RUNX2 expression. FXR could be a potential therapeutic target for the treatment of bone diseases such as osteoporosis.

Molecules published new progress about Animal gene, COL1A1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 3964-57-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

He, Dandan; Zhong, Wentao; Zhou, Miaomiao; Wang, Bowen; Li, Meng; Jiang, Huanfeng; Wu, Wanqing published the artcile< Palladium-Catalyzed Regio- and Stereoselective Coupling of Alkynylsulfones with Alkenes: Access to Dichlorinated Vinyl Sulfones>, Electric Literature of 3240-10-6, the main research area is dichlorinated vinyl sulfone regioselective preparation diastereoselective; alkynylsulfone ester coupling palladium catalyst; alkene alkynylsulfone coupling palladium catalyst.

A palladium-catalyzed coupling reaction of alkynylsulfones with alkenes/ester was described, which provided an efficient and practical entry to various functionalized dichlorinated vinyl sulfones I [R1 = H, 4-Me, 3-F, etc.; R2 = Me, Ph, 4-ClC6H4, etc.]. This method featured excellent regio- and stereoselectivities, good functional group compatibility, as well as mild reaction conditions.

Organic Letters published new progress about Aryl alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Electric Literature of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brown, R. F. C.; Gardner, D. V.; McOmie, J. F. W.; Solly, R. K. published the artcile< New method for the synthesis of biphenylenes>, HPLC of Formula: 118-45-6, the main research area is .

The pyrolysis of phthalic anhydride (I) or substituted I gave biphenylene (II) or substituted II. The vapor of the compound was passed through a silica tube, in some cases packed with silica tubing or 1/4-in. porcelain Lessing rings, at 450-1100° at 0.1-2.0 mm. Given are starting material, product, and % yield: I, II, 17; 4-Cl derivative of I, 2,6-Cl2 derivative of II, 15; 4,5-Cl2 derivative of I, 2,3,6,7-Cl4 derivative of II, 6.5; 3,6-Cl2 derivative of I, 1,4,5,8-Cl4 derivative of II, 4; 3,4,5,6-Cl4 derivative of I, octachloro derivative of II, 26; 4,5-Me2 derivative of I, 2,3,6,7-Me4 derivative of II, 3. Pyrolysis of o-BrC6H4CO2H, diphenic acid, o-sulfobenzoic acid gave resp. a trace, 5%, and 5.5% II. No II or substituted II was formed in the pyrolysis of 4-PhCH2 derivative of I, 4-MeO derivative of I, o-ClC5H4CO2H, phthalimide (III), N-Me derivative of III, coumaran-2,3-dione, or disalicylide. Benzyne (IV) and substituted IV are probably intermediates in the reaction.

Chemical Communications (London) published new progress about 118-45-6. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, HPLC of Formula: 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yesmin, Sabina; Abbas, Sk Jahir; Ke, Shyue-Chu published the artcile< A powerful and multifunctional catalyst for organic synthesis, transformation, and environmental remediation: A polyImidazole supported trimetallic catalyst>, Quality Control of 3240-10-6, the main research area is polyImidazole trimetallic catalyst organic synthesis environmental remediation.

We have constructed a state-of-the-art polyimidazole-supported trimetallic composite, PIm/FeZnAg, for organic synthesis, transformation, and environmental remediation on a single platform. The sustainable chem. of organic reactions involving three-component coupling, CO2 insertion, [3 + 2]-click, Knoevenagel condensation, and CO2 cycloaddition reactions, and environmental pollutant reduction and bacterial inhibition are performed to comprehensively evaluate the power of this multifunctional catalyst. Most reactions withstand good functional group tolerance, producing forty-one derivatives with molecularly distinct moieties at good to near-quant. yields under benign reaction conditions. Full chem., microscopic, and structural characterizations reveal that metallic Ag, ZnO, and Fe2O3 with well-defined nanostructures are well interspersed and integrated on the PIm support. The metallic centers provide a conjugated multivalent architecture that work synergistically on a platform with moderate surface area and good CO2 adsorption capacity is the key to the multi-functionalities and effectiveness of PIm/FeZnAg, which is a current demand for developing green sustainable heterogeneous catalysts.

Applied Catalysis, B: Environmental published new progress about Adsorption. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Quality Control of 3240-10-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schnitzer, Tobias; Wennemers, Helma published the artcile< Deactivation of Secondary Amine Catalysts via Aldol Reaction-Amine Catalysis under Solvent-Free Conditions>, Recommanded Product: (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is secondary amine catalyst deactivation aldol reaction; solvent free enantioselective conjugate addition.

Despite intense interest in amine-catalyzed stereoselective reactions, high catalyst loadings of ≥10 mol % are still common and either due to low reactivity or catalyst deactivation. Yet, few deactivation pathways are well understood. Here, we unraveled the deactivation of secondary amines by undesired aldol reaction. Mechanistic studies with peptide and prolinol silyl ether catalysts showed the generality of this so-far underappreciated catalyst deactivation pathway. The insights enabled conjugate addition reactions between aldehydes and nitroolefins on a multigram scale in the absence of solvent-conditions that are attractive as environmentally benign processes-with excellent product yields and stereoselectivities in the presence of as little as 0.1 mol % of a chemoselective peptidic catalyst.

Journal of Organic Chemistry published new progress about Addition reaction kinetics. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Recommanded Product: (E)-1-Chloro-4-(2-nitrovinyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Renbo; Deng, Xiangping; Peng, Yijiao; Feng, Wanshi; Xiong, Runde; Zou, Yang; Lei, Xiaoyong; Zheng, Xing; Xie, Zhizhong; Tang, Guotao published the artcile< Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents>, Related Products of 22717-55-1, the main research area is flavonoid antitumor microtubules HIF1 alpha glycolysis VEGF gastric cancer; Anti-tumor; Flavonoid; Glycolysis; HIF-1α; Microtubules.

5,6,7-Trimethoxy flavonoid salicylate derivatives were designed by the joining of three important pharmacophores (TMP, flavonoid, and SA) according to the combination principle. A series of novel trimethoxy flavonoid salicylate derivatives were synthesized and their in vitro anti-tumor activities were evaluated. Among these derivatives, compound 7f exhibited excellent antiproliferative activity against HGC-27 cells and MGC-803 cells with IC50 values of 10.26 ± 6.94 μM and 17.17 ± 3.03 μM, resp. Subsequently, the effects on cell colony formation (clonogenic survival assay), cell migration (wound healing assay), cell cycle distribution (PI staining assay), cell apoptosis (Hoechst 33258 staining assay and annexin V-FITC/PI dual staining assay), lactate level (lactate measurement), microtubules disarrangement (immunofluorescence staining anal.) and docking posture (mol. docking simulation) were determined Further western blot anal. confirmed that compound 7f could effectively down-regulate the expression of glycolysis-related proteins HIF-1α, PFKM and PKM2 and tumor angiogenesis-related proteins VEGF. Overall, these studies suggested that compound 7f, as the representative compound of those, might be a promising candidate for the treatment of gastric cancer and deserved the further studies.

Bioorganic Chemistry published new progress about Antitumor agents. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Related Products of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics