Tag: M.W=150-200

Mistryukov, E. A. published the artcileSynthesis and steric structure of some 1-methyl-4-phenyl-4-piperidinols, COA of Formula: C7H16ClNO2, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1961), 623-6, database is CAplus.

cf. CA 52, 20159b. PhLi from 17 g. Li treated in Et₂O with 127.6 g. 1-methylperhydro-4-pyrindone gave, after refluxing 4 h. and treating with aqueous HCl, followed by NaOH, 44% 1-methyl-4-phenylperhydro-4-pyrindole (I), b_0.3 136-46°, m. 45.5-6.5° (HCl salt m. 221-2°), along with a small amount of a base, C₂₃H₂₉NO, m. 71-2°; the mother liquors gave a base, m. 4850° (picrate decomposed at 199-200°; propionate HCl salt m. 206-7°), whose structure was not determined I formed a picrate, m. 157-7.5°. PhLi and 1-methyldecahydro-4-quinolone gave 63.7% isomeric alcs. in 62:24:14 ratio: α-form of 1-methyl-4-phenyldecahydro-4-quinolol, m. 126.5-7°; β-form, m. 112-13° (HCl salt m. 216-19°); and γ-form, m. 148-50°. Heating (CCMe₂OH)₂ with p-MeC₆H₄SO₃H in the presence of pyrogallol at 100°/100 mm. 1 h. gave H₂O and CO₂ and a residue of 2,5-dimethyl-1,5-hexadien-3-yne, b₄₀ 46-9°, and 2,5-dimethyl-5-hexen-3-yn-2-ol, b₁₃ 64-7°. Treatment of 2,5-dimethyl-1,4-hexadien-3-one and its MeOH adducts (crude mixture, Nazarov and Bukhmutskaya, CA 42, 7733e) with 39% aqueous MeNH₂ 2 days at room temperature gave, after treatment with H₂O and aqueous HCl, followed by NaOH, 40% 1,2,2,5-tetramethyl-4-piperidone, b₁₅ 90-3°, n²⁰_D 1.4620 (HCl salt m. 195.5°; picrate m. 180-80.5°). This and PhLi gave only 1 isomer of 1,2,2,5-tetramethyl-4-phenyl-4-piperidinol, m. 81-2°; HCl salt m. 201° (hydrate m. 152-3°). This piperidinol probably had equatorial Ph and Me groups at C-5. Only I showed evidence of internal H-bonding in the IR spectrum.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Morita, Hirokazu published the artcileDifferential thermographic features of some crystalline biopolymers, HPLC of Formula: 6249-56-5, the publication is Biopolymers (1966), 4(2), 215-22, database is CAplus.

Thermograms are shown for globular, serum, and blood plasma proteins, calf thymus DNA, sodium triticonucleate, sodium thermonucleate, sperm DNA, yeast RNA, adenosine 3′-phosphate, adenosine 5′-phosphate, disodium adenosine triphospate, adenosine, and deoxyadenosine. A pronounced effect of moisture on the differential thermal properties of DNA was observed. Solid-state denaturation may be one of the prominent thermal effects recorded by the differential thermal analysis of proteins and nucleic acids.

Biopolymers published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ofner, P. published the artcileAmidone. Some isomeric chlorodialkylaminopropanes and their reaction with diphenylmethyl cyanide, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Journal of the Chemical Society (1951), 1800-3, database is CAplus.

MeCH(NMe₂)CO₂Et is reduced by the Bouveault-Blanc procedure to 55% of MeCH(NMe₂)CH₂OH (I), b. 145-8° (picrate, orange-yellow, m. 182-3°); 20 g. I in 45 cc. C₆H₆, added (20 min.) to 23 g. SOCl₂ in 90 cc. C₆H₆ at 0°, allowed to warm to room temperature, and refluxed 1.5 h., give 59% MeCH(NMe₂)CH₂Cl.HCl (II), m. 103-4°. Me₂NCH₂CHMeOH (III) yields a picrate, orange-yellow, m. 83-4°. III (20 g.) and 23 g. SOCl₂, as above, give 73% Me₂NCH₂CHMeCl.HCl (IV), m. 190-1°. I (20 g.) in 45 cc. C₆H₆, treated with 23 g. SOCl₂ in 90 cc. C₆H₆ and the gummy residue refluxed with 150 cc. Me₂CO, gives 34% IV; the II is removed by the Me₂CO. 1-Piperidino-2-propanol (b₇₆₂ 198-201°; picrate, m. 134-5°) gives with SOCl₂ 2-chloro-1-(1-piperidyl)propane-HCl (V), m. 213-14°. 1-(1-Piperidyl)-3-propanol (m. 66-7°) with SOCl₂ gives 1-chloro-3-(1-piperidyl)propane (VI), b₁₀ 79-80°; HCl salt, m. 213-14°. The mother liquor from V or VI did not contain the other isomer. 1-Allylpiperidine (picrate, m. 72-3°) does not add HCl. The base, Me₂NCH₂CHMeCl (VII), liberated from IV by dilute NH₄OH at 0° or with 40% NaOH at room temperature, is stable and gives the same picrate, even after distillation (b₃₅ 36-7°). The base liberated from II at room temperature by 40% NaOH solution is Me₂NCHMeCH₂Cl (VIII) (Schultz, et al., C.A. 42, 4934i). VIII can be heated in an inert solvent and can be agitated in an inert solvent with NaOH or NaNH₂ without undergoing decomposition or isomerization; on distillation in vacuo, VIII is isomerized and VII and VIII can be separated by fractional crystallization of the picrates. The relative proportions of the isomers formed in the alkylation of PhCH₂CN with VII or V were determined by effecting as complete as possible a separation of the isomers giving the more sparingly soluble salts. In the dimethylamino series, the N-compounds from the more sparingly soluble salts, whereas in the analogous piperidyl series, the salts of the iso compounds have the lowest solubility In the former series at least 60% of the cyanide was formed by isolation as 6-dimethylamino-4,4-diphenyl-3-heptane-HBr and in the latter at least 45% of the isocyanide as 3-imino-5-methyl-4,4-diphenyl-6-(1-piperidyl)hexane-2HCl. Thus, the relative proportions vary according to the nature of the basic groups of the Cl base employed in the alkylation.

Journal of the Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chibowski, Emil J. published the artcileSurface free energy and wettability of silyl layers on silicon determined from contact angle hysteresis, Recommanded Product: Dichloro(hexyl)(methyl)silane, the publication is Advances in Colloid and Interface Science (2005), 113(2-3), 121-131, database is CAplus and MEDLINE.

Using the literature data [A.Y. Fadeev and T.J. McCarthy, Langmuir 15(1999) 3759; A.Y. Fadeev and T.J. McCarthy, Langmuir 16(2000) 7268] of the advancing and receding contact angles for H₂O, diiodomethane and hexadecane measured on various hydrophobic silyl layers (mostly monolayers) produced on Si wafers the apparent surface free energies γ^tot_s were calculated by applying new model of the contact angle hysteresis interpretation. For the same silyl layer, the calculated γ^tot_s values to some degree depended on the probe liquid used. Therefore, thus calculated the surface free energies should be considered as apparent ones. Also, also the values of the dispersion component γ_s^d of these layers depend on the probe liquid used, but to a less degree. This must be due to the strength of the force field originating from the probe liquid and the spacing between the interacting mols. The relations between γ^tot_s and γ^d_s are discussed from the equations derived. It may be postulated that applying proposed model of the contact angle hysteresis and calculating the apparent total surface free energies and the dispersion contributions better insight into wetting properties of the silyled Si surface can be achieved.

Advances in Colloid and Interface Science published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Recommanded Product: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dawson, Thomas P. published the artcileReactions of certain halogen-substituted aryl, alkyl and dialkyl sulfides with benzylamines, Synthetic Route of 1002-41-1, the publication is Journal of the American Chemical Society (1933), 2070-5, database is CAplus.

The following sulfides, ClCH₂CH₂SR, are liquids of penetrating odor (R is given): Et, b₄₇ 63-5°, d₄²⁵ 1.0663, η × 10³ (C. G. S. units at 25°) 9.89; Pr, b₂ 43-5°, d. 1.0349, η 12.92; Bu, b₁ 58-9°, d. 1.0122, η 15.25; iso-Am, b₁ 68°, d. 0.9899, η 18.55; Ph, b_0.637 88-9°, d. 1.1769, η 30.86, PhCH₂, b_1.01 113-5°, d. 1.1479, η 50.61; BrCH₂CH₂SEt, b₆ 57-8°, d. 1.3908, 15.55. MeCHClCH₂SEt, b₁₇ 60°, d. 1.0265, 11.15; Cl(CH₂)₃SEt, b₁₇ 72°, d. 1.0427, η 13.30. (MeCHClCH₂)₂S, b₇ 94-5°, d. 1.1569, η 33; (ClCH₂CH₂CH₂)₂S, b₇ 111-2°, d. 1.1774, η 41.87. (ClCH₂)₂S, b₁₁ 51°, d. 1.4065, η 18.09. (ClC₂H₄)₂S₂, b₁₀ 124-7°, d₄²⁰ 1.3375, η 83.06. β-Chloroethyl α,β-dichlorovinyl sulfide, b₄ 79.5-80.5°, d₄²⁰ 1.4581, η 31.98. Et allyl sulfide, b. 115-6°, d₄²⁰ 0.8676, η 5.97. These sulfides were treated with PhCH₂NH₂ and Na₂CO₃ in absolute EtOH; the b. ps. are for the free bases, the m. ps. for the HCl salts: β-benzylaminoethyl Et sulfide, b₁₃ 162-4°, m. 214-5°; Pr derivative, b₁₃ 167-9°, m. 175°; Bu derivative, b₁₃ 172-230°, m. 152-3°; iso-Am derivative, b₁₇ 190-250°, m. 161-2°; Ph derivative, m. 152-3°; β-benzylaminopropyl Et sulfide, b₁₁ 157-8°, m. 115°; γ-isomer, b₁₂ 163-5°, m. 172°; 3-benzyl-1,3-thiazetidine, b₁₆ 175-85°, m. 201-3°; bis(β-benzylaminopropyl) sulfide, m. 239-40°; bis(β-benzylaminoethyl) disulfide, m. 269°; β-benzylaminoethyl α-(and β-)chlorovinyl sulfide, m. 211-2°; β-benzylaminoethyl α,β-dichlorovinyl sulfide, m. 174-6°. The results may be regarded as further substantiating the condensation theory of vesicant action but they entirely eliminate thiazane formation as an important factor and appear to demand a new limitation-that of a reactive halogen on the β-C atom.

Journal of the American Chemical Society published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Synthetic Route of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Debowski, Zbigniew published the artcileTechnology of aminoiminomethanesulfinic acid preparation, Formula: C4H8Cl2S2, the publication is Przemysl Chemiczny (1965), 44(2), 82-5, database is CAplus.

Aminoiminomethanesulfinic acid N₂NC(:NH)SO₂(OH) (I), m. 112-15°, was obtained when 2400 ml. 30% H₂O₂ was dropwise added with continuous stirring to 760 g. thiourea in 500 ml. H₂O and 100 ml. N HCl at 4°. The influence of temperature and H₂O₂ concentration on the yield and purity of I was examined and results shown in tables. The drying process of I was also examined The dependence of drying efficiency upon the temperature, as well as the H₂O content upon the velocity and time of drying at 55° under reduced and atm. pressure, were evaluated and their curves plotted. The mechanism of thiourea oxidation to I based on an analysis of its decomposition products was proposed.

Przemysl Chemiczny published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Haitang published the artcileSynthesis and fungicidal activity of 3-[5-(substituted thio)-4H-1,2,4-triazol-3-yl]-benzopyran-2-ones, Category: chlorides-buliding-blocks, the publication is Huaxue Tongbao (2019), 82(9), 831-836, 854, database is CAplus.

In order to find triazole lead compounds with fungicidal activity, a series of new triazole derivatives containing coumarin ring and thioether structure were synthesized by the introduction of coumarin ring and thioether structural unit into mols. of triazoles. They were structurally confirmed by ¹H NMR, ¹³C NMR, IR, MS and elemental anal. The preliminary bioactivity test showed that some of the target compounds have certain fungicidal activity at the test concentration

Huaxue Tongbao published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gan, Haifeng published the artcileFacile Preparation of Benzoxazoles from S₈-Promoted Cyclization of 2-Nitrophenols with Arylmethyl Chloride, COA of Formula: C7H6Cl2, the publication is ChemistrySelect (2019), 4(9), 2858-2860, database is CAplus.

A simple, metal-free methodol. has been obtained for the preparation of 2-arylbenzoxazoles I (R = H, 6-Me, 5-NHC(O)CH₃, etc.; R¹ = Ph, naphthalen-2-yl, pyridin-4-yl, etc.) from 2-nitrophenols 2-NO₂-R² -C₆H₃OH (R = H, 5-Me, 4-F, etc.) and arylmethyl chlorides R¹CH₂Cl via an elemental sulfur-promoted cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is applicable.

ChemistrySelect published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gan, Haifeng published the artcileFacile Preparation of Benzoxazoles from S₈-Promoted Cyclization of 2-Nitrophenols with Arylmethyl Chloride, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is ChemistrySelect (2019), 4(9), 2858-2860, database is CAplus.

A simple, metal-free methodol. has been obtained for the preparation of 2-arylbenzoxazoles I (R = H, 6-Me, 5-NHC(O)CH₃, etc.; R¹ = Ph, naphthalen-2-yl, pyridin-4-yl, etc.) from 2-nitrophenols 2-NO₂-R² -C₆H₃OH (R = H, 5-Me, 4-F, etc.) and arylmethyl chlorides R¹CH₂Cl via an elemental sulfur-promoted cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is applicable.

ChemistrySelect published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Name: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hansen, Bertil published the artcilePreparation of thiocholine esters. II. Esters of α- and β-methylthiocholine, Category: chlorides-buliding-blocks, the publication is Acta Chemica Scandinavica (1959), 159-62, database is CAplus.

cf. CA 52, 14538g. α-Methyl- and β-methylthiocholine halide esters of benzoic and the lower fatty acids were prepared in good yield from Me₂NCHMeCH₂SH (I), b₈₈ 71°, n²⁵_D 1.4538, d₂₅ 0.8693, and HSCHMeCH₂NMe₂ (II), b₇₀ 78.5°, n²⁵_D 1.4684, d₂₀ 0.9046, resp., by esterification with Ac₂O and quaternization with MeI. The α-Me esters were also prepared from 1,2-propylene sulfide by adding the acid bromide and then quaternizing with Et₃N. The II was synthesized (Renshaw, et al., CA 32, 7412¹) from Me₂NCH₂CHMeCl.HCl (III), m. 185°, and (H₂N)₂CS. An attempt to prepare I similarly from MeCHNMe₂CH₂Cl.HCl and (H₂N)₂CS gave only II; addition of Me₂NH to propylene sulfide, b₁ 74-6° (prepared in 58% yield from propylene oxide and (H₂N)₂CS, in Et₂O gave I as the only product. Esters of MeCHBrCH₂SH prepared were: 73% acetate, b₆ 72-3°; 66% propionate, b₉ 93-6°; 53% butyrate, b₈ 99.5-100.5°; and 53% valerate, b₁₀ 125-6.5°. Esters of α-methylthiocholine bromide: 63% acetate, m. 187°; 63% propionate, m. 154°; 54% butyrate, m. 170°; and 67% valerate, m. 179°. Also prepared were the acetate, b₁₁ 64.5-6°, propionate, b₁₂ 67-81°, butyrate, b₉ 80-8°, isobutyrate, b₁₀ 85-94°, valerate, b_0.07 53-60°, and benzoate, b_0.01 88-96°, of I, and the acetate, b₁₁ 76-82°, propionate, b₁₀ 78-88°, butyrate, b_1.8 74-85°, isobutyrate, b₁₂ 86-92°, valerate, b_0.3, and benzoate, b_0.03 120-5°, of II. α-Methylthiocholine bromide acetate, m. 188°, and the following β-methylthiocholine bromide esters (acetate, m. 168°, 67% butyrate, m. 164°, and 32% isobutyrate, m. 140°), α-methylthiocholine iodide esters (50% acetate, m. 164°, 61% propionate, m. 155°, 62% butyrate, m. 130°, 82% isobutyrate, m. 158°, 62% valerate, m. 152°, and 54% benzoate, m. 136°), and β-methylthiocholine iodide esters (70% acetate, m. 150°, 65% propionate, m. 132°, 67% butyrate, m. 164°, 32% isobutyrate, m. 140°, 31% valerate, m. 74°, and 76% benzoate, m. 194°) were prepared III refluxed 65 h. with (H₂N)₂CS in absolute EtOH gave 52% S-(1-dimethylamino-2-propyl)isothiuronium chloride hydrochloride, m. 154° (PrOH).

Acta Chemica Scandinavica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics