Tag: M.W=150-200

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Synthetic Route of 1878-65-5.

Wang, Guangcheng;Liu, Wenjing;Huang, Yong;Li, Yongjun;Peng, Zhiyun research published 《 Design, synthesis and biological evaluation of isoxazole-naphthalene derivatives as anti-tubulin agents》, the research content is summarized as follows. In this study, a novel series of isoxazole-naphthalene hybrids I [R = 2-ClC₆H₄, 4-EtOC₆H₄, 3,4,5-(MeO)₃C₆H₂, 2H-1,3-benzodioxol-5-yl, etc.] as tubulin polymerization inhibitors were designed, synthesized and evaluated for their anti-proliferative activities against human breast cancer cell line MCF-7. Most of the synthesized compounds I exhibited moderate to potent antiproliferative activity (IC₅₀ < 10.0μM), as compared to cisplatin (15.24 ± 1.27μM). Among them, compound I (R = 4-EtOC₆H₄) was found to be the most active compound with IC₅₀ value of 1.23 ± 0.16μM. Mechanistic studies revealed that this compound arrested cell cycle at G2/M phase and induced apoptosis. Furthermore, in vitro tubulin polymerization assay showed that the compound I (R = 4-EtOC₆H₄) displayed better inhibition activity on tubulin polymerization (IC₅₀ = 3.4μM) than colchicine (IC₅₀ = 7.5μM). Mol. docking study also revealed that this compound binds to the colchicine binding site of tubulin.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Synthetic Route of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 3-Chlorophenylacetic acid.

Wang, Guangcheng;Liu, Wenjing;Peng, Zhiyun;Huang, Yong;Gong, Zipeng;Li, Yongjun research published 《 Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization》, the research content is summarized as follows. A new series of pyrazole-naphthalene derivatives I (R = 4-Me, 3-MeO, 4-EtO, etc.) have been synthesized and evaluated for their anticancer activity against human breast cancer cell lines (MCF-7). Most of newly synthesized compounds, except I (R = 3,4-(MeO)₂, 4-F, 3-Cl) exhibited potent antiproliferative activity in the range of IC₅₀ = 2.78 +/- 0.24μM – 9.13 +/- 0.47μM. Among them, compound I (R = 4-EtO) (IC₅₀ = 2.78 +/- 0.24μM), bearing ethoxy at the 4-position of the Ph ring, was found to be the most active compound in this series of compounds, with five folds more active than the standard drug cisplatin (IC₅₀ = 15.24 +/- 1.27μM). In addition, compound I (R = 4-EtO) and colchicine showed the same ability to inhibit tubulin polymerization with the IC₅₀ values of 4.6μM and 6.7μM, resp. Cellular mechanism studies elucidated that compound I (R = 4-EtO) arrested the cell cycle at G2/M phase and induced apoptosis. Furthermore, mol. docking anal. revealed that compound I (R = 4-EtO) formed stable interactions in the colchicine-binding site of tubulin.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Recommanded Product: 3-Chlorophenylacetic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Reference of 1878-65-5.

Wang, Hongyu;Liu, Chen-Fei;Song, Zhihui;Yuan, Mingbin;Ho, Yee Ann;Gutierrez, Osvaldo;Koh, Ming Joo research published 《 Engaging α-Fluorocarboxylic Acids Directly in Decarboxylative C-C Bond Formation》, the research content is summarized as follows. The readily accessible α-monofluoro carboxylic acids, which are conventionally difficult substrates for cross-coupling, undergo direct decarboxylative cross-coupling with sp²– and sp³-hybridized organohalides afforded a wide assortment of fluorinated products. Reactions were typically promoted by a combination of 1 mol % of an Ir-based photocatalyst and 2-15 mol % of a bipyridine-Ni complex, delivering products in up to 86% yield under blue LED light irradiation Concise synthesis of key therapeutic candidates underscores utility, complementarity and distinct advantages compared with existing methods. DFT calculations were used to rationalize the distinct reactivity of α-fluoro carboxylic acid substrates (vs nonfluorinated parent acids) under decarboxylation conditions.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Reference of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Computed Properties of 1878-65-5.

Wang, Hui;Dong, Wei;Hou, Zhipeng;Cheng, Lidan;Li, Xiufen;Huang, Longjiang research published 《 Direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp₂Cl₂》, the research content is summarized as follows. A mild and efficient direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp₂Cl₂ was described. Arylacetic acid derivatives reacted with different amines to afford the corresponding amides in good to excellent yield except of aniline. Aryl formic acids failed to react with aniline but smoothly reacted with aliphatic amines and benzylamine in moderate to good yield, fatty acids reacting with benzyl and aliphatic amines give amides in good to excellent yield. Chiral amino acids derivatives were transformed into amides without racemization in moderate yield. The possible mechanism of direct amidation catalyzed by TiCp₂Cl₂ was discussed. This catalytic method was very suitable for the amidation of low sterically hindered arylacetic acid, fatty acids with different low sterically hindered amines except aniline, as well as the amidation of aryl formic acid with benzyl and aliphatic amines.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Computed Properties of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Quality Control of 1878-65-5.

Wang, Kaikai;Li, Yajun;Li, Xiaoyan;Li, Daliang;Bao, Hongli research published 《 Iron-Catalyzed Asymmetric Decarboxylative Azidation》, the research content is summarized as follows. The first iron-catalyzed asym. azidation of benzylic peresters has been reported with trimethylsilyl azide (TMSN₃) as the azido source. Hydrocarbon radicals that lack of strong interactions were capable to be enantioselectively azidated. The reaction features good functional group tolerance, high yields, and mild conditions. The chiral benzylic azides can further be used in click reaction, phosphoramidation, and reductive amination, which demonstrate the synthetic values of this reaction.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Quality Control of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Electric Literature of 1878-65-5.

Wang, Kang;Li, Shu-Sen;Wang, Jianbo research published 《 Cu(I)/Chiral Bisoxazoline-Catalyzed Enantioselective Doyle-Kirmse Reaction of Allenyl Sulfides with α-diazoesters》, the research content is summarized as follows. A Cu(I)-catalyzed enantioselective Doyle-Kirmse reaction of allenyl sulfides ArSCH=C=CH₂(Ar = 2,3,5,6-tetrafluorophenyl, 2-ethoxy-3,5,6-trifluoropyridin-4-yl, 2,3,5,6-tetrafluoro-4-methylphenyl, etc.)and α-diazoesters R¹C(=N₂)COOR (R = t-Bu, 1-adamantyl, 2-phenylpropan-2-yl, 2-methylbutan-2-yl; R¹ = Me, 4-fluorophenyl, naphthalen-2-yl, etc.) was reported, and provided an efficient synthetic route to enantio-enriched chiral tertiary homopropargylic sulfides R¹C(SAr)(COOR)CH₂CCH. This reaction features high enantioselectivities (up to 96% ee) and good functional group tolerance. The alkyl substituted α-diazoester has also been demonstrated as the efficient substrates in the asym. Doyle-Kirmse reaction. Mechanistic studies, including kinetic experiments, were conducted to gain insights into the details of the reaction pathway. The potential synthetic utility of this protocol has also been demonstrated.

Electric Literature of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Computed Properties of 6334-18-5.

Thorat, Nitin M.;Sarkate, Aniket P.;Lokwani, Deepak K.;Tiwari, Shailee V.;Azad, Rajaram;Thopate, Shankar R. research published 《 N-Benzylation of 6-aminoflavone by reductive amination and efficient access to some novel anticancer agents via topoisomerase II inhibition》, the research content is summarized as follows. Series of novel N-benzyl derivatives of 6-aminoflavone I (R = 3-nitrophenyl, 5-bromo-2-methoxyphenyl, quinolin-2-yl, etc.) were synthesized and evaluated for anticancer and topoisomerase II enzyme inhibition activity. All the synthesized compounds were screened for in vitro anticancer activity against human breast cancer cell line (MCF-7) and human lung cancer cell line (A-549). Among the synthesized compounds, I (R = 4-chlorophenyl (A); 4-bromophenyl (B)) were found to be the most potent anticancer agents against human breast cancer cell line (MCF-7) with IC₅₀ values of 9.35μM and 9.58μM, resp. Compounds I (R = 4-cyanophenyl; 2,3-dichlorophenyl (C); quinolin-2-yl) exhibited promising anticancer activity against human lung cancer cell line (A-549) with 43.71%, 46.48% and 44.26% inhibition at the highest concentration of 10μM, resp. Compounds (C), (A) and (B) have ability to inhibit the topoisomerase II enzyme. Compound (A) showed most potent topoisomerase II enzyme inhibition activity with IC₅₀ value of 12.11μM. Further, these compounds have a high potential to be developed as promising topoisomerase II inhibitors.

Computed Properties of 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Formula: C7H4Cl2O.

Thummala, Yadagiri;Raju, Chittala Emmaniel;Purnachandar, Dalovai;Sreenivasulu, Gottam;Doddi, Venkata Ramana;Karunakar, Galla V. research published 《 Gold-Catalyzed Regioselective Synthesis of Pyrazolo[1,4]oxazepines via Intramolecular 7-endo-dig Cyclization》, the research content is summarized as follows. Alkynyloxymethylpyrazoles I [R = Ph, 4-FC₆H₄, BuCH₂CH₂, Bu; R¹ = Ph, 2-naphthyl, 4-PhC₆H₄, 4-MeC₆H₄, 4-MeOC₆H₄, 3,4,5-(MeO)₃C₆H₂, 2,3-Cl₂C₆H₃, 2-ClC₆H₄; R² = Ph, 2-naphthyl, 4-MeC₆H₄, 4-t-BuC₆H₄, 4-MeOC₆H₄, cyclohexyl, 2-thienyl] underwent 7-endo-dig cyclization in the presence of Au(PEt₃)Cl and AgSbF₆ to yield pyrazolooxazepines II [R = Ph, 4-FC₆H₄, BuCH₂CH₂, Bu; R¹ = Ph, 2-naphthyl, 4-PhC₆H₄, 4-MeC₆H₄, 4-MeOC₆H₄, 3,4,5-(MeO)₃C₆H₂, 2,3-Cl₂C₆H₃, 2-ClC₆H₄; R² = Ph, 2-naphthyl, 4-MeC₆H₄, 4-t-BuC₆H₄, 4-MeOC₆H₄, cyclohexyl, 2-thienyl]. I [R = Ph, Bu, BuCH₂CH₂; R¹ = Ph, 4-MeC₆H₄, 3,4,5-(MeO)₃C₆H₂, 2-ClC₆H₄; R² = Ph, 4-MeOC₆H₄, 4-MeC₆H₄] underwent 6-exo-dig cyclization mediated by NaH to yield pyrazolo[1,4]oxazines III [R = Ph, Bu, BuCH₂CH₂; R¹ = Ph, 4-MeC₆H₄, 3,4,5-(MeO)₃C₆H₂, 2-ClC₆H₄; R² = Ph, 4-MeOC₆H₄, 4-MeC₆H₄].

Formula: C7H4Cl2O, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. HPLC of Formula: 1878-65-5.

Tian, Xun;Li, Xin;Duan, Shengzu;Du, Ya;Liu, Tongqi;Fang, Yongsheng;Chen, Wen;Zhang, Hongbin;Li, Minyan;Yang, Xiaodong research published 《 Room Temperature Benzofused Lactam Synthesis Enabled by Cobalt(III)-Catalyzed C(sp²)-H Amidation》, the research content is summarized as follows. A room temperature and robust synthesis of benzofused lactams, e.g., I through cobalt(III)-catalyzed C(sp₂)-H amidation has been described. In this protocol, in-situ formation of Cp*Co(III)(ligand) catalyst from Cp*Co(CO)I2 and ligand simplify the synthetic effort of cobalt complexes. Simple and readily synthesized 1,4,2-dioxazol-5-ones II [R = C₆H₅, 1-naphthyl, benzo[d][1,3]dioxol-5-yl, etc.] underwent room temperature intramol. C-H amidation and afforded a wide variety of functionalized benzofused lactams in up to 86% yield. The scalability of the reaction is also be demonstrated.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., HPLC of Formula: 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Electric Literature of 1878-65-5.

Tien, Chieh-Hung;Trofimova, Alina;Holownia, Aleksandra;Kwak, Branden S.;Larson, Reed T.;Yudin, Andrei K. research published 《 Carboxyboronate as a Versatile In Situ CO Surrogate in Palladium-Catalyzed Carbonylative Transformations》, the research content is summarized as follows. The application of carboxy-MIDA-boronate (MIDA=N-methyliminodiacetic acid) as an in situ CO surrogate for various palladium-catalyzed transformations is described. Carboxy-MIDA-boronate was previously shown to be a bench-stable boron-containing building block for the synthesis of borylated heterocycles. The present study demonstrates that, in addition to its utility as a precursor to heterocycle synthesis, carboxy-MIDA-boronate is an excellent in situ CO surrogate that is tolerant of reactive functionalities such as amines, alcs., and carbon-based nucleophiles. Its wide functional-group compatibility is highlighted in the palladium-catalyzed aminocarbonylation, alkoxycarbonylation, carbonylative Sonogashira coupling, and carbonylative Suzuki-Miyaura coupling of aryl halides. A variety of amides, esters, (hetero)aromatic ynones, and bis(hetero)aryl ketones were synthesized in good-to-excellent yields in a one-pot fashion.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Electric Literature of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics