Tag: M.W=150-200

Sagar, Sneha R. published the artcilePharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer’s disease, Formula: C7H7ClN2S, the publication is Bioorganic Chemistry (2019), 102992, database is CAplus and MEDLINE.

Alzheimer’s disease (AD) is the most prevalent disease of old age leading to dementia. Complex AD pathogenesis involves multiple factors viz. amyloid plaque formation, neurofibrillary tangles and inflammation. Herein we report of a new series of quinoxaline-bisthiazoles as multitarget-directed ligands (MTDLs) targeting BACE-1 and inflammation concurrently. Virtual screening of a library of novel quinoxaline-bisthiazoles was performed by docking studies. The most active mols. from the docking library were taken up for synthesis and characterized by spectral data. Compounds 8a-8n showed BACE-1 inhibition in micro molar range. One of the compounds, 8n showed BACE-1 inhibition at IC₅₀ of 3 ± 0.07 μM. Rat paw edema inhibition in acute and chronic models of inflammation were obtained at 69 ± 0.45% and 55 ± 0.7%, resp. Compound 8n also showed noteworthy results in AlCl₃ induced AD model. The treated rats exhibited excellent antiamnesic, antiamyloid, antioxidant, and neuroprotective properties. Behavioral parameters suggested improved cognitive functions which further validates the testimony of present study. Moreover, compound 8n was found to have inherent gastrointestinal safety. This new string of quinoxaline-bisthiazoles were identified as effective lead for the generation of potent MTDLs and compound 8n was found to showcase qualities to tackle AD pathogenesis.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gutch, Pranav K. published the artcileN,N-dichloro poly(styrene-co-divinyl benzene) sulfonamide polymeric beads: an efficient and recyclable decontaminating reagent for sulfur mustard, Synthetic Route of 1002-41-1, the publication is Journal of Polymer Materials (2011), 28(3), 431-442, database is CAplus.

An efficient and operationally simple method is developed for chem. decontamination of sulfur mustard. A new chlorine bearing reagent N,N-dichloropoly (styrene-co-divinyl benzene) sulfonamide was developed to deactivate the sulfur mustard in aqueous (acetonitrile: water) medium. This decontamination reaction was monitored by gas chromatog. and the products were analyzed by GC-MS. This reagent has advantage over earlier reported reagents in terms of effectiveness, stability, non toxicity, cost, ease of synthesis, recyclability (collected after filtration, rechlorinated and used for further reaction) and instantaneous decontamination of sulfur mustard at room temperature

Journal of Polymer Materials published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Synthetic Route of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nikhar, Sameer published the artcileDesign of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling, Formula: C7H8BClO2, the publication is European Journal of Medicinal Chemistry (2021), 113252, database is CAplus and MEDLINE.

Receptor interacting protein kinase-2 (RIPK2) is an enzyme involved in the transduction of pro-inflammatory nucleotide-binding oligomerization domain (NOD) cell signaling, a pathway implicated in numerous chronic inflammatory conditions. Herein, a pyrido[2,3-d]pyrimidin-7-one based class of RIPK2 kinase and NOD2 cell signaling inhibitors is described. For example, 33 (e.g. UH15-15) inhibited RIPK2 kinase (IC50 = 8 ± 4 nM) and displayed > 300-fold selectivity vs. structurally related activin receptor-like kinase 2 (ALK2). This mol. blocked NOD2-dependent HEKBlue NF-κB activation (IC50 = 20 ± 5 nM) and CXCL8 production (at concentrations > 10 nM). Mol. docking suggests that engagement of Ser25 in the glycine-rich loop may provide increased selectivity vs. ALK2 and optimal occupancy of the region between the gatekeeper and the αC-helix may contribute to potent NOD2 cell signaling inhibition. Finally, this compound also demonstrated favorable in vitro ADME and pharmacokinetic properties (e.g. Cmax = 5.7μM, Tmax = 15 min, t1/2 = 3.4 h and Cl = 45 mL/min/kg following single 10 mg/kg i.p. administration) further supporting the use of pyrido[2,3-d]pyrimidin-7-ones as a new structure class of RIPK2 kinase and NOD cell signaling inhibitors.

European Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lamaty, G. published the artcileAcid hydrolysis of 2-haloethylamines. I. Determination of kinetic conditions. Evaluation of the participant of the nitrogen lone pair in the loss of the halogen, Product Details of C5H13Cl2N, the publication is Bulletin de la Societe Chimique de France (1974), 2143-8, database is CAplus.

The kinetics of hydrolysis of haloamines, XCH2CH2NHR2+X- (I; R = H, Me, Et; X = Br, Cl) at 90 and 100° follow a first order rate law. Initial variations in linearity for the curve log [I] = kexp.(sec-1) are due to the competitive hydrolysis of I and its conjugate base. The rate of hydrolysis of the conjugate base is suppressed by the addition of small amounts of HClO4.

Bulletin de la Societe Chimique de France published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Product Details of C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pernot, Robert published the artcileThe reaction of ethylene with sulfur monochloride (S₂Cl₂) and with sulfur dichloride (S₂Cl₂ + Cl₂) in the preparation of bis(2-chloroethyl) sulfide (mustard gas), Safety of 1,2-Bis(2-chloroethyl)disulfane, the publication is Ann. chim. [12] (1946), 626-57, database is CAplus.

Crude mustard gas (I) as obtained in the Levinstein process is a clear yellow liquid, m. 10.5°, which does not deposit a trace of S when kept for over a year. On distillation in vacuo I gives 70% pure (ClCH₂CH₂)₂S.(II), m. 13.5°. I is only partially soluble in EtOH or ether. The m.p. is only slightly affected when byproducts are present. When 500 g. I is extracted with 500 cc. EtOH, 208 g. remains undissolved. On cooling the alc. solution, 130 g. II, m. 13.3°, crystallizes. When 500 g. I is cooled with ice-NaCl, 245 g. II, m. 12.5°, crystallizes. Distillation of 323 g. I gives 2 fractions, (a) 185 g., b₁₈ 110-15°, m. 13.3°, and (b) 40 g., b₁₈ 115-55°, m. 3.8°, the residue decomposing Redistillation of 40 g. of fraction a gives a fraction (c) 25 g., b₁₈ 110-15°, and 12 g., b₁₈ 120-35°, the latter being chiefly (ClCH₂CH₂)₂S₂ (III). Distillation of the EtOH solution gives II, but no III or (ClCH₂CH₂)₂S₃ (IV) is present. From the EtOH-insoluble part no definite product can be isolated even on distillation at 1 mm. It still contains a small amount of II which is removed by careful oxidation with H₂O₂, whereby II is oxidized to the H₂O-soluble sulfoxide while III and IV remain unchanged. The elementary composition of the residue after treatment with H₂O₂ corresponds to (ClCH₂CH₂)₂S₈ (V) which may be formed according to the following equation: 7S₂Cl₂ + 14C₂H₄ → 6 II + V. Treatment of 86 g. EtOH-insoluble product with moist NH₃ according to Felsing and Arenson (C.A. 15, 54) causes the separation of 16.5 g. S. The recovered product, now soluble in ether and C₆H₆, is free of N and has a composition corresponding to (ClCH₂CH₂)₂S₄ (VI). VI does not deposit S even after standing 6 mo. When VI is heated with S, the latter dissolves and seps. again on cooling. In an attempt to hydrolyze VI with alc. KOH no definite compound is formed. When VI is treated with Me₂CO, S is deposited with the formation of IV, m. 27°. IV is also formed when VI is treated with steam at 100 mm. An attempt to oxidize IV with BzO₂H, to transfer it into the iodine compound by heating it with NaI in a sealed tube, or to condense IV with PhONa or BzONa failed. Distillation of 50 g. IV at 1 mm. gives 40 g. yellow liquid, b₁ 120-35°. Redistillation of the latter gives 2 fractions, (d) 10 g., b₁ up to 120°, and (e) 28 g., b₁ 120-6°, containing chiefly IV, m. 26.5°. IV prepared according to Mann, et al. (C.A. 15, 2413), m. 25°; the mixed m.p. of the 2 preparations is 26°. When IV is heated with the theor. amount of S to form VI, the S dissolves but seps. again on cooling. IV when distilled at 40 mm. gives a small amount of III, b. 160-5°, which is not attacked by H₂O₂. When distilled at atm. pressure III gives a very small amount of II. These results show that III has the structure (ClCH₂CH₂S)₂ and not (ClCH₂CH₂)₂S:S, while IV has the structure ClCH₂CH₂S(:S)SCH₂CH₂Cl. When 220 g. EtOH-insoluble product is extracted 5 times with 200 cc. pure and dry Me₂CO and the Me₂CO is evaporated, 80 g. of yellow oil is obtained from which some (ClCH₂CH₂)₂SO crystallizes. The residual oil has a composition corresponding to (ClCH₂CH₂)₂S₅ (VII) and is insoluble in EtOH, petr. ether, and AcOH. Pyridine precipitates 8.5 g. S from 43 g. VII. Evaporation of the pyridine leaves an oil which on distillation at 3 mm. gives a mixture of III and IV. The Me₂CO-insoluble part (140 g.), when cooled, deposits 16 g. S. The filtrate consists of a polysulfide or a mixture of polysulfides high in S content (75.7-6.7%). The hypothesis that II is formed according to the equation S₂Cl₂ + 2C₂H₄ → II + S is not substantiated by the action of C₂H₄ upon S₅Cl₂. When 580 g. S₅Cl₂ is treated with C₂H₄, 733 g. reaction product is obtained from which 207 g. S deposits, giving 526 g. reaction product. From 342 g. S₂Cl₂, which equals 580 g. S₅Cl₂, and 142 g. C₂H₄, 484 g. reaction product is calculated while 526 g. is obtained. These results indicate that S₅Cl₂ reacts in the same way as S₂Cl₂. The following reaction mechanism is proposed: S₂Cl₂ + 3C₂H₄ gives a sesquimustard gas, (CH₂SCH₂CH₂Cl)₂ (VIII). VIII reacts with S₂Cl₂ to give 1 mol. II and ClSS₂CH₂CH₂Cl (IX); IX + C₂H₄ → IV. IV + S₂Cl₂ → Cl.S.CH₂CH₂Cl (X) + ClS₄CH₂CH₂Cl (XI); XI + C₂H₄ → II + VI, etc. SCl₂ + C₂H₄ gives 85% crude reaction product (XII), m. 5-8°. Distillation of 109.5 g. XII, m. 5.5°, gives 3 fractions: (f) 97.5 g., b₁₀ 93-6°, m. 10°; (g) 4.5 g., b₁₀ 96-105°; and 3.5 g. residue. Redistillation of 90 g. f gives a fraction, 76.5 g., b₁₂ 97-8°, m. 10°, which on redistillation gives 62.3 g., b₁₃ 101-2°, m. 10.2°, and 11.4 g., b₁₅ 102-4°, m. 11.8°. This indicates that with II other products come over. Because under the conditions used, SCl₂ can be considered to be a solution of Cl in a mixture of SCl₂ and S₂Cl₂, byproducts containing α-chlorinated compounds are formed which split off HCl with formation of ClCH:CHSCH₂CH₂Cl (XIII). II containing 8.8% XIII m. 9.9°. When SCl₂ in a 10% CCl₄ solution and C₂H₄ are allowed to react and the reaction product is distilled after the CCl₄ has been removed at 120°, II, b₁₀ 93.5-4°, m. 10.8°, is obtained. When 800 g. of the reaction product is extracted with EtOH only 31 g. insoluble product (XIV) is obtained. When Cl is passed into 250 g. XIV, the temperature rises to 45-50°. As soon as the temperature drops to room temperature the Cl current is stopped and the reaction product distilled in vacuo. Up to 70°/15 mm. the S-Cl compounds distill, and between 98° and 100° a few cc. of a turbid liquid distills. When C₂H₄ is passed at 30-40° into the residue, a vigorous reaction takes place. After the active Cl in the residue has disappeared, 303 g. of a clear red solution is obtained. Distillation of 238 g. of this solution gives 3 fractions: (h) 12.6 g., b₁₃ 40-97°; (i) 76.6 g., b₁₃ 97-107°; (j) 8.2 g., b₁₃ 107-25°. Redistillation of i gives a product, b₁₃ 98-101°, m. 8.6°. Oxidation of 4.3 g. of this product with H₂O₂ at 50° in AcOH gives 1.2 g. of a sulfoxide, m. 108°, which when mixed with the sulfoxide of II, m. 108°. These results indicate that the Cl splits the polysulfides, ClCH₂CH₂S(:S_x)S(:S_y)CH₂CH₂Cl, to give 2 mols. X, while the S is converted into SCl₂ which again reacts with C₂H₄ with excess formation of a certain amount of II. On the other hand, the Cl also reacts with X, giving rise to the formation of XIV.

Ann. chim. [12] published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Safety of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shapiro, David published the artcileSome derivatives of amidone, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Journal of Organic Chemistry (1949), 839-48, database is CAplus.

Because amidone (I) possesses biol. properties some ring-substituted I, its fluorene analog, 9-(2-dimethylaminopropyl)-9-propionylfluorene (II), and 4,5-diphenyl-4-(2-dimethylaminopropyl)-3-pentanone (III), have been synthesized. To crude PhCHBrCN (prepared by addition of 17 cc. Br to 35 g. PhCH₂CN at 105-10° within 0.5 hr.) in 150 cc. C₆H₆ is added within 20-30 min. 42 g. powd. AlCl₃ at 45-50°, the mixture heated 1 hr. at 60-5°, the C₆H₆ distilled off (up to 125° bath temperature), the residue decomposed with 800 cc. ice H₂O containing 20 cc. concentrated HCl, the mixture steam-distilled 20 min., and the reddish oil distilled, giving 74% Ph₂CHCN, b_0.2 121-5°, m. 75°. Ph(p-MeC₆H₄)CHCN (IV), prepared in a similar way in 65% yield, b₄ 164-70°, m. 61°; Ph(p-MeOC₆H₄CHCN (V) (32%), b₂ 155-65°; Ph(p-BrC₆H₄)CHCN (VI) (80%), b_0.8 172-6°, m. 82-3°; Ph(PhCH₂)CHCN (VII), b_0.6 158-70°, m. 58°, is prepared in 32% yield by adding 38 g. PhCH₂Cl to 40 g. PhCH₂CN in 150 cc. BuOH containing 7 g. dissolved Na, and refluxing the mixture 4 hrs. Me₂NH (65 g.), 65 g. MeCH(OH)CH₂Cl, and 90 g. PhMe, mixed at 5°, are heated 10 hrs. in an autoclave at 95-100°, the mixture filtered, the residue washed with 250 cc. PhMe, the combined PhMe solution added at 10-15° to 165 g. SOCl₂ in 400 cc. PhMe, and the mixture heated 6 hrs. at 100°, giving 83% MeCHClCH₂NMe₂.HCl, from which the free base (VIII) is liberated with K₂CO₃. Treating 4.4 g. NaNH₂ suspended in 75 cc. PhMe containing 12 g. VIII with 19 g. 9-cyanofluorene in 180 cc. PhMe at 45-50°, heating the mixture 1 hr. at 55-60°, refluxing 1.25 hrs., extracting with 15% HCl, and making the washed aqueous solution alk. give 76% of a mixture (IX), viscous pale yellow oil, b_0.3 168-70°, of RCH₂MeNMe₂ and RCHMeCH₂NMe₂ (R = 9-cyano-9-fluorenyl), also obtained when MeCH(NMe₂)CH₂Cl (X) is used in lieu of VIII (cf. Schultz and Sprague, C.A. 42, 4934i). V and VIII (or X), treated in the same way, give 44% of a mixture b_0.1 162-8°, of Ph(p-R’C₆H₄)C(CN)CH₂CHMeNMe₂ (XI) and Ph(p-R’C₆H₄ C(CN)CHMeCH₂NMe₂ (XII) (R’ = MeO). IV and VIII (or X) give 69% of a mixture, b_0.1 148-55°, of XI and XII (R’ = Me); VI and VIII (or X) give 74% of a mixture, b_0.05 162-70°, of XI and XII (R’ = Br); VII and VIII (or X) give a mixture (XIII), b_0.1 148-55°, of Ph(PhCH₂)C(CN) CH₂CHMeNMe₂ and Ph(PhCH₂)C(CN) CHMeCH₂NMe₂. The nitriles are treated directly with EtMgBr and the resulting ketimines hydrolyzed. IX (20 g.) in 100 cc. C₆H₆ is added to EtMgBr from 6.5 g. Mg and 26 cc. EtBr in 60 cc. boiling ether, the ether being simultaneously distilled off, the mixture refluxed 10 hrs., decomposed with ice-cold NH₄Cl, extracted with cold 25% H₂SO₄, the sq. solution washed with C₆H₆, 50 cc. H₂SO₄ added, and the mixture heated 1.5 hrs. at 100° and made alk., giving 65% II, b_0.6 152-8°, m. 66-8° (HCl salt, m. 262-4°). In the same way mixtures of R”CH₂CHMeNMe₂ (XIV) and R”CHMeCH₂NMe₂ (XV) [R” = Ph(p-R’C₆H₄)(EtCO)C] are prepared (R’, yield, b.p., m.p. of HCl salt (a) and picrate (b) in the order given); Me, 82%, b₂ 175-80°, a 202-4°, b 138-40°; MeO, 60%, b_0.1 160-3°, a 162-3°, b 178-9°; Br, 80%, b_0.1 175-80°, a 205-7°, b 153-4°. Treatment of XIII in the same way gives 75% of a mixture, b_0.2 174-8°, of XIV and XV [R” = Ph(PhCH₂)(EtCO)C][HCl salt, crystallizing with H₂O, m. 100-3°, (H₂O-free) m. 145-7°; picrate m. 164-6°, from which III [XIV, R” = Ph(PhCH₂)(EtCO)C], m. 67-8°, is obtained with NaOH]. MeCH:CHCOPh (42 g.) and 30 g. NHMe₂ in 60 g. PhMe mixed at 5-10°, then heated 18 hrs. at 60°, the solvent evaporated in vacuo, and the residue heated 2 hrs. at 70°, give 45 g. β-(dimethylamino)butyrophenone (XVI), decompose on purification (picrate, m. 122-3°). XVI with EtMgBr gives 1,1-diphenyl-3-dimethylamino-1-butanol (XVII), m. 120-2° (picrate m. 160-2°). XVII is not reduced in HClO₄ in the presence of Raney Ni or Pd. Heating XVII with KHSO₄ 1.5 hrs. at 150-60° gives 1,1-diphenyl-3-dimethylamino-1-butene, oil (picrate, m. 195-6°), which is hydrogenated in 6 hrs. with Ni at 20° and atm. pressure to the butane analog (picrate, m. 138-40°). XVI and PhCH₂MgBr give 28% 4,5-diphenyl-2-dimethylamino-4-pentanol (XVIII), m. 94-5° (picrate, m. 135-7°). Dehydration of XVIII with KHSO₄ and hydrogenation of the pentene give 4,5-diphenyl-2-(dimethylamino)pentane [picrate (XIX), m. 168-70°]. Heating 1 g. III with 0.8 g. NaOH and 5 cc. triethyleneglycol 4 hrs. at 220-5°, extracting the mixture with ether, and treating the ether extract with picric acid give XIX. The ultraviolet absorption curves of the ketones are given. II in doses of 0.5-5 mg./kg. shows a slight analgetic action; with 10 mg./kg. tono-clonic convulsions are observed in rabbits. The lethal dose is 62 mg./kg. II has also a spasmolytic effect of about the same order as papaverine-HCl.

Journal of Organic Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C4H6N2, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Strzelczyk, Marek published the artcileSynthesis of 7-9-membered heterocyclic systems containing nitrogen and sulfur with expected pharmacological activity. I. Synthesis of perhydro-1,4,5-thiadiazocine, -1,4,6-thiadiazonine, and -1,2,5,7-dithiadiazonine derivatives, Name: 1,2-Bis(2-chloroethyl)disulfane, the publication is Acta Poloniae Pharmaceutica (1985), 42(4), 337-44, database is CAplus.

RCONHNHCOR (R = Me, Et, Ph, 2,4-Cl₂C₆H₃) were converted with NaNH₂ in C₆H₆ into the di-Na salts, which, condensed with Cl(CH₂)₂S(CH₂)₃Cl (I) in DMF, yielded 4,5-diacylperhydro-1,4,5-thiadiazocines II. 4,5-Bis(phenylsulfonyl)perhydro-1,4,5-thiadiazocine was prepared analogously from PhSO₂NHNHSO₂Ph. An analogous reaction with (MeNH)₂CO (III) gave thiadiazonine IV (X = CH₂), which was also obtained directly from I and III, refluxed in hexanol containing some Na₂CO₃. The latter method was also used to obtain the dimer IV (X = S) from III and (ClCH₂CH₂S)₂ (V), whereas meso-2,3-diaminobutane-2HCl, condensed under similar conditions with V, yielded VI.

Acta Poloniae Pharmaceutica published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C8H11NO, Name: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Strzelczyk, Marek published the artcileSynthesis of perhydro-1,2,5-dithiazepine derivatives of potential pharmacological activity, Application In Synthesis of 1002-41-1, the publication is Polish Journal of Pharmacology and Pharmacy (1984), 36(5), 473-84, database is CAplus and MEDLINE.

Perhydro-1,2,5-dithiazepines, e.g., I [R = H (II), Ph₂CH (III)] were prepared via cyclocondensation of ClCH₂CH₂SSCH₂CH₂Cl with amines. II and III showed spasmolytic, antihistaminic, and anticholinergic activities stronger than their analogs containing a perhydro-1,4-thiazepine system, but weaker than diphenhydramine.

Polish Journal of Pharmacology and Pharmacy published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C15H14O3, Application In Synthesis of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vineet Kumar Singh, Amrita Parle published the artcileSynthesis, characterization and antioxidant activity of 2-aryl benzimidazole derivatives, Synthetic Route of 6313-54-8, the publication is Asian Journal of Pharmaceutical Research and Development (2020), 8(2), 35-44, database is CAplus.

In the present study 19 benzimidazole derivatives were synthesized by reacting O-phenylenediamine as the primary reactant with different aromatic aldehydes and benzoic acids. Reactions were monitored using thin layer chromatog. technique, and the newly synthesized derivatives were characterized by ATIR and ¹HNMR techniques. The antioxidant assay was performed using ABTS [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] method and DPPH [2,2-diphenyl-1-picrylhydrazyl] method.

Asian Journal of Pharmaceutical Research and Development published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C7H13NO2, Synthetic Route of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Williams, A. H. published the artcileThermal decomposition of bis(2-chloroethyl) sulfide, COA of Formula: C4H8Cl2S2, the publication is Journal of the Chemical Society (1947), 318-20, database is CAplus and MEDLINE.

The decomposition of (ClCH₂CH₂)₂S (I) was studied at 180°, the b.p (about 220°), 350°, and 450° (the last 2 by dropping I into a heated column packed with quartz rings). The products of decomposition at the above temperatures (in percentages of the initial weight of I) are: HCl 8.0, 21.2, 25.8, 31.5; C₂H₄ 4.2 11.2, 7.9, 10.4; C₂H₄Cl₂ 6.9, 11.1, -, -; H₂S -, -, 3.9, 5.2; CH₂:CHCl -, -, 14.6, 19.4; dithiane 1.3, 3.3, trace, trace; (ClC₂H₄)₂S₂ 5.8, 8.5, 2.0, -; I recovered 56.0, 14.2, 13.0, -; residue 12.2, 25.7, 31, 32; CS₂ -, -, 1, l. The residue of the 1st 2 experiments (after heating at 120°/4 mm.) contained 43-4% S and 17-17.5% Cl; that of the last 2 experiments was distributed over the interior of the column and could not be analyzed. The introduction of SiO₂ in the 2nd experiment did not produce any CH₂:CHCl but gave a small quantity of H₂S and some acceleration of the normal reaction; the decomposition of I in glass at the b.p. is not a surface reaction.

Journal of the Chemical Society published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C19H14Cl2, COA of Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics