Tag: M.W=150-200

Allgeier, Alan M. published the artcileElectrochemically Controlling Ligand Binding Affinity for Transition Metals via RHLs: The Importance of Electrostatic Effects, HPLC of Formula: 1002-41-1, the publication is Journal of the American Chemical Society (1997), 119(3), 550-559, database is CAplus.

Redox-switchable hemilabile ligands (RHLs) were synthesized that incorporates ferrocene as the redox group and phosphine ether or phosphine thioether moieties as binding groups. These ligands, which complex to Rh(I) and Pd(II), yield electrochem. control over ligand binding affinity for transition metals in complexes of the following type: [M(η⁴-(η⁵-C₅H₄XCH₂CH₂PR₂)₂Fe)]^y+ (I: M = Rh, X = O, R = Ph (phenyl), y = 1; II: M = Rh, X = O, R = Cy (cyclohexyl), y = 1; III: M = Rh, X = S, R = Ph, y = 1; IV: M = Pd, X = O, R = Ph, y = 2; V: M = Pd, X = O, R = Cy, y = 2). In the case of V, ligand based oxidation decreases the ligand to metal binding constant by nearly ten orders of magnitude. An examination of the crystal structures of I, III, IV, and V and the electrochem. behavior of RHL-complexes and isoelectronic model complexes reveals that electrostatic effects play a significant role in the charge dependent behaviors of these complexes. Addnl., there is a correlation between the phosphine substituents and RHL-complex stability. As a general rule cyclohexyl groups stabilize the complexes in their oxidized states over Ph groups. RHLs provide a viable means of electrochem. controlling ligand binding affinity and thus the steric and electronic environment of bound transition metals.

Journal of the American Chemical Society published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, HPLC of Formula: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lankova, Martina published the artcileAuxin influx inhibitors 1-NOA, 2-NOA, and CHPAA interfere with membrane dynamics in tobacco cells, Product Details of C8H7ClO3, the publication is Journal of Experimental Botany (2010), 61(13), 3589-3598, database is CAplus and MEDLINE.

The phytohormone auxin is transported through the plant body either via vascular pathways or from cell to cell by specialized polar transport machinery. This machinery consists of a balanced system of passive diffusion combined with the activities of auxin influx and efflux carriers. Synthetic auxins that differ in the mechanisms of their transport across the plasma membrane together with polar auxin transport inhibitors have been used in many studies on particular auxin carriers and their role in plant development. However, the exact mechanism of action of auxin efflux and influx inhibitors has not been fully elucidated. In this report, the mechanism of action of the auxin influx inhibitors (1-naphthoxyacetic acid (1-NOA), 2-naphthoxyacetic acid (2-NOA), and 3-chloro-4-hydroxyphenylacetic acid (CHPAA)) is examined by direct measurements of auxin accumulation, cellular phenotypic anal., as well as by localization studies of Arabidopsis thaliana auxin carriers heterologously expressed in Nicotiana tabacum, cv. Bright Yellow cell suspensions. The mode of action of 1-NOA, 2-NOA, and CHPAA has been shown to be linked with the dynamics of the plasma membrane. The most potent inhibitor, 1-NOA, blocked the activities of both auxin influx and efflux carriers, whereas 2-NOA and CHPAA at the same concentration preferentially inhibited auxin influx. The results suggest that these, previously unknown, activities of putative auxin influx inhibitors regulate overall auxin transport across the plasma membrane depending on the dynamics of particular membrane vesicles.

Journal of Experimental Botany published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hwang, Jong Yeon published the artcileOptimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei, COA of Formula: C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(14), 4127-4131, database is CAplus and MEDLINE.

We previously reported the phenylchloronitrobenzamides (PCNBs), a novel class of compounds active against the species of trypanosomes that cause Human African Trypanosomiasis (HAT). Herein, we explored the potential to adjust the reactivity of the electrophilic chloronitrobenzamide core. These studies identified compound 7d that potently inhibited the growth of trypanosomes (EC₅₀ = 120 nM for Trypanosoma b. brucei, 18 nM for Trypanosoma b. rhodesiense, and 38 nM for Trypanosoma b. gambiense) without significant cytotoxicity against mammalian cell lines (EC₅₀ > 25 μM for HepG2, HEK293, Raji, and BJ cell lines) and also had good stability in microsomal models (t_1/2 > 4 h in both human and mouse). Overall these properties indicate the compound 7d and its analogs are worth further exploration as potential leads for HAT.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hahn, Witold E. published the artcileDicarboxylic acid imides. VI. N-Aminoalkoxyphenyl derivatives of 4-cyclohexene-1,2-dicarboximide, Computed Properties of 4584-49-0, the publication is Acta Poloniae Pharmaceutica (1980), 37(4), 403-8, database is CAplus.

Eighteen imide derivatives (I; n = 2, 3; R = Me, Et, Me₂CH, 1-piperidinyl, 1-pyrrolidinyl) were prepared by reaction of Cl(CH₂)_nNR₂ with the corresponding phenolic compound (II) in Me₂CO in the presence of K₂CO₃. An alternative route of synthesis involved the reaction of II with Br(CH₂)_nBr and subsequent treatment of the thus formed III with R₂NH. Hypotensive and psychotropic activity of several I was claimed.

Acta Poloniae Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Computed Properties of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

El-Sakka, Sahar Said published the artcileBehaviour of 4-[4-methoxy-3-methylphenyl]-4-oxobutenoic acid towards nitrogen-containing nucleophiles, SDS of cas: 3696-23-9, the publication is Journal of Chemical Sciences (Bangalore, India) (2014), 126(6), 1883-1891, database is CAplus.

A series of novel amino acid derivatives has been synthesized by the reaction of 4-[4-methoxy-3-methylphenyl]-4-oxobutenoic acid with primary and secondary amines. The treatment of amino acids with hydrazine afforded pyridazine. Phenylhydrazone was obtained from the reaction of the acid with Ph hydrazine in ethanol. On the other hand, the acid underwent heterocyclization upon the treatment with 2-aminopyridine, o-phenylenediamine, aryldithiocarbamates and thiourea derivatives to give the corresponding pyridopyrimidine, quinoxalone, 2-thioxo-1,3-thiazole and 4-hydroxy-1,3-thiazole, resp. The thiazolopyridazine derivatives were obtained from the reaction of 4-hydroxy-1,3-thiazole with hydrazine and phenylhydrazine, resp. The behavior of the 4-hydroxy-1,3-thiazole toward acetic anhydride and bromine was also studied. Some of the synthesized compounds also exhibited anti-microbial activities.

Journal of Chemical Sciences (Bangalore, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hamdy, Rania published the artcileDesign and synthesis of new drugs inhibitors of Candida albicans hyphae and biofilm formation by upregulating the expression of TUP1 transcription repressor gene, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is European Journal of Pharmaceutical Sciences (2020), 105327, database is CAplus and MEDLINE.

Here, new compounds were designed to selectively inhibit C. albicans hyphae formation without affecting human cells to afford sufficient safety. The newly designed 5-[3-substitued-4-(4-substituedbenzyloxy)-benzylidene]-2-thioxo-thiazolidin-4-one derivatives, named SR, I (R¹ = 4-Me, 4-CF₃, 3-CF₃; R² = OMe, Cl, Br) showed very specific and effective inhibition activity against C. albicans hyphae formation. SR compounds caused hyphae inhibition activity at concentrations 10-40 fold lower than the concentration required to inhibit Candida yeast and bacterial growths. The anti-hyphae inhibition activities of SR compounds were via activation of the hyphae transcription repressor gene, TUP1. Correlation studies between the expression of TUP1 gene and the activity of SR compounds confirmed that the anti-C. albicans activities of SR compounds were via inhibition of hyphae formation. The newly designed SR compounds showed 10-40% haemolytic activity on human erythrocytes when compared to 100% haemolysis by 0.1% triton employed as pos. control. Furthermore, theor. prediction of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of SR compounds confirmed their safety, efficient metabolism and possible oral bioavailability. With the minimal toxicity and significant activity of the newly-designed SR compounds, a future optimization of pharmaceutical formulation may develop a promising inhibitor of hyphal formation not only for C. albicans but also for other TUP1-dependent dimorphic fungal infections.

European Journal of Pharmaceutical Sciences published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rao, B. Vittal published the artcileSynthesis of 2,3-diphenyl-6-(p-substituted phenyl)-5H- and (or) -methyl-7H-oxofuro[3,2-g][1]benzopyrans as possible antifertility agents, HPLC of Formula: 4584-49-0, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1980), 19B(3), 232-4, database is CAplus.

Synthesis and antiimplantation activity of benzopyrans I [R = Me₂NCH₂CHMe, 3-piperidinopropyl, 2-morpholinoethyl, 3-piperazinoethyl, 2-(1-pyrrolidinyl)ethyl, Me₂NCH₂CH₂; R¹ = H, Me] are reported. I (R = Me₂NCH₂CHMe; R¹ = Me) shows significant activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, HPLC of Formula: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rao, B. Vittal published the artcileSynthesis and antifertility activity of 5-oxo-5H-benzofuro(6,5-c)[2]benzopyran and its basic ether derivatives, SDS of cas: 4584-49-0, the publication is Journal of the Indian Chemical Society (1980), 57(8), 837-40, database is CAplus.

Benzofurobenzopyranones I (R = H, aminoalkyl) were prepared from 2-BrC₆H₄CO₂H and benzenediols via 7-hydroxy-3,4-benzocoumarins and cyclization of the corresponding desyl ethers. I caused â‰?3.3% inhibition of fetal implantation at 10 mg/kg i.p. in rats.

Journal of the Indian Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sousa-Pereira, Danilo published the artcileSynthetic (E)-3-phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium chloride derivatives as promising chemotherapy agents on cell lines infected with HTLV-1, Product Details of C7H7ClN2S, the publication is Molecules (2020), 25(11), 2537, database is CAplus and MEDLINE.

Synthesis of four compounds belonging to mesoionic class, (E)-3-phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium chloride derivatives (5a-d) and their biol. evaluation against MT2 and C92 cell lines infected with human T-cell lymphotropic virus type-1, which causes adult T-cell leukemia/lymphoma (ATLL), and non-infected cell lines (Jurkat) are reported. The compounds were obtained by convergent synthesis under microwave irradiation and the cytotoxicity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Results showed IC50 values of all compounds in the range of 1.51-7.70μM in HTLV-1-infected and non-infected cells. Furthermore, it was observed that 5b could induce necrosis after 24 h for Jurkat and MT2 cell lines. The exptl. (fluorimetric method) and theor. (mol. docking) results suggested that the mechanism of action for 5b could be related to its capacity to intercalate into DNA. Moreover, the preliminary pharmacokinetic profile of the studied compounds (5a-d) was obtained through human serum albumin (HSA) binding affinity using multiple spectroscopic techniques (CD, steady-state and time-resolved fluorescence), zeta potential and mol. docking calculations The interaction HSA:5a-d is spontaneous and moderate (Ka ~104 M-1) via a ground-state association, without significantly perturbing both the secondary and surface structures of the albumin in the subdomain IIA (site I), indicating feasible biodistribution in the human bloodstream.

Molecules published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C3H8N2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Samet, Alexander V. published the artcileAn Efficient Synthesis of Fused 2-Aryliminothiazolines via a Solvent-Free Cyclopropyliminium Rearrangement, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is ChemistrySelect (2016), 1(10), 2373-2376, database is CAplus.

A series of (Z)-3-aryliminopyrrolo[1,2-c]thiazoles I (Ar = Ph, 4-chlorophenyl, 4-methylphenyl, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, 3-trifluoromethylphenyl) was synthesized by a base-induced dehydrobromination of 3-arylaminopyrrolo[1,2-c]thiazolium bromides II, which in turn, was obtained via an efficient solvent-free cyclopropyliminium rearrangement of the corresponding 4-cyclopropylthiazole hydrobromides III proceeding in melt at high rate and in excellent yields. Biol. evaluation using phenotypic sea urchin embryo assay showed that 2-arylamino-4-cyclopropylthiazoles IV displayed an antimitotic tubulin-unrelated activity, whereas fused-ring rearrangement products III were proposed to inhibit Ca-Zn-dependent metalloproteases.

ChemistrySelect published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics