Tag: M.W=100-200

Recommanded Product: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Synthesis and crystal structure of an optically active, internally coordinated alkylchloroborane. The boron-centered anomeric effect. Author is Shiner, Christopher S.; Garner, Charles M.; Haltiwanger, R. Curtis.

The synthesis and crystal structure of (S)-(O-B)-chloro[(1S,2R,3S,5S)-2-[2-(R)-methoxyethyl]-6,6-dimethyl-3-norpinyl]borane, an optically active, internally coordinated alkylchloroborane monomer, are described. This is the 1st crystallog. structure determination for a chiral organoborane, and the 1st complete x-ray anal. of a monoborane-ether complex. Key features of the structure, including the configuration of the stereogenic B atom, the unusually long B-Cl bond (d = 1.890 Å), and the geometry of the trivalent O, are manifestations of a novel B-centered anomeric effect. An improved preparation of BH2Cl.SMe2 was also devised.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides, published in 2020-10-16, which mentions a compound: 35836-73-8, Name is 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, Molecular C11H18O, Computed Properties of C11H18O.

The first continuous flow process was developed to synthesize N-Me secondary amines from alkyl mesylates and epoxides via a nucleophilic substitution using aqueous methylamine. A variety of N-Me secondary amines were produced in good to excellent yields, including a number of bioactive compounds, or their precursors. Up to 10.6 g (88% yield) of a N-Me secondary amine was produced in 140 min process time. The amination procedure included an in-line workup, and the starting mesylate material was also produced in continuous flow from the corresponding alc. Finally, an in-line process combining the mesylate synthesis and nucleophilic substitution was developed.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dhanawat, Meenakshi; Gupta, Sumeet; Mehta, Dinesh Kumar; Das, Rina researched the compound: Piperidine-3-carboxylic acid( cas:498-95-3 ).Recommanded Product: 498-95-3.They published the article 《Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug》 about this compound( cas:498-95-3 ) in Drug Research (Stuttgart, Germany). Keywords: pentylenetetrazole serine nipecotic acid blood brain barrier. We’ll tell you more about this compound (cas:498-95-3).

Nipecotic acid is considered to be one of the most potent inhibitors of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Due to its hydrophilic nature, nipecotic acid does not readily cross the blood-brain barrier (BBB). Large neutral amino acids (LAT1)-knotted nipecotic acid prodrug was designed and synthesized with the aim to enhance the BBB permeation by the use of carrier-mediated transport. The synthesized prodrug was tested in animal models of Pentylenetetrazole (PTZ)-induced convulsions in mice. Further pain studies were carried out followed by neurotoxicity estimation by writhing and rota-rod test resp. HPLC data suggests that the synthesized prodrug has improved penetration through BBB. Nipecotic acid-L-serine ester prodrug with considerable anti-epileptic activity, and the ability to permeate the BBB has been successfully synthesized.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Carbon-13 nuclear magnetic resonance studies. Camphene racemization. III. endo-Methyl migration problem.Category: chlorides-buliding-blocks.

By means of 13C labeling at the 8 position of camphene, it was possible to effect simultaneous analysis by NMR for the amount of the isotope label at each of the possible positions (8,9, and 10) after partial racemization. With these data, it is possible to make full use of integrated rate equations developed earlier and thus obtain a more precise and significant value for the extent of endo-Me migration during racemization. It is also possible to provide reasonably exact rate constants for all of the various processes contributing to racemization, including tricyclene formation. The endo-Me migration appears to be very small: certainly less than 5% (as compared with the previously reported 22%) but very likely not actually zero.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about A manganese catalyst for highly reactive yet chemoselective intramolecular C(sp3)-H amination. Author is Paradine, Shauna M.; Griffin, Jennifer R.; Zhao, Jinpeng; Petronico, Aaron L.; Miller, Shannon M.; Christina White, M..

C-H bond oxidation reactions underscore the existing paradigm wherein high reactivity and high selectivity are inversely correlated. The development of catalysts capable of oxidizing strong aliphatic C(sp3)-H bonds while displaying chemoselectivity (i.e., tolerance of more oxidizable functionality) remains an unsolved problem. Here, we describe a catalyst, manganese tert-butylphthalocyanine [Mn(tBuPc)], that is an outlier to the reactivity-selectivity paradigm. It is unique in its capacity to functionalize all types of C(sp3)-H bond intramolecularly, while displaying excellent chemoselectivity in the presence of π functionality. Mechanistic studies indicate that [Mn(tBuPc)] transfers bound nitrenes to C(sp3)-H bonds via a pathway that lies between concerted C-H insertion, observed with reactive noble metals such as rhodium, and stepwise radical C-H abstraction/rebound, as observed with chemoselective base metals such as iron. Rather than achieving a blending of effects, [Mn(tBuPc)] aminates even 1° aliphatic and propargylic C-H bonds, demonstrating reactivity and selectivity unusual for previously known catalysts.

Although many compounds look similar to this compound(35836-73-8)Quality Control of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, numerous studies have shown that this compound(SMILES:CC1(C)[C@@]2([H])CC=C(CCO)[C@]1([H])C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Asymmetric Anionic Polymerization of N-Substituted Maleimides with n-Butyllithium-Methylene-Bridged 2,2-Bis(oxazoline) Complexes. Author is Onimura, Kenjiro; Tsutsumi, Hiromori; Oishi, Tsutomu.

Asym. anionic homopolymerizations of achiral N-substituted maleimide [RMI: R = cyclohexyl (CHMI), R = Ph (PhMI), R = tert-Bu (TBMI)] were carried out with n-butyllithium (n-BuLi)-chiral bis(oxazoline) complexes to obtain optically active polymers. (-)-2,2′-(1-Ethylpropylidene)bis(4-alkyl-2-oxazoline) derivatives [4-alkyl(R’): R’ = benzyl ((S,S)-Bnbox), R’ = iso-Bu ((S,S)-i-Bubox), R’ = iso-Pr ((S,S)-i-Prbox), and R’ = Ph ((R,R)-Phbox)] were prepared from amino alcs. and diethylmalonic acid. The polymer initiated by n-BuLi-(S,S)-Bnbox showed the highest sp. rotation [poly(CHMI), [α]43525 +111.4°]. The poly(PhMI) prepared with (S,S)-i-Prbox as chiral ligand showed a neg. sp. rotation (-19.1°). The poly(TBMI) initiated by n-BuLi-(R,R)-Phbox showed a large sp. rotation (-63.2°). The sp. rotations were attributed to different contents between stereogenic centers (S,S) and (R,R) based on threo-diisotactic structures of the main chain.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《N-Substituted 1,2,3,4-tetrahydroquinolines》. Authors are Rachinskii, F. Yu.; Slavachevskaya, N. M.; Sovalkova, L. K..The article about the compound:2-(3,4-Dihydroquinolin-1(2H)-yl)ethanaminecas:37481-18-8,SMILESS:NCCN1CCCC2=C1C=CC=C2).Formula: C11H16N2. Through the article, more information about this compound (cas:37481-18-8) is conveyed.

Passage of ethylene oxide into 266 g. 1,2,3,4-tetrahydroquinoline and 1 ml. H2O at 25-30° gave 48 g. N-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinoline (I), b5 140-4° n20D 1.5740, d20 1.1041, 68 g. N-[2-(2-hydroxyethoxy)ethyl]analog, b4 167-70°, 1.5523, 1.1055, and 7 g. N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]analog, b5 205-7°, 1.5420, 1.1053. I.HBr m. 120-2°. Adding 0.1 mole N-(2-cyanoethyl)1,2,3,4-tetrahydroquinoline (II) in EtOH to 40 g. powd. Ni-Al alloy in 1% NaOH and refluxing 4 hrs. gave after addition of HCl, evaporation, and treatment with NaOH, 63% N-(3-aminopropyl)-1,2,3,4-tetrahydroquinoline, b5 137-40°, 1.5777, 1.0450 (di-HBr salt m. 195-7°). II refluxed with alc. KOH gave 73% N-(2-carboxyethyl)-1,2,3,4-tetrahydroquinoline, m. 70-2°. Tetra-hydroquinoline and BrCH2CH2NH2.HBr treated with EtONa in EtOH and refluxed 2 hrs. gave 7% N-(2-aminoethyl)-1,2,3,4-tetrahydroquinoline, b5 130-2°, 1.5830, 1.0645. Similarly was prepared 10% N-(2-diethylaminoethyl)analog, b5 160-1°, 1.5475, 0.9836. Tetrahydroquinoline and ethylene sulfide in C6H6 in 5 hrs. refluxing gave 6.7% N-(2-mercaptoethyl)-1,2,3,4-tetrahydroquinoline, b5 145°, 1.5990, 1.0903, which treated with a stream of air in EtOH in the presence of FeSO4 gave the corresponding disulfide, isolated as di-HCl salt, m. 118-20°. The mercapto derivative formed an HBr salt, m. 176-7°. Tetrahydroquinoline, CS2, and KOH in C6H6-H2O gave in 2 hrs. 65% K 1,2,3,4-tetrahydroquinolyldithiocarbamate, m. 264-6°. Tetrahydroquinoline and o-C6H4(CO)2O in C6H6 refluxed 3 hrs. gave 57% N,N’-di(1,2,3,4-tetrahydroquinolyl)phthalamide, m. 173-4°. Similarly, o-MeO2CC6H4COCl gave 30% 2-carbomethoxyphthalo-1,2,3,4-tetrahydroquinolide, m. 63-5°, b5 210°. Tetrahydroquinoline and undecylenic acid heated finally at 230° gave 23% N-undecylenyl-1,2,3,4-tetrahydroquinoline, b5 152°, 1.519, 0.9872. Tetrahydroquinoline failed to react with ethylenimine. The products above were tested successfully as antioxidants, insect repellents, and anticorrosion agents.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and biological evaluation of fluorescent GAT-ligands based on asymmetric substituted BODIPY dyes, published in 2020-04-30, which mentions a compound: 498-95-3, mainly applied to fluorescent GAT ligand asymmetry BODIPY dye, Recommanded Product: 498-95-3.

The present study aimed at the development of fluorescent inhibitors addressing the GABA transporters mGAT1-mGAT4 as potential tool compounds in fluorescence based biol. assays. The design of these fluorescent GAT inhibitors followed the structural motifs common for many GAT1-GAT4 inhibitors publicly known except that the lipophilic domain present in this compounds was replaced by a BODIPY moiety to serve as a fluorescent subunit. The fluorescent compounds obtained that way were tested for their inhibitory potencies and subtype selectivities at the four murine GABA transporter subtypes mGAT1-mGAT4 and for their binding affinity for mGAT1. All BODIPY derivatives displayed only low inhibitory potencies and subtype selectivities at the GABA transport proteins mGAT1-mGAT4, as well as low affinities for mGAT1. Still, compounds were found with reasonable binding affinities towards mGAT1 (pKi ∼ 5.0) and inhibitory potencies at mGAT2 and mGAT4 (pIC50 ∼ 5.0).

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Foye, William O.; Ghosh, Krishnendu published an article about the compound: Thiazole-2,4-diamine hydrochloride( cas:72792-54-2,SMILESS:NC1=NC(N)=CS1.[H]Cl ).Application of 72792-54-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:72792-54-2) through the article.

Bis(methylthio) and methylthio amino derivatives of 1-methylpyridinium (and quinolinium)-2-dithioacetic acids, found to have protective activity in mice vs. LDs of γ-radiation, were converted to Cu(II) complexes. The complexes were isolated as double salts with CuCl2, and some were sufficiently soluble to be assayed for superoxide dismutase (SOD) activity. This was done by measuring the inhibition of the superoxide reduction of nitroblue tetrazolium. A pos. correlation was found in both the pyridinium and quinolinium series between the extent of SOD activity and the degree of radiation protection. This provides evidence for a mechanism of whole body radiation protection, based on the ability to dismutate superoxide. Copper complexes of a variety of other heterocyclic ligands showed much less ability to mimic SOD activity.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《N1- and N4-Substituted sulfanilamides. I》. Authors are De, S. C.; Datta, P. K..The article about the compound:Thiazole-2,4-diamine hydrochloridecas:72792-54-2,SMILESS:NC1=NC(N)=CS1.[H]Cl).Application In Synthesis of Thiazole-2,4-diamine hydrochloride. Through the article, more information about this compound (cas:72792-54-2) is conveyed.

A note stating the various derivatives made by combining heterocyclic rings (pyrazolone, hydroxypyrimidine, and thiazole) with the N1 and N4 of sulfanilamide. The following compounds were prepared 1-(p-Sulfamylphenyl)-3-methyl-5-pyrazolone, m. 246°; 1-(p-sulfamylphenyl)-3-methyl-4-(p-sulfamylazobenzene)-5-pyrazolone, m. 298°; 1-(p-carboxyphenyl)-3-methyl-5-pyrazolone, m. 278°; 1-(p-carboxyphenyl)-3-methyl-4-(p-sulfamylazobenzene)-5-pyrazolone, m. 291°; 1-(p-sulfophenyl)-3-methyl-5-pyrazolone, m. 306°; 1-(p-sulfophenyl)-3-methyl-4-(p-sulfamylazobenzene)-5-pyrazolone, m. above 320°; N1-antipyryl-N4-acetylsulfanilamide, m. 265°; N1-antipyrylsulfanilamide, m. 249°; 4-(p-sulfamylazobenzene)-3-amino-5-pyrazolone, m. 274°; 2-(N-acetylsulfanilyl)-3-methyl-5-pyrazolone, m. 195°; 2-sulfanilyl-3-methyl-5-pyrazolone, m. 169°; 1-(N-acetylsulfanilyl)-3-methyl-5-pyrazolone, m. 167°; 2,4-diaminothiazole hydrochloride; 2,4-diamino-5-(sulfamylazobenzene)thiazole, m. 185°; 2,4-diamino-6-hydroxy-5-pyrimidyl(p-sulfamylazobenzene), m. above 300°; sulfanilylguanidine, m. 189°. Details to be published.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics