Tag: M.W=100-200

Electric Literature of 6940-78-9, The chemical industry reduces the impact on the environment during synthesis 6940-78-9, name is 1-Bromo-4-chlorobutane, I believe this compound will play a more active role in future production and life.

Example 47:7 – hydroxy – 250 ml 111H-quin -2 – ketone (8.06g, unitunitunitant ), potassium carbonate (0.05 muM, unitunitunitant 0.075 muM), N, N’ – 50 ml dimethylacetamide), N, N?-dimethylformamido 40 C), and 7.95g bromo 10 min-chlorobutane (10.29g 1 – 0.06 muM, unitunitunits -4 -) were added to the unitunito-type reaction flask. Unitunitaceous . 50 C was stirred under the unitunitaceous 5 hours conditions. After completion of the reaction, water is quenched, solid precipitated, filtered, washed, and the solid obtained is recrystallized, obtaining 7 – (4 – polychloroprene) – 111H-quinoline -2 – ketone 11.8g, 93.7% and gave a Kunit, and a 98.5% purity Kunitz . Example 47 of data characterization: 7 – (4 – Chlorphenoxy) – 111H-quinolin -2 -one prepared.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-chlorobutane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang University of Technology; Weng Yiyi; Yang Ting; (25 pag.)CN109970705; (2019); A;,
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Application of 93-50-5, These common heterocyclic compound, 93-50-5, name is 4-Chloro-2-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 8-chloro-4-oxo-chromene-2-carboxylic acid (Int-1, lg, 4.45 mmol) in DCM (20 mL) was added 4-chloro-2-methoxyaniline (842 mg, 5.34 mmol), DIPEA (1.15 g, 8.9 mmol) and HATU (3.3 g, 8.9 mmol) at room temperature and the resulting mixture was then stirred at room temperature for 18 hours. After the reaction was completed, the mixture was diluted with water (30 mL) and extracted with EtOAc (50 mL) three times. The combined organic layer was washed with brine, dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by silica gel flash chromatography (elution with PE/EtOAc=lO:l~l:3) to give 8-chloro-N-(4-chloro-2-methoxyphenyl)-4-oxo-chromene-2-carboxamide (1.3 g, 80.3 %) as a yellow solid. MS obsd. (ESI+) [(M+H)+]: 364.1.

The synthetic route of 93-50-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Song; LIANG, Chungen; LIU, Yongfu; TAN, Xuefei; WU, Jun; WANG, Jianping; (134 pag.)WO2020/79106; (2020); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 932-32-1, name is 2-Chloro-N-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-Chloro-N-methylaniline

Weigh BTC (58mg, 0.2mmol) in a 25mL two-neck bottle.Add 5 mL of anhydrous dichloromethane, magnetically stir, add equivalents of N-methyl-o-chloroaniline, triethylamine (0.25 mmol) and 5 mL of dichloromethane in a 25 mL constant pressure dropping funnel.Under the ice bath,Slowly add dropwise, remove the ice salt bath after the end of the addition, and stir at room temperature for 4 h.HZA (40 mg, 0.1 mmol) was added to a 10 ml vial, and traces of DMAP, 5 mL of dichloromethane were added, and magnetically stirred at room temperature until completely dissolved. The solution was slowly added dropwise to the above reaction solution under ice salt bath, and the ice salt bath was removed by dropwise addition, and stirred at room temperature. After the reaction is completed, 3 to 6 times the volume of the reaction liquid is added to the above reaction liquid, and distilled water is added.The organic layer was extracted with EtOAc (EtOAc) (EtOAc m.The crude product was then eluted with a petroleum ether:ethyl acetate volume ratio of 20:1 in a mixed solvent, and a thin layer was detected to collect an eluent having a strong ultraviolet at 254 nm and a polarity less than HZA.The combined eluate and the product obtained by evaporating the solvent under reduced pressure are dried to obtain HZAM-12.The yield was 88%.

The synthetic route of 932-32-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University of Technology; Zhan Zhajun; Shan Weiguang; Chen Yan; Shu Renhuan; Wang Jianwei; Ma Liefeng; (31 pag.)CN109956952; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139512-70-2, name is 4-Chloro-5-fluorobenzene-1,2-diamine, A new synthetic method of this compound is introduced below., Product Details of 139512-70-2

General procedure: A mixture of compounds 1a-l (0.013 mol) and 4-chloro-5-fluoro-ophenylenediamine(2) (0.01 mol) in methanol (10 mL) was irradiatedwith ultrasonic irradiation at 50 C for 7 min (8 min for 3a) Afterreaction completion (monitored by TLC, ethyl acetate/hexane = 3:1), themixture was poured onto water and the precipitated product was filtrated off, washed with water and recrystallised from ethanol/water, 3:1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Mente?e, Emre; Kahveci, Bahittin; Mente?e, Meltem; Journal of Chemical Research; vol. 42; 6; (2018); p. 329 – 331;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 102-49-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 102-49-8 as follows.

5.1.2.5 (2r)-N1,N3-Bis(3,4-dichlorobenzyl)-2-nitrocyclohexane-1,3-diamine (7d) 3,4-Dichlorobenzylamine (221 mg, 1.3 mmol) was added to a solution of nitrodiol 6 (101 mg, 0.6 mmol) in H2O (5 mL) and the suspension was stirred overnight at rt. A few drops of CH3OH were added and the mixture was stirred at rt for another 24 h. The mixture was cooled to -6 ¡ãC for a few days. The resulting precipitate was collected by filtration and dried. Colorless solid, mp 92 ¡ãC, yield 258 mg (86percent). C20H21CI4N3O2 (477.2). Rf = 0.78 (CH3OH). 1H NMR (CDCl3): delta (ppm) = 1.08 (qd broad, 2J = 3J = 12.6 Hz, 3J = 3.6 Hz, 2H, 4-Ha, 6-Ha), 1.29 (qt, 2J = 3J = 13.2 Hz, 3J = 3.2 Hz, 1H, 5-Ha), 1.81 (dquint, 2J = 13.8 Hz, 3J = 3.3 Hz, 1H, 5-He), 2.16 (dq, 2J = 13.1 Hz, 3J = 3.4 Hz, 2H, 4-He, 6-He), 3.00 (td, 3J = 11.1 Hz, 3J = 4.1 Hz, 2H, 1-H, 3-H), 3.65 (d, 2J = 13.7 Hz, 2H, Ph-CH2), 3.81 (d, 2J = 13.7 Hz, 2H, Ph-CH2), 4.17 (t, 3J = 10.4 Hz, 1H, 2-H), 7.08-7.12 (m, 2H, Ph-H), 7.33-7.38 (m, 4H, Ph-H). Signals for the NH-protons are not visible in the 1H NMR spectrum. IR: (cm-1) = 3329 (m, nu (N-H)), 1557 (s, nu (NO2)), 1359 (m, nu (NO2)), 820 (m, out-of-plane (Ar-H)). MS (EI): m/z (percent) = 477 (M+, <1), 174 (C7H5Cl2NH+, 56), 159 (C7H5Cl2+, 100). According to the analysis of related databases, 102-49-8, the application of this compound in the production field has become more and more popular. Reference:
Article; Bourgeois, Christian; Werfel, Elena; Schepmann, Dirk; Wuensch, Bernhard; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3316 – 3324;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

139512-70-2, name is 4-Chloro-5-fluorobenzene-1,2-diamine, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 4-Chloro-5-fluorobenzene-1,2-diamine

General procedure: A mixture of compounds 1a-l (0.013 mol) and 4-chloro-5-fluoro-ophenylenediamine(2) (0.01 mol) in methanol (10 mL) was irradiatedwith ultrasonic irradiation at 50 C for 7 min (8 min for 3a) Afterreaction completion (monitored by TLC, ethyl acetate/hexane = 3:1), themixture was poured onto water and the precipitated product was filtrated off, washed with water and recrystallised from ethanol/water, 3:1.

The synthetic route of 139512-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mente?e, Emre; Kahveci, Bahittin; Mente?e, Meltem; Journal of Chemical Research; vol. 42; 6; (2018); p. 329 – 331;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 348-59-4, name is 2,5-Dichlorofluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 348-59-4, Quality Control of 2,5-Dichlorofluorobenzene

Reference Example 2-46 2,5-Dichloro-4-fluorobenzoic acid Following the procedure described in Reference Example 2-25, the title compound was prepared from 1,4-dichloro-2-fluorobenzene (68% yield). NMR (CDCl3) delta: 7.33 (1H, d, J=8.8 Hz), 7.45 (1H, br s), 8.15 (1H, d, J=7.6 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Uchikawa, Osamu; Mitsui, Keita; Asakawa, Akiko; Morimoto, Shigeru; Yamamoto, Masataka; Kimura, Hiroyuki; Moriya, Takeo; Mizuno, Masahiro; US2003/187014; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 1005-56-7,Some common heterocyclic compound, 1005-56-7, name is O-Phenyl carbonochloridothioate, molecular formula is C7H5ClOS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(Scheme 1) to 500 mg (1.49mmol) fluorescent dye, 516 mg (2.98mmol) sulfur generation of chlorine phenyl formate (384 mg, 2 . 98mmol) and N, N – diisopropylethylamine (DIPEA) dissolved in 15 ml dichloromethane in, then 25 C stirring reaction under 9h, after steaming and to get the crude product, last-used methylene chloride: methanol=60:1 system carrying out column chromatography separation, get the pure product 647 mg, and the yield is 92

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route O-Phenyl carbonochloridothioate, its application will become more common.

Reference:
Patent; University of Jinan; Wang, Yawei; Zhang, Meng; Wu, Liu; Liu, Caiyun; Duan, Qingxia; Wang, Zuokai; Zhu, Baocun; (12 pag.)CN106543097; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2729-34-2, name is 3,5-Dichloro-4-fluoroaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H4Cl2FN

(3,5-Dichloro-4-fluoro-phenyl)-[l-(4-methoxy-benzyl)-5-morpholin-4-yl-lH-[l,2,4]triazol-3- yl] -amine – In a 2-5 mL microwave vial, 4-(3-bromo-l-(4-methoxybenzyl)-lH-l,2,4-triazol-5-yl)morpholine (133.5 mg, 378 muiotaetaomicron, Eq: 1.00), 3,5-dichloro-4-fluoroaniline (81.6 mg, 454 muiotaetaomicron, Eq: 1.20), sodium tert-butoxide (109 mg, 1.13 mmol, Eq: 3.00), tris(dibenzylideneacetone)dipalladium (0) (20.8 mg, 22.7 muiotaetaomicron, Eq: 0.06) and di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (38.5 mg, 90.7 muiotaetaomicron, Eq: 0.24) were combined. The system was evacuated and recharged with nitrogen (2x). Toluene (1.08 ml) was then added. The mixture was stirred at room temperature for 5 minutes and then heated at 85C for 15 h. After cooling to room temperature, the reaction mixture was partitioned between EtOAc and water. The organic layer was removed, washed with brine, dried (Na2S04) and concentrated over celite. The crude material was purified by flash chromatography (silica gel, SF15-24 g, 20% to 100% EtOAc in hexanes) to gove 90 mg (53%) of desired product.

The synthetic route of 2729-34-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DING, Qingjie; JIANG, Nan; WEIKERT, Robert James; WO2014/135472; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Chloro-2-chloromethyl-1-propene

Compound 1 (100 g, 0.8 mol)With 18-crown-6 ether (5 g)And pinacol (8 g)Dissolved in bromoform (400 g)An aqueous solution of sodium hydroxide (30% by mass, 1.0 L) was added dropwise at 10 C to 25 C,The reaction was then stirred at room temperature for 24 hours.TLC (petroleum ether / ethyl acetate = 10/1, volume ratio, the same below) shows the end of the reaction. The reaction system was concentrated and purified by column chromatography (petroleum ether / ethyl acetate = 5/1 to 1/1) to give compound 2 (168 g) in a yield of 70.7%

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shanghai Syn-The-All medical research and development Co . ltd; Shanghai Syn-The-All Pharmaceutical Co. Ltd.; CHANGZHOU HEQUAN PHARMACEUTICAL CO LTD; Wan, xiaojun; Bi, zengliang; Wang, HaiHui; Shen, wanjun; Peng, Yannan; Cheng, Yuan; Shao, WenQing; Chen, YuYan; Yuan, Xiaobin; Yu, LingBo; Li, Lei; Ha, Weijie; Chai, YanPing; Zhou, LeLe; Wu, Xuan; Zhu, Xiwen; Ma, Kunyan; Chen, Yuanli; He, Zhenmin; Ma, RuJian; Chen, Minzhang; Fu, XiaoYong; Wang, Wengui; (5 pag.)CN105294442; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics