Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 95-81-8, name is 2-Chloro-5-methylaniline, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

(A-82-21) tert-Butyl 4-(2-chloro-5-methylphenylcarbamoyl)-3-[4-cyclopropyl-5-(3-isobutylcyclobutyl)isoxazol-3-yl]butanoate Mono-tert-butyl 3-[4-cyclopropyl-5-(3-isobutylcyclobutyl)isoxazol-3-yl]glutarate (2.83 g) and DMF (28 mL) were mixed. After an addition of 2-chloro-5-methylphenylamine (1.184 g), HOBt.H2O (1.28 g) and WSC.HCl (1.60 g) to the resultant solution, the mixture was stirred at RT for 2 days. To the reaction mixture was added saturated aqueous sodium bicarbonate, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium bicarbonate, water and brine, then dried over sodium sulfate. The sodium sulfate was filtered off and the filtrate was concentrated in vacuo. The resultant residue was purified by silica gel column chromatography (Eluent: ethyl acetate/hexane=1/15?1/10?1/8) to give the title compound (1.241 g).

The synthetic route of 95-81-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JAPAN TOBACCO INC.; US2012/322837; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93-50-5, name is 4-Chloro-2-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks

General procedure: B. To a suspension of compound 7b (1 .69 g, 10.7 mmol, 1 eq) in concentrated HCl (25 mL) and acetic acid (10 mL) at 0 C was added a solution of sodium nitrite (740 mg, 10.7 mmol, 1 eq) in water (10 mL) dropwise. The suspension was warmed to 60 C for 1.5 hrs. The solution was cooled to 0 C and a solution of SnCl2 (5.32 g, 23.6 mmol, 2.2 eq) in concentrated HCl (25 mL) was added. After 30 minutes, a precipatate was collected by filtration to give compound 7c (2.06 g, 93%). 1H NMR (DMSO-d6) delta: 9.94 (br. s., 2H), 7.72 (br. s., 1H), 7.07 (s, 1H), 7.00 (s, 2H). 3.85 (s, 3H). Following the procedure described above for Example 7 and substituting the appropriate reagents, starting materials and purification methods known to those skilled in the art, the following intermediates to compounds of the present invention were prepared:

According to the analysis of related databases, 93-50-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; WINTERS, Michael, P.; SUI, Zhihua; WO2014/28805; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1435-48-9, name is 2,4-Dichloro-1-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435-48-9, category: chlorides-buliding-blocks

(S)-3-((R)-2-Ethoxy-1-hydroxyethyl)pyrrolidine-1-carboxylic acid t-butyl ester (25.0 mg, 96.4 mmol) was dissolved in DMF (200 muL). NaH (2776 mug, 115.7 mmol) was added and the mixture was stirred at room temperature for 15 minutes. 2,4-Dichloro-1-fluorobenzene (22.6 muL, 192.8 mumol) was added and the mixture was stirred at 70 C. for 3 hours. The mixture was concentrated then dissolved in 1.2M HCl in EtOH (1.0 mL, 1.2 mmol) and stirred overnight. The product was concentrated and purified by preparative HPLC (10-40%, 60 min, BDS) to yield the title compound as a mono-TFA salt oil (24.4 mg, 100% purity). MS m/z: [M+H]+ calcd for C14H19Cl2NO2, 304.08; found 304.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dichloro-1-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; STANGELAND, Eric; SCHMIDT, Jane; SAITO, Daisuke Roland; HUGHES, Adam; PATTERSON, Lori Jean; US2011/21597; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-24-2, name is (2-Chloroethyl)benzene, A new synthetic method of this compound is introduced below., Safety of (2-Chloroethyl)benzene

To a solution of substituted hydrazine (3 mmol) and carbon disulfide (8 mmol) Triton-B (2 mmol) were slowly added while stirring at room temperature. The stirring was continued till 0.5 h after which required amount of alkyl halide (3 mmol) was added (Scheme-I). The reaction was further continued until the completion of reaction (Table-1) under argon. The obtained mixture was poured into water (20 mL) and the extraction of organic layer was done with EtOAc (3 ¡Á 10 mL). The organic layer was washed with 0.1 N hydrochloric acid (20 mL), sodium bicarbonate solution (25 mL), brine solution (30 mL) and dried sodium sulfate and concentrated to get the desired compound I. Later, the desired compounds were confirmed by IR, NMR and elemental analysis.

The synthetic route of 622-24-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zaidi, Sadaf; Saxena, Mridula; Asian Journal of Chemistry; vol. 31; 7; (2019); p. 1581 – 1584;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., Recommanded Product: 5-(Chloromethyl)benzo[d][1,3]dioxole

4- (1,3_-benzodioxol-dioxan-5-methoxy) -2_ hydroxyacetophenone Synthesis[0078] In a 500mL three-necked flask, 3.0g (0.02mol) 2 , 4-hydroxyacetophenonewas dissolved in 150mL acetone, 0.8gKI, 2.0gK 2C03, a small amount of the TBAB,heated to reflux with stirring, slowly added dropwise containing 3.14g(0.02mol) 5_-chloro-methyl-1, 3 – benzodioxol dioxane acetone 150mL. Afterthe dropwise addition, it was refluxed for one hour, cooled, filtered offsolid, and concentrated to give a pale yellow solid which was recrystallizedfrom ethanol to give white needle crystals, 4.0g,

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Southeast University; Chi, Jin; Ji, min; (19 pag.)CN103539760; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 26487-67-2

Example 2: Synthesis of 2-((2-(azepan-1-yl)ethoxy)methyl)pyrazolo[1 ,5-a]pyridine maleate 0.12 g (3 mmol) of a 60percent NaH suspension in mineral oil were added under nitrogen to a solution of pyrazolo[1 ,5-a]pyridin-2-ylmethanol (100 mg, 0.67 mmol) in 5 mL of dry THF. The mixture was stirred for 5 h at room temperature, and after this time, was added 1 -(2-chloroethyl)azepane hydrochloride (201 mg, 1 .01 mmol) suspended in 8 ml_ of THF with 200muIota of triethylamine (TEA). The mixture was heated at 55 5C for 18 h, allowed to cool to room temperature, quenched with water and extracted with EtOAc, and washed with water. The organic layers were dried over Na2S04 and concentrated under vacuum to afford 0.22 g (65percent) of brown oil. Maleate salt was obtained following the same procedure as for example 1 . 1 H NMR (CDCI3) delta ppm: 8.42 (d, J = 6.8 Hz, 1 H), 7.52 (d, J = 8.8 Hz, 1 H), 7.20 – 7.06 (m, 1 H), 6.78 (t, J = 6.9 Hz, 1 H), 6.49 (s, 1 H), 6.30 (s, 2H), 4.74 (s, 2H), 4.08 – 3.89 (m, 2H), 3.70 – 3.51 (m, 2H), 3.36 – 3.25 (m, 2H), 3.19 – 2.99 (m, 2H), 2.15 – 1 .92 (m, 2H), 1 .92 – 1 .72 (m, 4H), 1 .72 – 1 .54 (m, 2H).

The synthetic route of 26487-67-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE S.A.; DIAZ FERNANDEZ, Jose Luis; CUBERES ALTISENT, Ma Rosa; WO2013/124341; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 29671-92-9, name is Carbamimidic chloride hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Carbamimidic chloride hydrochloride

To a solution of the ethyl [2-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}-phenyl)cyclopropyl]acetate (Step 6, Example 1, 3.52 g, 0.01 mol) in dry dichloromethane (20 mL) was added 4N HCl in dioxane (12.5 mL, 0.05 mol). The solution was stirred at room temperature for 2 hours and solvent evaporated to give white solid as HCl salt. To a solution of carbamidic chloride hydrochloride (2.03 g, 0.0176 mol) in acetonitrile (30 mL) and triethylamine (11 mL) was added crude amine (2.75 g, 0.0088 mol) in acetonitrile (20 mL). The reaction mixture was refluxed overnight and solvent concentrated to give solid residue used without further purification. The mass spectrum was consistent with the proposed structure. M+=320.

The synthetic route of Carbamimidic chloride hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nagarajan, Srinivasan R.; Khanna, Ish Kumar; Clare, Michael; Gasiecki, Alan; Rogers, Thomas; Chen, Barbara; Russell, Mark; Lu, Hwang-Fun; Yi, Yu; Huff, Renee M.; Desai, Bipinchandra N.; Devadas, Balekudru; Parikh, Mihir D.; Penning, Thomas; US2004/92538; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 4584-46-7, These common heterocyclic compound, 4584-46-7, name is 2-Chloro-N,N-dimethylethanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Bromophenol (1 g, 5.8 mmol), (2-chloroethyl) dimethylamine hydrochloride (1.25 g, 8.7 mmol) and cesium carbonate (5.67 g, 17.4 mmol) were added to 5 mL of DMA, and then heated to 90 C. for 2 hours. After cooling to room temperature, ethyl acetate and water were added to the reaction mixture for extraction. The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give 1.3 g of title product.

The synthetic route of 4584-46-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANCUREALL PHARMACEUTICAL (SHANGHAI) CO., LTD.; Si, Jutong; Wang, Guan; Jiang, Meifeng; YANG, Zhihe; Zhou, Chentao; (118 pag.)US2019/345139; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, A new synthetic method of this compound is introduced below., Safety of 3-Chloropropan-1-amine hydrochloride

To a solution of phenol D4 (60.0 mg, 0.17 mmol, 1.0equiv) in dry CH3CN (4 mL) was added tetrabutylammonium hydrogen sulfate (16.0 mg, 0.05allowed to stir at room temperature for 30 minutes, at which point 4-(2-chloroethyl)morpholine hydrochloride (63.0 mg, 0.34 mmol, 2.0 equiv) was added to the solution. The mixture was then placed in an oil bath that had been preheated to 55 C, and was allowed to stir at this temperaturefor 14 hours. Following determination of reaction completion by TLC and LCMS analysis, the solution was then removed from the oil bath and allowed to cool to room temperature. Upon cooling, the mixture was diluted with EtOAc (20 mL) prior to the addition of H20 (10 mL), which served to dissolve all of the inorganic solids present. Following separation of the layers, the aqueous layer was extracted with EtOAc (20 mL). The organic layer was then washed withbrine (10 mL), dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure.The residue was then purified through flash column chromatography (12 g silica gel cartridge, 0- 50% EtOAc/Hexanes, followed by 0-20% MeOHICH2C12, and desired product eluted during 2%MeOH, to yield the desired product (48.0 mg, 61%) as a light yellow oil. Additionally, at thispoint, the compound appeared to exist as a single diastereomer based on the obtained NIVIR data.?H NMR (400 MHz, CHLOROFORM-d) 7.18 -7.24 (m, 1H), 6.72-6.83 (m, 3H), 4.09-4.14 (m, 2H), 3.71 -3.79 (m, 4H), 2.73 -2.85 (m, 3H), 2.56 -2.65 (m, 4H), 1.89-2.15 (m, 9H), 1.78- 1.87 (m, 5H), 1.65 – 1.75 (m, 6H), 1.56 – 1.65 (m, 1H), 1.32 – 1.44 (m, 1H); ?3C NIVIR (100 IVIFIz, CHLOROFORM-d) 158.8, 147.4, 129.5, 119.4, 113.4, 112.1, 111.4, 109.0, 73.2, 66.9, 65.6, 57.7, 54.1, 42.1, 42.0, 41.3, 36.8, 36.5, 35.8, 34.9, 34.8, 34.3, 32.7, 31.0, 26.9, 26.5, 25.9,23.6; MS (ESI) calculated for C28H40N05 [M + H] m/z 470.29, found 470.22

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; TALUKDER, Poulami; RENSLO, Adam, Robert; BLANK, Brian, Richard; MUIR, Ryan, Keith; EVANS, Michael, John; (270 pag.)WO2019/5977; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, A new synthetic method of this compound is introduced below., Recommanded Product: 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine

99A. Preparation of 2,4-dichloropyrrolo[1,2-f][1,2,4]triazine-7-carbaldehyde To a solution of POCl3 (1.24 mL, 13.3 mmol) at 0 C. was added DMF (0.52 mL, 6.6 mmol) and the reaction was stirred until gas evolution subsided. The reaction was then warmed to ambient temperature and 2,4-dichloropyrrolo[1,2-f][1,2,4]triazine (250 mg, 1.33 mmol) was added as a solid in one portion. The reaction was warmed to 95 C. and stirred for five hours, then cooled to room temperature. The mixture was poured into ice cold 1:1 saturated aqueous NaHCO3/CH2Cl2 (50 mL). The layers were separated and the aqueous layer extracted with CH2Cl2 (3*25 mL). The combine organic layers were dried (Na2SO4), filtered and concentrated. The crude product was purified by flash chromatography (SiO2,40 g column, 50% CH2Cl2/Hexanes to 75% CH2Cl2/Hexanes, 25 minute gradient) to afford the desired product as a powder (170 mg, 60%). 1H-NMR (DMSO) delta 10.3 (s, 1H), 7.68 (d, 1H, J=4.8 Hz), 7.32 (d, 1H, J=4.8 Hz. HPLC tR=2.35 min (YMC S5 Combiscreen ODS 4.6*50 mm, 10-90% aqueous methanol containing 0.2% H3PO4, 4 min gradient, monitored at 254 nm).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Bristol-Myers Squibb Company; US2008/45496; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics