Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 39989-43-0, name is 3,5-Dichlorobenzylamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39989-43-0, category: chlorides-buliding-blocks

A mixture of [(3,5-dichlorophenyl) methyl]amine (100 mg), 2-bromo- 1,1bis (methyloxy)ethane (123 muL) and K2C03 (95 mg) in anhydrous DMF (2 mL) was processed by microwave irradiation at 150C for 10 min (3 cycles). The mixture was allowed to cool to rt, water was added and mixture extracted three times with AcOEt, the organic phases collected, washed with brine, dried and evaporated under vacuum to give a crude which was purified by flash cromathography eluting with CH: AcOEt= 9: 1 to 85:15 to afford the title compound (120 mg) as a colourless oil. MS (ES/+) : m/z=264 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dichlorobenzylamine, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2005/121122; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 445-13-6, name is 3-Chloro-4-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Quality Control of 3-Chloro-4-(trifluoromethyl)aniline

A solution of 4-amino-2-chlorobenzotrifluoride (9.780 g; 50.007 mmol) in MeCN (65 ml) was treated with copper(ll) bromide (1 1.169 g; 50.007 mmol), and the green heterogeneous mixture was heated to 45C. A solution of tert-butyl nitrite (6.53 ml; 55.008 mmol) in MeCN (10 ml) was then added dropwise over 30 min., and the resulting mixture was further stirred at 45C for 2h20. The dark heterogeneous reaction mixture was allowed to cool to rt, and was directly purified by FC (DCM). After concentration to dryness under reduced pressure, the expected product 4-bromo-2-chloro-1-trifluoromethyl-benzene was obtained as a yellow oil (12.82O g; 50%). LC-MS: tR = 1.10 min.; [M+H]+: no ionisation.

The synthetic route of 445-13-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/78291; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108-70-3, name is 1,3,5-Trichlorobenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H3Cl3

Add phenothiazine,1,3,5-trichlorobenzene,Cuprous iodide,18-Crown-6 and potassium carbonate were added to the single-mouth round bottom flask.Sealed then protected by nitrogen,Add o-dichlorobenzene to dissolve and stir,The reaction was refluxed at 185C for 24 h.After the reaction was completed, the reaction solution was quenched by the addition of deionized water and then extracted with dichloromethane. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. Finally, a white solid product was obtained after purification by chromatography column in 31% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nanjing Tech University; An Zhongfu; Huang Wei; Wu Qi; Shi Huifang; (13 pag.)CN107793377; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 7781-10-4, These common heterocyclic compound, 7781-10-4, name is 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.40 g (8 [MMOL)] of 3-methoxycarbonyl-1 H-indole are added to 30 cm3 of dimethylformamide at a temperature in the region of [20C] under an argon atmosphere, and 0.32 g (10 [MMOL)] of sodium hydride are then added. The reaction mixture is stirred at a temperature in the region of [20C] for 1 hour, 1.35 g (8.05 [MMOL)] of 4-chloro-7- methyl-7H-pyrrolo [2,3-d] pyrimidine in 10 cm3 of dimethylformamide are then added, and the mixture is heated at a temperature in the region of [100C] for 16 hours. The reaction mixture is then cooled to a temperature in the region of [20C] and then poured into a mixture of 200 cm3 of ethyl acetate and 200 cm3 of water. The organic phase is separated out after the phases have settled, washed with twice 200 cm3 of water and then with 200 cm3 of saturated aqueous sodium chloride solution, and then dried over magnesium sulphate and concentrated to dryness under reduced pressure (2.7 kPa). The residue is purified by flash chromatography on silica gel [eluent : cyclohexane/ethyl acetate (80/20 by volume)]. After the fractions containing the expected product have been concentrated to dryness under reduced pressure (2.7 kPa), 1.35 g of 3- [METHOXYCARBONYL-1- (7-METHYL-7H-PYRROLO] [2,3-d] pyrimidin-4-yl)-1 H-indole are obtained in the form of an off-white solid. Mass spectrum [(EL)] : m/e 306 [(M+)] (base peak).

The synthetic route of 7781-10-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AVENTIS PHARMA DEUTSCHLAND GMBH; WO2004/7479; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 694-80-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 694-80-4, name is 1-Bromo-2-chlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of aryl silane (0.5 mmol), aryl bromides (0.5 mmol), PdCl2(MeCN)2 (5 mol%), and CsF (0.5 mmol) was stirred at 100oC for 6 h in NMP under CO (1atm) (5 mL). Afterwards, 2 mL water was added to the reaction solution and then filtered through a filter paper and the solution was extracted by Et2O (2 mL) for three times. The organic phase was combined and evaporated under reduced pressure. The residue was purified on a SiO2 column to afford the desired product(ethyl acetate/hexane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-chlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chang, Sheng; Jin, Ying; Zhang, Xiu Rong; Sun, Yong Bing; Tetrahedron Letters; vol. 57; 19; (2016); p. 2017 – 2020;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 2613-30-1, These common heterocyclic compound, 2613-30-1, name is 4-Chloro-2,5-difluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2. Preparation of 1-Bromo-4-chloro-2,5-difluorobenzene Anhydrous copper (II) bromide (2.7 g, 12.1 mmol) and t-butyl nitrite (1.56 g, 15.1 mmol) were combined in anhydrous acetonitrile (25 mL). The resulting mixture was heated to 65¡ã C. and a solution of 4-chloro-2,5-difluoro-phenylamine (1.65 g, 10.1 mmol) in anhydrous acetonitrile (2 mL) was added dropwise (vigorous gas evolution was noted). After the reaction mixture cooled ambient temperature, it was added to 2N HCl and extracted with ether twice. The organic extracts were then combined, washed with 2N HCl, washed with saturated sodium bicarbonate, dried, concentrated and purified by flash chromatography on silica gel (hexanes) to give the title compound as a white solid (1.11 g, 48.4percent yield): 1H NMR (CDCl3): delta 7.38 (dd, 2H), 7.21 (dd, 2H).

Statistics shows that 4-Chloro-2,5-difluoroaniline is playing an increasingly important role. we look forward to future research findings about 2613-30-1.

Reference:
Patent; Epp, Jeffrey B.; Schmitzer, Paul R.; Guenthenspberger, Katherine A.; Lo, William C.; Siddall, Thomas L.; US2009/62125; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 2533-69-9, These common heterocyclic compound, 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl trichloroacetimidate (32.8 g=22.75 ml) is added all at once to a solution of 2,3-diaminopyridine (19.7 g) in acetic acid (400 ml) and the reaction mixture is left to stand at the ambient temperature (20 to 25 C.) for 72 hours. The reaction mixture obtained is then poured onto ice-water (1.5 liters). The crystalline precipitate is drained, washed with water and dried. 2-Trichloromethylimidazo[4,5-b]pyridine (21.15 g) of melting point 210 C. is thus obtained.

The synthetic route of 2533-69-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Rhone-Poulenc Agrochimie; US4579853; (1986); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 82485-84-5, The chemical industry reduces the impact on the environment during synthesis 82485-84-5, name is 2-Chloro-4,6-dimethoxyaniline, I believe this compound will play a more active role in future production and life.

EXAMPLE 31 (+-)-N-(2-chloro-4,6-dimethoxyphenyl)-3-[1-(1-methoxymethyl)propyl]-5-methyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine The product of Part B from Example 27 was treated with 2-chloro-4,6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as a white crystalline solid (mp 149-150 C.). Elemental analysis for C18 H23 ClN6 O3: Theory C: 53.14, H: 5.70 N: 20.66. Found: C: 53.36, H: 5.72, N: 20.49.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4,6-dimethoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dupont Pharmaceuticals; US6107300; (2000); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 367-22-6, name is 4-Chloro-3-fluoroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 367-22-6, SDS of cas: 367-22-6

(145d) 4-Amino-Lambda/-(4-chloro-3-fluoro-phenyl)-2-methyl-5-nitro-benzamide 4-Amino-2-methyl-5-nitro-benzoylchloride (950 mg, 4.4 mmol) was added to a stirred mixture of 4-chloro-3-fluoro-aniline (644 mg, 4.4 mmol) and TEA (0.74 ml_, 5.3 mmol) in 80 ml. THF. After stirring for 2h the mixture was concentrated /.vac. The residue was taken up in water and filtrated.Yield: 1.4O g (98%) mass spectrum: (M+H)+ = 324/326 (chlorine isotopes)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-fluoroaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; PFAU, Roland; ARNDT, Kirsten; DOODS, Henri; HAUEL, Norbert; KLINDER, Klaus; KUELZER, Raimund; MACK, Juergen; PRIEPKE, Henning; STENKAMP, Dirk; WO2010/34796; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 7051-16-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7051-16-3 as follows.

General procedure: To a solution of 4-bromoanisole (200.8 mg, 1.09 mmol, 1.0 equiv) in acetonitrile (2 mL) was added N-chlorosuccinimide(NCS) (158.3 mg, 1.19 mmol, 1.1 equiv) at rt to give a slightly cloudy mixture. Chlorotrimethylsilane (TMSCl) (14 muL, 0.11 mmol, 0.1 equiv) was then added drop-wise to the reaction mixture. Within a few minutes, the reaction mixture became clear pale yellow solution. The mixture continued to stir at rt for 1 h and was diluted with hexane. The biphasic mixture was concentrated on a rotary evaporator to a crude white solid-oil mixture. This mixture was taken up in hexane and filtered through a short plug of SiO2 and eluted with 5-10% EtOAc-hexane solution. The clear filtrate was concentrated to obtain a mixture of 4-bromo-2-chloro-1-methoxybenzene (2a-Cl) and 2,4-dichloro-1-methoxybenzene (2a-diCl) 237.0 mg (88% of 2a-Cl and 11% of 2a-diCl,based on NMR ratio 2a-Cl: 2a-diCl = 7.1: 1.0; as a pale yellow solid).

According to the analysis of related databases, 7051-16-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Maibunkaew, Tapanee; Thongsornkleeb, Charnsak; Tummatorn, Jumreang; Bunrit, Anon; Ruchirawat, Somsak; Synlett; vol. 25; 12; (2014); p. 1769 – 1775;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics