Tag: M.W=100-200

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Manganese-Mediated Direct Functionalization of Hantzsch Esters with Alkyl Iodides via an Aromatization-Dearomatization Strategy, published in 2021-05-21, which mentions a compound: 35836-73-8, mainly applied to Hantzsch ester alkyl iodide manganese catalyst alkylation; alkyl Hantzsch ester preparation, Reference of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol.

Manganese-mediated direct functionalization of the Hantzsch esters with readily accessible alkyl iodides through an aromatization-dearomatization strategy was reported for the first time. Applying this protocol, a library of valuable 4-alkyl-1,4-dihydropyridines were facilely afforded in good yields. This simple and practical reaction proceeded under visible-light irradiation at room temperature and displays high functional-group compatibility. Addnl., the method was applicable for gram-scale synthesis and late-stage functionalization of complex mols.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lardy, Samuel W.; Schmidt, Valerie A. published an article about the compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8,SMILESS:CC1(C)[C@@]2([H])CC=C(CCO)[C@]1([H])C2 ).Computed Properties of C11H18O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:35836-73-8) through the article.

We report a radical method for the removal of benzyl and p-methoxybenzyl groups from amines and alcs. using a selective hydrogen-atom abstraction under aerobic conditions. The key usage of the strongly electrophilic thiyl radical derived from com. available pentafluorothiophenol as the H-atom abstracting agent allowed for a chemoselective abstraction process leading to C-N or C-O bond cleavage. This approach is applicable to an array of alcs. and amines, operating under aerobic conditions with no need for further addition of a stoichiometric external oxidant or hazardous reagents.

Here is a brief introduction to this compound(35836-73-8)Computed Properties of C11H18O, if you want to know about other compounds related to this compound(35836-73-8), you can read my other articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jiang, Zhiyong; Pan, Yuanhang; Zhao, Yujun; Ma, Ting; Lee, Richmond; Yang, Yuanyong; Huang, Kuo-Wei; Wong, Ming Wah; Tan, Choon-Hong researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Formula: C8H11NO2.They published the article 《Synthesis of a Chiral Quaternary Carbon Center Bearing a Fluorine Atom: Enantio- and Diastereoselective Guanidine-Catalyzed Addition of Fluorocarbon Nucleophiles》 about this compound( cas:4144-22-3 ) in Angewandte Chemie, International Edition. Keywords: stereoselective guanidine catalyzed conjugate addition fluorocarbon nucleophiles; crystallog chiral adduct quaternary carbon center fluorine atom. We’ll tell you more about this compound (cas:4144-22-3).

The title reaction provides adducts having quaternary carbon centers bearing a fluorine atom with high ee and d.r. values (see scheme). The mechanism and origin of stereoselectivity were elucidated by DFT calculations The bifunctional mode of the guanidine catalysis was demonstrated in the transition states resulting from the DFT results.

Here is a brief introduction to this compound(4144-22-3)Formula: C8H11NO2, if you want to know about other compounds related to this compound(4144-22-3), you can read my other articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ) is researched.Application of 35836-73-8.Akgun, Burcin; Hall, Dennis G. published the article 《Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation》 about this compound( cas:35836-73-8 ) in Angewandte Chemie, International Edition. Keywords: boronate formation click bioorthogonal conjugation protein; bioorthogonality; boronates; boronic acids; click chemistry; protein labeling. Let’s learn more about this compound (cas:35836-73-8).

A new click bioorthogonal reaction system was devised to enable the fast ligation (kON ≈ 340 M-1 s-1) of conjugatable derivatives of a rigid cyclic diol (nopoldiol) and a carefully optimized boronic acid partner, 2-methyl-5-carboxymethylphenylboronic acid. Using NMR and fluorescence spectroscopy studies, the corresponding boronates form reversibly within minutes at low micromolar concentration in water, providing submicromolar equilibrium constant (Keq≈105-106 M-1). Efficient protein conjugation under physiol. conditions was demonstrated with model proteins thioredoxin and albumin, and characterized by mass spectrometry and gel electrophoresis.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Ruthenium-Catalyzed Cross-Coupling of Maleimides with Alkenes. Author is Morita, Tomohiro; Akita, Mitsutoshi; Satoh, Tetsuya; Kakiuchi, Fumitoshi; Miura, Masahiro.

The cross-coupling of maleimides with electron-deficient alkenes such as acrylates proceeds smoothly under ruthenium catalysis. This unique C-C coupling provides a simple, straightforward synthetic method for preparing alkylidene succinimide derivatives

Here is a brief introduction to this compound(4144-22-3)Name: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, if you want to know about other compounds related to this compound(4144-22-3), you can read my other articles.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 498-95-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about Noncanonical transmission of a measles virus vaccine strain from neurons to astrocytes.

Viruses, including members of the herpes-, entero-, and morbillivirus families, are the most common cause of infectious encephalitis in mammals worldwide. During most instances of acute viral encephalitis, neurons are typically the initial cell type that is infected. However, as replication and spread ensue, other parenchymal cells can become viral targets, especially in chronic infections. Consequently, to ascertain how neurotropic viruses trigger neuropathol., it is crucial to identify which central nervous system (CNS) cell populations are susceptible and permissive throughout the course of infection, and to define how viruses spread between distinct cell types. Using a measles virus (MV) transgenic mouse model that expresses human CD46 (hCD46), the MV vaccine strain receptor, under the control of a neuron-specific enolase promoter (NSE-hCD46+ mice), a novel mode of viral spread between neurons and astrocytes was identified. Although hCD46 is required for initial neuronal infection, it is dispensable for heterotypic spread to astrocytes, which instead depends on glutamate transporters and direct neuron-astrocyte contact. Moreover, in the presence of RNase A, astrocyte infection is reduced, suggesting that nonenveloped ribonucleoproteins (RNP) may cross the neuron-astrocyte synaptic cleft. The characterization of this novel mode of intercellular transport offers insights into the unique interaction of neurons and glia and may reveal therapeutic targets to mitigate the life-threatening consequences of measles encephalitis.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol(SMILESS: CC1(C)[C@@]2([H])CC=C(CCO)[C@]1([H])C2,cas:35836-73-8) is researched.Application of 498-95-3. The article 《Chiral Primary Amine/Ketone Cooperative Catalysis for Asymmetric α-Hydroxylation with Hydrogen Peroxide》 in relation to this compound, is published in Journal of the American Chemical Society. Let’s take a look at the latest research on this compound (cas:35836-73-8).

Carbonyls and amines are yin and yang in organocatalysis as they mutually activate and transform each other. These intrinsically reacting partners tend to condense with each other, thus depleting their individual activity when used together as cocatalysts. Though widely established in many prominent catalytic strategies, aminocatalysis and carbonyl catalysis do not coexist well, and, as such, a cooperative amine/carbonyl dual catalysis remains essentially unknown. Here we report a cooperative primary amine and ketone dual catalytic approach for the asym. α-hydroxylation of β-ketocarbonyls with H2O2. Besides participating in the typical enamine catalytic cycle, the chiral primary amine catalyst was found to work cooperatively with a ketone catalyst to activate H2O2 via an oxaziridine intermediate derived from an in-situ-generated ketimine. Ultimately, this enamine-oxaziridine coupling facilitated the highly controlled α-hydroxylation of several β-ketocarbonyls in excellent yield and enantioselectivity. Notably, late-stage hydroxylation for peptidyl amide or chiral esters can also be achieved with high stereoselectivity. In addition to its operational simplicity and mild conditions, this cooperative amine/ketone catalytic approach also provides a new strategy for the catalytic activation of H2O2 and expands the domain of typical amine and carbonyl catalysis to include this challenging transformation.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 870-24-6, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 870-24-6, Name is 2-Chloroethanamine hydrochloride, SMILES is ClCCN.[H]Cl, belongs to chlorides-buliding-blocks compound. In a article, author is Ci, Yu-hui, introduce new discover of the category.

In order to extract lignin, a novel near-neutral deep eutectic solvent (DES) was developed to treat wheat straw which facilitated its subsequent enzymatic glycation. The DES, whose in situ complexation promotes lignin depolymerization, was composed of choline chloride (ChCl), boric acid (BA), and polyethylene glycol-200 (PEG-200). Our results showed that this kind of DES could dissolve a large amount of lignin and hemicellulose yet retained cellulose well. Under optimum conditions (DES ratio of 1 : 1 : 1.5, 120 degrees C, 4 h), the proportions of lignin and hemicellulose removed amounted to 88.39% and 84.38%, respectively, with enzymatic digestibility reaching 59.3% in the subsequent enzymatic saccharification with a limited timeframe (5 days) and low enzyme load (30 FPU g(-1)). The results also demonstrated that lignin’s removal rate was positively correlated with the amount of BA used in the DES. The 2D-HSQC NMR, FTIR and TG analyses showed the regenerated lignin to be a typical H-G-S type retaining its intact structure (e.g., beta-O-4, beta-beta, beta-5, etc.), whose carbon chain backbone is stable. GPC analysis revealed that this extracted lignin had low molecular weight and a narrower distribution range. Density functional theory showed that BA could bond with -OH similar to Cl-, and it occupied more effective sites than Cl- to break the hydrogen-bonding network between lignin and cellulose. Importantly, the DES can be used multiple times without significantly reducing its efficiency, and its structure and properties remain virtually unchanged throughout the use cycle.

Electric Literature of 870-24-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 870-24-6.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In an article, author is Ling, Jordy Kim Ung, once mentioned the application of 638-07-3, Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate, Name is Ethyl 4-chloro-3-oxobutanoate, molecular formula is C6H9ClO3, molecular weight is 164.5869, MDL number is MFCD00000939, category is chlorides-buliding-blocks. Now introduce a scientific discovery about this category.

The fruit wastes of Mangifera pajang were found to exhibit excellent antioxidant capacity. However, its application can be limited by its poor stability. Therefore, this study aims to improve its stability by solubilizing them in a novel choline chloride/ascorbic acid natural deep eutectic solvent (CHCL/AA NADES) system. The degradation of the antioxidant extracts in the aqueous and NADES system under effects of temperature (25 degrees C, 40 degrees C, 60 degrees Cand 80 degrees C) and pH (3.0-8.0) were studied by modeling the degradation kinetics. For both systems, the degradation process followed the first-order kinetics. Remarkably, a lower degradation rate constant was found for the antioxidant-CHCL/AA NADES system, suggesting the ability of CHCL/AA NADES in protecting the antioxidant against extreme temperature and pH. Moreover, the half-life values for the antioxidant-CHCL/AA NADES was higher by 4.17-25% as compared to the antioxidant-aqueous system, suggesting that the CHCL/AA NADES is feasible to improve the stability of antioxidants.

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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Reference of 2687-12-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 2687-12-9, Name is Cinnamyl chloride, SMILES is ClCC=CC1=CC=CC=C1, belongs to chlorides-buliding-blocks compound. In a article, author is Nimmervoll, Manuela, introduce new discover of the category.

In this paper the corrosion behavior of high temperature corrosion resistant alloys is investigated in a gas atmosphere containing HCl and H2S at 480 degrees C and 680 degrees C. By considering the vapor pressures of the metal chlorides and the water gas shift reaction, as well as the influence of H2S, the different corrosion behavior at 480 degrees C compared to 680 degrees C can be explained and a model of the course of corrosion is proposed. Corrosion tests were performed for 240 h with the austenitic stainless steels S31400 (20 wt% Ni) and N08811 (30.4 wt% Ni) and with the Ni-based alloy N06600 (72.5 wt% Ni). It could be shown that with increasing Ni-content in the alloy, the corrosion rate at high temperatures decreased, but this effect could no longer be observed at lower temperatures. While for N08811 and N06600 the mass loss was lower at 680 degrees C, it increased at temperatures of 480 degrees C. In the case of S31400 the mass loss increased with rising temperature.

Reference of 2687-12-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 2687-12-9 is helpful to your research.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics