Tag: M.W=100-200

Recommanded Product: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Synthesis of cardamom peroxide analogues by radical cyclization of hydroperoxyalkenes.

Three pinenic hydroperoxides, e. g. I, were synthesized according to the Dussault method. Two of them could cyclize under radical conditions to give the exo-trig isomer as a single regioisomer. Only five- and six-member ring peroxides were obtained, whereas none of the possible seven-member ones was observed This strategy could be employed in the total synthesis of cardamom peroxide.

From this literature《Synthesis of cardamom peroxide analogues by radical cyclization of hydroperoxyalkenes》,we know some information about this compound(35836-73-8)Recommanded Product: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, but this is not all information, there are many literatures related to this compound(35836-73-8).

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C8H5ClN2O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-Chloroquinazoline-6,7-diol, is researched, Molecular C8H5ClN2O2, CAS is 1145671-36-8, about Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. Author is Tsang, Jonathan E.; Urner, Lorenz M.; Kim, Gyudong; Chow, Kingsley; Baufeld, Lynn; Faull, Kym; Cloughesy, Timothy F.; Clark, Peter M.; Jung, Michael E.; Nathanson, David A..

The epidermal growth factor receptor (EGFR) is genetically altered in nearly 60% of glioblastoma tumors; however, tyrosine kinase inhibitors (TKIs) against EGFR have failed to show efficacy for patients with these lethal brain tumors. This failure is attributed to the inability of clin. tested EGFR TKIs to cross the blood-brain barrier (BBB) and achieve adequate pharmacol. levels to inhibit various oncogenic forms of EGFR that drive glioblastoma. Through SAR anal., we developed compound 5 (JCN037)(I) from an anilinoquinazoline scaffold by ring fusion of the 6,7-dialkoxy groups to reduce the number of rotatable bonds and polar surface area and by introduction of an ortho-fluorine and meta-bromine on the aniline ring for improved potency and BBB penetration. Relative to the conventional EGFR TKIs erlotinib and lapatinib, JCN037 displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 4144-22-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Synthesis of Fused or Spiro Polyheterocyclic Compounds via the Dehydrogenative Annulation Reactions of 2-Arylindazoles with Maleimides.

A dehydrogenative annulation of 2-arylindazoles with maleimides for the switchable synthesis of indazolo[2,3-a]pyrrolo[3,4-c]quinolinones or spiroindolo[1,2-b]indazole-11,3′-pyrrolidinones is presented. Mechanistically, the formation of the title compounds involves a Rh(III)-catalyzed C-H metalation of 2-arylindazole, followed by maleimide insertion and intramol. cyclization. Interestingly, the selectivity to form the fused or spiro compounds could be switched by resorting to different additives. The notable features of this protocol include simple substrates and excellent atom economy and regioselectivity.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Min, Jaeki; Guo, Kexiao; Suryadevara, Praveen K.; Zhu, Fangyi; Holbrook, Gloria; Chen, Yizhe; Feau, Clementine; Young, Brandon M.; Lemoff, Andrew; Connelly, Michele C.; Kastan, Michael B.; Guy, R. Kiplin published an article about the compound: 4-Chloroquinazoline-6,7-diol( cas:1145671-36-8,SMILESS:OC1=CC2=C(Cl)N=CN=C2C=C1O ).Application of 1145671-36-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1145671-36-8) through the article.

We previously reported a novel inhibitor of the ataxia-telangiectasia mutated (ATM) kinase, which is a target for novel radiosensitizing drugs. While our initial lead, compound 4, was relatively potent and nontoxic, it exhibited poor stability to oxidative metabolism and relatively poor selectivity against other kinases. The current study focused on balancing potency and selectivity with metabolic stability through structural modification to the metabolized site on the quinazoline core. We performed extensive structure-activity and structure-property relationship studies on this quinazoline ATM kinase inhibitor in order to identify structural variants with enhanced selectivity and metabolic stability. We show that, while the C-7-methoxy group is essential for potency, replacing the C-6-methoxy group considerably improves metabolic stability without affecting potency. Promising analogs 20, 27g, and 27n were selected based on in vitro pharmacol. and evaluated in murine pharmacokinetic and tolerability studies. Compound 27g possessed significantly improve pharmacokinetics relative to that of 4. Compound 27g was also significantly more selective against other kinases than 4. Therefore, 27g is a good candidate for further development as a potential radiosensitizer.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Fles, D. D.; Hace, D.; Ranogajec, F.; Vukovic, R.; Fles, D. researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Computed Properties of C8H11NO2.They published the article 《The application of Taft-Hancock steric constants to the free-radical initiated copolymerization of N-alkylmaleimides with α-methylstyrene》 about this compound( cas:4144-22-3 ) in Polymer Bulletin (Berlin). Keywords: methylstyrene polymerization kinetics alkylmaleimide; steric constant alkylmaleimide polymerization methylstyrene; polar substituent constant polymerization alkylmaleimide. We’ll tell you more about this compound (cas:4144-22-3).

The rates of free-radical-initiated alternating copolymerization of α-methylstyrene with N-alkylmaleimides decrease in the following order: Me > Et > n-Pr ≈ n-Bu ≈ n-Hex > iso-Pr > tert-Bu. A linear relationship was established in the plots of log(kR/kMe) against the polar substituent constants, σ*, “”true steric”” factors, ES, and corrected steric factors, ESC. The best fit was obtained in plots of log (kR/kMe) vs. σ* and ESC whereas a large scattering of results was observed in the plot of log (kR/kMe) vs. ES.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Photoinduced polymerization of monofunctional maleimides and donor monomers. Author is Clark, S. C.; Doucet, G. J.; Joensson, S.; Mattson, G. A.; Hoyle, C. E..

The inherent reactivity of a maleimide/donor formulation was established by polymerizing in the presence of a photoinitiator, e.g., 2,2-dimethoxy-2-phenylacetophenone. Donors, e.g, N-vinylpyrrolidone and N-Me vinylacetamide, were polymerized with maleimides, e.g., tert-butylmaleimide (I) and 2-ethylcarbonate ethylmaleimide (II). II had a greater reactivity with the corresponding donor monomers than I.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4144-22-3, is researched, SMILESS is O=C(C=C1)N(C(C)(C)C)C1=O, Molecular C8H11NO2Journal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Cross-Coupling of Acrylamides and Maleimides under Rhodium Catalysis: Controlled Olefin Migration, Author is Sharma, Satyasheel; Han, Sang Hoon; Oh, Yongguk; Mishra, Neeraj Kumar; Lee, Suk Hun; Oh, Joa Sub; Kim, In Su, the main research direction is acrylamide maleimide cross coupling reaction rhodium catalysis olefin migration; succinimide substituted preparation.Electric Literature of C8H11NO2.

The rhodium(III)-catalyzed direct cross-coupling reaction of electron-deficient acrylamides with maleimides is described. This protocol displays broad functional group tolerance and high efficiency, which offers a new opportunity to access highly substituted succinimides. Dependent on the substituent positions of acrylamides and reaction conditions, olefin migrated products were obtained with high regio- and stereoselectivity.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 498-95-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about Introduction of Cyclopropyl and Cyclobutyl Ring on Alkyl Iodides through Cobalt-Catalyzed Cross-Coupling.

A cobalt-catalyzed cross-coupling between alkyl iodides and cyclopropyl, cyclobutyl, and alkenyl Grignard reagents is disclosed. The reaction allows the introduction of strained rings on a large panel of primary and secondary alkyl iodides. The catalytic system is simple and nonexpensive, and the reaction is general, chemoselective, and diastereoconvergent. The alkene resulting from the cross-coupling can be transformed to substituted cyclopropanes using a Simmons-Smith reaction. The formation of radical intermediates during the coupling is hypothesized.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C11H18O. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Hexabromoacetone and ethyl tribromoacetate: a highly efficient reagent for bromination of alcohol. Author is Tongkate, Pratoomrat; Pluempanupat, Wanchai; Chavasiri, Warinthorn.

A new and efficient method for the bromination of alcs. utilizing Br3CCOCBr3/PPh3 and Br3CCO2Et/PPh3 is described. Various alcs. can be converted smoothly into their corresponding alkyl bromides in high yields under mild conditions with short reaction times. Based upon 1H NMR studies using competitive reactions between selected brominating agents and Cl3CCN, Br3CCOCBr3 displays the highest reactivity approx. 9 times that of CBr4.

There is still a lot of research devoted to this compound(SMILES：CC1(C)[C@@]2([H])CC=C(CCO)[C@]1([H])C2)Electric Literature of C11H18O, and with the development of science, more effects of this compound(35836-73-8) can be discovered.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about B-Iso-2-(2-diethylaminoethyl)apopinocampheyl-9-borabicyclo[3.3.1]nonyl hydride – an improved chiral reducing agent for straight chain aliphatic ketones. Author is Weissman, Steven A.; Ramachandran, P. Veeraraghavan.

A series of chirally modified borohydrides of the type lithium B-iso-2-(alkyl)apopinocampheyl-9-borabicyclo[3.3.1]nonyl hydride were prepared to enable a strategic development of chiral reagents for the reduction of straight chain aliphatic ketones. The reagent (alkyl = 2-diethylaminoethyl) reduces 2-octanone in 82% ee, significantly higher than that obtained with NB-Enantride under identical conditions. An improved methodol. for these reductions is also described.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics