Tag: M.W=100-200

Hwang, Joon Young; Ji, A. Young; Lee, Sang Hyeok; Kang, Eun Joo published the article 《Redox-Selective Iron Catalysis for α-Amino C-H Bond Functionalization via Aerobic Oxidation》. Keywords: redox selective iron catalyst aerobic oxidation.They researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Synthetic Route of C8H11NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4144-22-3) here.

Single-electron oxidation and α-deprotonation of tertiary anilines using Fe(phen)3(PF6)3 afford α-aminoalkyl radicals, which can be coupled with electrophilic partners to afford various tetrahydroquinolines. Mechanistically, the Fe(phen)n2+/3+ catalytic cycle is maintained by O2 or a TBHP oxidant, and the presence of the oxygen bound iron complex, Fe(III)-OO(H), was elucidated by ESR and electrospray ionization mass spectrometry. This redox-selective nonheme iron catalyst behaves similarly to bioinspired heme iron catalysts.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Piperidine-3-carboxylic acid( cas:498-95-3 ) is researched.Recommanded Product: 498-95-3.Buran, Kerem; Reis, Rengin; Sipahi, Hande; Oenen Bayram, F. Esra published the article 《Piperazine and piperidine-substituted 7-hydroxy coumarins for the development of anti-inflammatory agents》 about this compound( cas:498-95-3 ) in Archiv der Pharmazie (Weinheim, Germany). Keywords: piperazine piperidine antiinflammatory agent; anti-inflammatory activity; coumarin; nitrite reduction; piperazine; piperidine. Let’s learn more about this compound (cas:498-95-3).

Coumarins (2H-1-benzopyran-2-one), derivatives that can be isolated from several plants, have been reported for their anticoagulant, antimicrobial, anti-inflammatory, or anticancer activity. Some of these structures are currently approved for the treatment of cardiovascular diseases, as antibiotics or as an anticancer drug. Given the great potential of this structure and the limited number of studies that focus on mols. derived from carbon 8 of the benzopyranone heterocycle, we synthesized in this project 38 coumarin derivatives by substituting carbon 8 of the benzopyran ring with some aromatic and aliphatically substituted piperidines and piperazines. As a few of these structures were already shown to exhibit some carbonic anhydrase (CA) inhibition and as CA enzymes are reported to be closely related to inflammation, the synthesized derivatives were evaluated for their anti-inflammatory activity in vitro. The results indicated that compounds 20 and 31 revealed promising anti-inflammatory activity, as they demonstrated better activity than the reference drugs.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Cobalt-catalyzed 2-(1-methylhydrazinyl)pyridine-assisted cyclization of thiophene-2-carbohydrazides with maleimides: efficient synthesis of thiophene-fused pyridones, the main research direction is pyrrolothienopyridine preparation; carbohydrazide thiophene maleimide cycloaddition reaction cobalt catalyst.Recommanded Product: 4144-22-3.

A cobalt-catalyzed direct C-H/N-H functionalization of thiophene-2-carbohydrazides, e.g., I, with maleimides such as., 1-methyl-pyrrole-2,5-dione by utilizing 2-(1-methylhydrazinyl)pyridine (MHP) as an easily removable bidentate directing group has been developed. This formal [4+2] cycloaddition has been achieved for the first time, and it provides an alternative and versatile approach to construct thiophene-fused pyridones, e.g., II, using an inexpensive cobalt catalyst. The C-H/N-H activation cascade protocol showed a high efficiency and a broad substrate scope, and the products were obtained in good to excellent yields.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Gaodeng Xuexiao Huaxue Xuebao called Porous phosphate heterostructure materials as green catalysts in Prins condensation, Author is Wang, Xue-yan; Hua, Wei-ming; Yue, Ying-hong; Gao, Zi, which mentions a compound: 35836-73-8, SMILESS is CC1(C)[C@@]2([H])CC=C(CCO)[C@]1([H])C2, Molecular C11H18O, Related Products of 35836-73-8.

Various ion-exchanged porous phosphate heterostructure (PPH) materials were prepared and characterized by SEM, N2 adsorption and IR spectra of pyridine adsorption (Py-IR). Their catalytic behavior for the Prins condensation of β-pinene with paraformaldehyde was investigated. All catalysts exhibit good activities and selectivities towards nopol. Zn-ZrP is a more selective one in comparison to others, due to abundant Lewis acid sites and less Bronsted acid sites on the surface. The conversion of β-pinene and the yield of nopol on the catalyst reach 91% and 83% at 80°C. The catalyst is stable and reusable, and the product yield is only reduced by 12% after five runs. The reduction in activity is probably caused by deposition of coke on the active sites and partial collapse of porous structure.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Cascade Functionalization of C(sp3)-Br/C(sp2)-H Bonds: Access to Fused Benzo[e]isoindole-1,3,5-trione via Visible-Light-Induced Reductive Radical Relay Strategy. Author is Zhu, Jia-Nan; Wang, Wen-Kang; Zhu, Yuan; Hu, Yin-Qiu; Zhao, Sheng-Yin.

A reductive radical relay strategy for the construction of fused benzo[e]isoindole-1,3,5-trione through a reaction of α-bromo ketones with maleimides in the presence of Ir(ppy)3 under visible-light irradiation is described. The protocol employs very mild reaction conditions and offers satisfactory yields. Moreover, the reaction proceeds through a cascade C(sp3)-Br/C(sp2)-H functionalization, double C-C bond formation, and oxidative aromatization sequence.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Butler, Richard N.; Coyne, Anthony G.; McArdle, Patrick; Sibley, Lisa M.; Burke, Luke A. published the article 《Uncharacteristic thione behavior in a Huisgen cycloaddition reaction: A kinetic and theoretical study》. Keywords: dipolar Huisgen cycloaddition adamantanethione phthalazinium cyanomethanide thiazolophthalazine.They researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).HPLC of Formula: 4144-22-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4144-22-3) here.

In the reaction of phthalazinium-2-dicyanomethanide with adamantanethione the rare ring system [1,3]thiazolo[2,3-a]phthalazine was obtained. An x-ray crystal structure of the product shows regioselectivity with the thione carbon bonded to the dicyanomethanide terminus of the 1,3-dipole. UV kinetic measurements and DFT calculations showed that the rate of cycloaddition of adamantanethione was significantly slower than that of DMAD and no super-dipolarophile character was exhibited. This arose from exceptional lowering of the HOMO energy of the 1,3-dipole by the cyano substituents.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.HPLC of Formula: 4144-22-3.Bartoli, Giuseppe; Bosco, Marcella; Carlone, Armando; Cavalli, Andrea; Locatelli, Manuela; Mazzanti, Andrea; Ricci, Paolo; Sambri, Letizia; Melchiorre, Paolo published the article 《Organocatalytic asymmetric conjugate addition of 1,3-dicarbonyl compounds to maleimides》 about this compound( cas:4144-22-3 ) in Angewandte Chemie, International Edition. Keywords: conjugate addition reaction stereoselective maleimide dicarbonyl quinine catalyst. Let’s learn more about this compound (cas:4144-22-3).

The natural alkaloids quinine and quinidine serve as efficient bifunctional organocatalysts in the asym. conjugate addition of 1,3-dicarbonyl compounds to maleimides. Very high selectivity is observed in this one-step construction of highly functionalized compounds with two adjacent stereogenic centers from com. available precursors.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Inherent chirality through a simple dialkylation of 2,14-dithiacalix[4]arene. Author is Kortus, D.; Kundrat, O.; Tlusty, M.; Cejka, J.; Dvorakova, H.; Lhotak, P..

The dialkylation of 2,14-dithiacalix[4]arene was studied employing various synthetic procedures known for the parent macrocycles (thiacalixarenes and/or classical calixarenes). The best results for distal dialkylation were achieved using the Mitsunobu reaction with the corresponding alcs. Interestingly, due to the lower symmetry of the starting compound, the dialkylated derivatives represent inherently chiral systems. The introduction of chiral substituents thus leads to mixtures of diastereomers potentially useful for the separation of individual stereoisomers as demonstrated by chiral HPLC. The conformational behavior of the novel compounds was studied both in solution (NMR) and in the solid state (X-ray).

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of Piperidine-3-carboxylic acid. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about Adaptive Mechanisms of Baroreflectory Regulation of the Cardiovascular System in Extreme Hyperoxia. Author is Zhilyaev, S. Yu.; Platonova, T. F.; Alekseeva, O. S.; Nikitina, E. R.; Demchenko, I. T..

We hypothesized that all of these responses are components of the baroreflex that regulates blood pressure and circulation in hyperoxia. To test this hypothesis, we carried out experiments on awake rats in which the dynamics of arterial blood pressure, organ blood flow (brain, kidney, lower limbs) and ECG was tracked in response to oxygen breathing at 1, 3 and 5 ATA. The afferent and efferent baroreflex pathways were studied using denervation of the carotid baroreceptors and transection of the aortic depressor nerves and vagus nerve. The baroreflex effectiveness was assessed using phenylephrine injections or spontaneous changes in blood pressure. To activate the GABAergic system, nipecotic acid was injected into the lateral ventricle of the brain. Bradycardia and a decrease in cardiac output, resulting from baroreflex activation by hyperoxia, are actualized via efferent sympathetic and parasympathetic pathways. At 1 and 3 ATA the baroreflex effectiveness increased compared to atm. air breathing, but extreme hyperoxia (5 ATA) suppressed the baroreflex mechanism. Activation of the GABAergic system in the cerebral cortex by nipecotic acid prevented the loss of the hyperoxic baroreflex. In hyperoxia, the baroreflex mechanism realizes adaptive responses of the cardiovascular system aimed at restraining the delivery of excess oxygen to an organism and mitigates activation of the sympathetic nervous system.

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Chlorides – an overview | ScienceDirect Topics

Recommanded Product: Piperidine-3-carboxylic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B. Author is Knez, Damijan; Colettis, Natalia; Iacovino, Luca G.; Sova, Matej; Pislar, Anja; Konc, Janez; Lesnik, Samo; Higgs, Josefina; Kamecki, Fabiola; Mangialavori, Irene; Dolsak, Ana; Zakelj, Simon; Trontelj, Jurij; Kos, Janko; Binda, Claudia; Marder, Mariel; Gobec, Stanislav.

The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymic activity with cardiovascular, neurol., and oncol. disorders. This has promoted increased research into selective MAO-A and MAO-B inhibitors. Here, we shed light on how selective inhibition of MAO-A and MAO-B can be achieved by geometric isomers of cis- and trans-1-propargyl-4-styrylpiperidines. While the cis isomers are potent human MAO-A inhibitors, the trans analogs selectively target only the MAO-B isoform. The inhibition was studied by kinetic anal., UV-vis spectrum measurements, and X-ray crystallog. The selective inhibition of the MAO-A and MAO-B isoforms was confirmed ex vivo in mouse brain homogenates, and addnl. in vivo studies in mice show the therapeutic potential of 1-propargyl-4-styrylpiperidines for central nervous system disorders. This study represents a unique case of stereoselective activity of cis/trans isomers that can discriminate between structurally related enzyme isoforms.

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics