Tag: M.W=100-200

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Enantioselective Michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN salt, published in 2010-07-07, which mentions a compound: 4144-22-3, Name is 1-(tert-Butyl)-1H-pyrrole-2,5-dione, Molecular C8H11NO2, Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione.

An unprecedented enantioselective Michael addition of various ketones to maleimides catalyzed by a simple bifunctional primary amine, monosulfonyl DPEN salt, is reported. The reaction provides the desired pyrrolidine diones, e.g., I in good to excellent yields (up to 99%) with excellent enantioselectivities (up to 99%).

There are many compounds similar to this compound(4144-22-3)Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections, published in 2020, which mentions a compound: 35836-73-8, mainly applied to orthopoxvirus infection adamantane monoterpene conjugates, Recommanded Product: 35836-73-8.

Currently, the spectrum of agents against orthopoxviruses, in particular smallpox, is very narrow. Despite the fact that smallpox is well controlled, there is, for many reasons, a real threat of epidemics associated with this or a similar virus. In order to search for new low mol. weight orthopoxvirus inhibitors, a series of amides combining adamantane and monoterpene moieties were synthesized using 1- and 2-adamantanecarboxylic acids as well as myrtenic, citronellic and camphorsulfonic acids as acid components. The produced compounds exhibited high activity against the vaccinia virus (an enveloped virus belonging to the poxvirus family), which was combined with low cytotoxicity. Some compounds had a selectivity index higher than that of the reference drug cidofovir; the highest SI = 1123 was exhibited by 1-adamantanecarboxylic acid amide containing the (-)-10-amino-2-pinene moiety. The produced compounds demonstrated inhibitory activity against other orthopoxviruses: cowpox virus (SI = 30-406) and ectromelia virus (mousepox virus, SI = 39-707).

In addition to the literature in the link below, there is a lot of literature about this compound(2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol)Recommanded Product: 35836-73-8, illustrating the importance and wide applicability of this compound(35836-73-8).

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 498-95-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about A convenient catalytic silicon-assisted route towards new non-proteinogenic amino acids with methylenebisphosphonic acids moieties. Author is Prishchenko, Andrey A.; Alekseyev, Roman S.; Livantsov, Mikhail V.; Novikova, Olga P.; Livantsova, Ludmila I.; Petrosyan, Valery S..

The new non-proteinogenic amino acids with methylenebisphosphonic acids moieties are synthesized for the first time via unique reaction of tris(trimethylsilyl) phosphite and various N-formyl amino acids at the presence of effective catalyst – trimethylsilyl triflate under mild conditions. The further treatment of initially formed trimethylsilyl intermediates with the methanol excess resulted in the water-soluble non-proteinogenic amino acids with methylenebisphosphonic acids moieties in high yields. The catalytic scheme of target substances formation is proposed and discussed in detail. The structures of target functionalized amino acids and their precursors were confirmed by the 1H, 13C, 31P NMR spectra and high resolution mass spectra. The resulted compounds are of great interest as promising antiviral substances and effective ligands.

In addition to the literature in the link below, there is a lot of literature about this compound(Piperidine-3-carboxylic acid)Related Products of 498-95-3, illustrating the importance and wide applicability of this compound(498-95-3).

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Studies of initiation mechanism of maleimide/vinyl ether copolymerizations, published in 2000, which mentions a compound: 4144-22-3, Name is 1-(tert-Butyl)-1H-pyrrole-2,5-dione, Molecular C8H11NO2, Electric Literature of C8H11NO2.

Previous work has shown that transferable hydrogens play an important role in the photoinduced polymerization of maleimides and vinyl ethers. In order to study this effect systematically, several maleimide and vinyl ether combinations (with/without transferable hydrogens) were prepared The polymerization rate and extent of conversion were evaluated by real-time FTIR. In addition, laser flash photolysis was used to investigate the quenching processes of the excited triplet state of each maleimide by various vinyl ether monomers. Quenching of the triplet state of maleimides by vinyl ethers occurs by an electron transfer process that is independent of the presence of transferable hydrogens. Transferable hydrogens are essential for rapid polymerization indicating that radicals capable of initiating polymerization are produced from the anion radical of the maleimide via a proton transfer process.

I hope my short article helps more people learn about this compound(1-(tert-Butyl)-1H-pyrrole-2,5-dione)Electric Literature of C8H11NO2. Apart from the compound(4144-22-3), you can read my other articles to know other related compounds.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C6H11NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS. Author is Romano, Giulia; Holodkov, Nikola; Klima, Raffaella; Feiguin, Fabian.

Alterations in the function of the RNA-binding protein TDP-43 are largely associated with the pathogenesis of amyotrophic lateral sclerosis (ALS), a devastating disease of the human motor system that leads to motoneurons degeneration and reduced life expectancy by mol. mechanisms not well known. In our previous work, we found that the expression levels of the glutamic acid decarboxylase enzyme (GAD1), responsible for converting glutamate to γ-aminobutyric acid (GABA), were downregulated in TBPH-null fies and motoneurons derived from ALS patients carrying mutations in TDP-43, suggesting that defects in the regulation of GAD1 may lead to neurodegeneration by afecting neurotransmitter balance. In this study, we observed that TBPH was required for the regulation of GAD1 pre-mRNA splicing and the levels of GABA in the Drosophila central nervous system (CNS). Interestingly, we discovered that pharmacol. treatments aimed to potentiate GABA neurotransmission were able to revert locomotion defciencies in TBPH-minus fies, revealing novel mechanisms and therapeutic strategies in ALS.

I hope my short article helps more people learn about this compound(Piperidine-3-carboxylic acid)Formula: C6H11NO2. Apart from the compound(498-95-3), you can read my other articles to know other related compounds.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kaminski, Z. J.; Kolesinska, B.; Markowicz, S. W. published an article about the compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8,SMILESS:CC1(C)[C@@]2([H])CC=C(CCO)[C@]1([H])C2 ).Formula: C11H18O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:35836-73-8) through the article.

Sym., trisubstituted derivatives of cyanuric and isocyanuric acid, resp. were prepared by treatment of cyanuric chloride with appropriate terpenic alcs. Under less basic conditions involving treatment of appropriate terpenic alcs. with metallic sodium, less polar cyanuric acid derivatives were obtained in 74-85% yield. Under more basic conditions, in the presence of sodium hydride, isocyanuric acid derivatives were prepared in 71-88% yield. Cytostatic activity of (1R,2S,5R)-menthol derivative of cyanuric acid was evaluated on 9 cancer subtypes including 62 tumor cell lines. The studies have shown that contrary to expectations, 2,4,6-trimentholoxy-1,3,5-triazine revealed a weak or moderate activity against most of the cell lines.

I hope my short article helps more people learn about this compound(2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol)Formula: C11H18O. Apart from the compound(35836-73-8), you can read my other articles to know other related compounds.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called N-tosyloxycarbamates as a source of metal nitrenes: rhodium-catalyzed C-H insertion and aziridination reactions, published in 2005-10-19, which mentions a compound: 35836-73-8, Name is 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, Molecular C11H18O, Application In Synthesis of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol.

The rhodium-catalyzed decomposition of N-tosyloxycarbamates to generate metal nitrenes which undergo intramol. C-H insertion or aziridination reaction is described. Aliphatic N-tosyloxycarbamates produce oxazolidinones with high yields and stereospecificity through insertion in benzylic, tertiary, and secondary C-H bonds. Intramol. aziridination occurs with allylic N-tosyloxycarbamates to produce aziridines as single diastereomers. The reaction proceeds at room temperature using a rhodium catalyst and an excess of potassium carbonate and does not require the use of strong oxidant, such as hypervalent iodine reagents. A rhodium nitrene species is presumably involved, as both reactions are stereospecific.

I hope my short article helps more people learn about this compound(2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol)Application In Synthesis of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. Apart from the compound(35836-73-8), you can read my other articles to know other related compounds.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Nippon Kagaku Kaishi called Amine salt as an effective catalyst for synthesis of N-substituted maleimide, Author is Kita, Yuichi; Kashitani, Takayoshi; Kishino, Kazuo; Nakagawa, Koichi, which mentions a compound: 4144-22-3, SMILESS is O=C(C=C1)N(C(C)(C)C)C1=O, Molecular C8H11NO2, Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione.

Synthesis of N-substituted maleimide by dehydration and ring-closure of N-substituted maleamic acids in organic solvent was investigated. Anal. of the reaction products proved that three types of compounds were mainly produced. The N-substituted maleimides were yielded by dehydration of N-substituted maleamic acids. Maleic acid was formed by hydrolysis of N-substituted maleamic acid and subsequent isomerization resulted in fumaric acid. Reaction scheme which was confirmed by energy calculation was proposed. Based on these considerations, hydrolysis of N-substituted maleamic acids was prevented by coexistence of primary amine. N-substituted maleimides were synthesized from N-substituted maleamic acids with high selectivity by employing acid and its primary amine salt mixture as catalyst.

I hope my short article helps more people learn about this compound(1-(tert-Butyl)-1H-pyrrole-2,5-dione)Application In Synthesis of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. Apart from the compound(4144-22-3), you can read my other articles to know other related compounds.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of the thiazoles. II. Synthesis of 4-aminothiazole derivatives, published in 1945, which mentions a compound: 72792-54-2, mainly applied to , COA of Formula: C3H6ClN3S.

AcCO2Et (8 g.) was treated with 11 g. Br in 80 cc. CS2 and excess HBr removed with BaCO3. The crude ester was treated with 3 g. MeCSNH2 in EtOH and the product worked up in the usual manner to give 1 g. Et 2-methyl-4-thiazolecarboxylate (I), colorless elongated plates, m. 64-5°. I could not be converted to 2-methyl-4-acetamidothiazole by the Curtius method described above. A solution of 8.9 g. CS(NH2)2 in 50 cc. hot 50% EtOH was treated with 8.9 g. ClCH2CN. The clear solution was refluxed 15 min., when it set to a crystalline mass, and then it was cooled, filtered, washed with EtOH, and dried to give 17.9 g. 2,4-diaminothiazole-HCl (II), thick rectangular plates, turns brown at 170°, does not m. below 275°; picrate, darkens at 210°, m. 290° (decomposition). The free base could not be isolated. Other thioureas did not give the required 4-aminothiazoles by this method. HCSNH2 and MeCSNH2 with ClCH2CN yielded 1 mol. NH4Cl and an unidentified oil. NH4SCONH2 yielded 1 mol. NH4Cl and NH3. NH2CSCO2Et condensed with ClCH2CN to give 4-keto-2-thiazolinecarboxylate, m. 140°. II (2 g.) was refluxed 45 min. with 5 cc. Ac2O and 5 cc. pyridine, diluted with H2O, and the 2.4 g. of solid which separated was crystallized from H2O to give 2,4-diacetamidothiazole (III), m. 239-41°. A mixture of 4 g. Et 2-amino-4-thiazolecarboxylate and 3 cc. 84% N2H4 in 10 cc. EtOH was refluxed 6 h. and the solvent was distilled The residue was dissolved in boiling H2O, decolorized with charcoal, and evaporated to give 3.5 g. 2-amino-4-thiazolecarboxylic hydrazide (IV), m. 183-94° (H2O). Treatment of 2 g. crude IV in 15 cc. H2O and 3 cc. AcOH at 0° with 1 g. NaNO2 in 6 cc. H2O yielded 1.8 g. of the azide, brown solid, which was decomposed by warming with a mixture of 3 cc. Ac2O and 5 cc. AcOH to give III.

I hope my short article helps more people learn about this compound(Thiazole-2,4-diamine hydrochloride)COA of Formula: C3H6ClN3S. Apart from the compound(72792-54-2), you can read my other articles to know other related compounds.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Quality Control of 1-(tert-Butyl)-1H-pyrrole-2,5-dione.Zhan, Bei-Bei; Li, Ya; Xu, Jing-Wen; Nie, Xing-Liang; Fan, Jun; Jin, Liang; Shi, Bing-Feng published the article 《Site-selective δ-C(sp3)-H alkylation of amino acids and peptides with maleimides via a six-membered palladacycle》 about this compound( cas:4144-22-3 ) in Angewandte Chemie, International Edition. Keywords: amino acid alkylation Michael peptide maleimide palladacycle hydrogen bond; peptide alkylation Michael type maleimide isoleucinol; alkylation mechanism palladacycle transition state Curti Hammett principle; alkylation; palladacycles; palladium; peptides; site selectivity. Let’s learn more about this compound (cas:4144-22-3).

The site-selective functionalization of unactivated C(sp3)-H bonds remains one of the greatest challenges in organic synthesis. Herein, we report on the site-selective δ-C(sp3)-H alkylation of amino acids and peptides with maleimides via a kinetically less favored six-membered palladacycle in the presence of more accessible γ-C(sp3)-H bonds. Exptl. studies revealed that C-H bond cleavage occurs reversibly and preferentially at γ-Me over δ-Me C-H bonds while the subsequent alkylation proceeds exclusively at the six-membered palladacycle that is generated by δ-C-H activation. The selectivity can be explained by the Curtin-Hammett principle. The exceptional compatibility of this alkylation with various oligopeptides renders this procedure valuable for late-stage peptide modifications. Notably, this process is also the first palladium(II)-catalyzed Michael-type alkylation reaction that proceeds through C(sp3)-H activation.

There are many compounds similar to this compound(4144-22-3)Quality Control of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics