Tag: M.W=100-200

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 37481-18-8, is researched, Molecular C11H16N2, about 2-Methoxy-6-chloro-9-(N-substituted-amino)-acridines. II. Compounds Derived from Cyclic Secondary Amines, the main research direction is ACRIDINE DYES/chemistry.Recommanded Product: 37481-18-8.

The γ-substituted propionitriles were prepared by adding the secondary amines to an excess of CH2:CHCN: 1-pyrrolidyl, b28 110-12°, 81% (flavianate, m. 140-5°); 1-piperidyl, b27 125-30°, 74%; 2-methyl-1-piperidyl, b30 137-40°, 99%; 3-isomer, b28 126-8°, 97%; 4-isomer, b27-8 127-30°, 87%; 2,3-dimethyl-1-piperidyl, b35 140-2°, 99%; 2,4-isomer, b29 130-3°, 68%; 2, 6-isomer, b26-8 121-5°, 82%. The nitriles were reduced by Raney Ni in ether-NH3 or with Na in EtOH; 3-substituted propylamines: 1-pyrryl, b30 117-20°, 86% (picrate, m. 135-7°); 1-pyrrolidyl, b26 85-7°, 71% (picrate, m. 219-31° (decomposition)); 1-piperidyl, b31 110-15°, 77% (picrate, m. 195-204° (decomposition)); 2-methyl-1-piperidyl, b755 163-70°, 45% (picrate, m. 212-15°); 3-isomer, b27 110-12°, 85% (picrate, m. 185-7°); 4-isomer, b18 90-2°, 74% (picrate, m. 212-14°; phenylthiourea, m. 140-1°); 2, 3-dimethyl-1-piperidyl, b22 114-15°, 62% (picrate, m. 208-10°); 2,4-isomer, b34 120-2°, 52% (picrate, m. 203-5°); 2,6-isomer, b31-2 122-30°, 38% (picrate, m. 206-8°). 2-Methylpiperidine-HCl (67.7 g.), 290 g. Me2CO, 160 mL. H2O, and 90 mL. 37% HCHO, refluxed overnight, give 47.5 g. 4-(2-methyl-1-piperidyl)-2-butanone, b17-18 87-91°; the oxime b2 116-20°; reduction with Na in EtOH gives 4-(2-methyl-1-piperidyl)-2-butylamine, b26 113-16°. N-Substituted 2-methoxy-6-chloro-9-aminoacridine di-HCl salts: 3-(1-pyrryl)propyl, m. 210-13°; 3-(1-pyrrolidyl)propyl, m. 228-30°; 3-(1-piperidyl)propyl, m. 245-7°; 3-(2-methyl-1-piperidyl)propyl, m. 255-7°; 3-Me isomer, m. 241-2° (decomposition); 4-Me isomer, m. 256-7° (decomposition); 3-(2,3-dimethyl-1-piperidyl)propyl, m. 238-40°; 2, 4-di-Me isomer, m. 234-6°; 2,6-di-Me isomer, m. 239-41°; 4-(2-methyl-1-pperidyl)-3-Bu, m. 247-8°. 1,2,3,4-Tetrahydroquinoline (20 g.), 28.1 g. C6H4(CO)2NC2H4Br, 2 g. KI, and 25 mL. Methyl Cellosolve, heated on a steam bath overnight, give N-[2-(1,2,3,4-tetrahydro-1-quinolyl)ethyl]phthalimide, m. 131-3°; the resulting ethylamine gives 2-methoxy-6-chloro-9-[2-(1,2,3,4-tetrahydro-1-quinolyl)ethylamino]-acridine-2HCl, m. 156-8°. Histamine gives a small yield of 2-methoxy-6-chloro-9-[2-(4(or 5)-imidazolyl)ethylamino]acridine-2HCl, m. 250-5°.

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Reference:
Chloride – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Vyglazov, O. G.; Urbanovich, T. R.; Manukov, E. N.; Chuiko, V. A.; Udarov, B. G. researched the compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ).Name: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol.They published the article 《Solvolysis products of 2-[(tosyloxy)ethyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene》 about this compound( cas:35836-73-8 ) in Zhurnal Organicheskoi Khimii. Keywords: acetolysis tosyloxyethyldimethyl bicycloheptene. We’ll tell you more about this compound (cas:35836-73-8).

Acetolysis of the title tosylate gave a mixture of aromatic and bi- and tricyclic products, with alcs. I and II predominating, in 79% combined yield. Oxidizing β-pinene with Pb(OAc)4 in C6H6 gave 78% trans-3-acetoxy-2(10)-pinene, which was cyclopropanated with :CCl2 to give 88% dichlorospiro ester and then reduced with LiAlH4 in dioxane to give 73% I.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Piperidine-3-carboxylic acid, is researched, Molecular C6H11NO2, CAS is 498-95-3, about RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis, the main research direction is RASS enabled bond formation DNA encoded library; DNA encoded library; nickel cross-coupling; reversible adsorption to solid support; sulfonamide; sulfone.Quality Control of Piperidine-3-carboxylic acid.

DNA encoded libraries (DEL) showed promise as a valuable technol. for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to libraries of unprecedented size, their production has been hampered by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible chem. to dilute aqueous environments. Recently reversible adsorption to solid support (RASS) has been demonstrated as a promising method to expand DEL reactivity using standard organic synthesis protocols. Here the authors demonstrate a suite of on-DNA chemistries to incorporate medicinally relevant and C-S, C-P and N-S linkages into DELs, which are underrepresented in the canonical methods.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione(SMILESS: O=C(C=C1)N(C(C)(C)C)C1=O,cas:4144-22-3) is researched.Quality Control of Diiodo(1,5-cyclooctadiene)platinum(II). The article 《Rhodium-Catalyzed Site-Selective ortho-C-H Activation: Enone Carbonyl Directed Hydroarylation of Maleimides》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:4144-22-3).

Enone carbonyl directed 1,4-addition of ortho-C-H bond in chalcones to maleimides was developed under the catalysis of Rh(III). This reaction furnished a variety of chalcone-based pharmacol. useful 3-arylated succinimide derivatives in good yields with excellent selectivity.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lv, Ningning; Liu, Yue; Xiong, Chunhua; Liu, Zhanxiang; Zhang, Yuhong published an article about the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3,SMILESS:O=C(C=C1)N(C(C)(C)C)C1=O ).Formula: C8H11NO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4144-22-3) through the article.

The first example of oxidant-free cobalt-catalyzed synthesis of five-membered spirocycles, e.g. I, is reported from benzimidates and maleimides utilizing nitrobenzene as promoter. In contrast to previously known cobalt-catalyzed oxidative C-H functionalization reactions, this transformation occurs efficiently in the absence of oxidant and is accompanied by liberation of hydrogen. The spiro-lactams were readily achieved by the hydrolysis of as-prepared spirocyclic compounds The Cp*Rh(III) catalyst shows poor reactivity.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Feng; Zhou, Yirong; Yang, Heng; Liu, Dandan; Sun, Bing; Zhang, Fang-Lin published the article 《Assembly of Diverse Spirocyclic Pyrrolidines via Transient Directing Group Enabled Ortho-C(sp2)-H Alkylation of Benzaldehydes》. Keywords: formylaryl succinimide regioselective diversity oriented preparation; spirocyclic imide preparation; ruthenium catalyst transiently directed regioselective alkylation aryl aldehyde maleimide; spirocyclization formylaryl succinimide.They researched the compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ).Recommanded Product: 4144-22-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4144-22-3) here.

In the presence of [RuCl2(p-cymene)]2, AgSbF6, and 4-chlorobenzoic acid, aryl aldehydes such as 2,4-dimethylbenzaldehyde underwent directed regioselective alkylation reactions with maleimides such as N-ethylmaleimide via formation of transient imine directing groups with 2-methyl-3-trifluoromethylaniline to yield formylarylsuccinimides such as I chemo- and regioselectively. Alkylation by maleimides proximal to the aldehyde is preferred over alkylation near other directing groups such as carbamates and pyrazoles, allowing for the synthesis of formylaryl-substituted imides. Spirocyclization of I with a variety of reactants such as 1,2,3,4-tetrahydroisoquinoline yielded nine pyrrolidine-containing spirocycles such as II. Only 0.5 mol % of ruthenium catalyst was sufficient to prepare I on 100 mmol scale (22 g scale, 86% yield) without column chromatog. purification

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Computed Properties of C8H11NO2.Sakai, Norio; Matsumoto, Shun; Ogiwara, Yohei published the article 《Cobalt-catalyzed oxidative annulation of aromatic tertiary amines with electron-deficient maleimides leading to tetrahydroquinoline derivatives》 about this compound( cas:4144-22-3 ) in Tetrahedron Letters. Keywords: tetrahydroquinoline preparation; tertiary amine maleimide oxidative annulation cobalt catalyst. Let’s learn more about this compound (cas:4144-22-3).

A CoCl2-TBHP (t-Bu hydroperoxide) system that efficiently catalyzes the oxidative annulation of aromatic tertiary amines such as N-phenylpiperidine, N,N-dimethyl-p-toluidine, N-methyl-N-ethylaniline, etc. with a typical electron-deficient alkene, N-substituted maleimides I (R = Ph, benzyl, t-Bu, 4-chlorophenyl, 4-methylphenyl), producing the corresponding polycyclic tetrahydroquinoline derivatives, e.g., II, has been described. This oxidizing system could also be applied to the annulation of an electron-rich alkene.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C11H18O. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about Iron-Catalyzed C-C Single-Bond Cleavage of Alcohols.

An iron-catalyzed deconstruction/hydrogenation reaction of alcs. e.g., 1-(4-methoxyphenyl)cyclohexan-1-ol through C-C bond cleavage was developed through photocatalysis to produce ketones RC(O)R1 [R = Ph, Me, 4-bromophenyl, etc. ; R1 = Et, n-Bu, 3,3-difluoropentyl, etc.; RR1 = (CH2)5]/aldehydes R2CHO (R2 = Ph, cyclopentylmethyl, n-hexyl, etc.) as the products. Tertiary, secondary, and primary alcs. e.g., 1-(4-methoxyphenyl)cyclohexan-1-ol bearing a wide range of substituents are suitable substrates. Complex natural alcs. can also perform the transformation selectively. The investigation of the mechanism reveals a procedure that involves chlorine radical improved O-H homolysis, with the assistance of 2,4,6-collidine.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mozhaitsev, Evgenii S.; Zakharenko, Alexandra L.; Suslov, Evgeniy V.; Korchagina, Dina V.; Zakharova, Olga D.; Vasil’eva, Inna A.; Chepanova, Arina A.; Black, Ellena; Patel, Jinal; Chand, Raina; Reynisson, Johannes; Leung, Ivanhoe K. H.; Volcho, Konstantin P.; Salakhutdinov, Nariman F.; Lavrik, Olga I. published the article 《Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments》. Keywords: monoterpenoid adamantane DNA repair enzyme fragment; 3,7-dimethyloctanol; Citronellol; chemical space; cytotoxicity; esters; inhibitors; molecular modelling; terpene..They researched the compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ).Safety of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:35836-73-8) here.

The DNA repair enzyme tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a current inhibition target to improve the efficacy of cancer chemotherapy. Previous studies showed that compounds combining adamantane and monoterpenoid fragments are active against TDP1 enzyme. This investigation is focused on the synthesis of monoterpenoid derived esters of 1-adamantane carboxylic acid as TDP1 inhibitors. New esters were synthesized by the interaction between 1-adamantane carboxylic acid chloride and monoterpenoid alcs. The esters were tested against TDP1 and its binding to the enzyme was modeling. 13 Novel ester-based TDP1 inhibitors were synthesized with yields of 21-94%; of these, nine esters had not been previously described. A number of the esters were found to inhibit TDP1, with IC50 values ranging from 0.86-4.08μM. Mol. modeling against the TDP1 crystal structure showed a good fit of the active esters in the catalytic pocket, explaining their potency. A non-toxic dose of ester, containing a 3,7-dimethyloctanol fragment, was found to enhance the cytotoxic effect of topotecan, a clin. used anti-cancer drug, against the human lung adenocarcinoma cell line A549. The esters synthesized were found to be active against TDP1 in the lower micromolar concentration range, with these findings being corroborated by mol. modeling. Simultaneous action of the ester synthesized from 3,7-dimethyloctanol-1 and topotecan revealed a synergistic effect.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yu, Gu-Sheng; Freedman, Teresa B.; Nafie, Laurence A. researched the compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ).Name: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol.They published the article 《Dual circular polarization Raman optical activity of related terpene molecules: comparison of backscattering DCPI and right-angle ICP spectra》 about this compound( cas:35836-73-8 ) in Journal of Raman Spectroscopy. Keywords: Raman optical activity terpene; circular polarization Raman terpene; absolute configuration Raman optical activity. We’ll tell you more about this compound (cas:35836-73-8).

The backscattering in-phase dual circular polarization (DCDPI) Raman and Raman optical activity (ROA) for a series of terpene mols. is reported. The selected mols. were studied in three groups of closely related structures and correlations between ROA features and structural elements among mols. within these groups are discussed. One aim of this study was to uncover addnl. details regarding the sensitivity of ROA to stereo-structural features in mols. and to elucidate further the degree of local character of this new stereochem. probe. Another was to compare the backscattering DCPI ROA intensities reported with those obtained using depolarized right-angle incident circularly polarized (ICP) ROA for some of the same mols. more than a decade ago.

As far as I know, this compound(35836-73-8)Name: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics