Tag: M.W=100-200

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ) is researched.Recommanded Product: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol.Khomenko, Tatyana; Zakharenko, Alexandra; Odarchenko, Tatyana; Arabshahi, Homayon John; Sannikova, Victoriya; Zakharova, Olga; Korchagina, Dina; Reynisson, Johannes; Volcho, Konstantin; Salakhutdinov, Nariman; Lavrik, Olga published the article 《New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties》 about this compound( cas:35836-73-8 ) in Bioorganic & Medicinal Chemistry. Keywords: hydroxycoumarin monoterpenoid preparation tyrosyl DNA phosphodiesterase inhibitor modeling antitumor; Coumarin; Molecular modeling; Monoterpene; Tyrosyl-DNA Phosphodiesterase I inhibitor. Let’s learn more about this compound (cas:35836-73-8).

A number of derivatives of 7-hydroxycoumarins containing aromatic or monoterpene substituents at hydroxy-group were synthesized based on a hit compound from a virtual screen. The ability of these compounds to inhibit tyrosyl-DNA phosphodiesterase I (Tdp 1), important target for anti-cancer therapy, was studied for the first time. The 7-hydroxycoumarin derivatives with monoterpene pinene moiety are effective inhibitors of Tdp 1 with the most active derivative 7-(((1S,5R)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methoxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one (compound (+)-25c) with IC50 value of 0.675 μM. This compound has low cytotoxicity (CC50 >100 μM) when tested against human cancer cells which is crucial for presupposed application in combination with clin. established anticancer drugs. The ability of the new compounds to enhance the cytotoxicity of camptothecin, an established topoisomerase 1 poison, was demonstrated.

As far as I know, this compound(35836-73-8)Recommanded Product: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 4144-22-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Ruthenium(II)-catalyzed redox-free [3 + 2] cycloaddition of N-sulfonyl aromatic aldimines with maleimides. Author is Tamizmani, Masilamani; Ramesh, Balu; Jeganmohan, Masilamani.

A ruthenium(II)-catalyzed redox-free cycloaddition of N-sulfonyl aromatic aldimines with maleimides providing 1-aminoindanes, e. g., I, in good yields is described. The proposed mechanism was strongly supported by the DFT calculations and isolation of a ruthenacycle intermediate.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of C8H11NO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Structural Studies on α-Pyrone Cycloadducts. Manifestation of the Early Stages of CO2 Extrusion by retro Hetero-Diels-Alder Reaction. Author is Roth-Barton, Jesse; Goh, Yit Wooi; Karnezis, Asimo; White, Jonathan M..

Structures of the α-pyrone (pyran-2-one) cycloadducts 4-8 show deviations of some bond distances from their normal values, consistent with manifestation of the early stages of the retro hetero-Diels-Alder decarboxylation reaction in the ground state structures. Thus the bridgehead C-O(CO) and C-CO(O) bonds are lengthened and the bridging C-O bond is shortened. The degree of lengthening of the C-O(CO) and C-CO(O) bonds is similar, whereas in the calculated transition state structure there is significant asymmetry in the extent of C-CO(O) and C-O(CO) bond breaking.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ) is researched.Category: chlorides-buliding-blocks.Gu, Jia-Yi; Zhang, Wei; Jackson, Seth R.; He, Yan-Hong; Guan, Zhi published the article 《Photoinduced umpolung addition of carbonyl compounds with α,β-unsaturated esters enables the polysubstituted γ-lactone formation》 about this compound( cas:35836-73-8 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: unsaturated ester carbonyl compound iridium photocatalyst umpolung addition transesterification; aryl lactone diastereoselective preparation. Let’s learn more about this compound (cas:35836-73-8).

The photoinduced intermol. umpolung addition of aromatic ketones/aldehydes with α,β-unsaturated esters via ketyl radical intermediates was reported. Following an intramol. transesterification, a variety of γ-lactone derivatives were readily accessed. Mechanistic investigations demonstrated the significant role of Hantzsch ester, which served both as the electron and proton donor.

As far as I know, this compound(35836-73-8)Category: chlorides-buliding-blocks can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C11H18O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about A Study of Transesterification of Chiral (-)-Pinanediol Methylboronic Ester with Various Structurally Modified Diols. Author is Roy, Chandra D.; Brown, Herbert C..

The transesterification of chiral (-)-pinanediol methylboronic ester (I) was studied with various structurally modified diols by 1H NMR to understand the factors influencing the unusual stability of this boronic ester as well as to find ways of recovering pinanediol from its methylboronic ester. In all the cases, reactions were allowed to proceed to equilibrium The preliminary experiments indeed have shown some encouraging results (displacement of pinanediol up to 40-53%). Amongst cyclopentane-based cis-1,2-diols, endo-2-phenyl-exo,exo-2,3-norbornane-diol appeared to be the most effective diol in displacing pinanediol (38%). In the cases of pinane-based diols, the best result was obtained with 2-ethyl-6,6-dimethylbicyclo[3.1.1]heptane-cis-2,3-diol (53%). It was interesting to observe that the transesterification with 2-phenyl-6,6-dimethylbicyclo[3.1.1]heptane-cis-2,3-diol resulted in a 50% conversion after 4 days only, whereas the former diol took 24 days to reach equilibrium

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Self-Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation. Author is McDaniel, Jonathan R.; Bhattacharyya, Jayanta; Vargo, Kevin B.; Hassouneh, Wafa; Hammer, Daniel A.; Chilkoti, Ashutosh.

We covalently attached 14 different maleimide derivatives of small mols. to a chimeric polypeptide (CP). The CP consisted of a hydrophilic, biodegradable polypeptide and a cysteine-rich Cys(Gly-Gly-Cys)7 segment. An elastin-like polypeptide was selected as the hydrophilic segment of the CP. Attachment of small mols. above a critical threshold of hydrophobicity triggers self-assembly of the CP into soluble nanoparticles. The conjugation-triggered self-assembly can package a hydrophobic drug into soluble nanoparticles.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Enantioselective transport of amino acid through supported chiral liquid membranes, published in 1993-12-02, which mentions a compound: 35836-73-8, Name is 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, Molecular C11H18O, Product Details of 35836-73-8.

Two chiral alcs., nopol and (2S)-(-)-methyl-1-butanol, immobilized in the pores of a polyethylene film, were used for the enantioselective transport of amino acid hydrochlorides. The degree of stereoselectivity of the permeation process varied from 0.39 to 1.52 depending on both the type of the chiral membrane phase and the properties of the amino acid. Evaluation of the ability of the membrane to sep. stereoisomers was performed by a step-by-step anal. procedure, considering the effect of amino acids, hydrophobicity, polarity and degree of chirality. For the purpose of this paper, the chirality measure was introduced. The enantioselectivity was affected mainly by the degree of chirality, and the nopol membrane was the more efficient one.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of C11H18O. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol, is researched, Molecular C11H18O, CAS is 35836-73-8, about A new class of enantioselective organoboron reducing agents. Borane complexes with chiral terpenic 1,2-azaboracyclohexanes. Author is Midland, M. Mark; Kazubski, Aleksander.

Borane complexes of N-substituted-10,10-dimethyl-5-aza-6-boratricyclo[7.1.1.02,7]undecane, e.g., I (R = Me, CH2Ph, Pr), are readily prepared by hydroboration of nopyl amines. These complexes reduce aromatic and aliphatic ketones to enantiomerically enriched alcs. For example, 3,3-dimethyl-2-butanol, 1-phenyl-1-ethanol, and 2-octanol are obtained in 82, 77 and 64% ee, resp., with use of I (R = Pr) as reducing agent.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Product Details of 4144-22-3.Matsumoto, Akikazu; Kubota, Toru; Otsu, Takayuki published the article 《Synthesis and characterization of poly(N-tert-alkylmaleimides). 1. Radical polymerization of N-tert-butylmaleimide leading to a less-flexible poly(substituted methylene)》 about this compound( cas:4144-22-3 ) in Polymer Bulletin (Berlin, Germany). Keywords: butylmaleimide polymerization kinetics; polybutylmaleimide flexibility polymerization reactivity. Let’s learn more about this compound (cas:4144-22-3).

In presence of AIBN, N-tert-butylmaleimide (I) readily polymerized in spite of the bulky N-substituent to give a high-mol.-weight, semiflexible polymer. The rate of polymerization (Rp) in C6H6 was given by Rp = k[AIBN]0.51[I]1.4, and the overall activation energy was 99.6 kJ/mol. The polymerization of I to high mol. weight was assumed to result from a decrease in the rate of bimol. termination between rigid polymer radicals bearing bulky substituents. The flexibility of the polymer chain was examined by viscometric and light scattering methods, and the flexibility effect on the polymerization reactivity was discussed.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol( cas:35836-73-8 ) is researched.Safety of 2-((1R,5S)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol.Kaminski, Z. J.; Kolesinska, B.; Markowicz, S. W.; Pokrzeptowicz, K. published the article 《Terpenic alcohols – source of chirality in condensing reagents in peptide chemistry》 about this compound( cas:35836-73-8 ) in Polish Journal of Chemistry. Keywords: terpenyloxytriazine preparation enantiodifferentiation reagent peptide coupling; triazine dichloroterpenyloxy preparation enantiodifferentiation peptide coupling. Let’s learn more about this compound (cas:35836-73-8).

Chiral 2,4-dichloro-6-terpenyloxy-1,3,5-triazines, obtained by treatment of cyanuric chloride with isomyrtanol, nopol, isopinocampheol and borneol, are useful as enantiodifferentiating coupling reagent in the synthesis of dipeptides.

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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics