Tag: M.W=100-150

Zhao, Liang’s team published research in Huaxue Xuebao in 69 | CAS: 5034-06-0

Huaxue Xuebao published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C26H26N4O7, Recommanded Product: trimethyloxosulphonium chloride.

Zhao, Liang published the artcileSynthesis of polymethylene-based macromonomer by living polymerization of ylides, Recommanded Product: trimethyloxosulphonium chloride, the publication is Huaxue Xuebao (2011), 69(5), 591-595, database is CAplus.

Two kinds of polymethylene-based macromonomers were prepared by living polymerization of ylides. One macromonomer PM-methacrylate was obtained by the transformations of hydroxyl group at the chain end of polymethylene obtained by living polymerization of ylides. The other macromonomer PM-styryl was synthesized via living polymerization of ylides which initiated by organoborane which was prepared by hydroboration of divinylbenzene, and after the oxidation by trimethylamine-N-oxide dehydrate (TAO), α-p-vinylphenyl-ω-hydroxypolymethylene were obtained. The chain structure, mol. weight and its distribution of the two macromonomers were investigated by high temperature 1H NMR spectra, FT-IR and high temperature GPC.

Huaxue Xuebao published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C26H26N4O7, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Anchordoguy, Thomas J.’s team published research in Archives of Biochemistry and Biophysics in 283 | CAS: 5034-06-0

Archives of Biochemistry and Biophysics published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Anchordoguy, Thomas J. published the artcileEffects of protein perturbants on phospholipid bilayers, Synthetic Route of 5034-06-0, the publication is Archives of Biochemistry and Biophysics (1990), 283(2), 356-61, database is CAplus and MEDLINE.

Series of alcs., amides, ureas, and sulfoxides with increasingly longer hydrocarbon chains lower progressively the thermal denaturation temperature of proteins. Several classes of compounds were investigated for effects on the stability of phospholipid vesicles. Many compounds that are known to perturb protein function also destabilize phospholipid bilayers as reflected by solute-induced loss of vesicle contents.

Archives of Biochemistry and Biophysics published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Anchordoguy, Thomas J.’s team published research in Cryobiology in 28 | CAS: 5034-06-0

Cryobiology published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Name: trimethyloxosulphonium chloride.

Anchordoguy, Thomas J. published the artcileInsights into the cryoprotective mechanism of dimethyl sulfoxide for phospholipid bilayers, Name: trimethyloxosulphonium chloride, the publication is Cryobiology (1991), 28(5), 467-23, database is CAplus and MEDLINE.

DMSO is a widely used cryoprotectant for biol. structures such as membranes. Despite hundreds of studies on the effects of this mol., surprisingly little is known about its cryoprotective mechanism. This study investigates the ability of various DMSO analogs to serve as cryoprotectants for liposomes. The data show that an increase in hydrophobicity progressively reduces the cryoprotective effect of sulfoxides. Addnl. experiments using phospholipid vesicles of varying composition demonstrate that DMSO is markedly less effective on liposomes carrying a net neg. charge. In fact, cryoprotection by DMSO was virtually eliminated in vesicles composed of 30% phosphatidylserine (a neg. charged lipid). Based on these results, it is suggested that the polar sulfoxide moiety of DMSO interacts electrostatically with phospholipid membranes and that this interaction is critical for DMSO’s cryoprotective effect for membranes.

Cryobiology published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Name: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Blaschette, Armand’s team published research in Inorganic and Nuclear Chemistry Letters in 5 | CAS: 5034-06-0

Inorganic and Nuclear Chemistry Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Blaschette, Armand published the artcileVibrational spectra of some trimethyl-h9(and d9)-sulfoxonium halides, Formula: C3H9ClOS, the publication is Inorganic and Nuclear Chemistry Letters (1969), 5(8), 639-42, database is CAplus.

The ir and Raman spectra of Me3SO)X (X = Cl, Br, I) and [(CD3)3SO]X1 (X1 = Cl, I) are reported; assignment of the vibrational bands are given. The size of the anions has a definite yet slight influence on the positions of the ir bands. Similarly as with trimethylphosphine oxide and silanolate, the deuteration changes the character of several vibrations.

Inorganic and Nuclear Chemistry Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hobbs, Heather’s team published research in Journal of Medicinal Chemistry in 62 | CAS: 5034-06-0

Journal of Medicinal Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Hobbs, Heather published the artcileDiscovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway, Formula: C3H9ClOS, the publication is Journal of Medicinal Chemistry (2019), 62(15), 6972-6984, database is CAplus and MEDLINE.

4-(Pyrimidin-4-yl)morpholines are privileged pharmacophores for PI3K and PIKKs inhibition by virtue of the morpholine oxygen, both forming the key hydrogen bonding interaction and conveying selectivity over the broader kinome. Key to the morpholine utility as a kinase hinge binder is its ability to adopt a coplanar conformation with an adjacent aromatic core favored by the morpholine nitrogen nonbonding pair of electrons interacting with the electron deficient pyrimidine π-system. Few selective morpholine replacements have been identified to date. Herein we describe the discovery of a potent non-nitrogen containing morpholine isostere with the ability to mimic this conformation and its application in a potent selective dual inhibitor of mTORC1 and mTORC2 (29b).

Journal of Medicinal Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuen, Tsz Ying’s team published research in Journal of Organic Chemistry in 85 | CAS: 5034-06-0

Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C5H5NO3S, Quality Control of 5034-06-0.

Yuen, Tsz Ying published the artcileSynthesis of chiral alkenyl cyclopropane amino acids for incorporation into stapled peptides, Quality Control of 5034-06-0, the publication is Journal of Organic Chemistry (2020), 85(3), 1556-1566, database is CAplus and MEDLINE.

α,α’-Disubstituted amino acids serve as important non-proteinogenic amino acids in the construction of stabilized helical peptides. To expand the repertoire of α,α’-disubstituted amino acids, chiral alkenyl-containing cyclopropane amino acids were synthesized via a two-step olefination and cyclopropanation procedure. Herein, we report the first example of the use of alkenyl cyclopropane building blocks to constrain MDM2-targeting helical peptides. The increased potency and efficacy associated with C-terminal cyclopropane substitution is postulated to be driven by a combined effect of net hydrophobicity and enhanced protein association rates.

Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C5H5NO3S, Quality Control of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lysenko, V. P.’s team published research in Zhurnal Obshchei Khimii in 48 | CAS: 5034-06-0

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Name: trimethyloxosulphonium chloride.

Lysenko, V. P. published the artcilePhosphorus-containing sulfoxonium ylides. II. Properties of ylides stabilized by phosphorus(V), Name: trimethyloxosulphonium chloride, the publication is Zhurnal Obshchei Khimii (1978), 48(5), 978-84, database is CAplus.

Me2S+(O)CH2P(Y)(OR)2 X– (Y = O, NSO2C6H4Me-p, R = Et, Pr, Ph; X = Cl, 2,4,6-(O2N)3C6H2O, F3CCO2) were prepared in 81-92% yields by treating Me2S+(O)C–HP(Y)(OR)2 (I) with HX. Reaction of I with PhNCO, Ac2O, and p-R1C6H4CHO (R1 = H, NO2) gave Me2S+(O)C–R2P(O)(OR)2 (R2 = CONHPh, Ac, CH(OH)C6H4R1–p) resp. Reaction of Me2S+(O)C–HP(OEt)2 with RN3 (R = Ph, p-MeC6H4SO2) and N2C(CO2Et)2 gave Me2S+(O)C–HP(:X)(OEt)2 (X = NR, NN:C(CO2Et)2] resp.

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Name: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lysenko, V. P.’s team published research in Zhurnal Obshchei Khimii in 49 | CAS: 5034-06-0

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Lysenko, V. P. published the artcilePhosphorus-containing sulfoxonium ylides. IV. Ylides containing substituents with trivalent phosphorus, Synthetic Route of 5034-06-0, the publication is Zhurnal Obshchei Khimii (1979), 49(6), 1230-5, database is CAplus.

Reaction of Me2S(O):CH2 with FP(OEt)2 gave Me2S(O):CHP(OEt)2 which reacts with S, RX (R = Me, Et; X = halo) and Cl3CCHO to give Me2S(O):CHR1 (R1 = P(S)(OEt)2, P(O)R(OEt), P(O)(OEt)OCH:CCl2 resp.). Reaction of Me2S(O):CH2 with Cl3PX1 (X1 = -, O, S) gave X1P[CH2S+(O)Me2]3 3Cl–.

Zhurnal Obshchei Khimii published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Satyamurthy, Nagichettiar’s team published research in Phosphorus and Sulfur and the Related Elements in 19 | CAS: 5034-06-0

Phosphorus and Sulfur and the Related Elements published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Recommanded Product: trimethyloxosulphonium chloride.

Satyamurthy, Nagichettiar published the artcileSynthesis and stereochemistry of 1-oxa-6-heteraspiro[2.5]octanes. Single-crystal analysis of 6-phenyl-1-oxa-6-phosphaspiro[2.5]octane 6-sulfide, Recommanded Product: trimethyloxosulphonium chloride, the publication is Phosphorus and Sulfur and the Related Elements (1984), 19(1), 113-29, database is CAplus.

The synthesis of several title spiro compounds is reported. Stereochem. anal. via NMR studies and single-crystal x-ray diffraction of 6-phenyl-1-oxa-6-phosphaspiro[2.5]octane 6-sulfide provide the basis for correlations of structures for other members of the families yet unknown. The phosphorinane ring assumes a slightly flattened chair conformation with the Ph-P bond equatorial and the P:S bond axial. The plane of the epoxide is virtually coincident with a pseudo-mirror plane through P(6), C(3), C(9) and S(15). The Ph group is rotated out of this plane by 28.2°. Although the P-ring C distances are 1.813(3) and 1.819(3) Å, resp., and appear about normal, the P-Ph bond of 1.813(3) Å is longer than that in a few model systems. The C(3)-O(1) bond in the epoxide is axial, or rather pseudo-axial. Ring deformations are consistent with a few model epoxides. Epoxidation of cis-2,6-diphenyl-4-thianone with Me2S(O):CH2 in DMSO led, surprisingly, to a tertiary alc., presumably via ring cleavage of the expected intermediate epoxide.

Phosphorus and Sulfur and the Related Elements published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rozema, Michael J.’s team published research in Organic Process Research & Development in 26 | CAS: 5034-06-0

Organic Process Research & Development published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Safety of trimethyloxosulphonium chloride.

Rozema, Michael J. published the artcileDevelopment of a Scalable Enantioselective Synthesis of JAK Inhibitor Upadacitinib, Safety of trimethyloxosulphonium chloride, the publication is Organic Process Research & Development (2022), 26(3), 949-962, database is CAplus.

Process development of a six-stage synthesis of upadacitinib, a JAK1 inhibitor, was described. It was highlighted by an enantioselective and diastereoselective hydrogenation of a tetrasubstituted olefin to set the two pyrrolidine stereocenters. Preparation of the main fragments and strategies to link them together, optimization of the imidazole cyclization and in-depth understanding of the formation of the urea moiety at the final stage were discussed.

Organic Process Research & Development published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Safety of trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics