Tag: M.W=100-150

Li, Zi-Hao; Fiser, Bela; Jiang, Biao-Lin; Li, Jian-Wei; Xu, Bao-Hua; Zhang, Suo-Jiang published the artcile< N-Hydroxyphthalimide/benzoquinone-catalyzed chlorination of hydrocarbon C-H bond using N-chlorosuccinimide>, COA of Formula: C4H4ClNO2, the main research area is hydroxyphthalimide benzoquinone catalyzed chlorination benzylic bond chlorosuccinimide.

The direct chlorination of C-H bonds has received considerable attention in recent years. In this work, a metal-free protocol for hydrocarbon C-H bond chlorination with com. available N-chlorosuccinimide (NCS) catalyzed by N-hydroxyphthalimide (NHPI) with 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) functioning as an external radical initiator is presented. Aliphatic and benzylic substituents and also heteroaromatic ones were found to be well tolerated. Both the experiments and theor. anal. indicate that the reaction goes through a process wherein NHPI functions as a catalyst rather than as an initiator. On the other hand, the hydrogen abstraction of the C-H bond conducted by a PINO species rather than the highly reactive N-centered radicals rationalizes the high chemoselectivity of the monochlorination obtained by this protocol as the latter is reactive towards the C(sp3)-H bonds of the monochlorides. The present results could hold promise for further development of a nitroxy-radical system for the highly selective functionalization of the aliphatic and benzylic hydrocarbon C-H.

Organic & Biomolecular Chemistry published new progress about C-H bond (hydrocarbon). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, COA of Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bali, Sumit; Singh, Ajai K.; Sharma, Pankaj; Toscano, R. A.; Drake, J. E.; Hursthouse, M. B.; Light, M. E. published the artcile< 2-[2-(4-Methoxyphenyltelluro)ethyl]thiophene (L1) bis[2-(2-thienyl)ethyl] telluride (L2) and their metal complexes; crystal structure of trans-dichlorobis{2-(2-(4-methoxyphenyltelluro)ethyl)thiophene-Te}palladium(II) and {bis[2-(2-thienyl)ethyl] telluride}dichloro(p-cymene)ruthenium(II)>, Quality Control of 19995-38-1, the main research area is methoxyphenyltelluroethylthiophene preparation transition metal complex; crystal structure palladium methoxyphenyltelluroethylthiophene ruthenium; bisthienylethyltelluride preparation palladium ruthenium complex.

The reaction of ArTe- (Ar = 4-MeOC6H4) and Te2- generated in situ by borohydride reduction of Ar2Te2 and Te, resp., with 2-(2-thienyl)ethyl chloride resulted in 2-[2-(4-methoxyphenyltelluro)ethyl]thiophene (L1) and bis[2-(2-thienyl)ethyl] telluride (L2), resp. Their complexes [AgNO3(L1)] (1) [PdCl2(L1)2] (2) [PtCl2(L1)2] (3) [HgBr2(L1)]2 (4) [Ru(p-cymene)Cl2(L1)] (5) [Ru(p-cymene)Cl2(L2)] (6) and [PdCl2(L2)2] were synthesized. The ligands and complexes exhibit characteristic 1H and 13C{1H} NMR spectra. Both the ligands coordinate only through Te in all the complexes. The single crystals of 2 and 6 were characterized by x-ray diffraction. Compound 2 has square planar geometry around Pd and trans arrangement of ligands. The Pd-Te bond distances 2.5951(7) and 2.5872(7) Å are longer than the values expected due to strong trans influence. The unique intermol. secondary Te···Cl interaction (distance = 3.450/3.449 Å) between neighboring mols. was observed in the crystal structure of 2. The distance between Pd atoms of two neighboring mols. 3.2143(10) Å also was found less than the sum of van der Waals radii 3.26 Å. These secondary interactions in 2 gave a dimeric species, which remains intact even in the solution Compound 6 is a half sandwich having three coordination sites occupied by two Cl atoms and the Te atom of L2 with Ru-Te bond distance of 2.6528(9) Å and Ru-Cl, 2.415(2)/2.422(2) Å.

Journal of Organometallic Chemistry published new progress about Crystal structure. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Quality Control of 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rogers, David A.; Gallegos, Jillian M.; Hopkins, Megan D.; Lignieres, Austin A.; Pitzel, Amy K.; Lamar, Angus A. published the artcile< Visible-light photocatalytic activation of N-chlorosuccinimide by organic dyes for the chlorination of arenes and heteroarenes>, SDS of cas: 128-09-6, the main research area is arene chlorosuccinimide methylene green catalyst photochem chlorination.

A variety of arenes and heteroarenes are chlorinated in moderate to excellent yields using N-chlorosuccinimide (NCS) under visible-light activated conditions. A screening of known organic dye photocatalysts resulted in the identification of methylene green as the most efficient catalyst to use with NCS. According to mechanistic studies described within, the reaction was speculated to proceed via a single electron oxidation of NCS utilizing methylene green under visible-light photoredox pathway. The photo-oxidation of NCS amplifies the electrophilicity of the chlorine atom of the NCS, thus led to enhanced reactivity as a chlorinating reagent with aromatic substrates.

Tetrahedron published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, SDS of cas: 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yan, Tao; Zhao, Liqin; He, Mian; Soule, Jean-Francois; Bruneau, Christian; Doucet, Henri published the artcile< Reactivity of 3-substituted fluorobenzenes in palladium-catalysed direct arylations with aryl bromides>, Recommanded Product: 1-Chloro-3,5-difluorobenzene, the main research area is fluoroarene aryl bromide direct arylation reactivity palladium catalyst; fluorobiaryl preparation reactivity Hammett constant substituent effect.

The influence of both electron-withdrawing and electron-donating substituents such as nitro, nitrile, chloro, bromo and methoxy at C-3 on fluorobenzenes for their palladium-catalyzed direct C-2 arylation was explored. With electron-withdrawing substituents, the reaction proceeds nicely using 2-4 mol% of an air-stable palladium complex and potassium pivalate/dimethylacetamide (PivOK/DMA) as catalytic system; and in general, a very regioselective arylation at C-2 was observed Moreover, a variety of substituents on the aryl bromide coupling partner, such as benzoyl, formyl, nitro, nitrile, chloro and Me, and also heteroaryl bromides were tolerated.

Advanced Synthesis & Catalysis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Recommanded Product: 1-Chloro-3,5-difluorobenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hou, Jiahao; Wang, Kai; Zhang, Changjun; Wei, Tingting; Bai, Renren; Xie, Yuanyuan published the artcile< Metal-Free Electrochemical Oxidative Dihalogenation of Quinolines on the C5 and C7 Positions Using N-Halosuccinimides>, Category: chlorides-buliding-blocks, the main research area is electrochem oxidative dihalogenation quinoline halosuccinimide.

An efficient and convenient method for electrochem. oxidative dichlorination or dibromination of 8-aminoquinolines on C5 and C7 positions using N-halosuccinimides (NCS and NBS) as the halogen source was described. Substrates with various functional groups were transformed smoothly and the halogenated products were obtained in good to excellent yields. These transformations feature transition-metal-free, oxidant-free, and short reaction time.

European Journal of Organic Chemistry published new progress about Electrochemical redox reaction. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Emokpae, Thomas A.; Eguavuen, Osa; Hirst, Jack published the artcile< The kinetics of the reactions of picryl chloride, with some substituted anilines. Part 5>, Synthetic Route of 29027-20-1, the main research area is picryl chloride substitution aniline kinetics; substituent effect aniline substitution; additivity aniline substitution picryl.

Arrhenius parameters were determined for the reactions of picryl chloride in MeCN with 3,5-RR1C6H3NH2 [R = H2N, Me, R1 = H; R = H2N, R1 = O2N (I); R = F, R1 = MeSO2; R = NO2, OMe, Me, F, Cl, Br, iodo, R1 = Me; R = R1 = F, Cl, Br, iodo]. A total of 33 3,5-disubstituted anilines was examined for the additivity of substituent effects on the free energy of activation, and, with the exception of I, this hypothesis reproduces exptl. rate constants within a factor of 2. A rationalization is proposed for the deviations that occur in some cases when more stringent criteria of additivity are used.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about Additivity. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Synthetic Route of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Mu-Yi; Pannecoucke, Xavier; Jubault, Philippe; Besset, Tatiana published the artcile< Pd-Catalyzed Selective Chlorination of Acrylamides at Room Temperature>, Computed Properties of 128-09-6, the main research area is palladium catalyzed stereoselective chlorination acrylamide.

In this Letter, the transition-metal-catalyzed chlorination of alkenes is reported. In the presence of the com. available and inexpensive N-chlorosuccinimide and without additive, the Pd-catalyzed chlorination of acrylamides by C-H bond activation was developed at room temperature under air. Under these mild reaction conditions, the versatility of the methodol. was demonstrated as an array of acrylamides was functionalized to selectively provide the corresponding difficult-to-synthesize chlorinated olefins as a single Z stereoisomer. Mechanistic studies were conducted to get insights into the reaction mechanism, and post-functionalization reactions further demonstrated the synthetic utility of the approach toward the access to high value-added chlorinated compounds

Organic Letters published new progress about Acrylamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Computed Properties of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Hang; Wang, Peng; Suzuki, Shin; Farmer, Marcus E.; Yu, Jin-Quan published the artcile< Ligand Promoted meta-C-H Chlorination of Anilines and Phenols>, Synthetic Route of 29027-20-1, the main research area is regioselective chlorination aniline phenol norbornene mediator.

Pd-Catalyzed meta-C-H chlorination of anilines and phenols was developed using norbornene as the mediator. Heterocycles, including indole, thiophene, and indazole, are tolerated. The identification of a new pyridone-based ligand, I (R = CF3, cyano), was crucial for the success of this meta-C-H chlorination reaction. Subsequent diverse transformations of the chlorinated products demonstrate the versatility of meta-C-H chlorination.

Journal of the American Chemical Society published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Synthetic Route of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nishii, Yuji; Ikeda, Mitsuhiro; Hayashi, Yoshihiro; Kawauchi, Susumu; Miura, Masahiro published the artcile< Triptycenyl Sulfide: A Practical and Active Catalyst for Electrophilic Aromatic Halogenation Using N-Halosuccinimides>, COA of Formula: C4H4ClNO2, the main research area is arene triptycenyl sulfide catalyst electrophilic aromatic halogenation halosuccinimide regioselective; aryl halide preparation.

A Lewis base catalyst Trip-SMe (Trip = triptycenyl) for electrophilic aromatic halogenation using N-halosuccinimides (NXS) is introduced. In the presence of an appropriate activator (as a noncoordinating-anion source), a series of unactivated aromatic compounds were halogenated at ambient temperature using NXS. This catalytic system was applicable to transformations that are currently unachievable except for the use of Br2 or Cl2: e.g., multihalogenation of naphthalene, regioselective bromination of BINOL, etc. Controlled experiments revealed that the triptycenyl substituent exerts a crucial role for the catalytic activity, and kinetic experiments implied the occurrence of a sulfonium salt [Trip-S(Me)Br][SbF6] as an active species. Compared to simple dialkyl sulfides, Trip-SMe exhibited a significant charge-separated ion pair character within the halonium complex whose structural information was obtained by the single-crystal X-ray anal. A preliminary computational study disclosed that the π system of the triptycenyl functionality is a key motif to consolidate the enhancement of electrophilicity.

Journal of the American Chemical Society published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, COA of Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cao, Xiufang; Xu, Shengzhen; Li, Xuegang; Shen, Xiaoxia; Zhang, Qingye; Li, Jianhong; Chen, Changshui published the artcile< N-nitrourea derivatives as novel potential fungicides against Rhizoctonia solani: synthesis, antifungal activities, and 3D-QSAR>, Application In Synthesis of 29027-20-1, the main research area is antifungal nitrourea derivative.

N-nitrourea derivatives bearing various aryl substituents were obtained via three steps, including nitration, carbamic chlorination, and aminolysis reactions. The structures of all the newly synthesized compounds were characterized and confirmed by IR, 1H-NMR, MS, and elemental anal. Bioassays indicated that five of the compounds possess fungicidal activity against Rhizoctonia solani. Structure-activity relationship (SAR) is also discussed based on the exptl. data, and the further quant. structure-activity relationship (QSAR) was analyzed using comparative mol. field anal. and comparative mol. similarity indexes anal.

Chemical Biology & Drug Design published new progress about Fungicides (antifungal). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application In Synthesis of 29027-20-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics