Tag: M.W=100-150

Sun, Bin; Shi, Xiayue; Zhuang, Xiaohui; Huang, Panyi; Shi, Rongcheng; Zhu, Rui; Jin, Can published the artcile< Photoinduced EDA Complexes Enabled Radical Tandem Cyclization/Arylation of Unactivated Alkene with 2-Amino-1,4-naphthoquinones>, Category: chlorides-buliding-blocks, the main research area is oxopyrrolidinyl arylamino naphthalenedione preparation photochem regioselective green chem; amino naphthoquinone allyl bromo difluoroacetamide cyclization arylation EDA complex.

A visible-light-induced radical tandem cyclization/arylation between 2-amino-1, 4-naphthoquinone and N-allyl-2-bromo-2,2-difluoroacetamides has been developed without an external photocatalyst. The transformation could be carried out at room temperature and gave a variety of C-3-functionalized 2-amino-1,4-naphthoquinone derivatives I (R1 = Ph, 4-MeOC6H4, 2-MeC6H4, etc.; R2 = H, 4-i-Pr, 3-Br, etc.) in moderate to excellent yields. Moreover, mechanistic studies revealed that the reaction is driven by the formation of an electron donor-acceptor (EDA) complex.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hutchinson, George; Alamillo-Ferrer, Carla; Bures, Jordi published the artcile< Mechanistically Guided Design of an Efficient and Enantioselective Aminocatalytic α-Chlorination of Aldehydes>, Product Details of C4H4ClNO2, the main research area is aldehyde NCS Jorgensen Hayashi catalyst regioselective chlorination; chloro aldehyde stereoselective preparation.

The enantioselective aminocatalytic α-chlorination of aldehydes is a challenging reaction because of its tendency to proceed through neutral intermediates in unselective pathways. Herein we report the rational shift to a highly selective reaction pathway involving charged intermediates using hexafluoroisopropanol as solvent. This change in mechanism has enabled us to match and improve upon the yields and enantioselectivities displayed by previous methods while using cheaper aminocatalysts and chlorinating agents, 80-95% less amount of catalyst, convenient temperatures, and shorter reaction times.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Product Details of C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Guerrand, Helene D. S.; Vaultier, Michel; Pinet, Sandra; Pucheault, Mathieu published the artcile< Amine-Borane Complexes: Air- and Moisture-Stable Partners for Palladium-Catalyzed Borylation of Aryl Bromides and Chlorides>, Category: chlorides-buliding-blocks, the main research area is amine borane complex air moisture stable palladium catalyzed borylation; hetero aryl bromide chloride triflate iodide palladium catalyzed borylation; aminoborane preparation; boronium ion preparation deprotonation; boronic acid derivative preparation.

A method for using amine-borane complexes directly in palladium catalyzed borylation has been developed. The reaction proceeds through the sequential formation of a boronium species followed by deprotonation leading to the aminoborane. This reagent is then directly used in the borylation process leading, after work-up, to various boronic acid derivatives The reaction was applied to (hetero)aryl triflates, iodides, bromides and chlorides.

Advanced Synthesis & Catalysis published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hong, Xi; Zhou, Quan; Huang, Shuang; Cui, He-Zhen; Li, Zhi-Ming; Hou, Xiu-Feng published the artcile< Transition metal catalyzed C7 and ortho-selective halogenation of 2-arylbenzo[d]oxazoles>, Application In Synthesis of 128-09-6, the main research area is halosuccinimide phenyl benzoxazole rhodium catalyst regioselective halogenation; halophenyl benzoxazole preparation; phenyl halo benzoxazole preparation.

A transition metal catalyzed chlorination, bromination and iodination of 2-arylbenzo[d]oxazole with N-halosuccinimide, in which ruthenium-catalyzed halogenation occurred on the C7-position and rhodium-catalyzed halogenation occurred on the ortho-position. The C7 halogenation was only observed for 5-methyl-2-(p-substituted)arylbenzo[d]oxazoles under rhodium catalysis. Preliminary mechanistic experiments and d. functional theory (DFT) calculations suggested that the C7-halogenation catalyzed by Ru might have a single-electron-transfer (SET) radical process, while the ortho-selective halogenation catalyzed by Rh proceeds probably through a redox-neutral SN2-type mechanism. The different selectivity of Rh catalyzed halogenation was due to the charge difference between benzo[d]oxazolyl and aryl rings. The two kinds of halogenated products were proved to be versatile by constructing aryl and alkynyl groups on the C-X site via Suzuki and Sonogashira cross-coupling reactions.

Organic Chemistry Frontiers published new progress about Benzoxazoles Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application In Synthesis of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Bin; Shi, Xiayue; Zhuang, Xiaohui; Huang, Panyi; Shi, Rongcheng; Zhu, Rui; Jin, Can published the artcile< Photoinduced EDA Complexes Enabled Radical Tandem Cyclization/Arylation of Unactivated Alkene with 2-Amino-1,4-naphthoquinones>, Category: chlorides-buliding-blocks, the main research area is oxopyrrolidinyl arylamino naphthalenedione preparation photochem regioselective green chem; amino naphthoquinone allyl bromo difluoroacetamide cyclization arylation EDA complex.

A visible-light-induced radical tandem cyclization/arylation between 2-amino-1, 4-naphthoquinone and N-allyl-2-bromo-2,2-difluoroacetamides has been developed without an external photocatalyst. The transformation could be carried out at room temperature and gave a variety of C-3-functionalized 2-amino-1,4-naphthoquinone derivatives I (R1 = Ph, 4-MeOC6H4, 2-MeC6H4, etc.; R2 = H, 4-i-Pr, 3-Br, etc.) in moderate to excellent yields. Moreover, mechanistic studies revealed that the reaction is driven by the formation of an electron donor-acceptor (EDA) complex.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Misawa, Rena; Matsuhashi, Chihiro; Yamaji, Minoru; Mutai, Toshiki; Yoshikawa, Isao; Houjou, Hirohiko; Noguchi, Keiichi; Maki, Shojiro; Hirano, Takashi published the artcile< Halogen-substituent effect on the spectroscopic properties of 2-phenyl-6-dimethylaminobenzothiazoles>, Name: 1-Chloropyrrolidine-2,5-dione, the main research area is halogen substituent phenyl dimethyl aminobenzothiazole spectroscopic property.

The 6-dimethylamino-2-phenylbenzothiazole (1-H) is a push-pull benzothiazole fluorophore mimicking the firefly oxyluciferin structure. We newly prepared 7-chloro and 7-bromo derivatives of 1-H and its 4-acetyl derivative (2-H), and their spectroscopic and photophys. properties were investigated. The halogenated derivatives showed the blue-shifted electronic absorption maxima and fluorescence emission maxima compared to 1-H and 2-H, resulted from the deformations of the NMe2 groups and the electron withdrawing properties of the halogen groups. In addition, the halogen substitutions accelerate intersystem crossing by heavy atom effect, resulting in a decrease in fluorescence quantum yields. Interestingly, however, the halogenated derivatives of 2-H still showed moderate fluorescence quantum yields. The halogenation effect is one of the guides to design push-pull benzothiazole fluorophores for tuning fluorescence properties.

Tetrahedron Letters published new progress about Absorption. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Name: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xiong, Jin; Liu, Yunyun published the artcile< Transition-Metal-free C5, C7-Dihalogenation and the Switchable C5 Halogenation of 8-Hydroxyquinolines>, Recommanded Product: 1-Chloropyrrolidine-2,5-dione, the main research area is dihalogenated hydroxyquinoline preparation; hydroxyquinoline acyl chloride halosuccinimide dihalogenation; halogenated hydroxyquinoline preparation; quinolinyl benzoate halosuccinimide halogenation.

The first example of the C5, C7-dihalogenation of 8-hydroxyquinolines based on an in situ O-acyl 8-hydroxyquinoline formation was realized under catalyst-free condition in toluene to synthesize 5,7-dihalogenated-8-hydroxyquinolines I [Ar = Ph, 4-FC6H4, 3-ClC6H4, etc.; R = H, 2-Me; X = Cl, Br, I]. Modifying the reaction conditions by directly utilizing O-acylated 8-hydroxyquinolines in the presence of AlCl3 enabled the electrophilic halogenation in the C5 position, led to the tunable synthesis of C5 halogenated products. The O-acyl group could be easily removed from the product to provide halogenated quinolines containing free hydroxyl group by simple hydrolysis.

ChemistrySelect published new progress about Esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Recommanded Product: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shegavi, Mahadev L.; Agarwal, Abhishek; Bose, Shubhankar Kumar published the artcile< Efficient synthesis of alkylboronic esters via magnetically recoverable copper nanoparticle-catalyzed borylation of alkyl chlorides and bromides>, Synthetic Route of 19995-38-1, the main research area is green chem alkyl boronic ester preparation; borylation copper nanoparticle catalyst alkyl chloride bromide green chem.

We report a magnetically separable Cu nanocatalyst (Fe-DOPA-Cu) for the borylation of alkyl halides with alkoxy diboron reagents, providing alkylboronic esters in high yields, with broad functional group tolerance under mild reaction conditions. The procedure is also applicable to the borylation of benzyl chlorides and bromides. Radical clock experiments support a radical-mediated process. Easy recycling of the catalyst resulted in no significant loss of activity up to ten runs.

Green Chemistry published new progress about Adsorption. 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Synthetic Route of 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formenti, Dario; Topf, Christoph; Junge, Kathrin; Ragaini, Fabio; Beller, Matthias published the artcile< Fe2O3/NGr@C- and Co-Co3O4/NGr@C-catalysed hydrogenation of nitroarenes under mild conditions>, Application of C7H8ClN, the main research area is aniline preparation green chem chemoselective; nitroarene hydrogenation reaction doped graphene iron cobalt nanocatalyst.

An improved hydrogenation of nitroarenes such as nitrobenzene, 2-nitrobiphenyl, 2,4,6-tri-t-butylnitrobenzene, etc. using nano-structured iron- and cobalt-based catalysts has been presented. Modifications of the heterogeneous catalysts by N-doped graphene-flakes are crucial for the success of selective reductions The use of polar solvents and basic additives has a significant pos. influence on the rate of reduction of nitroarenes. This allows performing non-noble metal-catalyzed hydrogenations under very mild reaction conditions (e.g. 70 °C and 20 bar). On the basis of the obtained catalytic results a heterolytic mechanism for the hydrogenation process is postulated, too.

Catalysis Science & Technology published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Application of C7H8ClN.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Qu, Zheng-Wang; Zhu, Hui; Grimme, Stefan published the artcile< Mechanistic Insights for Dimethyl Sulfoxide Catalyzed Aromatic Chlorination Reactions>, Name: 1-Chloropyrrolidine-2,5-dione, the main research area is dimethyl sulfoxide catalyst aromatic chlorination reaction mechanism.

Recently, the DMSO O=SMe2 catalyzed aromatic chlorination reaction using N-chlorosuccinimides (NsCl) under mild conditions has proven useful for bioactive compounds potentially containing various functional groups such as amide and hydroxyl. A novel catalytic mechanism is revealed by extensive DFT calculations using the anisole PhOMe as electron-rich model substrate. The Cl+ transfer from NsCl to O=SMe2 slowly reacts via the S-chloro sulfoxonium O=SClMe2+ to the S-chloro ylide O=SClMeCH2, followed by facile Cl+ transfer from NsCl to the ylide CH2 site to initialize efficient electrophilic Cl+ transfer to nucleophilic substrates. According to the new proposal, the polarizable S and electroneg. O sites of O=SMe2 may act as efficient Cl+ and H+ shuttles, resp., in catalytic aromatic chlorination. If O=SMe2 is present in high concentration, it can trap intermediate SMe2OH+ into a stable H+-bound dimer (SMe2O)2H+ to inhibit efficient protic NsCl activation. These mechanistic insights may be generally useful for the rational design of novel dual functional halonium transfer catalysts.

ChemCatChem published new progress about Activation energy. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Name: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics