Tag: M.W=100-150

Margaretha, P. published the artcile< Synthesis by substitution of oxygen functionalities>, HPLC of Formula: 19995-38-1, the main research area is review chloroalkane preparation oxygen substitution organic synthesis.

A review of the preparation of chloroalkanes via substitution of oxygen functionalities.

Science of Synthesis published new progress about Chloroalkanes Role: SPN (Synthetic Preparation), PREP (Preparation). 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, HPLC of Formula: 19995-38-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thiabaud, Gregory; He, Guangan; Sen, Sajal; Shelton, Kathryn A.; Baze, Wallace B.; Segura, Luke; Alaniz, Julie; Macias, Ruben Munoz; Lyness, Greg; Watts, Alan B.; Kim, Hyun Min; Lee, Hyunseung; Cho, Mi Young; Hong, Kwan Soo; Finch, Rick; Siddik, Zahid H.; Arambula, Jonathan F.; Sessler, Jonathan L. published the artcile< Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents>, Computed Properties of 128-09-6, the main research area is preparation oxaliplatin prodrug conjugate gadolinium texaphyrin antitumor drug resistance; cancer; drug development; drug resistance; platinum prodrug; texaphyrins.

Described here is the development of gadolinium(III) texaphyrin-platinum(IV) conjugates capable of overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting enhanced cancer cell uptake, and 3) reactivating p53 in platinum-resistant models. Side by side comparative studies of these Pt(IV) conjugates to clin. approved platinum(II) agents and previously reported platinum(II)-texaphyrin conjugates demonstrate that the present Pt(IV) conjugates are more stable against hydrolysis and nucleophilic attack. Moreover, they display high potent antiproliferative activity in vitro against human and mouse cell cancer lines. Relative to the current platinum clin. standard of care (SOC), a lead Gd(III) texaphyrin-Pt(IV) prodrug conjugate emerging from this development effort was found to be more efficacious in s.c. mouse models involving both cell-derived xenografts and platinum-resistant patient-derived xenografts. Comparative pathol. studies in mice treated with equimolar doses of the lead Gd texaphyrin-Pt(IV) conjugate or the US Food and Drug Administration (FDA)-approved agent oxaliplatin revealed that the conjugate was better tolerated. Specifically, the lead could be dosed at more than three times (i.e., 70 mg/kg per dose) the tolerable dose of oxaliplatin (i.e., 4 to 6 mg/kg per dose depending on the animal model) with little to no observable adverse effects. A combination of tumor localization, redox cycling, and reversible protein binding is invoked to explain the relatively increased tolerability and enhanced anticancer activity seen in vivo. On the basis of the present studies, we conclude that metallotexaphyrin-Pt conjugates may have substantial clin. potential as antitumor agents.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Antitumor agent resistance (to platinum). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Computed Properties of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rogers, David A.; Hopkins, Megan D.; Rajagopal, Nitya; Varshney, Dhruv; Howard, Haley A.; LeBlanc, Gabriel; Lamar, Angus A. published the artcile< U.S. Food and Drug Administration-Certified Food Dyes as Organocatalysts in the Visible Light-Promoted Chlorination of Aromatics and Heteroaromatics>, Product Details of C4H4ClNO2, the main research area is aryl chloride regioselective preparation; arene chlorosuccinimide visible light promoted chlorination food dye organocatalyst.

Seven FDA-certified food dyes were investigated as organocatalysts. As a result, Fast Green FCF and Brilliant Blue FCF were discovered as catalysts for the chlorination of a wide range of arenes and heteroarenes in moderate to excellent yields and high regioselectivity. Mechanistic investigations of the sep. systems indicated that different modes of activation are in operation, with Fast Green FCF being a light-promoted photoredox catalyst that was facilitating a one-electron oxidation of N-chlorosuccinimide (NCS) and Brilliant Blue FCF serving as a chlorine-transfer catalyst in its sulfonphthalein form with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as stoichiometric chlorine source. Dearomatization of naphthol and indole substrates was observed in some examples using the Brilliant Blue/DCDMH system.

ACS Omega published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Product Details of C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Molander, Gary A.; Wisniewski, Steven R. published the artcile< Stereospecific Cross-Coupling of Secondary Organotrifluoroborates: Potassium 1-(Benzyloxy)alkyltrifluoroborates>, Formula: C6H3ClF2, the main research area is aldehyde copper diboration benzylation alkoxylation acylation; potassium acyloxy alkoxyalkyltrifluoroborate preparation palladium arylchloride heteroarylchloride Suzuki Miyaura; aryl acyloxy alkoxy secondary alc stereospecific preparation; stereospecific retention Suzuki Miyaura catalyst palladium preparation.

Potassium 1-(alkoxy/acyloxy)alkyltrifluoroborates have been synthesized through a copper-catalyzed diboration of aldehydes and subsequent conversion of the resulting potassium 1-(hydroxy)alkyltrifluoroborates. The palladium-catalyzed Suzuki-Miyaura reaction employing the potassium 1-(benzyloxy)alkyltrifluoroborates with aryl and heteroaryl chlorides provides access to protected secondary alcs. in high yields. The β-hydride elimination pathway is avoided through use of the benzyl protecting group, which is proposed to stabilize the diorganopalladium intermediate by coordination of the arene to the metal center. This cross-coupling is stereospecific with complete retention of stereochem.

Journal of the American Chemical Society published new progress about Acylation. 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Formula: C6H3ClF2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Verma, Piyush Kumar; Prasad, K. Sujit; Varghese, Dominic; Geetharani, K. published the artcile< Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides>, Recommanded Product: 2-(2-Chloroethyl)thiophene, the main research area is cobalt catalyzed borylation unactivated alkyl bromide chloride diboron reagent; alkyl boronic ester preparation.

A Co-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B2pin2 or B2neop2) was developed under mild reaction conditions, demonstrating the 1st Co-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this Co-mediated catalytic cycle.

Organic Letters published new progress about Boronic acids, esters Role: SPN (Synthetic Preparation), PREP (Preparation) (alkyl boronic esters). 19995-38-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H7ClS, Recommanded Product: 2-(2-Chloroethyl)thiophene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gupta, Shiv Shankar; Manisha; Kumar, Rakesh; Dhiman, Ankit Kumar; Sharma, Upendra published the artcile< Predictable site-selective functionalization: Promoter group assisted para-halogenation of N-substituted (hetero)aromatics under metal-free condition>, Safety of 1-Chloropyrrolidine-2,5-dione, the main research area is halo heteroaromatic compound preparation regioselective; heteroaromatic compound halosuccinimide halogenation.

Regioselective para-C-H halogenation of N-pyrimidyl (hetero)aromatics (such as 5-bromo-1-(pyrimidin-2-yl)indoline, N-(4-bromophenyl)pyrimidin-2-amine, 6-bromo-1-(pyrimidin-2-yl)-1,2,3,4-tetrahydroquinoline, etc.) through SEAr (electrophilic aromatic substitution) type reaction is disclosed. SEAr type reaction has been utilized for the C5-bromination of indolines (para-selective) (such as 1-(pyrimidin-2-yl)indoline, 6-fluoro-1-pyrimidin-2-yl-2,3-dihydro-1H-indole, 1-pyrimidin-2-yl-2,3-dihydro-1H-indole-2-carboxylic acid Et ester, etc.) with N-bromosuccinimide under metal and additive-free conditions in good to excellent yields. The developed methodol. is also applicable for iodination and challenging chlorination. The pyrimidyl group is identified as a reactivity tuner that also controls the regioselectivity. The present method is also applicable for selective halogenation of aniline, pyridine, indole, oxindole, pyrazole, tetrahydroquinoline, isoquinoline, and carbazole. DFT studies such as Fukui nucleophilicity and natural charge maps also support the observed p-selectivity. Post-functionalization of the title compound into the corresponding arylated, olefinated and dihalogenated products (5-phenyl-1-(pyrimidin-2-yl)indoline, 5-bromo-7-chloro-1-(pyrimidin-2-yl)indoline, (E)-1-(pyrimidin-2-yl)-5-styrylindoline) is achieved in a one-pot, two step fashion. Late-stage C-H bromination was also executed on drug/natural mols. (harmine, etoricoxib, clonidine, and chlorzoxazone) to demonstrate the applicability of the developed protocol.

Organic & Biomolecular Chemistry published new progress about Bromination, regioselective. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Safety of 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oda, Susumu; Kumano, Wataru; Hama, Toshiki; Kawasumi, Ryosuke; Yoshiura, Kazuki; Hatakeyama, Takuji published the artcile< Carbazole-Based DABNA Analogues as Highly Efficient Thermally Activated Delayed Fluorescence Materials for Narrowband Organic Light-Emitting Diodes>, Formula: C6H3ClF2, the main research area is carbazole DABNA delayed fluorescence TADF OLED electroluminescent device; borylation; carbazole; organic light-emitting diodes; organoboron; thermally activated delayed fluorescence.

Carbazole-based DABNA analogs (CzDABNAs) were synthesized from triarylamine by regioselective one-shot single and double borylation. The reaction proceeded selectively at the ortho position of the carbazolyl group, where the HOMO is mainly localized owing to the difference in the electron-donating abilities of the diarylamino and carbazolyl groups. The facile and scalable method enabled synthesis of CzDABNAs, exhibiting narrow-band thermally activated delayed fluorescence with emission spectra ranging from deep blue to green. The organic light-emitting diode devices employing these products as emitters exhibited deep-blue, sky-blue, and green emission with high external quantum efficiencies of 19.5, 21.8, and 26.7%, resp.

Angewandte Chemie, International Edition published new progress about Band structure. 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Formula: C6H3ClF2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mai, Thi Ly; Tran, Vinh Hung published the artcile< DFT study of electronic structure properties of SrAFe4As4 (A = Rb and Cs) superconductors>, Reference of 128-09-6, the main research area is strontium rubidium cesium iron arsenide DFT electronic structure property.

Using the full-potential linearised APW method and the PBE generalized gradient approximation, the electronic structure properties of SrAFe4As4 (A = Rb and Cs) superconductors were determined and compared with those of their parents SrFe2As4 (Fmmm), SrFe2As2 (I4/mmm), RbFe2As2 and CsFe2As2. It is found that associated with the Van Hove singularities, densities of states of SrAFe4As4 around Fermi energy level, mostly caused by Fe-3d orbitals, are relatively high but not enough to account for enhancement of Tc in these materials. We suggest rather a relationship between Tc values and interband scattering strength, which depends on the number of electronic bands crossing EF and forming hole-like pockets around the G point and electron-like pockets at the corners of Brillouin zone. It is established that Fermi surfaces of SrAFe4As4 are described by 2D and manifest the behavior of ±s-wave gap in Cs- and nodal gap in Rb-based. Electron Localization Function demonstrates the presence of both valence and metallic bondings. However, there is a stronger covalent bonding in AF2As2 than in SrAFe4As4, suggesting that the weakness of covalency accompanies higher Tc values.

Computational Materials Science published new progress about Brillouin zone. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Reference of 128-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

El-Zahraa, F.; El-Basil, S.; El-Sayed, M.; Ghoneim, K. M.; Khalifa, M. published the artcile< Synthesis and pharmacological screening of certain N-substituted amides structurally related to some local anesthetics>, Product Details of C7H8ClN, the main research area is anesthesia pivalamide diphenylacetamide; pivalamide preparation anesthetic; diphenylacetamide preparation anesthetic.

Eighteen Ph2CHCONHR (I; R = e.g., 2,6-, 2,5-, 2,4-, 3,4-, 3,5-Me2C6H3, 4,5-MeClC6H3, 4-O2NC6H4) and 14 Me3CCONHR1 (II; R1 = e.g., 3,6-Me2C6H3, 3-pyridyl, 4-nitro-2-pyridyl) were prepared in 45-90% yield by reaction of the acid chloride with the resp. amine. The most active intradermal anesthesia in guinea pigs was I (R = 4-methyl-5-chlorophenyl); its activity was more than double that of procaine hydrochloride. As a corneal anesthetic II (R1 = 2,6-Me2C6H3) was the most active anesthetic and for plexus anesthesia I (R = 2,6-Me2C6H3) was the most active.

Pharmazie published new progress about Anesthetics. 29027-20-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H8ClN, Product Details of C7H8ClN.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arena, Chiara; Gado, Francesca; Di Cesare Mannelli, Lorenzo; Cervetto, Chiara; Carpi, Sara; Reynoso-Moreno, Ines; Polini, Beatrice; Vallini, Erika; Chicca, Stefano; Lucarini, Elena; Bertini, Simone; D′Andrea, Felicia; Digiacomo, Maria; Poli, Giulio; Tuccinardi, Tiziano; Macchia, Marco; Gertsch, Jurg; Marcoli, Manuela; Nieri, Paola; Ghelardini, Carla; Chicca, Andrea; Manera, Clementina published the artcile< The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis>, Safety of 1-Chloropyrrolidine-2,5-dione, the main research area is endocannabinoid modulator preparation multiple sclerosis cannabinoid receptor analgesic; 1,2-Dihydropyridine-2-oxo-3-carboxamides; EAE mouse Model multiple sclerosis; Endocannabinoid system; Glutamate release; Microglial cell; Neuropathic pain.

Multiple sclerosis is a chronic inflammatory demyelinating disorder of the central nervous system that eventually leads to progressive neurodegeneration and disability. Recent findings highlighted the emerging role of each target of the endocannabinoid system in controlling the symptoms and disease progression of multiple sclerosis. Therefore, multi-target modulators of the endocannabinoid system could provide a more effective pharmacol. strategy as compared to the single target modulation. In this work, N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide (B2) was identified as the most promising compound with dual agonism at cannabinoid receptors type-1 and cannabinoid receptors type-2 and good drug-like properties. In in vitro assays, B2 reduced glutamate release from rat synaptosomes through interaction with cannabinoid receptors type-1 and modulated the production of the pro- and anti-inflammatory cytokines (interleukins IL-1β and IL-6 and interleukin IL-10 resp.) via cannabinoid receptors type-2 activation. Furthermore, B2 demonstrated antinociceptive effects in an animal model of neuropathic pain and efficacy in an exptl. autoimmune encephalomyelitis model of multiple sclerosis.

European Journal of Medicinal Chemistry published new progress about Analgesics. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Safety of 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics