Tag: 400-500

Ratiometric Flapping Force Probe That Works in Polymer Gels was written by Yamakado, Takuya;Saito, Shohei. And the article was included in Journal of the American Chemical Society in 2022.Recommanded Product: 5137-55-3 The following contents are mentioned in the article:

Polymer gels have recently attracted attention for their application in flexible devices, where mech. robust gels are required. While there are many strategies to produce tough gels by suppressing nanoscale stress concentration on specific polymer chains, it is still challenging to directly verify the toughening mechanism at the mol. level. To solve this problem, the use of the flapping mol. force probe (FLAP) is promising because it can evaluate the nanoscale forces transmitted in the polymer chain network by ratiometric anal. of a stress-dependent dual fluorescence. A flexible conformational change of FLAP enables real-time and reversible responses to the nanoscale forces at the low force threshold, which is suitable for quantifying the percentage of the stressed polymer chains before structural damage. However, the previously reported FLAP only showed a negligible response in solvated environments because undesirable spontaneous planarization occurs in the excited state, even without mech. force. Here, we have developed a new ratiometric force probe that functions in common organogels. Replacement of the anthraceneimide units in the flapping wings with pyreneimide units largely suppresses the excited-state planarization, leading to the force probe function under wet conditions. The FLAP-doped polyurethane organogel reversibly shows a dual-fluorescence response under sub-MPa compression. Moreover, the structurally modified FLAP is also advantageous in the wide dynamic range of its fluorescence response in solvent-free elastomers, enabling clearer ratiometric fluorescence imaging of the mol.-level stress concentration during crack growth in a stretched polyurethane film: (a) Synthesis of a segmented polyurethane elastomer (SPU1) that is chem. doped with FLAP1-OH as a force probe. (b) Stress-strain curves of different SPUs. (c) FL spectral change of SPU1 during the tensile test. Photographs of the specimen under UV light are shown on the right side. (d) Absorption spectral change of SPU1 during the tensile test. (e) FL intensity ratio plotted against nominal stress in the tensile test. I_533 nm/I_472 nm was used as the ratio for SPU1 and SPU1-BC, and I_525 nm/I_474 nm was used for SPU0. (f) Photographs (RGB) and stress mapping (FL ratio) of the notched SPU1 film. The images were acquired using a hyperspectral camera, and the photographs were reconstructed from the RGB channels (R = 700 nm, G = 545 nm, B = 480 nm). (g) FL spectra averaged over the regions A-C shown in the left panel (bandwidth: 5 nm), and the estimated local stress based on the calibration in the panel (e). Strain rate: 0.17 s^-1 for the panels (b-e), and 0.2 min^-1 for the panel (f). This study involved multiple reactions and reactants, such as N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3Recommanded Product: 5137-55-3).

N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 5137-55-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

High performance of ionic-liquid-based materials to remove insecticides was written by Francisco, Rafael;Almeida, Catarina;Sousa, Ana C. A.;Neves, Marcia C.;Freire, Mara G.. And the article was included in International Journal of Molecular Sciences in 2022.SDS of cas: 5137-55-3 The following contents are mentioned in the article:

Neonicotinoids are systemic insecticides commonly used for pest control in agriculture and veterinary applications. Due to their widespread use, neonicotinoid insecticides (neonics) are found in different environmental compartments, including water, soils, and biota, in which their high toxicity towards non-target organisms is a matter of great concern. Given their widespread use and high toxicity, the development of strategies to remove neonics, while avoiding further environmental contamination is of high priority. In this work, ionic-liquid-based materials, comprising silica modified with tetraalkylammonium cations and the chloride anion, were explored as alternative adsorbent materials to remove four neonics insecticides, namely imidacloprid, acetamiprid, thiacloprid, and thiamethoxam, from aqueous media. These materials or supported ionic liquids (SILs) were first synthesized and chem. characterized and further applied in adsorption studies. It was found that the equilibrium concentration of the adsorbate in the solid phase decreases with the decrease in the SIL cation alkyl chain length, reinforcing the relevance of hydrophobic interactions between ionic liquids (ILs) and insecticides. The best-identified SIL for the adsorption of the studied insecticides corresponds to silica modified with propyltrioctylammonium chloride ([Si][N3888]Cl). The saturation of SILs was reached in 5 min or less, showing their fast adsorption rate towards all insecticides, in contrast with activated carbon (benchmark) that requires 40 to 60 min. The best fitting of the exptl. kinetic data was achieved with the Pseudo Second-Order model, meaning that the adsorption process is controlled at the solid-liquid interface. On the other hand, the best fitting of the exptl. isotherm data is given by the Freundlich isotherm model, revealing that multiple layers of insecticides onto the SIL surface may occur. The continuous removal efficiency of the best SIL ([Si][N3888]Cl) by solid-phase extraction was finally appraised, with the maximum adsorption capacity decreasing in the following sequence: imidacloprid > thiacloprid > thiamethoxam > acetamiprid. Based on real reported values, under ideal conditions, 1 g of [Si][N3888]Cl is able to treat at least 106 m3 of wastewater and water from wetland contaminated with the studied neonics. In summary, the enhanced adsorption capacity of SILs for a broad diversity of neonics was demonstrated, reinforcing the usefulness of these materials for their removal from aqueous matrixes and thus contributing to preventing their introduction into the ecosystems and reducing their detrimental effects in the environment and human health. This study involved multiple reactions and reactants, such as N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3SDS of cas: 5137-55-3).

N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 5137-55-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cation Effect of Chloride Salting Agents on Transition Metal Ion Hydration and Solvent Extraction by the Basic Extractant Methyltrioctylammonium Chloride was written by Lommelen, Rayco;Onghena, Bieke;Binnemans, Koen. And the article was included in Inorganic Chemistry in 2020.SDS of cas: 5137-55-3 The following contents are mentioned in the article:

The addition of a nonextractable salt has an important influence on the solvent extraction of metal ions, but the underlying principles are not completely understood yet. However, relating solute hydration mechanisms to solvent extraction equilibrium is key to understanding the mechanism of solvent extraction of metal ions as a whole. We have studied the speciation of Co(II), Zn(II), and Cu(II) in aqueous solutions containing different chloride salts to understand their extraction to the basic extractant methyltrioctylammonium chloride (TOMAC). This includes the first speciation profile of Zn(II) in chloride media with the three Zn(II) species [Zn(H₂O)₆]²⁺, [ZnCl₃H₂O]^–, and [ZnCl₄]^2-. The observed differences in extraction efficiency for a given transition metal ion can be explained by transition metal ion hydration due to ion-solvent interactions, rather than by ion-solute interactions or by differences in speciation. Chloride salting agents bearing a cation with a larger hydration Gibbs free energy reduce the free water content more, resulting in a lower hydration for the transition metal ion. This destabilizes the transition metal chloro complex in the aqueous phase and increases the extraction efficiency. Salting agents with di- and trivalent cations reduce the transition metal chloro complex hydration less than expected, resulting in a lower extraction efficiency. The cations of these salting agents have a very large hydration Gibbs free energy, but the overall hydration of these salts is reduced due to significant salt ion pair formation. The general order of salting-out strength for the extraction of metal ions from chloride salt solutions is Cs⁺ < Rb⁺ < NH₄⁺ ≈ K⁺ < Al³⁺ ≈ Mg²⁺ ≈ Ca²⁺ ≈ Na⁺ < Li⁺. These findings can help in predicting the optimal conditions for metal separation by solvent extraction and also contribute to a broader understanding of the effects of dissolved salts on solutes. Addition of a nonextractable salt influences the stability and solvent extraction efficiency of metal complexes. Cations of different chloride salts reduce the solution free water content as a function of their increasing hydration energy and decreasing tendency for ion pair formation with chloride anions. These ion-solvent interactions reduce the hydration of metal complexes, increasing their distribution ratios. These effects influence aqueous transition metal complexes more than direct ion-solute interactions and changes in complex speciation. This study involved multiple reactions and reactants, such as N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3SDS of cas: 5137-55-3).

N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 5137-55-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Environmental friendly approach for selective extraction and recovery of molybdenum (Mo) from a sulphate mediated spent Ni-Mo/Al₂O₃ catalyst baked leach liquor was written by Parhi, P. K.;Misra, P. K.. And the article was included in Journal of Environmental Management in 2022.Recommanded Product: N-Methyl-N,N-dioctyloctan-1-aminium chloride The following contents are mentioned in the article:

Solvent extraction separation of molybdenum (Mo) from the sulfate mediated leach solution bearing Aluminum (Al) and Nickel (Ni) was carried out using N-Methyl-N, N, N-tri-octyl-ammonium chloride. Extensive investigation for extraction study molybdenum in the function of time, Eq.pH, extractant concentration, diluents, temperature, strip solution concentration and phase ratio(A:O) for both extraction and stripping was examined to attain a suitable condition on its selective and enriched extraction As per the equilibrium study and increasing trend of Eq. pH (pH_e) at the correspondence initial pH, it was apparent about association of 1 mol of H⁺ ion during extraction which with was further supported on extraction of Mo as HMO₄^– at the pH_e of 3.48. The association of 1 mol of exrractant during the extraction of Mo was also well evident from the slope anal. study. This indicates about anion exchange phenomenon due to Cl^– ion of the N-Methyl-N, N, N-tri-octyl-ammonium chloride (extractant) with HMo₄^– from aqueous phase during complex formation reaction. The FTIR of the organic sample before and after extraction further confirms in support of the complex formation of the molybdenum with the extractant during extraction The extraction isotherm was constructed at optmum extraction condition: pH_e of 3.48 with 0.08M N-Methyl-N, N, N-tri-octyl-ammonium chloride predicts on need of 2-counter current stages for quant. extraction of Mo at A:O = 3:1. To investigate the regeneration behavior of adopted extractant along with enriched stripping of molybdenum, ammoniacal reagents were used in stripping study. The stripping of Mo showed promising and efficient using the mixture of the ammoniacal reagents (NH₄OH + NH₄Cl) over the either of the solo reagents. The stripping Mc-Cabe Thiele diagram was plotted using 2M NH₄OH + NH₄Cl ensures on quant. stripping of Mo at SO: SS = 2:1 at 2 number of stages. Both extraction and stripping isotherm results are validated at predicted isotherm conditions by 6-cycles counter current simulation (CCS) study leading to obtain 6-fold enrichment of Mo in stripped solution phase. The subsequent enriched content of Mo (∼60 g/L) in stripped solution phase was precipitated out followed by calcinations 400 °C to obtain a high pure MoO₃. The recovered calcined product as MoO₃ resulted through the proposed processing approach was as ascertained from XRD anal. This study involved multiple reactions and reactants, such as N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3Recommanded Product: N-Methyl-N,N-dioctyloctan-1-aminium chloride).

N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: N-Methyl-N,N-dioctyloctan-1-aminium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochlorideOn October 31, 2012 ,《Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe》 appeared in Nature Chemistry. The author of the article were Xie, Hexin; Mire, Joseph; Kong, Ying; Chang, Mi Hee; Hassounah, Hany A.; Thornton, Chris N.; Sacchettini, James C.; Cirillo, Jeffrey D.; Rao, Jianghong. The article conveys some information:

Early diagnosis of tuberculosis can dramatically reduce both its transmission and the associated death rate. The extremely slow growth rate of the causative pathogen, Mycobacterium tuberculosis (Mtb), however, makes this challenging at the point of care, particularly in resource-limited settings. Here the authors report the use of BlaC (an enzyme naturally expressed/secreted by tubercle bacilli) as a marker and the design of BlaC-specific fluorogenic substrates as probes for Mtb detection. These probes showed an enhancement by 100-200 times in fluorescence emission on BlaC activation and a >1000-fold selectivity for BlaC over TEM-1 β-lactamase, an important factor in reducing false-pos. diagnoses. Insight into the BlaC specificity was revealed by successful co-crystallization of the probe/enzyme mutant complex. A refined green fluorescent probe (CDG-OMe) enabled the successful detection of live pathogen in less than ten minutes, even in unprocessed human sputum. This system offers the opportunity for the rapid, accurate detection of very low numbers of Mtb for the clin. diagnosis of tuberculosis in sputum and other specimens. In the part of experimental materials, we found many familiar compounds, such as (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Reference of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Reference of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cheng, Qing-fang published an article in Huaxue Shiji. The title of the article was 《Improvement and synthesis of 7-amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate hdyrochloride》.Computed Properties of C21H20Cl2N2O3S The author mentioned the following in the article:

7-Amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate hydrochloride was synthesized from diphenylmethyl 7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride by condensation, N-alkylation and hydrolysis in an overall yield of 77.8%. The purity of the title compound was over 98% by HPLC. This procedure was simple, mild and safe, suitable for scale-up production(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Computed Properties of C21H20Cl2N2O3S) was used in this study.

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C21H20Cl2N2O3S Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Ultrasonic-assisted synthesis of two t-butoxycarbonylamino cephalosporin intermediates on SiO2》 were Xue, Feng; Wei, Yibin; Ju, Shengui; Xing, Weihong. And the article was published in Journal of Chemistry in 2016. Quality Control of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride The author mentioned the following in the article:

Herein, a facile and high efficient strategy for the synthesis of two forms of the 7β-t-butoxycarbonylamino- 3-chloromethyl-3-cephem-4-carboxylates I [R = 4-MeOC6H4CH2, HCCH(Ph)2] using ultrasonic irradiation was described. By SiO2 as weak Lewis acid catalyst, compound I were successfully synthesized through the efficient protection of the N-tbutoxycarbonyl (N-Boc) and the reactions occurred at low temperature requiring short reaction times and exhibiting excellent isolated yields (96% and 96.2%, resp.). The advantages of this reaction route included the usage of economical reagents and mild reaction conditions and high isolated yield make the two significant t-butoxycarbonylamino cephalosporin intermediates possible in large-scale production The results came from multiple reactions, including the reaction of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Quality Control of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Quality Control of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Katsura, Yousuke; Aratani, Matsuhiko published their research in Tetrahedron Letters on December 19 ,1994. The article was titled 《A convenient protective method for the 7-amino function on a cephem derivative in Wittig vinylation》.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride The article contains the following contents:

A novel preparative pathway for diphenylmethyl 7β-amino-3-vinylceph-3-em-4-carboxylate from 3-chloromethyl derivative is described. As a convenient protecting group for the 7-amino function in a Wittig reaction, six membered azine derivatives, e.g., I, incorporating the 7-amino group were developed as a surrogate of conventional protecting groups. The experimental process involved the reaction of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 79349-53-4On May 30, 1993, Okita, Takaaki; Imae, Kiyoto; Hasegawa, Toshifumi; Iimura, Seiji; Masuyoshi, Shinji; Kamachi, Hajime; Kamei, Hideo published an article in Journal of Antibiotics. The article was 《Synthesis and antibacterial activity of cephalosporins having a catechol in the C3 side chain》. The article mentions the following:

Cephalosporins I [R = H, Me, CMe2CO2H, R1 = (E)-CH:CHCH2O2CC6H3(OH)2-3,4, O2CC6H3(OH)2-3,4; R = Me, R1 = O2CCH2C6H3(OH)2-3,4] were prepared I [ R = CMe2CO2H, R1 = (E)-CH:CHCH2O2CC6H3(OH)2-3,4, O2CC6H3(OH)2-3,4] showed excellent activity against Gram-neg. bacteria including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia. In the experiment, the researchers used many compounds, for example, (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4SDS of cas: 79349-53-4)

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.SDS of cas: 79349-53-4 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochlorideOn September 30, 1995 ,《Studies on 3′-quaternary ammonium cephalosporins II. Synthesis and antibacterial activity of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]cephalosporin derivatives bearing various quaternary ammonium methyl groups at the 3 position》 was published in Journal of Antibiotics. The article was written by Ohki, Hidenori; Kawabata, Kohji; Okuda, Shinya; Kamimura, Toshiaki; Sakane, Kazuo. The article contains the following contents:

Synthesis and antibacterial activity of quaternary ammonium cephalosporins is reported. Extremely potent broad-spectrum activity against both Gram-pos. bacteria, including S. aureus, and Gram-neg. bacteria, including P. aeruginosa, is exhibited by 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(3-amino-2-methylpyrazolio)-methyl-3-cephem-4-carboxylate.(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride) was used in this study.

(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics