Tag: 300-400

Improving stability of tear film lipid layer via concerted action of two drug molecules: a biophysical view was written by Eftimov, Petar;Olzynska, Agnieszka;Melcrova, Adela;Georgiev, Georgi As.;Daull, Philippe;Garrigue, Jean-Sebastien;Cwiklik, Lukasz. And the article was included in International Journal of Molecular Sciences in 2020.Synthetic Route of C25H46ClN The following contents are mentioned in the article:

The tear film at the ocular surface is covered by a thin layer of lipids. This oily phase stabilizes the film by decreasing its surface tension and improving its viscoelastic properties. Clin., destabilization and rupture of the tear film are related to dry eye disease and are accompanied by changes in the quality and quantity of tear film lipids. In dry eye, eye drops containing oil-in-water emulsions are used for the supplementation of lipids and surface-active components to the tear film. We explore in detail the biophys. aspects of interactions of sp. surface-active compounds, cetalkonium chloride and poloxamer 188, which are present in oil-in-water emulsions, with tear lipids. The aim is to better understand the macroscopically observed eye drops-tear film interactions by rationalizing them at the mol. level. To this end, we employ a multi-scale approach combining experiments on human meibomian lipid extracts, measurements using synthetic lipid films, and in silico mol. dynamics simulations. By combining these methods, we demonstrate that the studied compounds specifically interact with the tear lipid film enhancing its structure, surfactant properties, and elasticity. The observed effects are cooperative and can be further modulated by material packing at the tear-air interface. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Synthetic Route of C25H46ClN).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C25H46ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Use of capillary electrophoresis for characterisation of vinyl-terminated Au nanoprisms and nanooctahedra was written by Adelantado, Carlos;Algarra, Manuel;Zougagh, Mohammed;Rios, Angel. And the article was included in Electrophoresis in 2018.Electric Literature of C25H46ClN The following contents are mentioned in the article:

It is described a simple, rapid and efficient methodol. to characterize and sep. gold nanoprisms and nanooctahedra by capillary electrophoresis. This technique is suitable to distinguish between morphologies and it can be used as a powerful separation tool after a customised synthesis of both structures. This synthesis was carried out by amending two parameters, temperature and pH, and a sharp decrease was found in nanotriangles when temperature was increased from 70 up to 95°. However, when the synthesis was performed at a given temperature, an increase in pH did not promote an important change in isolation of any structure until pH = 9.5, critical in the final morphol. of the nanoparticle. Gold nanoprisms and nanooctahedra were successfully separated by capillary electrophoresis according to differences in charge-to-mass ratio of the morphologies. Final particle morphol. was confirmed by TEM anal. Under optimal working conditions, a mixture containing both shapes of gold nanoparticles was initially injected and two major peaks were obtained for each structure. Capillary electrophoresis allowed to study pH and temperature influence on both morphologies. It was inferred that the ratio between triangles and octahedra decreased to a great extent when increasing both temperature and pH. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Electric Literature of C25H46ClN).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C25H46ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Detection of intracellular lamellar bodies as a screening marker for fibrotic lesions was written by Park, Eun-Jung;Kang, Min-Sung;Lim, Hyun-Ji;Kang, Tae Kyu;Jin, Seung-Woo;Lee, Seung Hyeun;Baek, Sun Hwa;Kang, Jeong Won. And the article was included in Toxicology and Applied Pharmacology in 2021.Synthetic Route of C25H46ClN The following contents are mentioned in the article:

With the rapid increase in application of disinfectants worldwide as a method to block the spread of coronavirus, many new products are being introduced into the market without thorough verification of their impacts on human health and the environment. In the present study, we aimed to propose a screening marker for materials that can induce fibrotic lung disease using disinfectants, which had been demonstrated as causative materials of chronic inflammation and interstitial fibrosis. We first calculated the corresponding LC50 level based on results from cell viability test and exposed the LC50 level of disinfectants to human bronchial epithelial cells for 24 h. Formation of lamellar body-like structures, cleavage of the nuclear matrix, structural damage of mitochondria were found in the cytosol of the treated cells. We also dosed disinfectants by pharyngeal aspiration to mice to determine the LD0 level. The mice were sacrificed on Day 14 after a single dosing, and lamellar body-like structures were observed in the lung tissue of mice. Herein, we hypothesize that DNA damage and metabolic disturbance may play central roles in disinfectant-induced adverse health effects. Addnl., we propose that formation of lamellar bodies can be a screening marker for interstitial fibrosis. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Synthetic Route of C25H46ClN).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C25H46ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XF^e96 Extracellular Flux Analyzer was written by Du Preez, G.;Fourie, H.;Daneel, M.;Miller, H.;Hoss, S.;Ricci, C.;Engelbrecht, G.;Zouhar, M.;Wepener, V.. And the article was included in Scientific Reports in 2020.Related Products of 122-18-9 The following contents are mentioned in the article:

Abstract: Caenorhabditis elegans presents functioning, biol. relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C. elegans in vivo effect-assessment methods are laborious and time consuming. Therefore, we developed a novel method to measure the oxygen consumption rate of C. elegans as a sublethal endpoint of toxicity. This protocol was tested by exposing 50 larval stage one C. elegans individuals for 48 h (at 20°C) to different concentrations of two toxicants i.e. benzylcetyldimethylammonium chloride (BAC-C16) and cadmium (Cd). Following exposures, the oxygen consumption rate of the C. elegans individuals were measured using the high-throughput functionality of the Seahorse XF^e96 Extracellular Flux Analyzer. Dose-response curves for BAC-C16 (R² = 0.93; P = 0.001) and Cd (R² = 0.98; P = 0.001) were created. Furthermore, a strong, pos. correlation was evidenced between C. elegans oxygen consumption rate and a commonly used, ecol. relevant endpoint of toxicity (growth inhibition) for BAC-C16 (R² = 0.93; P = 0.0001) and Cd (R² = 0.91; P = 0.0001). The data presented in this study show that C. elegans oxygen consumption rate can be used as a promising functional measurement of toxicity. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Related Products of 122-18-9).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 122-18-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enhancement of adsorption efficiency of heavy metal Cu(II) and Zn(II) onto cationic surfactant modified bentonite was written by Tohdee, Kanogwan;Kaewsichan, Lupong;Asadullah. And the article was included in Journal of Environmental Chemical Engineering in 2018.Reference of 122-18-9 The following contents are mentioned in the article:

This study sought to enhance the metal adsorption capacity of bentonite by improving its surfaces. Surface modification by the cationic surfactant (Bencylhexadecyldimethyl ammonium chloride, BCDMACl) was successful in this respect, and was characterized by FTIR spectroscopy, XRF, BET, and swelling test. A major characteristic of BCDMACl is forming micelles that can intercalate into interlayers of clay and prevent swelling. The adsorption of Cu (II) and Zn (II) from aqueous solutions was studied in batch experiments, varying both contact time and concentrations of the metal ions. Retention of the metals in solution was detected by Atomic Absorption Spectroscopy (AAS). The adsorption data were fitted with Langmuir, Freundlich, and Dubinin-Radushkevich isotherm models, of which the Langmuir isotherm provided the best fit with exptl. data (R² range 0.962-0.993). The results also revealed that the modified bentonite had significantly improved adsorption capacities (q_max 50.76 and 35.21mg/g for Cu(II) and Zn(II), resp.); about 2.5 and 2.0 fold improvements over natural bentonite. The pseudo-second-order rate equation provided the best fit to observed adsorption kinetics. This study demonstrated the modified bentonite as an effective adsorbent for the removal of heavy metals from aqueous solutions This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Reference of 122-18-9).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 122-18-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Surface tension of the oppositely charged sodium poly(styrene sulfonate) /benzyldimethylhexadecylammonium chloride and sodium poly(styrene sulfonate)/polyallylamine hydrochloride mixtures was written by Owiwe, Mina T.;Ayyad, Ahmed H.;Takrori, Fahed M.. And the article was included in Colloid and Polymer Science in 2020.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Oppositely charged polyelectrolyte/surfactant and the coacervate polyanion/polycation mixtures are known to display complex properties at water/air interface which are not fully elucidated. The change in surface tension of the anionic polyelectrolyte sodium poly(styrene sulfonate) (NaPSS) with either benzyldimethylhexadecylammonium chloride (BAC) as the cationic surfactant or the cationic polyelectrolyte polyallylamine hydrochloride (PAACl) as a function of temperature and added salts was investigated. Neither of the pure polyelectrolytes showed significant surface activity; however, addition of oppositely charged surfactant or polyelectrolyte to varying concentrations of NaPSS solutions had changed the surface activity drastically. The surface tension of the NaPSS/BAC complex is lower than that of pure BAC surfactant. The surface tension of these complexes showed significant decrease with increasing temperatures and the surface excess entropy was deduced from these measurements. Addition of ionic salts enhanced the association of the polyelectrolyte/surfactant mixture but had little effect on the polyelectrolytes coacervate. The surface tension of low concentrations of NaPSS/PAACl coacervate displayed a peak which can be attributed to charge inversion. Graphical abstract [graphic not available: see fulltext]. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Category: chlorides-buliding-blocks).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Engineering titanium carbide ultra-thin nanosheets for enhanced fire safety of intumescent flame retardant polylactic acid was written by Shi, Yongqian;Wang, Zixiao;Liu, Chuan;Wang, Hengrui;Guo, Jin;Fu, Libi;Feng, Yuezhan;Wang, Liancong;Yang, Fuqiang;Liu, Minghua. And the article was included in Composites, Part B: Engineering in 2022.Application In Synthesis of N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride The following contents are mentioned in the article:

As a biodegradable polymeric material, the polylactic acid (PLA) has broad applications resulting from its various advantages and unique characteristics. Nevertheless, the application of PLA in various fields is greatly limited by its high flammability. Our recent effort focuses on the manipulation of benzyldimethylhexadecylammonium chloride (HDBAC) modified titanium carbide (Ti3C2T_x) ultra-thin nanosheets which are then used to improve the fire safety of PLA composites filled with silicon microencapsulated ammonium polyphosphate (SiAPP). The flame retardant evaluation showed that when 2.0 wt% HDBAC modified Ti3C2T_x (HDBAC-Ti3C2T_x) and 13.0 wt% SiAPP were added, the LOI value was increased to 33.3%, and the UL-94 V-0 level was obtained, besides the peak heat release rate, total heat release, peak smoke production rate and total smoke release decreased by 49.8%, 31.9%, 60.3% and 52.7%, resp. The barrier and catalytic effects of the modified Ti3C2T_x nanosheets together with the subsequently formed TiO₂ and phosphorus-containing species forming intact expanded carbon layers and interrupting the combustion route are responsible for remarkably improving flame retardancy and suppressing toxic gases of PLA. This work provides a new approach for greatly reducing the fire hazard of PLA. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Application In Synthesis of N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formation of drug-participating catanionic aggregates for extended delivery of non-steroidal anti-inflammatory drugs from contact lenses was written by Torres-Luna, Cesar;Koolivand, Abdollah;Fan, Xin;Agrawal, Niti R.;Hu, Naiping;Zhu, Yuli;Domszy, Roman;Briber, Robert M.;Wang, Nam Sun;Yang, Arthur. And the article was included in Biomolecules in 2019.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

This paper focuses on extending drug release duration from contact lenses by incorporating catanionic aggregates. The aggregates consist of a long-chain cationic surfactant, i.e., cetalkonium chloride (CKC), and an oppositely charged anti-inflammatory amphiphilic drug. We studied three non-steroidal anti-inflammatory (NSAID) drugs with different octanol-water partition coefficients; diclofenac sodium (DFNa), flurbiprofen sodium (FBNa), and naproxen sodium (NPNa). Confirmation of catanionic aggregate formation in solution was determined by steady and dynamic shear rheol. measurements. We observed the increased viscosity, shear thinning, and viscoelastic behavior characteristic of wormlike micelles; the rheol. data are reasonably well described using a Maxwellian fluid model with a single relaxation time. In vitro release experiments demonstrated that the extension in the drug release time is dependent on the ability of a drug to form viscoelastic catanionic aggregates. Such aggregates retard the diffusive transport of drug mols. from the contact lenses. Our study revealed that the release kinetics depends on the CKC concentration and the alkyl chain length of the cationic surfactant. We demonstrated that more hydrophobic drugs such as diclofenac sodium show a more extended release than less hydrophobic drugs such as naproxen sodium. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Category: chlorides-buliding-blocks).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enhancement of Hot Electron Generation in Colloidal Plasmonic Nanocrystals by Adsorption of Pt Clusters was written by Yang, Yi;Wang, Kaiyu;Khan, Majid;Hu, Ningneng;Ni, Weihai. And the article was included in Advanced Optical Materials in 2022.Product Details of 122-18-9 The following contents are mentioned in the article:

Surface scattering of electrons is used to be recognized as a detrimental damping process of the plasmonic oscillation, whereas such electron-surface scattering generates hot electrons (HEs) inside the metal nanocrystals, being of great significance in practical applications, i.e., photodetection or photocatalytic reactions. However, utilizing surface scattering in colloidal plasmonic nanocrystals in realistic catalytic reactions remains challenging. This work presents a systematic study on the HE rates of colloidal Au nanocrystals, including nanospheres, nanocubes, and nanorods, and their enhancement from the adsorption of Pt clusters. Au nanocubes exhibit the highest single particle-averaged incident photon-to-electron conversion efficiency among the three types of the nanocrystals. The Au nanocrystals are further adsorbed with Pt clusters, and the highest photocurrent enhancement by nearly one order of magnitude is observed To explain the exptl. observations, the contribution of the Pt adsorption to the plasmon damping is characterized by single-particle dark-field spectroscopy, and the HE rates are calculated by employing the finite-element method. The overall significant enhancement of the photocurrent due to the Pt adsorption is finally explained by both electromagnetic and catalytic effects of the Pt clusters. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Product Details of 122-18-9).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 122-18-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ultrafast dynamics of ionic liquids in colloidal dispersion was written by Ren, Zhe;Kelly, Jordan;Gunathilaka, C. Prasad;Brinzer, Thomas;Dutta, Samrat;Johnson, Clinton A.;Mitra, Sunayana;Garrett-Roe, Sean. And the article was included in Physical Chemistry Chemical Physics in 2017.Application In Synthesis of N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride The following contents are mentioned in the article:

Ionic liquid (IL)-surfactant complexes have significance both in applications and fundamental research, but their underlying dynamics are not well understood. The authors apply polarization-controlled two-dimensional IR spectroscopy (2D-IR) to study the dynamics of [BMIM][SCN]/surfactant/solvent model systems. The authors examine the effect of the choice of surfactants and solvent, and the IL-to-surfactant ratio (W-value), with a detailed anal. of the orientation and structural dynamics of each system. Different surfactants create very different environments for the entrapped ILs, ranging from a semi-static micro-environment to a fluxional environment that evolves even faster than the bulk IL. The oil-phase also clearly affects the microscopic dynamics. The anisotropy decay for entrapped ILs completes within 10 ps, which is similar to free thiocyanate ion in water, while a significant reorientation-induced spectral diffusion (RISD) effect is observed The entrapped ionic liquid are highly dynamic for all W-values, and no core-shell structure is observed Authors hypothesize that, instead of an ionic liquid-reverse micelle (IL-RM), the microscopic structure of this system is small colloidal dispersions or pairs of IL and surfactants. A detailed anal. of the polarization-controlled 2D-IR spectra of AOT system reveals a potential ion-exchange mechanism. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Application In Synthesis of N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics