Tag: 200-300

Constructing positively charged acid-resistant nanofiltration membranes via surface postgrafting for efficient removal of metal ions from electroplating rinse wastewater was written by Bai, Yong;Gao, Peng;Fang, Rong;Cai, Jing;Zhang, Li-Dan;He, Qin-Yuan;Zhou, Zi-Hao;Sun, Shi-Peng;Cao, Xue-Li. And the article was included in Separation and Purification Technology in 2022.Application In Synthesis of Trimesoylchloride This article mentions the following:

To efficiently recycle metal ions from electroplating wastewater, a pos. charged acid-resistant nanofiltration membrane was prepared by coupling interfacial polymerization and postgrafting modification with an ethanol grafting solution containing N-(3-aminopropyl)-imidazole (ANPI). Ethanol, as the grafting solvent, not only slightly swelled the original polyamide (PA) layer but also is mutually miscible with n-hexane, which prevented the formation of addnl. PA layers. ANPI, as the grafting monomer, was covalently bound to the -COCl groups of the PA layer to guarantee grafting stability. Due to the inhibited hydrolysis of the -COCl group by ethanol, more ANPI was grafted on the PA layer, which could be easily protonated under low pH. This resulted in a looser, thinner and pos. charged selectivity layer. The membrane permeability was improved by 56.0 卤 0.55% with high interception performance (> 98% for Cu²⁺ and Ni²⁺ ions) in electroplating rinse wastewater. The formed pos. protective layer prevented H+ ions from attacking the -CO-NH- bonds, resulting in strong stability after immersion in 10 wt% H₂SO₄ and H₃PO₄. Therefore, the obtained membrane shows promise for application in highly acidic wastewater. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application In Synthesis of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of Fenton process to remove organic matter and PCBs from waste (fuller’s earth) contaminated with insulating oil was written by Apolinario da Silva, Milady Renata;Rodrigues, Eduardo de Oliveira;Espanhol-Soares, Melina;Silva, Flavio Soares;Kondo, Marcia Matiko;Gimenes, Rossano. And the article was included in Environmental Technology in 2019.Related Products of 3386-33-2 This article mentions the following:

Polychlorinated biphenyls (PCBs) are carcinogenic to humans and can be found in fuller’s earth used for the treatment of used transformer oil. This work describes an optimization of the Fenton process for the removal of contaminants from fuller’s earth. The effects of pH (2.5 and 4.0), [H₂O₂] (1.47 and 2.07 mol L^-1), and [Fe²⁺] (1.7 and 40 mmol L^-1) were studied. The Fenton process efficiency was monitored using the decreases in the COD (COD) and the concentrations of oil and grease, total carbon (TC), PCBs, and H₂O₂. The fuller’s earth contaminated with insulating oil presented 35% (weight/weight) of TC, 34% (weight/weight) of oil and grease, 297.0 g L^-1 COD, and 64 mg of PCBs per kg. The material could therefore be considered a dangerous waste. After Fenton treatment, using a slurry mode, there was a removal of 55% of COD, 20% of oil and grease, and 20% of TC, achieved at pH 2.5 using 2.07 mol L^-1 of H₂O₂ and 40.0 mmol L^-1 of Fe²⁺. No PCBs were detected in the samples after the Fenton treatment, even using smaller amounts of Fenton reagents (1.47 mol L^-1 of H₂O₂, 1.7 mmol L^-1 of Fe²⁺, pH 2.5). The results indicated that the treated fuller’s earth was free from PCB residues and could be disposed of in a simple landfill, in accordance with Brazilian PCB regulations. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Related Products of 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Asymmetric synthesis of dihydroquinazolinones via directed ortho metalation and addition to tert-butanesulfinyl imines was written by Rajapakse, Hemaka A.;Young, Mary Beth;Zhu, Hong;Charlton, Samantha;Tsou, Nancy N.. And the article was included in Tetrahedron Letters in 2005.Electric Literature of C11H14ClNO2 This article mentions the following:

An asym. route to dihydroquinazolinones via the addition of ortho metalated substrates to tert-butanesulfinyl imines is reported. The scope of the nucleophile and electrophile components and the absolute stereochem. outcome are presented. This method was applied to the asym. synthesis of (+)-3,4-dihydro-4-phenyl-3-[1-(phenylmethyl)-4-piperidinyl]-2(1H)-quinazolinone [i.e., (+)-SM-154811 hydrochloride]. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Electric Literature of C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches was written by Villemagne, Baptiste;Flipo, Marion;Blondiaux, Nicolas;Crauste, Celine;Malaquin, Sandra;Leroux, Florence;Piveteau, Catherine;Villeret, Vincent;Brodin, Priscille;Villoutreix, Bruno O.;Sperandio, Olivier;Soror, Sameh H.;Wohlkonig, Alexandre;Wintjens, Rene;Deprez, Benoit;Baulard, Alain R.;Willand, Nicolas. And the article was included in Journal of Medicinal Chemistry in 2014.Synthetic Route of C10H13ClO3S This article mentions the following:

Tuberculosis remains a major cause of mortality and morbidity, killing each year more than one million people. Although the combined use of first line antibiotics (isoniazid, rifampicin, pyrazinamide, and ethambutol) is efficient to treat most patients, the rapid emergence of multidrug resistant strains of Mycobacterium tuberculosis stresses the need for alternative therapies. Mycobacterial transcriptional repressor EthR is a key player in the control of second-line drugs bioactivation such as ethionamide and has been shown to impair the sensitivity of the human pathogen Mycobacterium tuberculosis to this antibiotic. As a way to identify new potent ligands of this protein, we have developed fragment-based approaches. In the current study, we combined surface plasmon resonance assay, x-ray crystallog., and ligand efficiency driven design for the rapid discovery and optimization of new chemotypes of EthR ligands starting from a fragment. The design, synthesis, and in vitro and ex vivo activities of these compounds will be discussed. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Synthetic Route of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A sulfonamide sialoside analogue for targeting Siglec-8 and -F on immune cells was written by Nycholat, Corwin M.;Duan, Shiteng;Knuplez, Eva;Worth, Charli;Elich, Mila;Yao, Anzhi;O’Sullivan, Jeremy;McBride, Ryan;Wei, Yadong;Fernandes, Steve M.;Zhu, Zhou;Schnaar, Ronald L.;Bochner, Bruce S.;Paulson, James C.. And the article was included in Journal of the American Chemical Society in 2019.Electric Literature of C7H4ClF3O2S This article mentions the following:

The Siglec family of cell surface receptors have emerged as attractive targets for cell-directed therapies due to their restricted expression on immune cells, endocytic properties, and ability to modulate receptor signaling. Human Siglec-8, for instance, has been identified as a therapeutic target for the treatment of eosinophil and mast cell disorders. A promising strategy to target Siglecs involves the use of liposomal nanoparticles with a multivalent display of Siglec ligands. A key challenge for this approach is the identification of a high affinity ligand for the target Siglec. Here, we report the development of a ligand of Siglec-8 and its closest murine functional orthologue Siglec-F that is capable of targeting liposomes to cells expressing Siglec-8 or -F. A glycan microarray library of synthetic 9-N-sulfonyl sialoside analogs was screened to identify potential lead compounds The best ligand, 9-N-(2-naphthyl-sulfonyl)-Neu5Ac伪2-3-[6-O-sulfo]-Gal尾1-4GlcNAc (6′-O-sulfo ^NSANeu5Ac) combined the lead 2-naphthyl sulfonyl C-9 substituent with the preferred sulfated scaffold. The ligand 6′-O-sulfo ^NSANeu5Ac was conjugated to lipids for display on liposomes to evaluate targeted delivery to cells. Targeted liposomes showed strong in vitro binding/uptake and selectivity to cells expressing Siglec-8 or -F and, when administered to mice, exhibit in vivo targeting to Siglec-F⁺ eosinophils. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of oxidation of 4-oxoacids by N-chlorosaccharin in aqueous acetic acid medium was written by Farook, N. A. Mohamed. And the article was included in Asian Journal of Chemistry in 2007.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

Kinetics of oxidation of substituted and unsubstituted 4-oxoacids (S) by N-chlorosaccharin (NCSA) in aqueous acetic acid medium were studied. The reaction follows first-order kinetics, each in 4-oxoacids, NCSA and H⁺. The effect of changes in the electronic nature of the substrate reveals that there is a development of pos. charge in the transition state. From the kinetic results and product anal., a suitable mechanism was proposed for the reaction of NCSA with 4-oxoacids. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors was written by Rossi, Cristina;Fincham, Christopher I.;D’Andrea, Piero;Porcelloni, Marina;Ettorre, Alessandro;Mauro, Sandro;Bigioni, Mario;Binaschi, Monica;Maggi, Carlo A.;Nardelli, Federica;Parlani, Massimo;Fattori, Daniela. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Reference of 63624-28-2 This article mentions the following:

A series of N-substituted 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of histone deacetylase (HDAC) inhibitors (zinc binding moiety-linker-capping group) has been previously reported by our group. Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells. We report here the second part of the strategy used in our research group to find a new class of HDAC inhibitors, namely the SAR study for the compounds bearing a sulfonyl group on the piperidine nitrogen. In the present work, we have considered both sulfonamides and sulfonyl ureas. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Validation of the SkinEthic HCE Time-to-Toxicity test method for eye hazard classification of chemicals according to UN GHS was written by Alepee, N.;Grandidier, M. H.;Teluob, S.;Amaral, F.;Caviola, E.;De Servi, B.;Martin, S.;Meloni, M.;Nardelli, L.;Pasdelou, C.;Tagliati, V.;Viricel, A.;Adriaens, E.;Michaut, V.. And the article was included in Toxicology In Vitro in 2022.Application of 96568-04-6 This article mentions the following:

This study describes the within- and between-laboratory reproducibility (WLR and BLR) of a Time-to-Toxicity (TTT) approach for chems. based on the SkinEthic HCE tissue construct, capable to distinguish chems. that do not require classification for serious eye damage/eye irritation (No Cat.) from chems. that require classification for eye irritation (Cat. 2), and serious eye damage (Cat. 1). The WLR and BLR was assessed with three participating laboratories Each laboratory tested 40 coded chems. in three independent runs. The predictive capacity of the method was assessed on a larger set of 150 chems. (70 liquids and 80 solids) by combining the results of this study with the results of the test method developer. The WLR for the 20 liquids ranged from 85% to 95% with a BLR of 90%. For the 20 solids, a WLR and BLR of 100% was obtained. The test method developer obtained a WLR of 80% and 95%, based on 50 liquids and 48 solids tested in three independent runs, resp. Regarding the predictive capacity, the SkinEthic HCE TTT test method identified 80.8% Cat. 1, 69.2% Cat. 2, and 74.9% No Cat. correctly. An independent peer review panel concluded that based on all available data, the relevance and reliability of the SkinEthic HCE TTT has been demonstrated for discriminating the three UN GHS eye hazard categories. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Application of 96568-04-6).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 96568-04-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ethyl 3-nitro-4-(n-propylamino)benzoate was written by Zhang, Guo-Hua;Wu, Yong Zhong;Li, Hao-Yuan;Liu, Bo-Nian;Guo, Cheng. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2009.Computed Properties of C9H8ClNO4 This article mentions the following:

In the mol. of the title compound, C₁₂H₁₆N₂O₄, an intramol. N-H…O hydrogen bond results in the formation of a six-membered ring having an envelope conformation. In the crystal structure, a bifurcated intra/intermol. N-H…(O,O) hydrogen bond generates inversion dimers. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Computed Properties of C9H8ClNO4).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C9H8ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of a Screening Library Using the Natural Product Scaffold 3-Chloro-4-hydroxyphenylacetic Acid was written by Kumar, Rohitesh;Sadowski, Martin C.;Levrier, Claire;Nelson, Colleen C.;Jones, Amy J.;Holleran, John P.;Avery, Vicky M.;Healy, Peter C.;Davis, Rohan A.. And the article was included in Journal of Natural Products in 2015.Quality Control of Methyl 3-chloro-4-hydroxyphenylacetate This article mentions the following:

The fungal metabolite 3-chloro-4-hydroxyphenylacetic acid (I) was utilized in the generation of a unique drug-like screening library using parallel solution-phase synthesis. A 20-membered amide library, II (R = CH₂CH₂CHMe₂, morpholinoethyl, CH₂CH₂NMe₂, etc.), III (R¹, R² = H, F, R³ = H, Br, Cl, F), and IV, was generated by first converting I to Me (3-chloro-4-hydroxyphenyl)acetate, then reacting this scaffold with a diverse series of primary amines via a solvent-free aminolysis procedure. The structures of the synthetic analogs II, III, and IV were elucidated by spectroscopic data anal. The structures of compounds III (R¹ = F, R² = R³ = H), IV (R¹ = R² = H, R³ = F), and the hydrate of II (R = CH₂CH₂NMe₂) were confirmed by single X-ray crystallog. anal. All compounds were evaluated for cytotoxicity against a human prostate cancer cell line (LNCaP) and for antiparasitic activity toward Trypanosoma brucei brucei and Plasmodium falciparum and showed no significant activity at 10 渭M. The library was also tested for effects on the lipid content of LNCaP and PC-3 prostate cancer cells, and it was demonstrated that the fluorobenzyl analogs IV (R¹ = R² = H, R³ = F; R¹ = R³ = H, R² = F; R¹ = F, R² = R³ = H) significantly reduced cellular phospholipid and neutral lipid levels. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Quality Control of Methyl 3-chloro-4-hydroxyphenylacetate).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of Methyl 3-chloro-4-hydroxyphenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics