Tag: 200-300

Synthesis and Photoluminescent Properties of 2-(3-Carboxymethylindazol-1-yl)anilines was written by Shetnev, A. A.;Panova, V. A.;Kutuzova, P. M.;Tarasenko, M. V.;Zhmykhova, M. V.;Baykov, S. V.;Filimonov, S. I.. And the article was included in Russian Journal of General Chemistry in 2021.Product Details of 16588-16-2 This article mentions the following:

A two-stage method for the preparation of 2-(3-carboxymethylindazol-1-yl)anilines using the N-arylation reaction of 3-carboxymethylindazoles with o-nitrohaloarenes and subsequent reduction of nitro-containing intermediates with tin(II) chloride was developed. The exptl. results showed that the use of the synthesized compounds as fluorophores in the visible region of the spectrum is promising. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Product Details of 16588-16-2).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 16588-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst was written by Cheung, Chi Wai;Buchwald, Stephen L.. And the article was included in Organic Letters in 2013.Name: tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

A general method for the Pd-catalyzed coupling of methanol with (hetero)aryl halides is described. The reactions proceed under mild conditions with a wide range of aryl and heteroaryl halides to give Me aryl ethers in high yield. E.g., in presence of palladacycle precatalyst I (L = tBuBrettPhos) and the ligand tBuBrettPhos, arylation of MeOH by 4-Me₃CC₆H₄Cl gave 93% 4-Me₃CC₆H₄OMe. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Name: tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and evaluation of new thiadiazole derivatives as potential inhibitors of human carbonic anhydrase isozymes (hCA-I and hCA-II) was written by Altintop, Mehlika Dilek;Ozdemir, Ahmet;Kucukoglu, Kaan;Turan-Zitouni, Gulhan;Nadaroglu, Hayrunnisa;Kaplancikli, Zafer Asim. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2015.Application of 6590-96-1 This article mentions the following:

2-[[5-(2,4-Difluoro/dichlorophenylamino)-1,3,4-thiadiazol-2-yl]thio]acetophenone derivatives were designed as human carbonic anhydrase isoenzymes (hCA-I and hCA-II) inhibitor and synthesized. HCA-I and hCA-II were purified from erythrocyte cells by affinity chromatog. The inhibitory effects of 18 newly synthesized acetophenones on hydratase activity of these isoenzymes were studied in vitro. The average IC₅₀ values of the new compounds for hydratase activity ranged from 0.033 to 0.14 渭M for hCA-I and from 0.030 to 0.11 渭M for hCA-II. Among the newly synthesized compounds, 2-[[5-(2,4-dichlorophenylamino)-1,3,4-thiadiazol-2-yl]thio]-4′-bromoacetophenone can be considered as a promising hCA-II inhibitor owing to its selective and potent inhibitory effect on hCA-II. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Solvent based variations in yield of bioactive extracts from the sclerotium of Pleurotus tuber-regium was written by Ohiri, Reginald C.;Ifeanacho, Mercy O.;Preye, Keku. And the article was included in Chemica Sinica in 2019.Synthetic Route of C18H37Cl This article mentions the following:

Background: The therapeutic effectiveness of herbs and fungi used for medicinal purposes is not only a factor of their bioactive constituents but also a factor of both the extraction solvent and extraction method. Objective: The objective of this study is to extract and analyze the bioactive components in the sclerotum of Pleurotus tuber-regium using different solvents, as to ascertain the solvent that gives a better yield. Method: A quantity of 10.0 kg of fresh sclerotia of P. tuber-regium purchased at Zarama Market in Southern Nigeria was washed, peeled and the white inner parts were sliced using a sterilized knife. The sliced samples were dried at room temperature for fourteen days. After grinding, the bioactive components were extracted by weighing 10 g of sample into three well stopper bottles and each was extracted in 20 mL of specific extraction solvent (methanol, hexane and dichloromethane), while that of soxleth extraction was done in a soxleth apparatus, using ethanol as the solvent. The process was repeated twice and the combined aliquot obtained were concentrated to 5.0 mL and purified. Two milliliters of the extracts were used for gas chromatog. and mass spectroscopy anal. Result: The highest peak on the chromatogram for the methanol extract was observed at 32.644 min., while hexane, dichloromethane and soxhlet extracts had their highest peaks at 31.459 min., 14.254 min. and 18.060 min. resp. The highest bioactive component in methanol extract was (3aR,4R,7R)-1,4,9,9-Tetramethyl-3, 4,5,6,7,8-hexahydro2H-3a,7-methane with a value of 62.856%, while hexane, dichloromethane and soxhlet extracts had Hexasiloxane, tetradecamethyl-, Bis(2-ethylhexyl) phthalate and Phthalic acid, 3-chlorobenzyl Bu ester with values of 29.170%, 5.092% and 25.490% resp. Conclusion: Hexane and dichloromethane extracts yielded more bioactive components with better nutriceutical and medicinal properties and may be regarded as better solvents for mushroom and fungi extractions. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Synthetic Route of C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quantitatively relating the structural performance of polyamide layer with skin layer modified via in-situ precipitation was written by Zuo, Hao-Ran;Pang, Shu-Ya;Duan, Ming;Su, Wei;Shu, Hang;Xu, Xiang-Feng. And the article was included in Journal of Membrane Science in 2022.Application In Synthesis of Trimesoylchloride This article mentions the following:

How the structure of skin layer determines the structure of incipient film and final membrane formed during interfacial polymerization is decisive for polyamide composite membranes but difficult to monitor. This work introduced a methodol. to predict an estimated initial molar ratio between monomers (畏) via introducing pore diameter (dp), porosity (蔚Skin), tortuosity (蟿Skin), and thickness (lSkin) of skin layer to Fick’s diffusion law to correct flux of monomers. The structure of skin layer was regulated via in-situ preparation of sacrificial precipitation With characterized parameters of dp = 25.91 nm, 蔚Skin = 8.32%, 蟿Skin = 7.41, and lSkin = 260 nm, 畏 was 4.25. The resultant forward osmosis membrane exhibited flux of 58.83 卤 3.58 L/(m2路h) and reverse salt flux of 10.68 卤 2.38 g/(m2路h) under AL-DS mode with 1.0 mol/L NaCl and DI as draw and feed solution, resp., which had broken historical upper boundary. The proposed methodol. can make quant. prediction for the structural performance of polyamide composite membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application In Synthesis of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

3,4,5-Trisubstituted isoxazoles as novel PPAR未 agonists. Part 2 was written by Epple, Robert;Azimioara, Mihai;Russo, Ross;Xie, Yongping;Wang, Xing;Cow, Christopher;Wityak, John;Karanewsky, Don;Bursulaya, Badry;Kreusch, Andreas;Tuntland, Tove;Gerken, Andrea;Iskandar, Maya;Saez, Enrique;Martin Seidel, H.;Tian, Shin-Shay. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Application In Synthesis of Methyl 3-chloro-4-hydroxyphenylacetate This article mentions the following:

A series of PPAR未-selective agonists was investigated and optimized for a favorable in vivo pharmacokinetic profile. Isoxazole LCI765 (I) was a potent and selective PPAR未 agonist with good in vivo PK properties in mouse (C_max = 5.1 渭M, t_1/2 = 3.1 h). LCI765 regulated expression of genes involved in energy homeostasis in relevant tissues when dosed orally in C57BL6 mice. A co-crystal structure of compound LCI765 and the LBD of PPAR未 is discussed. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Application In Synthesis of Methyl 3-chloro-4-hydroxyphenylacetate).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of Methyl 3-chloro-4-hydroxyphenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of thiourea and nicotinamide-containing sorafenib analogs as antitumor agents was written by Kong, Xiangkai;Yao, Zeyu;He, Zuopeng;Xu, Wenfang;Yao, Jianwen. And the article was included in MedChemComm in 2015.HPLC of Formula: 6590-96-1 This article mentions the following:

A series of thiourea and nicotinamide-containing sorafenib analogs (7a-n) were designed and synthesized and their antiproliferative activities were tested against HCT116, MDA-MB-231, PC-3 and HepG2 cell lines. Most of the compounds showed potent activities against the four cell lines, compound 7h showed better activities than sorafenib against all four cell lines, and compounds 7a and 7e showed better activities against HCT116 and MDA-MB-231 cell lines. The anti-angiogenic activities of 7e and 7h were also better than that of sorafenib in both in vitro HUVEC tube formation assay and ex vivo rat thoracic aorta ring assay. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1HPLC of Formula: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Borole/Borapyramidane Relationship was written by Sun, Qiu;Daniliuc, Constantin G.;Yu, Xiaoye;Mueck-Lichtenfeld, Christian;Kehr, Gerald;Erker, Gerhard. And the article was included in Journal of the American Chemical Society in 2022.SDS of cas: 76-83-5 This article mentions the following:

Boroles and borapyramidanes are classical and nonclassical constitutional isomers, resp. It is here shown that they can indeed be interconverted. Treatment of the bis(alkynyl)B(C₆F₅) SMe₂ adduct 3路SMe₂ with HB(C₆F₅)₂ gave borole 1路SMe₂, featuring trimethylsilyl substituents in both 伪 positions to B, by a 1,1-hydroboration/alkenylboration sequence. Photolysis of the classical borole adduct 1路SMe₂ resulted in rearrangement to its nonclassical structural isomer, borapyramidane 2, in high yield, which exhibits a vicinal pair of trimethylsilyl substituents at the square pyramidane base. Neutral borapyramidane 2 is a rare example of an isoster of the (CH)₅⁺ pyramidane cation. Thermolysis of borapyramidane 2 in the presence of SMe₂ at 60掳 re-formed borole 1路SMe₂, which converted at 100掳 to 2,3-bis-silyl-substituted borole isomer 8路SMe₂. Its photolysis also gave borapyramidane 2. Prolonged photolysis of 2 at elevated temperatures converted this to borapyramidane isomer 10 containing a pair of trimethylsilyl groups in 1,3-position at its square C₄-pyramidal base. The borole and borapyramidane isomers were characterized by x-ray diffraction, and the system was analyzed by d. functional theory (DFT) calculations In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5SDS of cas: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

4-(1-Adamantylmethyl)-N-(2-chloro-9-isopropyl-9H-purin-6-yl)aniline was written by Rouchal, Michal;Necas, Marek;Vicha, Robert. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2009.Quality Control of 2,6-Dichloro-9-isopropyl-9H-purine This article mentions the following:

The asym. unit of 4-(1-adamantylmethyl)-N-(2-chloro-9-isopropyl-9H-purin-6-yl)aniline, C₂₅H₃₀ClN₅, consists of 2 mols. with slightly different geometrical parameters. The dihedral angles between the purine and benzene rings are 39.54(5) and 23.69(5)掳 in the 2 mols. The adamantane cages consist of 3 fused cyclohexane rings in classical chair conformations, with C-C-C angles of 108(2)-111(2)掳. In the crystal, mols. are linked into dimers via 2 N-H路路路N H bonds. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Quality Control of 2,6-Dichloro-9-isopropyl-9H-purine).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 2,6-Dichloro-9-isopropyl-9H-purine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Phyto-chemical studies of methanol extracts of tinospora cordifolia stem by GC-MS was written by Sinha, Anita;Sharma, H. P.;Singh, Binod;Patnaik, Amit. And the article was included in World Journal of Pharmaceutical Research in 2017.Electric Literature of C18H37Cl This article mentions the following:

Plants are the almost exclusive source of drugs for majority of the world population. The phyto components present in Tinospora cordifolia, locally known as Gilloy, Guduchi or Amrita, is used in the treatment of various ailments in the long-established medicinal system in the state of Jharkhand, India and is also an anti-oxidant and immuno-modulator. Present study was carried out to investigate the phyto-constituenst of the Tinospora cordifolia which contain terpenoids, steroids, glycosides, flavonoids and phlobatannins etc. are confirmed by preliminary phyto-chem. studies. GC-MS anal. of methanol extract of the plant showed the presence of 64 bioactive compounds Some of them are of great interest as they are either anti- cancer or anti-oxidant or both, such as pentanoic acid, Pr ester or valproic acid, phytol or 2-hexadecen-1-ol and 9, 12-octadecadienoic acid (Z, Z), benzenepropanoic acid, 2, 5-dimethoxy-, hexadecanoic acid, Me Ester, octadecanoic acid, n-hexadecanoic acid or palmitic acid. Among all these reported anti-cancer compounds, n-hexadecanoic acid or palmitic acid was present in highest proportion (area 23.12%) in the GC-MS chromatogram. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Electric Literature of C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics