Tag: 200-300

Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors was written by Subramaniam, Rajesh;Haldar, Manas K.;Tobwala, Shakila;Ganguly, Bratati;Srivastava, D. K.;Mallik, Sanku. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Quality Control of 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:

A series of bis(arylsulfonamide) hydroxamate inhibitors were synthesized. These compounds exhibit good potency against MMP-7 and MMP-9 depending on the nature, steric bulk, and substitution pattern of the substituents in the benzene ring. In general, the preliminary structure-activity relationships (SAR) suggest that among the 2,3-diaminopropanoic acid hydroxamates (i) electron-rich benzene rings of the sulfonamides may produce better inhibitors than electron-poor analogs. However, potential H-bond acceptors can reverse the trend depending on the isoenzyme; (ii) isoenzyme selectivity between MMP-7 and -9 can be conferred through steric bulk and substitution pattern of the substituents in the benzene ring, and (iii) the MMP-10 inhibition pattern of the compounds paralleled that for MMP-9. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Quality Control of 2,4-Dimethoxybenzene-1-sulfonyl chloride).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 2,4-Dimethoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antitumor activity of bis(arylsulfonyl)dihydroimidazolinone derivatives was written by Sittihan, Satapanawat;Jumpathong, Watthanachai;Sopha, Pattarawut;Ruchirawat, Somsak. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Recommanded Product: 777-44-6 This article mentions the following:

A series of novel bis(arylsulfonyl)dihydroimidazolinones with different aryl substitution patterns, I (Ar = 4-MeC₆H₄, 2-naphthyl, 2,6-F₂C₆H₃, 8-quinolinyl, etc.) were readily synthesized and evaluated for their antitumor activities. Some of the newly synthesized compounds exhibited cytotoxicity at micromolar range against multiple cancer cell lines, including A549, HepG2, HuCCA-1, and MOLT-3. The most potent analog contained pentafluorobenzenesulfonyl groups, which could be chem. elaborated to serve as a potential pharmacophore. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Recommanded Product: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Practical synthesis of iminochlorothioformates: application of iminochlorothioformates in the synthesis of novel 2,3,4,9-tetrahydroisothiazolo[5,4-b][1,8]naphthyridine-3,4-diones and 2,3,4,9-tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione derivatives was written by Chu, Daniel T. W.;Claiborne, Akiyo K.. And the article was included in Journal of Heterocyclic Chemistry in 1990.COA of Formula: C10H8Cl2FNO3 This article mentions the following:

The synthesis of fluoropiperazinylcyclopropyltetrahydroisothiazolonaphthyridinedione and difluoropiperazinylcyclopropyltetrahydroisothiazoloquinolinediones I (X = N, CF) is described. The key step involves the one-pot formation of 2-phenylthio derivatives of dihydro-4-oxonaphthyridine-3-carboxylate II (R = Cl, X = N) and the corresponding quinoline derivative II (R = F, X = CF) by condensation of β-keto esters III with Ph iminochlorothioformate. A simple and practical synthesis of iminochlorothioformates using isothiocyanates and mercaptans is also described. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6COA of Formula: C10H8Cl2FNO3).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C10H8Cl2FNO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration was written by Ruzi, Rehanguli;Ma, Junyang;Yuan, Xiang-Ai;Wang, Wenliang;Wang, Shanshan;Zhang, Muliang;Dai, Jie;Xie, Jin;Zhu, Chengjian. And the article was included in Chemistry – A European Journal in 2019.Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

An unprecedented deoxygenative arylation of aromatic carboxylic acids was achieved, allowing the construction of an enhanced library of unsym. diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chem. allows for precise cleavage of a stronger C-O bond and formation of a weaker C-C bond by 1,5-aryl migration under mild reaction conditions. This new protocol was independent of substrate redox-potential, electronic, and substituent effects. It afforded a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A photoaffinity displacement assay and probes to study the cyclin-dependent kinase family was written by Grant, Emma K.;Fallon, David J.;Eberl, H. Christian;Fantom, Ken G. M.;Zappacosta, Francesca;Messenger, Cassie;Tomkinson, Nicholas C. O.;Bush, Jacob T.. And the article was included in Angewandte Chemie, International Edition in 2019.Safety of 2,6-Dichloro-9-isopropyl-9H-purine This article mentions the following:

The CDK family plays a crucial role in the control of the cell cycle. Dysregulation and mutation of the CDKs has been implicated in cancer and the CDKs have been investigated extensively as potential therapeutic targets. Selective inhibition of specific isoforms of the CDKs is crucial to achieve therapeutic effect while minimizing toxicity. We present a group of photoaffinity probes designed to bind to the family of CDKs. The site of crosslinking of the optimized probe, as well as its ability to enrich members of the CDK family from cell lysates, was investigated. In a proof of concept study, we subsequently developed a photoaffinity probe-based competition assay to profile CDK inhibitors. We anticipate that this approach will be widely applicable to the study of small mol. binding to protein families of interest. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Safety of 2,6-Dichloro-9-isopropyl-9H-purine).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of 2,6-Dichloro-9-isopropyl-9H-purine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The closeness of fit of antibenzoate antibodies about haptens and the orientation of the haptens in combination was written by Pressman, David;Siegel, Malcolm;Hall, Luther A. R.. And the article was included in Journal of the American Chemical Society in 1954.Related Products of 5344-49-0 This article mentions the following:

The inhibitory action of chloro-substituted phenylazobenzoates on the specific precipitation of antibodies formed against benzoate ions yielded information about the closeness of fit about hapten of the previously uninvestigated portion of the antibody complementary region. With antibodies to the o-azobenzoate ion, the fit about the benzene ring was closest in the 3- and 4-positions and least close in the 6-position. With antibodies to m-benzoate, the fit was closest in the 4-position, least close in the 5-position, and intermediate in the 2- and 6-positions. For those cases where 2 orientations for the combination of hapten with antibody are possible, such as with the chlorobenzoates, the relative distribution was calculated For example, m-chlorobenzoate, which has been considered to combine with anti-m-azobenzoate antibodies with the Cl in the azospecific site of the antibody, is calculated to combine to the extent of 10% in the nonpreferred orientation. The following substituted benzoic acids (R = p-hydroxyphenylazo) were prepared, m.ps. are given: 3,2-Cl, R, 187-9°; 4,2-Cl, R, 245-6°; 5,2-Cl, R, 231-3°; 6,2-Cl, R, 194-5°; 2,3-Cl, R, 219-21°; 4,3-Cl, R, 268-71°; 5,3-Cl, R, 239-41°; 6,3-Cl, R, 244-6°; 2,4-Cl, R, 213-15°; o-R, 207.8-8.2°; m-R, 230-2°; p-R, 277-9° (decomposition). In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Related Products of 5344-49-0).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 5344-49-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of composite thin-film nanofiltration membranes based on polyethersulfone for water purification was written by El-Zahhar, Adel A.;Alghamdi, Majed M.;Alshahrani, Norah M.;Awwad, Nasser S.;Idris, Abubakr M.. And the article was included in Journal of Polymers and the Environment in 2022.Recommanded Product: 4422-95-1 This article mentions the following:

The development of thin-film composite membranes has gained more importance as they exhibit higher permeability, higher solute rejection and improved antifouling behavior. The incorporation of hydrophilic nanomaterials within the composite thin film has reported to effectively increase the hydrophilicity and improve the membrane performance. In this study novel thin-film composite nanofiltration membranes were prepared by interfacial polymerization of trimesoyl chloride, polyvinylpyrolidone (PVP) and montmorillonite (MMT) composite on the porous polyethersulfone membrane. The effect of preparation parameters was studied as; reaction time, PVP concentration and MMT content. The properties of the prepared composite thin-film membranes were analyzed in terms of their chem. structure, surface morphol. features, pure water contact angle, zeta potential, pure water permeation flux (PWP) and solutes rejection. The prepared composite thin-film membranes showed smoother surfaces, different surfaces functionality and amphoteric surfaces with points of zero charge at pH 7-7.5. The PWP was found to increase with increasing MMT content up to 0.10 wt%. The rejection of crystal violet dye (CV) was studied using the prepared membranes. The membrane with 0.5% PVP, 0.10% MMT and 6 min reaction time showed PWP of 18.1 L/m2 h bar and CV rejection of 80.01%. The rejection of Na2SO4 and MgCl2 increased with increasing MMT content and reached 96% and 35.4%, resp. The steady state flux was decreased by 5% with increasing MMT content from 0.10 to 0.12 wt% indicating improved antifouling behavior with MMT. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Recommanded Product: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics