Tag: 200-300

Synthesis, biological evaluation, and docking study of indole aryl sulfonamides as aromatase inhibitors was written by Fantacuzzi, Marialuigia;De Filippis, Barbara;Gallorini, Marialucia;Ammazzalorso, Alessandra;Giampietro, Letizia;Maccallini, Cristina;Aturki, Zeineb;Donati, Enrica;Ibrahim, Reham S.;Shawky, Eman;Cataldi, Amelia;Amoroso, Rosa. And the article was included in European Journal of Medicinal Chemistry in 2020.Electric Literature of C8H9ClO4S This article mentions the following:

In order to identify new aromatase enzyme inhibitors, thirty aryl sulfonamide derivatives containing an indole nucleus have been synthesized. The enzyme inhibition assay showed that four compounds inhibit aromatase in the sub-micromolar range. Loading concentrations of these four compounds were afterwards tested for cell viability and cytotoxicity on MCF7 human breast cancer cells, revealing a time- and dose-dependent decrease of active metabolizing cells over the time of the culture (0-72 h), starting from a concentration of 100μM. Likewise LDH released raised up to 40% at early time of exposures (24 h). Finally, the docking study showed that the best active compounds efficiently bound in the active site of the aromatase; high values of HBD and low levels of HBA are the principal requirement evidenced by the QSAR model. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and molecular docking study of piperazine derivatives as potent urease inhibitors was written by Taha, Muhammad;Wadood, Abdul. And the article was included in Bioorganic Chemistry in 2018.Recommanded Product: 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Urease is known to be one of the major causes of diseases induced by Helicobacter pylori, thus allow them to survive at low pH inside the stomach and thereby, play an important role in the pathogenesis of gastric and peptic ulcer, apart from cancer as well. Keeping in view the great importance of urease inhibitors, here in this study the authors have synthesized piperazine derivatives (1-15) and evaluated for their urease inhibitory activity. All analogs showed excellent inhibitory potential with IC₅₀ values ranging between 1.1±0.01 and 33.40±1.50 μM when compared with the standard inhibitor thiourea (IC₅₀ = 21.30±1.10 μM). Structure activity relationship has been established for all compounds which are mainly based upon the substitution on Ph ring. Mol. docking study was performed to understand the binding interaction of the compounds in the active site of enzyme. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A synthesis of functionalized 2-imino-1,3-thiazoles from tetramethylguanidine, isothiocyanates, and 2-chloro-1,3-dicarbonyl compounds was written by Yavari, Issa;Malekafzali, Alaleh;Seyfi, Samereh. And the article was included in Journal of the Iranian Chemical Society in 2014.Computed Properties of C7H3Cl2NS This article mentions the following:

Synthesis of functionalized 2-imino-1,3-thiazoles I [R¹ = Et, Ph, PhCO, 4-FC₆H₄, etc.; R² = Me, OEt] via Hantzsch method modified by the reaction of 2-chloro-1,3-dicarbonyl compounds with 2-(amidosulfanylenemethyl)-1,1,3,3-tetramethylguanidines (prepared in situ from tetramethylguanidine and isothiocyanates) were reported. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Computed Properties of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Crude extract of Origanum vulgare L. induced cell death and suppressed MAPK and PI3/Akt signaling pathways in SW13 and H295R cell lines was written by Rubin, Beatrice;Mansi, Jacopo;Monticelli, Halenya;Bertazza, Loris;Redaelli, Marco;Sensi, Francesca;Zorzan, Maira;Scaroni, Carla;Mian, Caterina;Iacobone, Maurizio;Armanini, Decio;Bertolini, Cristina;Barollo, Susi;Boscaro, Marco;Pezzani, Raffaele. And the article was included in Natural Product Research in 2019.COA of Formula: C18H37Cl This article mentions the following:

Oregano (Origanum vulgare L.) is a common aromatic plant used in Mediterranean and Asian Regions for treating respiratory diseases, painful menstruation, rheumatoid arthritis, etc. Recently its role as an anticancer plant has been suggested, although oregano has been never evaluated into adrenocortical tumor cell models. This study analyzed for the first time the anticancer effects of a crude extract of wild mountain oregano (Origanum vulgare L.) in SW13 and H295R cell lines. The crude extract was characterised by GC/MS and the toxic effects of oregano were first analyzed by brine shrimp lethality assay. Our findings demonstrated that oregano decreased cell viability, survival, modified cell cycle and induced cell death (through necrotic process) and that the effects can be attributed to a blockade of MAPK and PI3 K/Akt pathways. These results suggest that oregano extract exerts anticancer activities in adrenocortical tumor cell lines, providing evidence for further research in higher models. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Molecular insights into the structure-property relationships of 3D printed polyamide reverse-osmosis membrane for desalination was written by He, Jinlong;Yang, Jason;McCutcheon, Jeffrey R.;Li, Ying. And the article was included in Journal of Membrane Science in 2022.HPLC of Formula: 4422-95-1 This article mentions the following:

3D-printing is an emerging method for manufacturing polyamide (PA) reserve osmosis (RO) membranes for water treatment and desalination, which can precisely control membrane structural properties, such as thickness, roughness, and resolution However, the synthesis-structure (i.e., degree of crosslinking (DC), m-phenylenediamine/trimesoyl chloride (MPD/TMC) ratio, and membrane thickness) to property (permeability and water-salt selectivity) relationships for these membranes has not been well understood. At the same time, a microscopic understanding of the phys. mechanism of water and salt transport is needed to guide the design of high-performance 3D-printed membranes and improve the printing efficiency. Thus, the at.-scale transport features and energetics of water and salt ions are studied at high pressure for the 3D-printed PA RO membranes with the different DCs and MPD/TMC ratios through non-equilibrium mol. dynamics (NEMD) simulations. Factoring in membrane structure properties, rejection ratio of salt ions and pressure-dependent water flux, 3D-printed PA membranes having an MPD/TMC ratio of 3.0:2.0 and a DC between 80%∼90% attains ideal performance: high water flux, high rejection of salt ions, and excellent structural integrity. Mechanistically, water permeability for highly cross-linked PA RO membranes depends on the temporary on-and-off channels that allow water mols. to jump from one cavity to another at high pressure. In addition, higher pressures cause rapid compaction of PA membranes’ free volume and membrane thickness. Membrane failure at high pressure is determined by the DC and MPD/TMC ratios-dependent compressive yield strength. In short, these findings provide phys. insights for optimizing existing PA membranes and designing next-generation desalination membranes at the mol. level. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1HPLC of Formula: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Antileishmanial potential of fused 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiols: synthesis, biological evaluations and computational studies was written by Patil, Sanjeev R.;Asrondkar, Ashish;Patil, Vrushali;Sangshetti, Jaiprakash N.;Kalam Khan, Firoz A.;Damale, Manoj G.;Patil, Rajendra H.;Bobade, Anil S.;Shinde, Devanand B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Product Details of 6590-96-1 This article mentions the following:

A series of newer benzylideneamino(pyrazinyl)triazole-thiols I [R = 2-HOC₆H₄, 2,4-di-HOC₆H₃, 4-FC₆H₄, 2-HO-naphthyl, etc.] and benzyl(pyrazinyl)sulfanyl-triazolyl-thioureas II [R = Ph, 4-FC₆H₄, 4-ClC₆H₄, 2-naphthyl, etc.] a triazole fused with pyrazine moiety of pharmacol. significance was synthesized. All the synthesized compounds were screened for their in vitro antileishmanial and antioxidant activities. Compounds I [R = 4-HOC₆H₄] (IC₅₀ = 79.0 μM) and II [R = 2,4-di-ClC₆H₃] (IC₅₀ = 79.0 μM) were shown significant antileishmanial activity when compared with standard sodium stibogluconate (IC₅₀ = 490.0 μM). Compounds I [R = 4-Me₂NC₆H₄] (IC₅₀ = 13.96 μM) and II [R = 3-FC₆H₄] (IC₅₀ = 13.96 μM) showed significant antioxidant activity. After performing mol. docking study and analyzing overall binding modes it was found that the synthesized compounds had potential to inhibit L. donovani pteridine reductase 1 enzyme. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Product Details of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Prediction of pK_a of organic compounds in acetonitrile with QSPR method was written by Xie, Kun;Qiao, Shu;Fu, Chuan;Cheng, Cong. And the article was included in Zhongguo Kexue Jishu Daxue Xuebao in 2010.COA of Formula: C7H4ClNO4 This article mentions the following:

The quant. structure-property relationships (QSPR) model for pK_a values of 43 organic compounds in acetonitrile were established by using electrotopol. state indexes as descriptors. Leave-one-out cross validation was performed, which confirmed the good stability and powerful prediction of this model. A satisfactory relationship is expressed as pK_a = 0.225E₂ – 0.146E₄ – 1.929E₅ – 7.799E₆ – 5.049E₈ + 0.532 7E₉ – 1.553E₁₀ + 20.528, where R = 0.986, s=0.532 without any random correlation. The result indicates that the electrotopol. state indexes can be effectively used for the prediction of pK_a values of organic compounds In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0COA of Formula: C7H4ClNO4).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives was written by Yang, Shan;Liu, Lingling;Zhou, Zheng;Huang, Zhibin;Zhao, Yingsheng. And the article was included in Organic Letters in 2021.Related Products of 777-44-6 This article mentions the following:

Herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction is reported. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation and characterization of novel thin film composite forward osmosis membrane with halloysite nanotube interlayer was written by Cheng, Bohao;Wang, Yifan;Wu, Xiaowen;Fang, Minghao;Min, Xin;Huang, Zhaohui;Liu, Yan’gai;Mi, Ruiyu. And the article was included in Polymer in 2022.Synthetic Route of C9H3Cl3O3 This article mentions the following:

In this study, the electrospun polyacrylonitrile (ePAN) fiber mats were used as support layer and natural mineral-halloysite nanotubes (HNTs) was used to construct the interlayer. Polydopamine modification was utilized to enhance the hydrophilicity of ePAN substrates and dispersibility of HNTs. The mHNTs interlayer effectively minified the surface pore size of substrates providing a better interface for interfacial polymerization forming an integrated and thin PA selective layers. Compared to the unmodified membranes, the water flux of the optimized membrane with mHNTs interlayer about 61.60% and 79.70% higher and the reverse salt flux of which was 38.95% and 45.08% lower in AL-FS mode and AL-DS mode resp. These results suggested that introducing halloysite nanotube interlayer is an effective, and low-cost way to fabricate high-performance FO membrane. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Synthetic Route of C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of polynuclear heterocycles. Part 4. imidazo[4,5-g][3,1]benzoxazinones, imidazo[4,5-g]quinazolinones, imidazo[4,5-g]quinazolinediones, and imidazo[4,5-f]indazolinones was written by Alkhader, Mohamed A.;Perera, R. Clinton;Sinha, Rajeshwar P.;Smalley, Robert K.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1979.Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate This article mentions the following:

Several 1,2-disubstituted 6-aminobenzimidazole-5-carboxylic acids and their Et esters were prepared in several steps from 4,3-Cl(O₂N)C₆H₃CO₂Et. The amino acids reacted with acyl halides in pyridine to give 7-arylimidazo[4,5-g][3,1]benzoxazin-5-ones, with urea or KCN to give imidazo[4,5-g]quinazoline-5,7-diones, and with HCONH₂ to give imidazo[4,5-g]quinazolin-5-ones. 6-Amino- and 6-(acylamino)imidazo[4,5-g]quinazolin-5-ones were prepared by treating the acylated amino esters with N₂H₄, or by cyclizing the derived aminohydrazides with an acylating agent. Imidazo[4,5-f]indazolin-5-ones were obtained by the action of ethanolic N₂H₄.H₂O on 6-azido-5-ethoxycarbonylbenzimidazoles. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: Ethyl 4-chloro-3-nitrobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics