Tag: 200-300

Pd-catalyzed Heck-conjoined amidation and concomitant chemoselective Michael-addition: an efficient tandem approach to highly functionalized tetrahydroquinazolines from o-haloanilines was written by Saunthwal, Rakesh K.;Patel, Monika;Danodia, Abhinandan K.;Verma, Akhilesh K.. And the article was included in Organic & Biomolecular Chemistry in 2015.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

An efficient palladium-catalyzed tandem approach for the synthesis of highly functionalized tetrahydroquinazolines by the reaction of o-haloanilines with acrylates and isothiocyanates/isocyanates via Heck-conjoined amidation/thioamidation and concomitant chemoselective Michael-addition is described. E.g., in presence of PdCl₂, PPh₃, and K₂CO₃ in DMF, reaction of 2-IC₆H₄NH2, CH₂:CHCO₂Me, and PhNCS gave 75% tetrahydroquinazoline derivative (I). A competitive experiment showed that isothiocyanates were more reactive than isocyanates. The developed methodol. offers an efficient chemoselective process for the synthesis of highly functionalized tetrahydroquinazolines under mild and operationally simple reaction conditions from inexpensive and com. available starting substrates. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Photocatalytic degradation of organic compounds by TFC membranes functionalized with Ag/rGO nanocomposites was written by Elbakry, Shimaa;Ali, Mohamed E. A.;Abouelfadl, Moustafa;Badway, Nagwa A.;Salam, Karima M. M.. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.HPLC of Formula: 4422-95-1 This article mentions the following:

Todays, semiconductor nanomaterials are used extensively as an effective photocatalyst for organic compound degradation The main challenge in photodegradation is the separation of nanomaterials from treated solutions To overcome this problem a novel crosslinked membrane composed of thin-film polyamide/silver/reduced graphene oxide (PA/Ag/rGO) was successfully deposited on the surface of cellulose acetate membrane (CA). The prepared Ag/rGO nanocomposite and Ag/rGO/CA/TFC membranes were characterized using SEM and FTIR. The crystal structure of Ag/rGO was confirmed by XRD. EDX anal. indicates the successful deposition of Ag/rGO nanocomposite in the polyamide thin film (TFC) matrix. The high hydrophilicity of the Ag/rGO/CA/TFC membrane was confirmed by contact angle measurements, which decreased from 76 ± 5° to 45 ± 1 upon modification. The prepared membranes were applied for photocatalytic degradation of methylene blue dye (MB). Within 20 min, the synthesized Ag/rGO nanocomposite achieved fast degradation equilibrium with an efficiency of 98%, Ag/rGO/CA/TFC membranes displayed a 92% efficiency, showing the remarkable ability for decomposition of MB and excellent efficiency for wastewater treatment. The degradability was greatly boosted with a high efficiency even after four runs. The increased photocatalytic activity of thin film (TFC) membrane-covered Ag/rGO nanocomposites could be useful in energy and environmental applications, as well as a potential choice for superior wastewater dyes removal. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1HPLC of Formula: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyanation of Unactivated Aryl Chlorides and Aryl Mesylates Catalyzed by Palladium and Hemilabile MOP-Type Ligands was written by Tu, Yahui;Zhang, Yi;Xu, Sheng;Zhang, Zhaoguo;Xie, Xiaomin. And the article was included in Synlett in 2014.Category: chlorides-buliding-blocks This article mentions the following:

Palladium-catalyzed cyanation of aryl halides and pseudo halides with potassium hexacyanoferrate is described employing the hemilabile, bulky, and electron-rich MOP-type ligands. When the mixture of t-BuOH and H₂O was used as the solvent and K₂CO₃ as the base, the MOP-type ligands showed high efficiency for the palladium-catalyzed cyanation. The effect of ligand structure was studied in detail, and 2-di-tert-butylphosphino-2′-isopropoxy-1,1′-binaphthyl was the more effective for the cyanation. The catalyst system allows the cyanation of unactivated aryl chlorides, and even aryl mesylates to occur in good yields. Furthermore, the reactivity of different arylated reagents in the catalytic system is: ArBr > ArCl >> ArOMs > ArOSO2Im > ArOSO2NMe2. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Category: chlorides-buliding-blocks).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors was written by Gilbert, Eric J.;Zhou, Guowei;Wong, Michael K. C.;Tong, Ling;Shankar, Bandarpalle B.;Huang, Chunli;Kelly, Joseph;Lavey, Brian J.;McCombie, Stuart W.;Chen, Lei;Rizvi, Razia;Dong, Youhao;Shu, Youheng;Kozlowski, Joseph A.;Shih, Neng-Yang;Hipkin, R. William;Gonsiorek, Waldemar;Malikzay, Asra;Lunn, Charles A.;Favreau, Len;Lundell, Daniel J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Related Products of 18437-66-6 This article mentions the following:

The triaryl bis-sulfone 1 was modified by converting the aryl A-ring to a piperidine ring. The piperidine ring was further elaborated to a spirocyclopropyl piperidine moiety. The effect on CB2 binding potency, rat calcium channel affinity, and CYP 2C9 inhibition is described. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Related Products of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed Benzylic C-H Insertion of 2-Substituted N-Iminopyridinium Ylides was written by Mousseau, James J.;Larivee, Alexandre;Charette, Andre B.. And the article was included in Organic Letters in 2008.Category: chlorides-buliding-blocks This article mentions the following:

Palladium-catalyzed direct benzylic C-H arylation of 2-alkyl substituted N-iminopyridinium ylides to afford the corresponding 2-arylalkyl-N-iminopyridinium ylides, e.g., I, is described. The insertion can be conducted with several electron-poor and electron-rich aryl chlorides in good yields. This work adds to the few examples of sp³ C-H insertions that have been reported so far. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Category: chlorides-buliding-blocks).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Diversity-oriented synthesis for novel, selective and drug-like inhibitors for a phosphatase from Mycobacterium tuberculosis was written by He, Rongjun;Bai, Yunpeng;Yu, Zhi-Hong;Wu, Li;Gunawan, Andrea Michelle;Zhang, Zhong-Yin. And the article was included in MedChemComm in 2014.Formula: C7H3Cl2NS This article mentions the following:

Mycobacterium protein tyrosine phosphatase B (mPTPB) is a potential drug target of tuberculosis (TB). Using small mol. inhibitors of mPTPB could be a treatment to overcome emerging TB drug resistance. Using a Diversity-Oriented Synthesis (DOS) strategy, we successfully developed a salicylic acid based and drug-like mPTPB inhibitor with an IC₅₀ of 2 μM and >20-fold specificity over many human PTPs, making it an excellent lead mol. for anti-TB drug discovery. In addition, DOS generated bicyclic salicylic acids are also promising starting points for acquiring inhibitors targeting other PTPs. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Distinct impact of substrate hydrophilicity on performance and structure of TFC NF and RO polyamide membranes was written by Dai, Ruobin;Yang, Zhe;Qiu, Zhiwei;Long, Li;Tang, Chuyang Y.;Wang, Zhiwei. And the article was included in Journal of Membrane Science in 2022.Application In Synthesis of Trimesoylchloride This article mentions the following:

Substrate properties have profound impacts on the structure and performance of both thin-film composite (TFC) nanofiltration (NF) and reverse osmosis (RO) polyamide (PA) membranes. Some studies have previously investigated the impact of substrate hydrophilicity on PA formation and TFC membrane performance. However, the observed phenomena and explanations remain contradictory in literature. Herein, we performed interfacial polymerization (IP) reactions of both piperazine (PIP)-trimesoyl chloride (TMC) and m-phenylenediamine (MPD)-TMC systems on substrates with different hydrophilicity. We found that the TFC RO membrane showed higher water permeance and NaCl rejection on the relatively hydrophobic substrate, while the TFC NF membrane favored the relatively hydrophilic substrate. The critical importance of interfacial degassing and local monomer concentration was highlighted to dissect the distinct impact of substrate hydrophilicity. For the MPD-TMC system, interfacial nanobubble generation was inhibited because of the decreased local MPD concentration and heat production for the more hydrophilic substrates, resulting in a decrease in the roughness feature and compromised water permeance of RO membranes. In contrast, interfacial degassing was not a dominant mechanism in the PIP-TMC system due to the slower reaction rate of PIP-TMC than MPD-TMC. Consequently, the PA layer of NF membrane became thinner and looser when the substrate became more hydrophilic, resulting from the diluted local PIP concentration Our study unveils the fundamental relationship among substrate hydrophilicity, PA structure, and separation performance of both TFC NF and RO PA membranes, providing important guides on their design and synthesis. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application In Synthesis of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One-pot synthesis of polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety was written by Ye, Zhenjun;Xu, Renbo;Shao, Xusheng;Xu, Xiaoyong;Li, Zhong. And the article was included in Tetrahedron Letters in 2010.Computed Properties of C10H8Cl2FNO3 This article mentions the following:

Polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety, e. g. I, were readily prepared in high yields via one-pot multicomponent reaction catalyzed by piperidine. This present protocol provides an efficient synthetic route to the target compounds with the characteristics of short reaction time, high yield, and easy separation of the products. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Computed Properties of C10H8Cl2FNO3).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C10H8Cl2FNO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and QSAR studies of thiosemicarbazides, 1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles derivatives as potential antibacterial agents was written by Desai, N. C.;Bhavsar, A. M.;Shah, M. D.;Saxena, Anil K.. And the article was included in Indian Journal of Chemistry in 2008.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Several new 2-(2-(4-chlorophenyl)acetyl)-N-arylhydrazinecarbothioamides, e.g., I, 5-(4-chlorobenzyl)-4-aryl-4H-1,2,4-triazole-3-thiols, e.g., II, 5-(4-chlorobenzyl)-N-aryl-1,3,4-thiadiazol-2-amines, e.g., III (X = S), and 5-(4-chlorobenzyl)-N-aryl-1,3,4-oxadiazol-2-amines, e.g., III (X = O), have been synthesized and screened for their antibacterial activity against the gram pos. and gram neg. bacteria S. aureus and E. coli. The QSAR studies of these compounds have been carried out in terms of structural and physicochem. parameters. A pos. contribution of bulkier substituents present at position 2 of I indicates an increase in hydrophobicity or steric bulk character. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of novel (thio)urea derivatives as potential antitumor agents was written by Jin, Chuanfei;Liang, Yong-Ju;He, Hongwu;Fu, Liwu. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2011.Formula: C7H3Cl2NS This article mentions the following:

A series of novel (thio)ureas containing the pyrimidinyl group was designed and synthesized. Their in-vitro antitumor activity against different human tumor cells was examined Some of the compounds showed potential antitumor activity, which provided some hints for further studies on structure modification. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics