Tag: 200-300

Cyclizations of Substituted Benzylidene-3-alkenylamines: Synthesis of the Tricyclic Core of the Martinellines was written by Frank, Kristine E.;Aube, Jeffrey. And the article was included in Journal of Organic Chemistry in 2000.Category: chlorides-buliding-blocks This article mentions the following:

The martinellines are natural products that possess both interesting biol. activity and chem. structure. During the investigation of a hetero Diels-Alder route to these mols., alternate Lewis acid-dependent cyclizations of (2′-amino-N’-tert-butoxycarbonyl-5′-chlorobenzylidene)-3-butenylamine were observed The reaction of a variety of imines with TMSOTf or TiCl₄ led to the formation of different heterocycles including iminodibenzo[b,f][1,5]diazocines, hexahydropyrido[1,2-c]quinazolin-6-ones, tetrahydropyrrolo[1,2-c]quinazolin-5-ones, 2-arylpiperidines, and 2-arylpyrrolidines. Tetrahydropyrrolo[1,2-c]quinazolin-5-one I, obtained via this new methodol., was used as an intermediate in the synthesis of the tricyclic ring system (II) of the martinellines. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Category: chlorides-buliding-blocks).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

GC-MS analysis of bioactive components in the methanolic extract of graviola (Gishta) seeds and their pharmacological activities was written by Saripalli, Harikrishna Ramaprasad;Dixit, Prasanna Kumar. And the article was included in International Journal of Pharma and Bio Sciences in 2021.COA of Formula: C18H37Cl This article mentions the following:

Bioactive substances are the leading-edge mols. in both the pharmaceutical and nutraceutical industries. Recently, bioactive compounds are gaining much importance for their enhanced resistance to numerous diseases and in boosting people′s health by both traditional and modern ways of administration. In traditional medicine, many plants have provided valuable clues for being used as potential antiparasitic, antimalarial, leishmanicidal, anti-tumor, fungicidal, and antibacterial compounds Still, several plants are yet to be screened for their abilities to stand forth as medicinal plants. Locally, Graviola (Gishta) fruits are being used for dietary purposes and traditional medicinal purposes, but their beneficial effects have never been attributed to the presence of active bio compounds Hence, the present investigation was undertaken to study Gas Chromatog.-Mass Spectrometry (GC-MS) anal. of methanolic extracts of Graviola seeds. GC-MS anal. method was employed with specific conditions such as Ion source temp 200°C, Interface temp 240°C, Scan range 40 – 1000 m/z, MS start time 5(min), MS end time 35 (min), Ionization EI (-70ev), Scan speed 2000. The methanolic extracts of Graviola seeds exhibited the presence of seventy types of bioactive compounds The foremost important compounds identified are 1H-Cyclopenta [l, 3] cyclopropa [l, 2] benzene, octa hydro-7-methyl-3-methylene-4-(1-Me ethyl) -, [3aS-(3a. alpha.,3b. beta., 4. beta., 7. alpha.,7 aS*)]-Bicyclo [4. 4. 0] dec-1-ene, 2-isopropyl-5-methyl-9-methylene-. gamma.-Muurolene. tetracosane, phytol and squalene. In an exceeding mass spectral view, each of the compounds has been identified based on their retention time and percentage of peak area(s). Analytes with high peak areas showed various pharmacol. properties such as antibacterial, antifungal, anticancer, etc. which provided exptl. evidence for its traditional medicinal claim. The spectra of phytochem. constituents found in the seed extracts signify the potential of the Graviola plant as a source of therapeutic agent(s) and may provide leads in the ongoing search for a novel phytotherapeutic agent. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetic and mechanistic consideration of the degradative oxidation of substituted mandelic acids by N-chlorosaccharin was written by Singh, V. P.;Khan, M. U.;Chauhan, D. B. S.;Verma, J. K.. And the article was included in Oxidation Communications in 1997.Application of 14070-51-0 This article mentions the following:

Kinetic data for the oxidation of p-chloro- and p-bromomandelic acids with N-chlorosaccharin (I) in aqueous AcOH were determined The reaction rate is a direct function of both [oxidant] and [substrate] in the lower concentration region, but tends toward zero order at higher substrate concentrations A retarding trend of H⁺ ions, solvent composition and saccharin on the system was observed The redox process proceeds via formation of an activated transition complex (1:1) between substrate and postulated HOCl reacting species of I, which slowly disintegrates into products. The oxidation products were confirmed, and a probable mechanism was suggested which was consistent with all observed kinetic results. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Application of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New application of 1,2,4-triazole derivatives as antitubercular agents. structure, in vitro screening and docking studies was written by Karczmarzyk, Zbigniew;Swatko-Ossor, Marta;Wysocki, Waldemar;Drozd, Monika;Ginalska, Grazyna;Pachuta-Stec, Anna;Pitucha, Monika. And the article was included in Molecules in 2020.Formula: C7H3Cl2NS This article mentions the following:

A series of 1,2,4-triazole derivatives I (Ar = 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridin-3-ylmethyl, pyridin-4-ylmethyl; R = 2-FC₆H₄, 2-ClC₆H₄, 4-MeOC₆H₄, etc.) were synthesized and assigned as potential anti-tuberculosis substances. The mol. and crystal structures for the model compounds I (Ar = 2-pyridyl; R = 2-FC₆H₄), I (Ar = 3-pyridyl, 4-MeOC₆H₄) and I (Ar = 2-pyridine-3-ylmethyl; R = 2,4-Cl₂C₆H₃) were determined using X-ray anal. The lipophilicity (logP) and electronic parameters as the energy of frontier orbitals, dipole moments, NBO net charge distribution on the atoms, and electrostatic potential distribution for all structures were calculated at AM1 and DFT/B3LYP/6-311++G(d,p) level. The in vitro test was done against M. tuberculosis H37Ra, M. phlei, M. smegmatis, and M. timereck. The obtained results clearly confirmed the antituberculosis potential of compound I (Ar = 2-pyridyl; 3,4-Cl₂C₆H₃) which turned out to be the most active against Mycobacterium H37Ra (MIC = 0.976μg/mL), Mycobaterium pheli (MIC = 7.81μg/mL) and Mycobacerium timereck (62.6μg/mL). Satisfactory results were obtained with compounds I (Ar = 3-pyridyl; R = 3,4-Cl₂C₆H₃), I (Ar = 2-pyridyl; R = C₆H₅) I (Ar =pyridin-4-ylmethyl; R = 3,4-Cl₂C₆H₃) vs. Myc. H37Ra, Myc. pheli, Myc. timereck (MIC = 31.25-62.5μg/mL). The mol. docking studies were carried out for all investigated compounds using the Mycobacterium tuberculosis cytochrome P 450 CYP121 enzyme as mol. a target connected with antimycobacterial activity. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rhenium Selenide Clusters Containing Alkynyl Ligands: Unexpected Reactivity of σ-Bound Phenylacetylide was written by Soto, Ernesto;Helmink, Katherine L.;Chin, Colleen P.;Ferguson, Michael;Peters, Steven J.;Szczepura, Lisa F.. And the article was included in Organometallics in 2022.Name: (Chloromethanetriyl)tribenzene This article mentions the following:

Three organometallic rhenium-based clusters containing phenylacetylide ligands, [Re₆Se₈(PEt₃)₅(CC-Ph)](SbF₆) (1) and cis- and trans-[Re₆Se₈(PEt₃)₄(CC-Ph)₂] (2 and 3), were synthesized and fully characterized including single-crystal x-ray diffraction analyses. Reactivity studies of 1 show that reaction with electrophilic reagents does not result in the formation of the vinylidene species as predicted; instead, elimination of the acetylide moiety is observed Products isolated from these reactions, including the Me sulfate complex, [Re₆Se₈(PEt₃)₅(OSO₃Me)](SbF₆) (4), have been characterized along with those obtained from the [2+2] cycloadditions of 1 with tetracyanoethylene and 7,7,8,8-tetracyanoquinodimethane. The relative reactivities of the electrophilic agents utilized are compared. Preliminary computational studies reveal useful information about the nature of the [Re₆Se₈]²⁺-acetylide bond and aid in our understanding of the reactivity associated with this cluster complex. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Name: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Photoredox-Mediated Mono- and Difluorination of Remote Unactivated Methylene C(sp³)-H Bonds of N-Alkyl Sulfonamides was written by Deng, Zhiqiang;Zhao, Zhenxiang;He, Gang;Chen, Gong. And the article was included in Organic Letters in 2021.Computed Properties of C8H9ClO4S This article mentions the following:

A photoredox-mediated δ-C(sp₃)-H fluorination of sulfonyl-protected primary alkylamines, e.g., N-cyclododecyl-4-methoxybenzenesulfonamide with Selectfluor is developed. The reaction can proceed in excellent monofluorination selectivity for amine substrates without α substituent. For α-substituted substrates R(CH₂)₃CH(R¹)NHS(O)₂-PMP (R = Me, Et, n-Bu; R¹ = Me, CH₂OBz), slightly modified reaction conditions with two rounds of operation gives the δ,δ-difluorination products RCF₂(CH₂)₂CH(R¹)NHS(O)₂-PMP in good yield. Mechanistic studies suggest SET oxidation of sulfonamide group directly generates the key sulfonamide N radical intermediate, which triggers a 1,5-HAT process to form the δ alkyl radical. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Computed Properties of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis was written by Meng, Ning;Tang, Hua;Zhang, Hao;Jiang, Chengshi;Su, Li;Min, Xiao;Zhang, Wannian;Zhang, Hua;Miao, Zhenyuan;Zhang, Wen;Zhuang, Chunlin. And the article was included in Free Radical Biology & Medicine in 2018.Electric Literature of C7H4ClF3O2S This article mentions the following:

Small-mol. inhibitors that block the Keap1-Nrf2 protein-protein interactions are being intensely pursued as a new therapeutic strategy for oxidative stress-related diseases, such as cancer, diabetes, Alzheimer’s disease, arteriosclerosis, inflammation and myocarditis. However, there are not enough studies on antioxidant treatments using small mols. in myocarditis. The authors herein provided a series of novel hydronaphthoquinones as the Keap1-Nrf2 interaction inhibitors targeting LPS-induced myocarditis both in vitro and in vivo. These compounds were designed through an in-silico fragment growing approach based on the previous reported compound The new compounds were predicted to form addnl. hydrogen bonds with the S363 residue, leading to higher inhibitory activity. Among these new derivatives, compounds I and II emerged as inhibitors with significant biochem. potency, as determined by fluorescent anisotropy assay and confirmed by surface plasmon resonance (SPR) and differential scanning fluorometry (DSF) assays. These inhibitors can dose-dependently protect the H9c2 cardiac cells against LPS-induced injury (100% at 2 μM and 4 μM) and effectively prolong survival or save the life of LPS-injured mice. Mechanistic studies showed that these inhibitors could release Nrf2 in H9c2 cells and LPS-inflammatory mouse models and translocate into the nucleus in a dose-response manner, which significantly increased the downstream genes (HO-1, NQO-1) and the pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), while ROS production dramatically decreased. Their protective effects and the mechanism of action were further confirmed by siNrf2 transfected experiment Collectively, the novel hydronaphthoquinones can be used as promising lead compounds for the study of Keap1-Nrf2 protein-protein interactions and further antimyocarditis drug development. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and properties of stearylhexylmethyl carboxyl betaine was written by Song, Hong-juan;Song, Bing-lei;Cui, Zheng-gang;Xu, Li-jun. And the article was included in Jingxi Huagong in 2015.Safety of 1-Chlorooctadecane This article mentions the following:

In order to gain insights into the effects of mol. structure on the properties of surfactants, an asym. double long-chain alkyl betaine, stearylhexylmethyl carboxyl betaine (C₁₈₊₆B), was synthesized using stearic acid and hexanoic acid as starting materials and its surface activity was measured and compared with that of didodecyl Me carboxyl betaine (diC₁₂B), a sym. double long-chain betaine with equal total carbon number The results showed that C₁₈₊₆B had a surface activity similar to that of diC₁₂B in general, but displays an aqueous solubility much better than that of diC₁₂B. As a surfactant for surfactant-polymer flooding free of alkali, C₁₈₊₆B seemed to be slightly less hydrophobic against Daqing crude oil, which solely could reduce the Daqing crude oil/connate water interfacial tension (IFT) to 10^-2 mN/m magnitude and gave a saturated adsorption 30% lower than that of diC₁₂B at Daqing sandstone/water interface at 45°C. C₁₈₊₆B solely could reduce C₇-C₉ n-alkanes/connate water IFT to 10^-3 mN/m magnitude at 45°C, and could reduce the Daqing crude oil/connate water IFT to 10^-3 mN/m magnitude at 45°C by mixing with the more hydrophobic surfactant diC₁₂B and other hydrophilic betaine surfactant, where the aqueous solubility of the formulation was greatly improved by the presence of C₁₈₊₆B. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Safety of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation was written by Nuti, Elisa;Santamaria, Salvatore;Casalini, Francesca;Yamamoto, Kazuhiro;Marinelli, Luciana;La Pietra, Valeria;Novellino, Ettore;Orlandini, Elisabetta;Nencetti, Susanna;Marini, Anna Maria;Salerno, Silvia;Taliani, Sabrina;Da Settimo, Federico;Nagase, Hideaki;Rossello, Armando. And the article was included in European Journal of Medicinal Chemistry in 2013.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:

Aggrecanases, in particular aggrecanase-2 (ADAMTS-5), are considered the principal proteases responsible for aggrecan degradation in osteoarthritis. For this reason, considerable effort was put on the discovery and development of aggrecanase inhibitors able to slow down or halt the progression of osteoarthritis. The authors report herein the synthesis and biol. evaluation of a series of arylsulfonamido-based hydroxamates as aggrecanase inhibitors. Compound I has a nanomolar activity for ADAMTS-5, ADAMTS-4 and MMP-13 and high selectivity over MMP-1 and MMP-14. Furthermore, this compound proved to be effective in blocking ex vivo cartilage degradation without having effect on cell cytotoxicity. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluation of essential oil, seed extracts, of carum carvi L was written by Abdalrhman, Tamador A.;Ezeldin, Mohamed;Masaad, Ali M.;Ishak, Christina Yacoub;Alnoor, Rawan;Alnoor, Wasma Abozeid;Mansour, Shimaa;Hassan, Zeinab;Almahal, Maisa. And the article was included in Elixir International Journal in 2016.Safety of 1-Chlorooctadecane This article mentions the following:

Carawey is biennial plant. It is a widely used and incredibly useful plant. The seeds are used for culinary purposes and medicinal treatment. Its seeds oil was extracted by cold extraction method used two solvents, n-hexane and petroleum ether. Extracts has been investigated by Gas Chromatog. Mass Spectrometry (GC/MS) technique. Total of 45 compounds were detected for n-hexane extract and 62 compounds likewise for petroleum ether. The two solvent extracts showed a chem. composition correlation. The most abundant compounds detected are hexadecanoic acid; Estragole; 9,12-octadecandienoic acid; 9-octadecanoic acid; Stearatric acid, D-Limonene, octadecanal, Eicosanoic acid, 11-Eicosanoic acid, dodec-9-ynyl Cyclohexanecarboxylicacid, 7-hexadecanoic acid, 9- octandecanone, 10-nonadecanone and anethole. Besides there are some new compounds that have not been previously reported. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Safety of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics