Tag: 200-300

Photochemical Regioselective C(sp³)-H Amination of Amides Using N-Haloimides was written by Pan, Lei;Elmasry, Joseph;Osccorima, Tomas;Cooke, Maria Victoria;Laulhe, Sebastien. And the article was included in Organic Letters in 2021.Formula: C7H4ClNO3S This article mentions the following:

A metal-free regioselective C(sp³)-H amination of amides using N-haloimides in the presence of lithium tert-butoxide and visible light is presented herein. This photoexcited approach is straightforward, and it aminates a wide variety of amides under mild conditions without the use of photocatalysts, external radical initiators, or oxidants. A halogen-bonded intermediate between the tert-butoxide base and the N-haloimide is proposed to be responsible for the increased photoreactivity. Calculations show that the formation of this electron donor-acceptor complex presents an exergonic energy profile. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Formula: C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Practical chemoselective aromatic substitution: the synthesis of N-(4-halo-2-nitrophenyl)benzenesulfonamide through the efficient nitration and halogenation of N-phenylbenzenesulfonamide was written by Yu, Xiao;Zhu, Wenjing;Liu, Hongyan;Liu, Yi;Li, Hongshuang;Han, Junfen;Duan, Guiyun;Bai, Zhushuang;Zhang, Pengfei;Xia, Chengcai. And the article was included in Organic & Biomolecular Chemistry in 2022.Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

A novel route involving the metal-promoted tandem nitration and halogenation of N-phenylbenzenesulfonamide to synthesize N-(4-halo-2-nitrophenyl)benzenesulfonamide derivatives has been developed. The method shows highly practical chemoselective and functional group compatibility. In addition, it employs insensitive and inexpensive Cu(NO₃)₂·3H₂O, Fe(NO₃)₃·9H₂O, and NH₄NO₃ as the nitration reagents, and it provides a direct approach for the preparation of 4-halo-2-nitroaniline, which is a crucial intermediate for the synthesis of benzimidazoles and quinoxaline derivatives In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fengycin A analogs with enhanced chemical stability and antifungal properties was written by Gimenez, Diana;Phelan, Aoife;Murphy, Cormac D.;Cobb, Steven L.. And the article was included in Organic Letters in 2021.Formula: C19H15Cl This article mentions the following:

Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chem. unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogs that display enhanced antifungal properties and chem. stability under both basic and acidic conditions. The analogs prepared also demonstrate that the fengycin core structure can be modified and simplified without the loss of antifungal activity. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

C-H Fluoroalkylsulfinylation/Intramolecular Rearrangement for Precise Synthesis of Fluoroalkyl Sulfoxides was written by Xing, Shuya;Zhu, Yu-Yi;Liu, Wen;Liu, Yong;Zhang, Jing;Zhang, Huarong;Wang, Yan;Ni, Shao-Fei;Shao, Xinxin. And the article was included in Organic Letters in 2022.Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

An efficient methodol. to access various fluoroalkyl sulfoxides bearing ortho/para-functionalized amine scaffolds, e.g. I from arylhydroxylamines was described. The transformation was featured with new electrophilic trifluoromethylthiolated reagents, good functional group tolerance, and late-stage modification of complex bioactive scaffolds, providing a rapid access to prepare numerous trifluoromethyl- and difluoromethyl-substituted sulfoxides. Mechanism studies and d. functional theory calculations suggest this reaction goes through a nucleophilic trifluoromethylthiolation of arylhydroxylamine and subsequent internal 2,3-sigmatropic rearrangement involving a sulfur and oxygen transfer process. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives was written by Srivastava, Sanjay K.;Jha, Amrita;Agarwal, Shiv K.;Mukherjee, Rama;Burman, Anand C.. And the article was included in Anti-Cancer Agents in Medicinal Chemistry in 2007.Recommanded Product: 96568-04-6 This article mentions the following:

The disease of cancer has been ranked second after cardiovascular diseases and plant-derived mols. have played an important role for the treatment of cancer. Nine cytotoxic plant-derived mols. such as vinblastine, vincristine, navelbine, etoposide, teniposide, taxol, taxotere, topotecan and irinotecan have been approved as anticancer drugs. Recently, epothilones are being emerging as future potential anti-tumor agents. However, targeted cancer therapy has now been rapidly expanding and small organic mols. are being exploited for this purpose. Amongst target specific small organic mols., quinazoline was found as one of the most successful chem. class in cancer chemotherapy as three drugs namely Gefitinib, Erlotinib and Canertinib belong to this series. Now, quinazoline related chem. classes such as quinolines and naphthyridines are being exploited in cancer chemotherapy and a number of mols. such as compounds EKB-569 (52), HKI-272 (78) and SNS-595 (127a) are in different phases of clin. trials. This review presents the synthesis of quinolines and naphthyridines derivatives, screened for anticancer activity since year 2000. The synthesis of most potent derivatives in each prototype has been delineated. A brief structure activity relationship for each prototype has also been discussed. It has been observed that aniline group at C-4, aminoacrylamide substituents at C-6, cyano group at C-3 and alkoxy groups at C-7 in the quinoline ring play an important role for optimal activity. While aminopyrrolidine functionality at C-7, 2′-thiazolyl at N-1 and carboxy group at C-3 in 1,8-naphthyridine ring are essential for eliciting the cytotoxicity. This review would help the medicinal chemist to design and synthesize mols. for targeted cancer chemotherapy. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Recommanded Product: 96568-04-6).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 96568-04-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Multicomponent Reactions for the Synthesis of Functionalized Imidazoles was written by Seyfi, Samereh;Hossaini, Zinatossadat;Rostami-Charati, Faramarz. And the article was included in Combinatorial Chemistry & High Throughput Screening in 2013.SDS of cas: 6590-96-1 This article mentions the following:

An efficient synthesis of functionalized tetrahydroimidazoles via a one-pot tandem reaction between ninhydrin, primary alkylamines, arylisocyanates or arylisothiocyanates, acetylenic esters and triphenylphosphine is described. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1SDS of cas: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study was written by Maccallini, Cristina;Gallorini, Marialucia;Sisto, Francesca;Akdemir, Atilla;Ammazzalorso, Alessandra;De Filippis, Barbara;Fantacuzzi, Marialuigia;Giampietro, Letizia;Carradori, Simone;Cataldi, Amelia;Amoroso, Rosa. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2021.Electric Literature of C8H9ClO4S This article mentions the following:

Nonsteroidal aromatase inhibitors (NSAIs) are well-established drugs for the therapy of breast cancer. However, they display some serious side effects, and their efficacy can be compromised by the development of chemoresistance. Previously, we have reported different indazole-based carbamates and piperidine-sulfonamides as potent aromatase inhibitors. Starting from the most promising compounds, here we have synthesized new indazole and triazole derivatives and evaluated their biol. activity as potential dual agents, targeting both the aromatase and the inducible nitric oxide synthase, being this last dysregulated in breast cancer. Furthermore, selected compounds were evaluated as antiproliferative and cytotoxic agents in the MCF-7 cell line. Moreover, considering the therapeutic diversity of azole-based compounds, all the synthesized compounds were also evaluated as antifungals on different Candida strains. A docking study, as well as mol. dynamics simulation, were carried out to shed light on the binding mode of the most interesting compound into the different target enzymes catalytic sites. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A new method for the construction of indole nucleus was written by Iwao, Masatomo. And the article was included in Heterocycles in 1994.Synthetic Route of C11H14ClNO2 This article mentions the following:

Directed lithiation of N-tert-butoxycarbonylanilines I (X = H, Y = H, F, MeO; X = Me, CF₃, MeO, Cl, F, Y = H) and subsequent reaction with 1-tert-butyldimethylsilyl-1-phenylsulfinylethene gave the conjugate addition products which, without isolation, were cyclized to 1-tert-butoxycarbonyl-2-(phenylthio)indolines II under thermal sila-Pummerer reaction conditions. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Synthetic Route of C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iron(III) triflate as a highly efficient, recyclable and green catalyst for the N-Boc protection of amines was written by Feng, Chengliang;Chu, Ningning;Zhang, Shuguang;Cai, Jin;Chen, Junqing;Hu, Huayou;Ji, Min. And the article was included in Journal of Chemical Research in 2013.Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

Iron(III) triflate was used as an efficient catalyst for N-t-butoxycarbonylation of amines with di-t-Bu dicarbonate under solvent-free conditions at room temperature Various aliphatic, aromatic, heterocyclic amines and aminols were protected as their corresponding mono-carbamates in excellent yields and short reaction times. Only two of the 23 monocarbamates were new. No competitive side reactions such as isocyanate, urea, nor N,N-di-Boc formation were observed The reported method is mild and has the advantages of low cost, chemoselectivity and, because no solvent is used and the catalyst can be recycled, it is classifiable as a green procedure. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Precise fabrication of porous polymer frameworks using rigid polyisocyanides as building blocks: from structural regulation to efficient iodine capture was written by Xu, Xun-Hui;Li, Yan-Xiang;Zhou, Li;Liu, Na;Wu, Zong-Quan. And the article was included in Chemical Science in 2022.Quality Control of (Chloromethanetriyl)tribenzene This article mentions the following:

Porous materials have recently attracted much attention owing to their fascinating structures and broad applications. Moreover, exploring novel porous polymers affording the efficient capture of iodine is of significant interest. In contrast to the reported porous polymers fabricated with small mol. blocks, we herein report the preparation of porous polymer frameworks using rigid polyisocyanides as building blocks. First, tetrahedral four-arm star polyisocyanides with predictable mol. weight and low dispersity were synthesized; the chain-ends of the rigid polyisocyanide blocks were then crosslinked, yielding well-defined porous organic frameworks with a designed pore size and narrow distribution. Polymers of appropriate pore size were observed to efficiently capture radioactive iodine in both aqueous and vapor phases. More than 98% of iodine could be captured within 1 min from a saturated aqueous solution (capacity of up to 3.2 g g^-1), and an adsorption capacity of up to 574 wt% of iodine in vapor was measured within 4 h. Moreover, the polymers could be recovered and recycled for iodine capture for at least six times, while maintaining high performance. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Quality Control of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics