Tag: 200-300

Synthesis and bioactivity of novel sulfonate scaffold-containing pyrazolecarbamide derivatives as antifungal and antiviral agents was written by Lei, Zhi-Wei;Yao, Jianmei;Liu, Huifang;Ma, Chiyu;Yang, Wen. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Synthetic Route of C7H4ClF3O2S This article mentions the following:

Novel I [R = Ph, 4-methylphenyl, 2-chlorophenyl, etc] bearing a sulfonate fragment were synthesized to identify potential antifungal and antiviral agents. All the structures of the key intermediates and target compounds were confirmed by NMR and high-resolution mass spectrometry. The single-crystal X-ray diffraction of the compound I [R = 3-trifluoromethyl phenyl] showed that pyrazole carbamide is a sulfonate. The in vitro antifungal activities of the target compounds against Colletotrichum camelliae, Pestalotiopsis theae, Gibberella zeae, and Rhizoctonia solani were evaluated at 50μg/mL. Among the four pathogens, the target compounds exhibited the highest antifungal activity against Rhizoctonia solani. The compound I [R = phenylethyl] (EC₅₀ = 0.45 mg/L) had higher antifungal activity than the com. fungicide hymexazol (EC₅₀ = 10.49 mg/L) against R. solani, almost similar to bixafen (EC₅₀ = 0.25 mg/L). Addnl., the target compounds exhibited protective effects in vivo against TMV. Thus, this study reveals that I. bearing a sulfonate fragment exhibited potential antifungal and antiviral activities. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Synthetic Route of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemometrical analysis of substituent effects. XIII. Comparison of substituent effects on dissociation and chemical shift in ¹³C NMR spectra of mono- and disubstituted benzoic acids was written by Kulhanek, Jiri;Pytela, Oldrich;Lycka, Antonin. And the article was included in Collection of Czechoslovak Chemical Communications in 2000.Synthetic Route of C7H4ClNO4 This article mentions the following:

The ¹³C chem. shifts have been measured of the carboxyl carbon atoms for all the 2-, 3-, and 4-substituted benzoic acids with H, CH₃, CH₃O, F, Cl, Br, I, and NO₂ substituents, as well as for all 3,4-, 3,5-, and 2,6-disubstituted benzoic acids with combinations of CH₃, CH₃O, Cl (or Br), NO₂ substituents and for sym. 2,6-disubstituted derivatives with Et, EtO, PrO, i-PrO, and BuO substituents. The chem. shifts of carboxylic group carbon atoms of the 3- and 4-substituted derivatives show correlation only with the substituent constants σ₁. For the 2-substituted derivatives was found the dependence only on σ₁ and on the υ constant describing steric effects (s = 0.122, R = 0.996, without the CH₃ derivative which has a distinct anisotropic effect). The substituent effects on the carboxylic carbon chem. shift show additivity with 3,4-, 3,5-, and 2,6-substituents, and the 2,6-disubstituted derivatives show a linear synergic effect of substituents due obviously to the steric hindrance to resonance. Application of the principal component anal. to the data matrix involving all the combinations of mono- and disubstitution involving the above-mentioned substituents has proved an identical substituent effect from all the positions on the chem. shift described by one latent variable, steric effects and anisotropic behavior of Me at the 2 and 2,6 positions being predominantly described by the second latent variable (with the total explained variability of 99.5%). Comparison of substituent effects on the chem. shift of carboxylic carbon with that on the dissociation constant measured in the same solvent has confirmed the anisotropy due to ortho Me group, the ortho halogen substituents in monosubstituted derivatives also having a different effect. The dependence of chem. shift on pK_a was not very close for the derivatives studied (s = 1.005, R = 0.690). The inclusion of anisotropy of ortho alkyl group by means of an indicator variable improved the correlation (s = 0.533, R = 0.925), and omitting of 2-F, 2-Cl, 2-Br, and 2-I substituents gave a regression without deviating points (s = 0.352, R = 0.968). In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Synthetic Route of C7H4ClNO4).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optimizing the surface properties of nanofiltration membrane by tailoring the diffusion coefficient of amine monomer was written by Wei, Xiuzhen;Xu, Xufeng;Huang, Jiahao;Wang, Ze;Li, Huan;Shao, Fangyuan;Guo, Zhongquan;Zhou, Qinghua;Chen, Jinyuan;Pan, Bingjun. And the article was included in Journal of Membrane Science in 2022.COA of Formula: C9H3Cl3O3 This article mentions the following:

High-performance hollow fiber NF membranes with network structure were successfully prepared by introducing macromol. polyvinyl alc. (PVA) into aqueous phase to change the diffusion coefficient of amine monomer (piperazine, PIP) in organic phase. Based on Wilke-Change equation, a theor. model (DAO) dealing with viscosity of aqueous phase, mol. weight of PVA, and diffusion coefficient of amine monomer in organic phase was proposed. The applicability of the DAO model was verified by UV spectrophotometry (UV) monitoring and one-dimensional diffusion model. Subsequently, the structure of NF membranes was analyzed by SEM and XPS. The results suggested that the diffusion coefficient of amine monomer was neg. correlated with aqueous phase’s viscosity and polymer’s mol. weight With PVA205 (Mol. weight is 205000 Da) used to change the viscosity of aqueous phase, the diffusion coefficient of PIP (in n-hexane) was close to 2.70 × 10^-6 cm²/s, and the resultant NF membrane (NF-PVA205-1) showed excellent performance; specifically, NF-PVA205-1 achieved a flux as 107 L/m²·h (4 bar), which is 3.5-times higher than that of pure polyamide NF membrane, and the rejection rate for sodium sulfate can reach 97.9%. Such a facile fabrication method proposed in this study can balance the “trade-off” effect of traditional NF membrane. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1COA of Formula: C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A practical synthesis of 2-aryl-indole-6-carboxylic acids was written by Gallou, Fabrice;Yee, Nathan;Qiu, Fenghe;Senanayake, Chris;Linz, Guenter;Schnaubelt, Juergen;Soyka, Rainer. And the article was included in Synlett in 2004.Recommanded Product: 16588-16-2 This article mentions the following:

A practical synthesis of 2-aryl-indole-6-carboxylic acids was developed via a sequence consisting of S_NAr reaction, reductive cyclization, hydrolysis and decarboxylation. This process is efficient in terms of operational simplicity, cost effectiveness and is amenable to large scale production In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: 16588-16-2).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 16588-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effects of polyvinylidene fluoride substrate characteristics on the selectivity of thin-film composite nanofiltration membrane was written by Zhu, Chenyu;Zhang, Xue;Li, Fuzhi;Zhao, Xuan. And the article was included in Journal of Applied Polymer Science in 2022.COA of Formula: C9H3Cl3O3 This article mentions the following:

Thin-film composite (TFC) nanofiltration (NF) membranes have been fabricated on polyvinylidene fluoride (PVDF) substrates to sep. Cl^– and SO₄^2-. With increasing polyvinylpyrrolidone (PVP) content (0-1.00 weight%) in PVDF casting solution, the corresponding substrates have similar surface pore size and hydrophilicity, but have enlarged surface porosity and bulk pore size. Obvious defects were found on TFC membrane surface, which were fabricated on the substrate with large and deep finger-like pores. On such substrates, piperazine solution is prone to sink to the pore bottom and cannot react with trimesoyl chloride to form a defect-free polyamide layer. Different from previous reports, the bulk pore size and structure, especially for the finger-like pore, is found to be a key factor influencing the interfacial polymerization (IP) process. The optimal TFC membrane was prepared on the substrate with 0.15 weight% PVP in casting solution, which had crater-shaped ridge-valley structures, relatively high permeability and the largest separation factor of 4.66 for Cl^– and SO₄^2-. Although the NF performance needs to be further improved, the results shed lights on the important effects of the substrate bulk pore size and structure on the IP process, which will enlarge the knowledge on the impact of substrate on IP process. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1COA of Formula: C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents was written by Houze, Sandrine;Hoang, Nha-Thu;Lozach, Olivier;Le Bras, Jacques;Meijer, Laurent;Galons, Herve;Demange, Luc. And the article was included in Molecules in 2014.Synthetic Route of C8H8Cl2N4 This article mentions the following:

In Africa, malaria kills one child each minute. It is also responsible for about one million deaths worldwide each year. Plasmodium falciparum, is the protozoan responsible for the most lethal form of the disease, with resistance developing against the available anti-malarial drugs. Among newly proposed anti-malaria targets, are the P. falciparum cyclin-dependent kinases (PfCDKs). There are involved in different stages of the protozoan growth and development but share high sequence homol. with human cyclin-dependent kinases (CDKs). We previously reported the synthesis of CDKs inhibitors that are structurally-related to (R)-roscovitine, a 2,6,9-trisubstituted purine, and they showed activity against neuronal diseases and cancers. In this report, we describe the synthesis and the characterization of new CDK inhibitors, active in reducing the in vitro growth of P. falciparum (3D7 and 7G8 strains). Six compounds are more potent inhibitors than roscovitine, and three exhibited IC50 values close to 1 μM for both 3D7 and 7G8 strains. Although, such mols. do inhibit P. falciparum growth, they require further studies to improve their selectivity for PfCDKs. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Synthetic Route of C8H8Cl2N4).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C8H8Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Regioselective synthesis of vic-halo alcohols and symmetrical or unsymmetrical vic-dihalides from epoxides using triphenylphosphine-N-halo imides was written by Iranpoor, Nasser;Firouzabadi, Habib;Azadi, Roya;Ebrahimzadeh, Farzaneh. And the article was included in Canadian Journal of Chemistry in 2006.HPLC of Formula: 14070-51-0 This article mentions the following:

A simple, novel, and highly regioselective cleavage of epoxides into vicinal halo alcs. and sym. or unsym. dihalides is described using different stoichiometries of triphenylphosphine and N-halosuccinimide or N-halosaccharine (NXSac). In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0HPLC of Formula: 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of some new substituted phenylglyoxals was written by Nardi, Dante;Tajana, Alberto;Massarani, Elena. And the article was included in Annali di Chimica (Rome, Italy) in 1969.Recommanded Product: 5344-49-0 This article mentions the following:

ArCOCHO (I) are prepared by 3 different methods. II are prepared from I and o-(H2N)2C6H4; ArCOCO2H are treated with o-(H2N)2C6H4 to give III. Thus, a mixture of 15 g o-MeOC6H4Ac, 13.32 g SeO2, 50 ml HOAc, and 10 ml H2O is refluxed 5 hr to give 50% o-methoxyphenylglyoxal, b0.1 81°. Similarly prepared are the following I (Ar and b.p./mm given): o-ClC6H4, 92°/l; m-ClC6H4, 90°/1.5 (hydrate m. 82-4°); 4,2-Cl(O2N)C6H3, 118°/0.4; 5,2-Cl(O2N)C6H3, 128°/0.6; 2,4-Cl(O2N)C6H3, 118°/0.5 (hemihydrate m. 88°); 2,5-Cl(O2N)-C6H3, 137°/0.8 (hydrate m. 91-3°); 4,3-Cl(O2N)C6H3, 134°/-0.6. IV are treated with HCl to give 5,2-Cl(O2N)C6H3COCHO and 4,2-Cl(O2N)C6H3COCHO. 2-Chlor-6-nitro-ω-diazoacetophenone (0.03 mole) is treated with 0.031 mole Ph3P to give 2,6-Cl(O2N)C6H3CH:NN:PPh3, m. 182°, which (4.87 g) is treated with 1.52 g NaNO2, 18 ml 2M HCl, and 3.9 g PhNHCH2CH2NHPh to give V [Ar = 2,6-Cl(O2N)C6H3] (VI), m. 151-2°. Similarly prepared are 2,4-Cl(O2N)C6H3CH:NN:PPh3, m. 162°, and V [Ar = 2,4-Cl(O2N)C6H3], m. 145-6°. VI (2.03 g) is treated with 6 ml HCl (d. 1.18) to give 30% 2,6-Cl(O2N)C6H3-COCHO, b0.3 110°; hydrate m. 102-4°. Similarly prepared is I [Ar = 2,4-Cl(O2N)C6H3]. Also prepared are the following II and III (Ar, m.p. II, and m.p. III given): o-MeOC6H4, 110°, 230°; o-ClC6H4, 94-5°, 237°; 4,2-Cl(O2N)C6H3, 195°, 322°; 5,2-Cl(O2N)C6H3, 166-7°, 306°; 2,4-Cl(O2N)C6H3, 175°, 313°; 2,5-Cl(O2N)C6H3, 216°, 324-5°; 4,3-Cl(O2N)C6H3, 187-8°, 298°. Also the following II (Ar and m.p. given): m-ClC6H4, 130°; 2,6-Cl(O2N)C6H3, 121-2°. Also the following III (Ar and m.p. given): M-MeOC6H4, 183°; m-O2NC6H3, 328-9°; p-O2NC6H4, 350°. Also the following IV (Ar and m.p. given): m-ClC6H4, 184°; 2,4-Cl(O2N)C6H3, 231°; 5,2-Cl(O2N)C6H3, 199-201°; 4,3-Cl(O2N)C6H3, 190°. Also the following compounds: 2,6-Cl-(O2N)C6H3COCHAcCO2Et (m. 68-9°), 2,6-Cl(O2N)C6H3Ac (m. 60°), 2,6-Cl(O2N)C6H3COCH2Ac (m. 85°), 2,4-Cl(O2N)C6H3Ac 4,2-Cl(O2N)C6H3Ac. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Recommanded Product: 5344-49-0).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 5344-49-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, molecular docking and biological evaluation of quinolone derivatives as novel anticancer agents was written by Li, Jie;Zheng, Tu-cai;Jin, Yi;Xu, Jian-guo;Yu, Jian-gang;Lv, Yan-wen. And the article was included in Chemical & Pharmaceutical Bulletin in 2018.Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

A series of novel quinolone derivatives (8a-j) I (R¹ = 4-F, 2,4-diF; R² = 4-CH₃, 2-Cl, 2,6-diCl, 2-CF₃, 3-CF₃) were synthesized, and their anticancer activities were 1 tested in human cancer cell lines, human lung carcinoma cell (A549), human promyelocytic leukemia cell (HL-60), and human cervical cancer cell (Hela). Compound 8i I (R¹ = 2,4-diF; R² = 2-CF₃) was found to be 5-times more potent in cell- killing activity for cell Iines A549, HL-60, and Hela than the pos. control irinotecan or cisplatin, with IC₅₀ of 0.009, 0.008 and 0.010μm, resp. The docking study revealed that compound 8i might have strong interactions with the active site of DNA-topoisomerase I. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A green preparation of N-chloro- and N-bromosaccharin was written by de Souza, Soraia P. L.;da Silva, Joaquim F. M.;de Mattos, Marcio C. S.. And the article was included in Synthetic Communications in 2003.Recommanded Product: 14070-51-0 This article mentions the following:

The reaction of the sodium salt of saccharin, potassium chloride or bromide and oxone in water at room temperature for 24 h produced pure N-chloro- and N-bromosaccharin in 58% and 64% yield, resp. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics