Tag: 200-300

Continuous-flow processing of gaseous ammonia using a teflon AF-2400 tube-in-tube reactor: synthesis of thioureas and in-line titrations was written by Browne, Duncan L.;O’Brien, Matthew;Koos, Peter;Cranwell, Philippa B.;Polyzos, Anastasios;Ley, Steven V.. And the article was included in Synlett in 2012.COA of Formula: C7H3Cl2NS This article mentions the following:

A simple tube-in-tube reactor based on the gas-permeable membrane Teflon AF-2400 was used in the continuous flow reaction of gaseous ammonia with isothiocyanates and one isocyanate. A colorimetric in-line titration technique is also reported as a simple method to quantify the amount of ammonia taken up by the solvent in the system. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1COA of Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

β-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences was written by Hansen, Jacob C.;Bjoern-Yoshimoto, Walden E.;Bisballe, Niels;Nielsen, Birgitte;Jensen, Anders A.;Bunch, Lennart. And the article was included in Journal of Medicinal Chemistry in 2016.SDS of cas: 777-44-6 This article mentions the following:

In this study inspired by previous work on 3-substituted Asp analogs, the authors designed and synthesized a total of 32 beta-sulfonamide Asp analogs and characterized their pharmacol. properties at the excitatory amino acid transporter subtypes EAAT1, EAAT2 and EAAT3. In addition to several potent EAAT inhibitors displaying IC₅₀ values ∼1 μM at all three subtypes, this elaborate structure-activity-relationship also identified analogs characterized by distinct preference or selectivity for one transporter subtype. Introduction of two fluorine atoms on the Ph ring yielded the analog that displayed an IC₅₀ of 0.8 μM at EAAT1 with a 14- and 9-fold preference over EAAT2 and EAAT3, resp. Conversely, the m-CF₃-Ph analog was a potent selective EAAT2-inhibitor (IC₅₀= 2.8 μM) exhibiting 30- and 50-fold selectivity over EAAT1 and EAAT3, resp. In conclusion, even small structural differences in these beta-sulfonamide Asp analogs provide analogs with diverse EAAT subtype selectivity profiles. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6SDS of cas: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents was written by Mizuhara, Tsukasa;Kato, Takayuki;Hirai, Atsushi;Kurihara, Hideki;Shimada, Yasuhiro;Taniguchi, Masahiko;Maeta, Hideki;Togami, Hiroaki;Shimura, Kazuya;Matsuoka, Masao;Okazaki, Shiho;Takeuchi, Tomoki;Ohno, Hiroaki;Oishi, Shinya;Fujii, Nobutaka. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.COA of Formula: C7H4ClNO4 This article mentions the following:

The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7COA of Formula: C7H4ClNO4).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and solution behaviour of metal-carbonyl amphiphiles with an Fp (CpFe(CO)₂) junction was written by Murshid, Nimer;El-Temtamy, Abdelrahman;Wang, Xiaosong. And the article was included in Journal of Organometallic Chemistry in 2017.Safety of 1-Chlorooctadecane This article mentions the following:

Metallo-amphiphilic macromols. with an iron-carbonyl junction (PEGPPh₂-FpR, PEGPPh₂: polyethylene glycol di-Ph phosphine, M_n, PEG = 550 or 2000 g/mol; R = octadecyl or hexyl; Fp = CpFe(CO)₂) are synthesized via migration insertion reaction of FpR in the presence of PEGPPh₂ and are characterized using ³¹P, ¹H NMR and IR. The prepared amphiphiles are air stable, soluble in most organic solvents, e.g.THF, DCM, DMF, and exhibit a reversible redox activity as indicated by cyclic voltammetry (CV) experiments Surface tension measurements indicate that the prepared mols. exhibit typical amphiphilic properties with critical micelle concentrations (CMC) in water ranging between 30 and 113 μM. The aqueous micelles aggregated from PEGPPh₂-FpR agglomerate into suspensions, which is similar with the solution behavior of Brij surfactants, the organic analog without the Fp junction. The redox activity of Fp junction in 1-4, which is sensitive to assembling structures, will be a possible advantage for further investigation on this agglomeration behavior. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Safety of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Metal-free C-N cross-coupling of electrophilic compounds and N-haloimides was written by Zhang, Luyan;Li, Yanru;Jin, Long-Yi;Liang, Fushun. And the article was included in RSC Advances in 2015.Electric Literature of C7H4ClNO3S This article mentions the following:

The methodol. represents an elegant example of applying the halogen bond activation strategy in an organic transformation. When DBU is added, the cross-coupling reaction between alkyl halides, RX (R = Bn, Et, 2-oxocyclopentyl, etc.; X = Cl, Br, I) and N-haloimides, e.g., I occurs, resulting in the formation of aminated products e.g., II. A halogen bond activated nucleophilic substitution mechanism was proposed. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Electric Literature of C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Assessing the impact of membrane support and different amine monomer structures on the efficacy of thin-film composite nanofiltration membrane for dye/salt separation was written by Wu, Ping-Han;Gallardo, Marwin R.;Ang, Micah Belle Marie Yap;Millare, Jeremiah C.;Huang, Shu-Hsien;Tsai, Hui-An;Lee, Kueir-Rarn. And the article was included in Journal of Polymer Research in 2022.Formula: C9H3Cl3O3 This article mentions the following:

The right choice of porous support and diamine monomer is crucial in fabricating TFC membranes with improved performance. In this study, the effect of the supporting layer and diamine monomer structure in preparing TFC membranes for dye/salt separation was investigated. Supports used are polysulfone (PSf), polyacrylonitrile (PAN), and hydrolyzed PAN (mPAN) while diamine monomers used are piperazine (PIP), 1,3-diaminopropane (DAPE), and 1,4-bis(3-aminopropyl) piperazine (BAPP). Changing the porous substrate and monomer not only affects membrane phys. and chem. morphol. but also the performance of TFC NF membranes. Characterization and NF tests revealed that the TFC membrane prepared using mPAN as support and PIP as diamine monomer had most hydrophilic, roughest surface, and lowest crosslinking degree, and it delivered the optimum NF performance: J = 127.66 ± 12.61 LMH; R_{Brilliant Blue} = 99.28 ± 0.57% R_Congo Red = 99.21 ± 0.08%; R_NaCl = 14.00 ± 6.16%. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Formula: C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comparison on the compositions of essential oils from the seed and pulp of Schisandra sphenanthera Rehd. et Wils. was written by Wang, Xiaorui;Liu, Yan;Zhou, Shichao;Qin, Xiaolu;Gu, Wei. And the article was included in Journal of Essential Oil-Bearing Plants in 2017.Recommanded Product: 3386-33-2 This article mentions the following:

Schisandra sphenanthera Rehd. et Wils. belongs to the Schisandra family and its fruits are known to be the effective parts in Traditional Chinese Medicine (TCM). The chem. compositions of the essential oils from different parts of fruits of S. sphenanthera isolated by hydrodistillation extraction were analyzed by GC-MS. The extraction yield percentage of the essential oils from the seed and pulp were 2.82% and 0.65% (% dry weight, v/w), resp. The color of the essential oils from the seed were ivory-white and yellowish for pulp, resp. A total of sixty compounds were identified and there were 15 mutual compounds existed in two different parts. Although the majority of these compounds (more than 65%) belonged to sesquiterpenes and oxygenated sesquiterpenes. The differences between seed and pulp were readily observed: ketones were only found in seed, and aldehyde, halogenated hydrocarbons, olefin hydrocarbons, acids and alcs. were only found in pulp. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Recommanded Product: 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

AI-PCSAFT approach: New high predictive method for estimating PC-SAFT pure component properties and phase equilibria parameters was written by Abdallah el hadj, A.;Laidi, M.;Hanini, S.. And the article was included in Fluid Phase Equilibria in 2022.Formula: C19H15Cl This article mentions the following:

In this work, a new approach based on the association of Artificial intelligence method (AI) and PC-SAFT equation of state is applied to conceive a model for estimating the solubility of solid drugs in supercritical carbon dioxide. Neuro-equation of state approach (NES) is the new technique that takes benefit from the advantages of both ANN and PC-SAFT equation of state. The new method decomposes into three main stages, first the optimization of direct ANN for predicting solids-scCO₂ phase equilibrium (where 15 binary systems are used), then the ANN inverse is performed to be an alternative to group contribution methods (GCMs) for estimating the pure components and phys. properties (reduce the uncertainty committed in estimating these properties) and enhance the PCSAFT equation of state to estimate phase equilibrium parameters and finally, ANN-PCSAFT approach is used to estimate the solubility of 213 solid solutes in supercritical carbon dioxide. The performance strategy has been carried out using a linear regression anal. of the predicted vs. exptl. outputs, as an indication of the predictive ability of the developed method. The new approach is successfully applied to the phase equilibrium modeling for 213 binary systems with high accuracy (the comparison in terms of average absolute relative deviation (AARD %) showed a variation from 2 to 6%) and allowed to enhance the phase equilibrium modeling by reducing the number of optimized parameters and surpass the main drawbacks faced in this area mainly the non-availability of phys. properties and EOS pure component properties and the limitation of the equation of state. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Suzuki-Miyaura Cross-Coupling of Potassium Dioxolanylethyltrifluoroborate and Aryl/Heteroaryl Chlorides was written by Fleury-Bregeot, Nicolas;Oehlrich, Daniel;Rombouts, Frederik;Molander, Gary A.. And the article was included in Organic Letters in 2013.HPLC of Formula: 18437-66-6 This article mentions the following:

A robust and efficient protocol for the introduction of the dioxolanylethyl moiety onto various aryl and heteroaryl halides has been developed, providing cross-coupling yields up to 93%. Copper-catalyzed borylation of 2-(2-bromoethyl)-1,3-dioxolane with bis(pinacolato)diboron followed by treatment with potassium bifluoride provides the key organotrifluoroborate reagent. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6HPLC of Formula: 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

High Proportion of Chiral Crystallization of Achiral Indolyl Sulfonamides: Effect of Intermolecular Interactions was written by Kikkawa, Shoko;Maeno, Isae;Katagiri, Kosuke;Murayama, Yuta;Nozawa, Mariko;Hikawa, Hidemasa;Azumaya, Isao. And the article was included in Crystal Growth & Design in 2021.Application of 777-44-6 This article mentions the following:

We investigated the effect of indole moieties on chiral crystallization In this regard, we assessed the influence of intermol. interactions and contacts on the assembly of these mols. A systematic anal. of 62 crystal structures of secondary aromatic sulfonamides bearing 4-, 5-, 6-, and 7-aminoindolyl groups revealed that the proportion of indolyl compounds showing chiral crystallization was apparently higher (21%, except for crypto-racemate) than that of nonindolyl sulfonamides (11%). Moreover, 33% (5 out of 15 crystals) and 44% (7 out of 16 crystals) of 4- and 7-indolyl sulfonamide derivatives preferred chiral crystallization, resp. This suggested a correlation between the type of contact and the chirality of the assembly of adjacent mols. Specifically, the proportion of achiral indolyl sulfonamides undergoing chiral crystallization was drastically increased by N(indole)H···O interactions, slightly increased by C(sp²)H···π interactions, and decreased owing to π···π interactions. These tendencies were also true for sulfonamides with different substituents, which suggested that the T-shape contact would be more favorable than π···π interactions for chiral crystallization In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics