Tag: 200-300

The effect of C_X (alkyl groups) on the migration insertion polymerization (MIP) of ^PFpC_X [^PFp = (PPh₂(CH₂)₃Cp)Fe(CO)₂] was written by Lo, Ping Hsun;Wang, Xiaosong. And the article was included in Polymer in 2022.COA of Formula: C18H37Cl This article mentions the following:

Migration insertion polymerization (MIP) of organometallic monomers, ^PFpC_X [^PFp = (PPh₂(CH₂)₃Cp)Fe(CO)₂, C_X = (CH₂)_X-1CH₃, X = 12 or 18] was performed under various conditions. The oligomerization occurred in accompany with the monomer cyclization generating ^PFpC_X small rings at the early stage, which was followed by a complete cyclization of the oligomers generating P(^PFpC_X)_n macrocycles. ^PFpC_X small rings could be completely removed via precipitating the crude products in a poor solvent for the macrocycles. The solution and bulk MIP of ^PFpC_X (X = 12 or 18) had a similar cyclization rate but both were significantly accelerated at a higher MIP temperature (100°C). It is explained by the temperature-dependent tendency for the cyclization. The dependence of d.p. (DP) on the MIP conditions was discussed and the self-assembly of resultant P(^PFpC₁₂)_n was examined In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Long-lived states to sustain SABRE hyperpolarised magnetisation was written by Roy, Soumya S.;Rayner, Peter J.;Norcott, Philip;Green, Gary G. R.;Duckett, Simon B.. And the article was included in Physical Chemistry Chemical Physics in 2016.Related Products of 442903-28-8 This article mentions the following:

The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here the authors illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarized spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. The authors achieve >4% net ¹H-polarization in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biol. important mol. nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future. In the experiment, the researchers used many compounds, for example, Methyl 2,4-dichloronicotinate (cas: 442903-28-8Related Products of 442903-28-8).

Methyl 2,4-dichloronicotinate (cas: 442903-28-8) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 442903-28-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Late-stage installation of dehydroamino acid motifs into peptides enabled by an N-chloropeptide strategy was written by Nanjo, Takeshi;Oshita, Takuma;Matsumoto, Ayaka;Takemoto, Yoshiji. And the article was included in Chemistry – A European Journal in 2022.Category: chlorides-buliding-blocks This article mentions the following:

Conventional methods for the construction of dehydroamino acids (ΔAAs), which are a unique class of non-proteinogenic amino acids, require the pre-installation of special amino acids. Herein, we report and demonstrate the practical utility of an N-chloropeptide strategy for the rapid construction of ΔAA-containing peptides. The electrophilic N-chlorination of peptide bonds is drastically accelerated by a catalytic amount of quinuclidine (ABCO), and the subsequent β-elimination of N-chloroamide efficiently provides ΔAA-containing peptides in high yield. The strategy enables, for the first time, the construction of a wide variety of ΔAA residues in peptides without any pre-functionalized side chains and facilitates the late-stage installation of ΔAA motifs into already-constructed oligopeptides, including a medicinally important macrocyclic peptide. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Category: chlorides-buliding-blocks).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient route to 3-chlorojuglones was written by Bloomer, James L.;Gazzillo, Joseph A.. And the article was included in Tetrahedron Letters in 1989.Name: 4-Chloro-2,5-dimethoxybenzaldehyde This article mentions the following:

4-Chloro-2,5-dimethoxybenzaldehyde was prepared and converted in only 3 steps to 5-acetoxy-7-carboethoxy-3-chloro-1,4-naphthaquinone (I). Diels-Alder reaction of I afforded the tetracyclic enol ether II in a regiospecific manner. In the experiment, the researchers used many compounds, for example, 4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5Name: 4-Chloro-2,5-dimethoxybenzaldehyde).

4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 4-Chloro-2,5-dimethoxybenzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Antimicrobial Activity of Some Novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene anchored 1,3,4-triazoles and 1,3,4-thiadiazoles was written by Gadhave, A. G.;Gaikar, R. B.;Kuchekar, S. R.;Karale, B. K.. And the article was included in Journal of Heterocyclic Chemistry in 2014.Recommanded Product: 6590-96-1 This article mentions the following:

A series of novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene-anchored 1,3,4-triazoles I (R = H, 2-F, 3-MeO, etc.) and 1,3,4-thiadiazoles II were synthesized from thiosemicarbazides III. The structures of these newly synthesized compounds were confirmed on the basis of IR, ¹H-NMR, mass spectral techniques, and elemental anal. The in vitro antimicrobial screenings of the synthesized compounds were carried out against four bacterial pathogens, namely Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa and three fungal pathogens Candida albicans, Aspergillus niger and Aspergillus clavatus, using broth microdilution min. inhibitory concentration method. The compounds I (R = H), II (R = H, 2-F), and III (R = 2-CF₃, 3-MeO) exhibited promising antibacterial activity against the tested strains, whereas some compounds were found to be active against one of the tested bacterial strains. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Biodegradation and detoxification of aliphatic and aromatic hydrocarbons by new yeast strains was written by Hashem, Mohamed;Alamri, Saad A.;Al-Zomyh, Sharefah S. A. A.;Alrumman, Sulaiman A.. And the article was included in Ecotoxicology and Environmental Safety in 2018.Name: 1-Chlorooctadecane This article mentions the following:

Seeking new efficient hydrocarbon-degrading yeast stains was the main goal of this study. Because microorganisms are greatly affected by the environmental factors, the biodegradation potentiality of the microorganisms varies from climatic area to another. This induces research to develop and optimize the endemic organisms in bioremediation technol. In this study, 67 yeast strains were tested for their growth potentiality on both aliphatic and aromatic hydrocarbons. The most efficient six strains were identified using sequence anal. of the variable D1/D2 domain of the large subunit 26S ribosomal DNA. The identity of these strains was confirmed as Yamadazyma mexicana KKUY-0160, Rhodotorula taiwanensis KKUY-0162, Pichia kluyveri KKUY-0163, Rhodotorula ingeniosa KKUY-0170, Candida pseudointermedia KKUY-0192 and Meyerozyma guilliermondii KKUY-0214. These species are approved for their ability to degrade both aliphatic and aromatic hydrocarbons for the first time in this study. Although, all of them were able to utilize and grow on both hydrocarbons, Rhodotorula taiwanensis KKUY-0162 emerged as the best degrader of octane, and Rhodotorula ingeniosa KKUY-170 was the best degrader of pyrene. GC-MS anal. approved the presence of many chem. compounds that could be transitional or secondary metabolites during the utilization of the hydrocarbons. Our results recommend the application of these yeast species on large scale to approve their efficiency in bioremediation of oil-contamination of the environment. Using these yeasts, either individually or in consortia, could offer a practical solution for aquatic or soil contamination with the crude oil and its derivatives in situ. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Name: 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine was written by He, Jun;Tang, Xue-Mei;Liu, Ting-Ting;Peng, Feng;Zhou, Qing;Liu, Li-Wei;He, Ming;Xue, Wei. And the article was included in Chemical Papers in 2021.Computed Properties of C7H4ClF3O2S This article mentions the following:

Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity against Xanthomonas oryzaepv. oryzae (Xoo), Xanthomonas axonopodispv. citri (Xac) and Ralstonia solanacearum (Rs). Among them, compounds 4m and 4p revealed excellent antibacterial activities against Rs with a concentration for 50% of maximal effect (EC₅₀) value of 4 and 4 μg/mL, which were better than the control drugs bismerthiazol (13 μg/mL) and thiodiazole-copper (185 μg/mL). As observed using scanning electron microscope (SEM), these compounds act by causing folding and deformation of the bacterial surface, resulting in incomplete bacterial structure, so as to achieve the goal of bacteriostasis. The myricetin derivatives synthesized are expected to guide the research direction of new antibacterial agents. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Computed Properties of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Characterization of Novel N-Propylaniline-Phenylpiperazine Sulfonamide and Urea Derivatives was written by Kazancioglu, Mustafa Zahrittin. And the article was included in Polycyclic Aromatic Compounds in 2022.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Two different amino piperazine derivatives bearing various halogen groups were synthesized in high yields and explored in further transformations. Reacting these amino piperazines with various sulfonyl chlorides yielded eight different sulfonamides. Addnl., eight different urea derivatives have been prepared by treating these amino piperazines with isocyanates. Finally, we were able to take advantage of the aryl bromide functionality present in the parent amino piperazines by subjecting them to the Suzuki coupling with phenylboronic acid. Overall, we developed a strategy to diversify the amino piperazine core and obtained a small library of potentially bioactive piperazine derivatives In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies-activities against blood stage P. falciparum Including PfKI3 C580Y mutants and liver stage P. berghei parasites was written by Wong, Ho Ning;Padin-Irizarry, Vivian;van der Watt, Mariette E.;Reader, Janette;Liebenberg, Wilna;Wiesner, Lubbe;Smith, Peter;Eribez, Korina;Winzeler, Elizabeth A.;Kyle, Dennis E.;Birkholtz, Lyn-Marie;Coertzen, Dina;Haynes, Richard K.. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2019.SDS of cas: 777-44-6 This article mentions the following:

We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clin. artemisinin derivatives dihydroartemisinin (DHA), artemether and artesunate, display potent activities in vitro against the asexual blood stages of Plasmodium falciparum (Pf). In particular, the compounds are active against late blood stage Pf gametocytes, and are strongly synergistic in combination with the redox active drug methylene blue. In order to fortify the eventual selection of optimum amino-artemisinins for development into new triple combination therapies also active against artemisinin-resistant Pf mutants, we have prepared new amino-artemisinins based on the easily accessible and inexpensive DHA-piperazine. The latter was converted into alkyl- and aryl sulfonamides, ureas and amides. These derivatives were screened together with the comparator drugs DHA and the hitherto most active amino-artemisinins artemiside and artemisone against asexual and sexual blood stages of Pf and liver stage P. berghei (Pb) sporozoites. Several of the new amino-artemisinins bearing aryl-urea and -amide groups are potently active against both asexual, and late blood stage gametocytes (IC₅₀ 0.4-1.0 nM). Although the activities are superior to those of artemiside (IC₅₀ 1.5 nM) and artemisone (IC₅₀ 42.4 nM), the latter are more active against the liver stage Pb sporozoites (IC₅₀ artemisone 28 nM). In addition, early results indicate these compounds tend not to display reduced susceptibility against parasites bearing the Pf Kelch 13 propeller domain C580Y mutation characteristic of artemisinin-resistant Pf. Thus, the advent of the amino-artemisinins including artemiside and artemisone will enable the development of new combination therapies that by virtue of the amino-artemisinin component itself will possess intrinsic transmission-blocking capabilities and may be effective against artemisinin resistant falciparum malaria. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6SDS of cas: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.SDS of cas: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Role of pKa in establishing crystal structures of six hydrogen-bonded compounds of with different isomers of chloro- and nitro-substituted benzoic acids was written by Ishida, Hiroyuki. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications in 2021.Category: chlorides-buliding-blocks This article mentions the following:

The structures of the six hydrogen-bonded 1:1 compounds of 4-methylquinoline (C₁₀H₉N) with chloro- and nitro-substituted benzoic acids (C₇H₄ClNO₄), namely, 4-methylquinolinium 2-chloro-4-nitrobenzoate, C₁₀H₁₀N⁺·C₇H₃ClNO^4-, (I), 4-methylquinoline-2-chloro-5-nitrobenzoic acid (1/1), C₁₀H₉N·C₇H₄ClNO₄, and (II), 4-methylquinolinium 2-chloro-6-nitrobenzoate, C₁₀H_9.63N_0.63⁺·C₇H_3.37ClNO₄^0.63-. The (III), 4-methylquinolinium 3-chloro-2-nitrobenzoate, C₁₀H_9.54N^0.54+·C₇H_3.46ClNO₄^0.54-, (IV), 4-methylquinolinium 4-chloro-2-nitrobenzoate, C₁₀H₁₀N⁺·C₇H₃ClNO^4-, (V), and 4-methylquinolinium 5-chloro-2-nitrobenzoate, C₁₀H₁₀N⁺·C₇H₃ClNO^4-, have been determined at 185-190 K. In each compound, the acid and base mols. are linked by a short hydrogen bond between a carboxy (or carboxylate) O atom and an N atom of the base. The O···N distances are 2.5652 (14), 2.556 (3), 2.5485 (13), 2.5364 (13), 2.5568 (13) and 2.5252 (11) Å, resp., for compounds (I)-(VI). In the hydrogen-bonded acid-base units of (III) and (IV), the H atoms are each disordered over two positions with O site:N site occupancies of 0.37 (3):0.63 (3) and 0.46 (3):0.54 (4), resp., for (III) and (IV). The H atoms in the hydrogen-bonded units of (I), (V) and (VI) are located at the N-atom site, while the H atom in (II) is located at the O-atom site. In all the crystals of (I)-(VI), π-π stacking interactions between the quinoline ring systems and C-H···O hydrogen bonds are observed Similar layer structures are constructed in (IV)-(VI) through these interactions together with π-π interactions between the benzene rings of the adjacent acid mols. A short Cl···Cl contact and an N-O···π interaction are present in (I), while a C-H···Cl hydrogen bond and a π-π interaction between the benzene ring of the acid mol. and the quinoline ring system in (II), and a C-H···π interaction in (III) are observed Hirshfeld surfaces for the title compounds mapped over dnorm and shape index were generated to visualize the weak intermol. interactions. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Category: chlorides-buliding-blocks).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics