Tag: 200-300

Direct C-H Sulfonylimination of Pyridinium Salts was written by Luo, Lihua;Tang, Juan;Sun, Rui;Li, Wenjing;Zheng, Xueli;Yuan, Maoling;Li, Ruixiang;Chen, Hua;Fu, Haiyan. And the article was included in Organic Letters in 2022.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

A direct pyridinium C-H sulfonylimination has been developed for the synthesis of sulfonyl iminopyridine derivatives I (R = H, CN, Ph, thiophen-2-yl, etc.; R¹ = H, OMe, Ph, thiophen-3-yl, etc.; R² = H, cyclopropyl, Ph, 4-bromophenyl, etc.; R¹R² = -CH=CH-CH=CH-; R³ = Me, Et, i-Pr, etc.; R⁴ = Et, Ph, pyridin-3-yl, etc.) with high efficiency. This transformation features the direct and efficient formation of a C=N bond with a high functional group tolerance under metal-free conditions. The spectroscopic properties potentially enable these sulfonyl iminopyridine compounds I to be useful new emitting materials. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A highly stereoselective and recyclable microgel-supported bifunctional sulfonamide organocatalyst for asymmetric alcoholysis of meso-cyclic anhydrides: a thermo-responsive “organic nanoreactor” was written by Xiong, Fei;Ma, Chao;Zhu, Yi-Ren;Sun, Chen;Chen, Lu;Zhang, Yan-Jun;Zhu, Yuan-Jie;Wang, Zhong-Hua. And the article was included in New Journal of Chemistry in 2022.Category: chlorides-buliding-blocks This article mentions the following:

A novel thermosensitive bifunctional sulfonamide microgel catalyst was synthesized by immobilization on a highly cross-linked three-dimensional network structure through covalent interactions. The microgel-supported organocatalyst was successfully applied to catalyze the asym. alcoholysis reaction in high yields and good stereoselectivity (up to 90% ee). Furthermore, the polymeric catalysts could be recovered easily and reused multiple times (5 runs) without apparent loss of catalytic activity and enantioselectivity. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Category: chlorides-buliding-blocks).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New information indexes for interactions in biological systems was written by Motoo, Ioan. And the article was included in MATCH in 1981.Application of 34662-36-7 This article mentions the following:

The superposition of n effectors in a given series reflects the topol. of the receptor space explored by the considered effectors. The investigated receptor space (IRS) is defined as the graph G whose overlap partition is G₁, …, G_n. The graph, G₁ (1 鈮?L 鈮?n), is the hydrogen-suppressed graph corresponding to the effector mol., L. One computes the mean [I虆(G)] and total [I(G)] quantity of information contained in the IRS. I(G) or I虆(G) induces an ordering of IRS’s and constitutes a criterion for IRS relevance. These indexes are of use in quant. structure-activity relations. Two concrete series of hapten-antibody interactions and one series of carboxypeptidase inhibitors were studied. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Application of 34662-36-7).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 34662-36-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and facile dearomatization of highly electrophilic nitroisoxazolo[4,3-b]pyridines was written by Bastrakov, Maxim A.;Fedorenko, Alexey K.;Starosotnikov, Alexey M.;Fedyanin, Ivan V.;Kokorekin, Vladimir A.. And the article was included in Molecules in 2020.HPLC of Formula: 59237-53-5 This article mentions the following:

A number of novel 6-R-isoxazolo[4,3-b]pyridines were synthesized and their reactions with neutral C-nucleophiles (1,3-dicarbonyl compounds, 蟺-excessive (het)arenes, dienes) were studied. The reaction rate was found to be dependent on the nature of the substituent 6-R. The most reactive 6-nitroisoxazolo[4,3-b]pyridines were able to add C-nucleophiles in the absence of a base under mild conditions. In addition, these compounds readily undergo [4+2]-cycloaddition reactions on aromatic bonds C=C(NO₂) of the pyridine ring, thus indicating the superelectrophilic nature of 6-NO₂-isoxazolo[4,3-b]pyridines. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5HPLC of Formula: 59237-53-5).

Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 59237-53-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Manganese-Catalyzed Oxime-Directed ortho-C-H Amidation in Ionic Liquids was written by Kong, Xianqiang;Xu, Bo. And the article was included in Asian Journal of Organic Chemistry in 2019.Application of 777-44-6 This article mentions the following:

An efficient amidation of aromatic oximes RR¹C=NOMe (R = H, Me, Bu; R¹ = Ph, 2-naphthyl, 3-bromophenyl, etc.; RR¹ = tetrahydronaphth-8-yl, 6-methoxytetrahydronaphth-8-yl) via C-H bond activation using readily available sulfonyl azides R²SO₂N₃ (R² = iso-Pr, cyclopropyl, 4-methylphenyl, 2-thiophenyl, 5-dimethylaminonaphth-1-yl, etc.) as amidation reagents has been developed. This reaction is catalyzed by a base metal catalyst system – MnBr(CO)₅/[Hmim]OTf. This method offers excellent chem. yields and regioselectivity with good functional group tolerance. The reusability of MnBr(CO)₅/[Hmim]OTf system makes it relatively practical for large scale C-H amidations. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evolution of the Thienopyridine Class of Inhibitors of I魏B Kinase-尾: Part I: Hit-to-Lead Strategies was written by Morwick, Tina;Berry, Angela;Brickwood, Janice;Cardozo, Mario;Catron, Katrina;DeTuri, Molly;Emeigh, Jonathan;Homon, Carol;Hrapchak, Matt;Jacober, Stephen;Jakes, Scott;Kaplita, Paul;Kelly, Terence A.;Ksiazek, John;Liuzzi, Michel;Magolda, Ronald;Mao, Can;Marshall, Daniel;McNeil, Daniel;Prokopowicz, Anthony III;Sarko, Christopher;Scouten, Erika;Sledziona, Cynthia;Sun, Sanxing;Watrous, Jane;Wu, Jiang Ping;Cywin, Charles L.. And the article was included in Journal of Medicinal Chemistry in 2006.Synthetic Route of C10H9ClN2O2 This article mentions the following:

High-throughput screening is routinely employed as a method for the identification of novel hit structures. Large numbers of active compounds are typically procured in this way and must undergo a rigorous validation process. This process is described in detail for a collection of screening hits identified as inhibitors of I魏B kinase-尾 (IKK尾), a key regulatory enzyme in the nuclear factor-魏B (NF-魏B) pathway. From these studies, a promising hit series was selected. Subsequent lead generation activities included the development of a pharmacophore hypothesis and structure-activity relationship (SAR) for the hit series. This led to the exploration of related scaffolds offering addnl. opportunities, and the various structural classes were comparatively evaluated for enzyme inhibition, selectivity, and drug-like properties. A novel lead series of thienopyridines was thereby established, and this series advanced into lead optimization for further development. In the experiment, the researchers used many compounds, for example, Ethyl-2-chloro-3-cyano-6-methylisonicotinate (cas: 40108-12-1Synthetic Route of C10H9ClN2O2).

Ethyl-2-chloro-3-cyano-6-methylisonicotinate (cas: 40108-12-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C10H9ClN2O2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and insecticidal evaluation of propesticides of benzoylphenylureas was written by Chen, Li;Wang, Qingmin;Huang, Runqiu;Mao, Chunhui;Shang, Jian;Bi, Fuchun. And the article was included in Journal of Agricultural and Food Chemistry in 2005.Reference of 18437-66-6 This article mentions the following:

Two series of benzoylphenylurea derivatives were synthesized as candidate propesticides by a nucleophilic addition reaction between 2,6-difluronbenzoyl isocyanate and N-substituted anilines. The new compounds were identified by ¹H NMR spectroscopy, electron ionization-mass spectrometry, and elemental analyses. The bioactivities of the new compounds were evaluated. All of the propesticides were soluble in most organic solvents, and their hydrophobicities were improved. The result of the bioactivities of the new compounds against Oriental armyworm showed that some of the new compounds are active as compared to diflubenzuron and penfluron. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Molecular shape descriptors. 3. Steric mapping of biological receptor was written by Motoc, I.;Marshall, G. R.;Labanowski, J.. And the article was included in Zeitschrift fuer Naturforschung, Teil A: Physik, Physikalische Chemie, Kosmophysik in 1985.HPLC of Formula: 34662-36-7 This article mentions the following:

An improved version of the SIBIS algorithm is presented and illustrated. SIBIS is a self-consistent type algorithm which is well suited to delineate the main steric features of the biol. receptor, identify missing relevant atoms and(or) the presence of superfluous atoms in the mols. studied, and to provide an approx. estimate for the receptor bulk tolerance. SIBIS calculations for a set of substituted benzoates in the anti-p-(p‘-azophenylazo)benzoate antibody system yield an excellent QSAR which is further supported by the information correlation coefficients, R (R‘s express quant. the pairwise degree of the mol. shape relatedness); the optimal receptor steric map is in agreement with exptl. evidences. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7HPLC of Formula: 34662-36-7).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 34662-36-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antibacterial activity of novel icariin derivatives was written by Wang, A.;Zhang, Aili;Xu, Y.. And the article was included in Pharmazie in 2019.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

A series of aromatic sulfonyls substituted icariin derivatives I (R = 4-FC₆H₄, 4-F₃CC₆H₄, 2-thienyl, etc.) was synthesized and their antibacterial activities against S. aureus (including drug-sensitive bacteria and drug-resistant bacteria) were evaluated. Among them, compound I (R = 4-F₃CC₆H₄) exhibited high potency against methicillin-sensitive (MSSA) and resistant strains of S. aureus (MRSA) with MIC values of 1-2 mmol/L. Reverse virtual screening and mol. docking anal. indicated that compound I (R = 4-F₃CC₆H₄) might bind the allosteric site of PBP2a that may inhibit cell wall synthesis, with the advantage of activity against multidrug resistant S. aureus. Surface plasmon resonance (SPR) experiment further confirmed the binding affinity. Therefore, aromatic sulfonyls at C-3 position substituted icariin derivatives have been considered to be a novel class of anti-MRSA agents worth of further investigation. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The pH sensitive fluorescence SiO₂@TEuTTA/CS composite films and inks for anti-counterfeiting was written by Li, Le;Xi, Peng;Li, Quan;Wang, Xiaoqing;Cheng, Bowen. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Application In Synthesis of Trimesoylchloride This article mentions the following:

Functional chitosan (CS) composite films have wide application prospects in many fields. Herein, the lanthanide inorganic-organic hybrid nanospheres with an average diameter of 252 nm (SiO₂@TEuTTA) were synthesized by surface modification of silica nanospheres. And the SiO₂@TEuTTA was used as luminescent materials and SiO₂@TEuTTA/CS composite films were prepared by a simple solution casting method. Subsequently, the compositions and structure, fluorescence and mech. properties of the SiO₂@TEuTTA/CS composite films were characterized. The results show that the SiO₂@TEuTTA/CS composite films not only have the smooth surface, high fluorescence property, good flexibility and transparency, but also can emit a bright red color under a 365 nm UV lamp. These provide an important basis for the application of the SiO₂@TEuTTA/CS composite films on the anti-counterfeiting packing labels. Addnl., the SiO₂@TEuTTA/CS solutions have been successfully used as anti-counterfeiting inks due to its transparency and pH sensitive properties. Compared with the traditional luminescent anti-counterfeiting inks, the pH sensitive SiO₂@TEuTTA/CS inks can improve the level of information security, which indicates that the SiO₂@TEuTTA/CS inks hold great promise for anti-counterfeiting fields. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application In Synthesis of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics