Tag: 200-300

Determination of positional weighting factors for the Swain and Lupton substituent constants f and r was written by Williams, S. G.;Norrington, F. E.. And the article was included in Journal of the American Chemical Society in 1976.Product Details of 5344-49-0 This article mentions the following:

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Previous workers (Swain, C. G. and Lupton, E. C., 1968) have shown that Hammett’s substituent constant σ and related parameters can all be expressed as a linear combination of two principal components F and R, which represent resp. the field and resonance effects of the substituent without regard for its position in the mol. A statistical anal. of data from 45 reaction series was carried out to determine positional weighting factors f and r for F and R, to enable the latter to be applied to the ortho, meta, and para positions of a benzene ring simultaneously. The fpara and rpara were both defined as 1.000. Fmeta was 0.980 (not significantly different from 1.000), fortho 1.248, rmeta 0.347, and rortho 0.863. These values agree roughly with the ad hoc assumptions made hitherto by classical organic chemists and enable good correlations to be found between physicochem. properties of the side chain and substituent parameters of mixed or multiply substituted populations of benzenoid compounds They also demonstrate that generalized σ-type parameters may be successfully applied to the ortho position, although the correlation with observed data is less good than with the meta and para positions due, no doubt, to the proximity of the substituent to the side chain of the mol. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Product Details of 5344-49-0).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 5344-49-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Total Synthesis of the Alleged Structure of Crenarchaeol Enables Structure Revision was written by Holzheimer, Mira;Sinninghe Damste, Jaap S.;Schouten, Stefan;Havenith, Remco W. A.;Cunha, Ana V.;Minnaard, Adriaan J.. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: 76-83-5 This article mentions the following:

Crenarchaeol is a glycerol dialkyl glycerol tetraether lipid produced exclusively in Archaea of the phylum Thaumarchaeota. This membrane-spanning lipid is undoubtedly the structurally most sophisticated of all known archaeal lipids and an iconic mol. in organic geochem. The 66-membered macrocycle possesses a unique chem. structure featuring 22 mostly remote stereocenters, and a cyclohexane ring connected by a single bond to a cyclopentane ring. Herein, we report the first total synthesis of the proposed structure of crenarchaeol. Comparison with natural crenarchaeol allowed us to propose a revised structure of crenarchaeol, wherein one of the 22 stereocenters is inverted. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Decarboxylative oxygenation of carboxylic acids with O₂via a non-heme manganese catalyst was written by Guan, Renpeng;Bennett, Elliot L.;Huang, Zhiliang;Xiao, Jianliang. And the article was included in Green Chemistry in 2022.Application of 76-83-5 This article mentions the following:

Decarboxylative oxygenation of carboxylic acids using a non-heme manganese catalyst under blue light irradiation with O₂ as the sole oxidant. Featuring mild reaction conditions, the protocol allowed readily available carboxylic acids to be converted into a wide variety of valuable aldehydes, ketones and amides. Mechanistic studies indicated that the decarboxylation and oxygenation involved the formation of active Mn-oxygen species. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed Synthesis of Tricyclic Indoles via a N-S Bond Cleavage Strategy was written by Zhang, Bo-Sheng;Wang, Fan;Gou, Xue-Ya;Yang, Ying-Hui;Jia, Wan-Yuan;Liang, Yong-Min;Wang, Xi-Cun;Li, Yuke;Quan, Zheng-Jun. And the article was included in Organic Letters in 2021.Quality Control of 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:

In palladium/norbornene (Pd/NBE) chem., the “ortho effect” has been proven to be a key factor in the process of β-carbon elimination to extrude NBE. Herein, it is found that the o-iodoaniline protected by a p-methoxybenzenesulfonyl group can recover the “ortho effect” and then undergo N-S bond cleavage with vinyl palladium, thus achieving a highly selective C-N coupling reaction in the Catallani-Lautens reaction system. On the basis of this discovery, a one-step synthesis of highly functionalized tricyclic indole derivatives was realized. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Quality Control of 2,4-Dimethoxybenzene-1-sulfonyl chloride).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 2,4-Dimethoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel platinum(II) and palladium(II) complexes with cyclin-dependent kinase inhibitors: Synthesis, characterization and antitumour activity was written by Szucova, Lucie;Travnicek, Zdenek;Zatloukal, Marek;Popa, Igor. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Category: chlorides-buliding-blocks This article mentions the following:

The Pt(II) and Pd(II) complexes of the types cis-[Pt(L₁)₂Cl₂]·H₂O (1), cis-[Pt(L₂)₂Cl₂]·3H₂O (2), trans-[Pd(L₁)₂Cl₂]·H₂O (3), trans-[Pd(L₂)₂Cl₂]·H₂O (4), trans-[Pd(L₃)₂Cl₂]·2DMF (5) and trans-[Pd(L₄)₂Cl₂]·2DMF (6) (L₁-L₄ = cyclin-dependent kinase inhibitors derived from 6-benzylamino-9-isopropylpurine) have been prepared and characterized. The complexes have been studied by elemental analyses, conductivity measurements, ES+ MS, FT-IR, ¹H, ¹³C and ¹⁹⁵Pt NMR spectra, differential scanning calorimetry and thermogravimetric anal. The mol. structures of L₁, trans-[Pd(L₃)₂Cl₂]·2DMF (5) and trans-[Pd(L₄)₂Cl₂]·2DMF (6) have been determined by single crystal x-ray anal. The complexes have been tested in vitro due to their presumable anticancer activity against the following human cancer cell lines: K-562, MCF7, G-361 and HOS. Satisfying results were obtained for the complex 1 with IC₅₀ values of 6 μM acquired against G-361 as well as against HOS cell lines. The lowest values of IC₅₀ were achieved for the complexes 3 and 4 against MCF 7 cell line with IC₅₀ 3 μM (for 3) and also 3 μM (for 4). In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Category: chlorides-buliding-blocks).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A novel one-pot synthesis of N,6-disubstituted 1,3,5-triazine-4,6-diamines from isothiocyanates and amidines was written by Liu, Chunjian;Lin, James;Leftheris, Katerina. And the article was included in Tetrahedron Letters in 2007.SDS of cas: 6590-96-1 This article mentions the following:

A one-pot procedure for the preparation of N,6-disubstituted-1,3,5-triazine-2,4-diamines and its scope of application are demonstrated with a number of examples. The procedure involves the treatment of isothiocyanates with sodium hydrogen cyanamide, followed by amidines in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1SDS of cas: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nano-ferrous ferric oxide (nano-Fe₃O₄). Powerful, reusable, and stable catalyst for N-Boc protection of amines was written by Zolfigol, Mohammad Ali;Moosavi-Zare, Ahmad Reza;Moosavi, Parvin;Khakyzadeh, Vahid;Zare, Abdolkarim. And the article was included in Comptes Rendus Chimie in 2013.Name: tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

Nano-ferrous ferric oxide (nano-Fe₃O₄) efficiently catalyzed N-boc protection of amines in high yields and acceptable reaction times. Nano-Fe₃O₄ was applied as an efficient, green, heterogeneous and reusable magnetite catalyst. Clean reaction, simple purification, short reaction time and high yield were some other advantages of this compound In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Name: tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Research on characteristics of composition and sedimentation separation of high calcium-type ASP produced water was written by Zhang, Jie;Hu, Hai-bing;Wei, Li;Li, Chun-ying;Yu, Gang. And the article was included in Harbin Shangye Daxue Xuebao, Ziran Kexueban in 2014.Formula: C18H37Cl This article mentions the following:

ASP-flooding is a new kind of flooding technol. The produced water reinjection is an important issue restricting the tech. promotion. Three-dimensional fluorescence spectra and GC-MS were applied for the research. The composition of organic and oil/water separation characteristics were studied. Results indicated that much more calcium ions and silicium ions could be detected in the high calcium-type ASP produced water. The value of BOD/COD was 0.1654. It had bad biodegradability, belonging to moderate salt industrial waste water. The kinds of main organic matters were 78. The extraction agent of Me tert-Bu ether was primarily hydrocarbons and alkanes. The extraction agent of n-hexane was a toxic matter, such as benzene series and naphthaline. After phys. sedimentation, the oil removal rate was 81.34%, and the suspended solids removal rate was 85.45%. The speed of oil-water separation was slow. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazoles as novel class of corticotropin releasing factor 1 receptor antagonists was written by Kojima, Takuto;Mochizuki, Michiyo;Takai, Takafumi;Hoashi, Yasutaka;Morimoto, Sachie;Seto, Masaki;Nakamura, Minoru;Kobayashi, Katsumi;Sako, Yuu;Tanaka, Maiko;Kanzaki, Naoyuki;Kosugi, Yohei;Yano, Takahiko;Aso, Kazuyoshi. And the article was included in Bioorganic & Medicinal Chemistry in 2018.HPLC of Formula: 6590-96-1 This article mentions the following:

A new class of corticotropin releasing factor 1 (CRF₁) receptor antagonists characterized by a tricyclic core ring was designed and synthesized. Novel tricyclic derivatives 2a-e were designed as CRF₁ receptor antagonists based on conformation anal. of our original 2-anilinobenzimidazole CRF₁ receptor antagonist. The synthesized tricyclic derivatives 2a-e showed CRF₁ receptor binding activity with IC₅₀ values of less than 400nM, and the 1,2,3,4-tetrahydropyrimido-[1,2-a]benzimidazole derivative 2e was selected as a lead compound with potent in vitro CRF₁ receptor binding activity (IC₅₀=7.1nM). To optimize the pharmacokinetic profiles of lead compound 2e, we explored suitable substituents on the 1-position and 6-position, leading to the identification of compound 42c-R, which exhibited potent CRF₁ receptor binding activity (IC₅₀=58nM) with good oral bioavailability (F=68% in rats). Compound 42c-R exhibited dose-dependent inhibition of [¹²⁵I]-CRF binding in the frontal cortex (5 and 10mg/kg, p.o.) as well as suppression of locomotor activation induced by intracerebroventricular administration of CRF in rats (10mg/kg, p.o.). These results suggest that compound 42c-R successfully binds CRF₁ receptors in the brain and exhibits the potential to be further examined for clin. studies. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1HPLC of Formula: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Structure-Activity Relationships of Novel 7-Substituted 1,4-Dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acids as Antitumor Agents. Part 1 was written by Tomita, Kyoji;Tsuzuki, Yasunori;Shibamori, Koh-ichiro;Tashima, Masanori;Kajikawa, Fumie;Sato, Yuji;Kashimoto, Shigeki;Chiba, Katsumi;Hino, Katsuhiko. And the article was included in Journal of Medicinal Chemistry in 2002.Recommanded Product: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:

Title compounds, e.g. I (R = H₂NCH₂CH₂NH, 1-pyrrolidinyl, 3-hydroxy-1-pyrrolidinyl), possess moderate cytotoxic activity. Structure-activity relationships of title compounds were investigated by changing substituents at N-1 and C-7 positions and the core ring structure itself and evaluated the synthesized compounds against several murine and human tumor cell lines. The 2-thiazolyl group at the N-1 position of the naphthyridine structure is the best substituent for antitumor activity and regarding core ring structure, the naphthyridine derivative is the most active followed by pyridopyrimidine analog. At the C-7 position, aminopyrrolidine derivatives are more effective than other amines or thioether derivatives I (R = 3-amino-4-methoxy-1-pyrrolidinyl, 3-amino-3-methyl-1-pyrrolidinyl, 3-aminopyrrolidinyl) were determined to be effective in vitro and in vivo antitumor assays, and their activity was comparable to that of etoposide. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Recommanded Product: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics