Tag: 200-300

Synthesis and biological activities of artemisinin-piperazine-dithiocarbamate derivatives was written by Yu, Jia-Ying;Li, Xue-Qiang;Wei, Meng-Xue. And the article was included in European Journal of Medicinal Chemistry in 2019.Recommanded Product: 1-Chlorooctadecane This article mentions the following:

Twelve derivatives of artemisinin-piperazine-dithiocarbamate, I (R = CH₂Ph, CH₂C₆H₄Me-4, n-pentyl, CH₂CO₂CH₂Ph, etc.), have been synthesized, and some of them show good in vitro cytotoxic activity. Compound I (R = CH₂C₆H₄CN-4) (II) exhibits the best inhibitory activity against SMMC-7721 cell lines with an IC₅₀ of 0.0025 ± 0.04 μM for 72 h, but the toxicity was lower against LO2 cell lines with an IC₅₀ of 0.18 ± 0.04 μM for 72 h. The results indicate that compound II is more cytotoxic towards cancer cell lines than towards benign cell lines compared with vincristine in vitro. And compound II also has good inhibitory activity against colon, breast and prostate cancer cells. Meanwhile, we have also proposed the six-member ring mechanism of DMSO in catalyzing the esterification of hydroxyl and acyl chloride. Instead of using the hydroxyl, we can obtain the nucleophilic substitution production simply and efficiently without a Lewis acid, which has not been reported previously. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Recommanded Product: 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of mono- and di-arylated acenaphthylenes and programmed access to dibenzo[j,l]fluoranthenes via palladium-catalysed C-H bond functionalisation was written by Shi, Xinzhe;Roisnel, Thierry;Soule, Jean-Francois;Doucet, Henri. And the article was included in Organic Chemistry Frontiers in 2018.Category: chlorides-buliding-blocks This article mentions the following:

C1-arylation and C1,C2-diarylation of acenaphthylenes via palladium-catalyzed direct arylation using either aryl bromides or benzenesulfonyl chlorides as aryl sources were reported. With aryl bromides, the mono-arylation was very selective, whereas with benzenesulfonyl chlorides C1,C2-diarylated acenaphthylenes were obtained in good yields. The reaction tolerated a wide variety of substituents including bromo or iodo. Moreover, the Pd-catalyzed intramol. C-H bond reaction of bromo-substituted C1,C2-diarylated acenaphthylenes provided the corresponding dibenzo[j,l]fluoranthenes. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactivity of N-chloro-substituted sulfonamides was written by Verma, Shiva M.;Srivastava, Ramesh C.. And the article was included in Indian Journal of Chemistry in 1966.Related Products of 14070-51-0 This article mentions the following:

The behavior of N-chloro-N-acyl- and N-chloro-N-aroyl-p-toluenesulfonamides in protonic and aprotic solvents was investigated. N-Acetyl- and N-benzoyl-p-toluenesulfonamides were prepared by acetylation (Ac2O and concentrated H2SO4) and benzoylation of p-MeC6H4SO2NH2, resp. N-Benzyl derivatives were obtained by the condensation of PhCH2NH2 with p-MeC6H4SO2Cl. The N-chloro derivatives were prepared by the action of excess HOCl on N-substituted p-toluenesulfonamides as described earlier (CA 63, 11421a); they could also be prepared by passing Cl into sodium salts of the parent sulfonamides. The following were prepared: N-chlorosaccharin, m. 152°: N-acetyl (benzyl and benzoyl)-N-chloro-p-toluenesulfonamides, m. 68°, 106°, and 96-8°, resp. All the N-chloro derivatives were crystalline compounds N-Chloro-N-acetyl derivatives in EtOH (with or without HCl) and in HOAc-H2SO4 media gave p-MeC6H4SO2NH2 and HOAc. The corresponding benzoyl derivatives in EtOH yielded the parent sulfonamide; in HOAc-H2SO4 medium the products formed were BzOH and p-MeC6H4SO2NH2. N-Chloro-N-benzoyl-p-toluenesulfonamide was stable toward these solvents. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Related Products of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives was written by Khan, Khalid Mohammed;Qurban, Saira;Salar, Uzma;Taha, Muhammad;Hussain, Shafqat;Perveen, Shahnaz;Hameed, Abdul;Ismail, Nor Hadiani;Riaz, Muhammad;Wadood, Abdul. And the article was included in Bioorganic Chemistry in 2016.COA of Formula: C7H3Cl2NS This article mentions the following:

Current study based on the synthesis of new thiazole derivatives via “one pot” multicomponent reaction, evaluation of their in vitro α-glucosidase inhibitory activities, and in silico studies. All synthetic compounds were fully characterized by ¹H NMR, ¹³C NMR and EIMS. CHN anal. was also performed. These newly synthesized compounds showed activities in the range of IC₅₀ = 9.06±0.10-82.50±1.70 μM as compared to standard acarbose (IC₅₀ = 38.25±0.12 μM). It is worth mentioning that most of the compounds exhibited potent inhibitory potential. Mol. docking study was performed in order to understand the mol. interactions between the mol. and enzyme. Newly identified α-glucosidase inhibitors except few were found to be completely nontoxic. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1COA of Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors was written by Xu, Li;Hartz, Richard A.;Beno, Brett R.;Ghosh, Kaushik;Shukla, Jinal K.;Kumar, Amit;Patel, Dipal;Kalidindi, Narasimharaju;Lemos, Nadine;Gautam, Shashyendra Singh;Kumar, Anoop;Ellsworth, Bruce A.;Shah, Devang;Sale, Harinath;Cheng, Dong;Regueiro-Ren, Alicia. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 76-83-5 This article mentions the following:

Galectin-3 is a member of a family of β-galactoside-binding proteins. A substantial body of literature reports that galectin-3 plays important roles in cancer, inflammation, and fibrosis. Small-mol. galectin-3 inhibitors, which are generally lactose or galactose-based derivatives, have the potential to be valuable disease-modifying agents. In our efforts to identify novel galectin-3 disaccharide mimics to improve drug-like properties, we found that one of the monosaccharide subunits can be replaced with a suitably functionalized tetrahydropyran ring. Optimization of the structure-activity relationships around the tetrahydropyran-based scaffold led to the discovery of potent galectin-3 inhibitors. Three compounds (identified within) were selected for further in vivo evaluation. The synthesis, structure-activity relationships, and in vivo evaluation of novel tetrahydropyran-based galectin-3 inhibitors are described. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Trifluoromethoxy Substituted Anilines: Metalation as the Key Step for Structural Elaboration was written by Leroux, Frederic;Castagnetti, Eva;Schlosser, Manfred. And the article was included in Journal of Organic Chemistry in 2003.HPLC of Formula: 18437-66-6 This article mentions the following:

Trifluoromethoxy-substituted anilines undergo hydrogen/lithium permutation (“metalation”) with optional site selectivity depending on the N-protective group employed. N-tert-Butoxycarbonyl-2- and -4-(trifluoromethoxy)aniline react with tert-BuLi at the nitrogen-adjacent 6- and 2-position affording, after electrophilic trapping, the corresponding substituted anilines I (R¹ = F₃CO, R² = H, R³ = HO₂C; R¹ = H, R² = F₃CO, R³ = Me, CHO, HO₂C, HOCH₂CH₂). In contrast, deprotonation of the N,N-bis(trimethylsilyl)-substituted 4-(trifluoromethoxy)aniline occurs at the oxygen-neighboring 3-position. Sec-BuLi attacks 3-trifluoromethoxy-N-(trimethylsilyl)aniline at the 2-position, but 3-trifluoromethoxy-N,N-bis(trimethylsilyl)aniline at the 4-position to provide the corresponding acids II (R⁴ = HO₂C, R⁵ = H; R⁴ = H, R⁵ = HO₂C), resp., after carboxylation. The synthesis of two new benzodiazepines III (R⁶ = F₃CO, R⁷ = H, R⁸ = F; R⁶ = Cl, R⁷ = HO, R⁸ = F₃CO) illustrates the preparative potential of the aniline functionalization mediated by organometallic reagents. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6HPLC of Formula: 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Bi(OTf)₃-Promoted Hydrosulfonylation of Alkenes with Sulfonyl Hydrazides: An Approach to Branched Sulfones was written by Zhou, Zheng;Liu, Qianqian;Huang, Zhibin;Zhao, Yingsheng. And the article was included in Organic Letters in 2022.Category: chlorides-buliding-blocks This article mentions the following:

The Bi(OTf)₃-promoted hydrosulfonylation of alkenes with sulfonyl hydrazides to produce branched sulfones was reported, in which various branched sulfones (â‰?0 examples) were prepared in moderate to good yields. The gram-scale reaction and synthesis of the exptl. inhibitor precursor showed the potential application. A preliminary mechanistic study revealed that double-bond migration to form the α,β-conjugated alkene is crucial for this transformation. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and evaluation of N-(benzofuran-5-yl)aromaticsulfonamide derivatives as novel HIF-1 inhibitors that possess anti-angiogenic potential was written by Wei, Jinlian;Yang, Yingrui;Li, Yali;Mo, Xiaofei;Guo, Xiaoke;Zhang, Xiaojin;Xu, Xiaoli;Jiang, Zhengyu;You, Qidong. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Hypoxia-inducible factor-1 (HIF-1) as a key mediator in tumor metastasis, angiogenesis, and poor patient prognosis has been recognized as an important cancer drug target. A novel series of N-(benzofuran-5-yl)aromaticsulfonamide derivatives were synthesized and evaluated as HIF-1 inhibitor. Among these compounds, 7q exhibited specific inhibitory effects on HIF-1 by downregulating the expression of HIF-1α under hypoxic conditions. It inhibited the HIF-1 transcriptional activity (IC₅₀ = 12.5 ± 0.7 μM) and secretion of VEGF (IC₅₀ = 18.8 μM) in MCF-7 cells. Meanwhile, it also significantly suppressed hypoxia-induced migration of HUVEC cells in nontoxic concentrations Addnl., tube formation assay demonstrated its anti-angiogenesis activity. Finally, the in vivo study indicated that compound 7q could retard angiogenesis in CAM model. These findings supported the HIF-1 inhibitory effect and anti-angiogenic potential of this class of compounds as HIF-1 inhibitor. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Direct Deoxyfluorination of Alcohols with KF as Fluorine Source was written by Xu, Jun;Peng, Chao;Yao, Bolin;Xu, Hua-Jian;Xie, Qiang. And the article was included in Journal of Organic Chemistry in 2022.Reference of 76-83-5 This article mentions the following:

This report described a method for the deoxyfluorination of alcs. with KF as fluorine source via in situ generation of highly active CF₃SO₂F. Diverse functionalities including halogen, nitro, ketone, ester, alkene and alkyne are well tolerated. Mild condition, short reaction time and wide substrate scope enable this method an excellent choice for the construction of C-F bonds. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Reference of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile fabrication of hypercrosslinked microporous polymer nanospheres for effective inhibition of triple negative breast cancer cells proliferation was written by Razzaque, Shumaila;Guo, Lijuan;Weng, Jun;Su, Li;Tan, Bien. And the article was included in Journal of Colloid and Interface Science in 2022.Safety of Trimesoylchloride This article mentions the following:

Treatment failure is one of the main lethal causes of human triple neg. breast cancer (TNBC) patients due to inefficient drug administration. The present study demonstrated the development of functional microporous organic polymers (MOPs) as a potential drug carrier and its controlled release. Due to the existence of abundant pores and high surface area, MOPs have promoted the high drug payloads, facilitating prolonged retention time and improved drug release. Herein, porous organic polymer has been fabricated via knitting strategy using the carbonyl bridged external crosslinker. Utilizing the imine chem., post-functionalization at the bridging carbon with the diamine resulted in the functional porous framework which had been further modified with single stranded DNA (ssDNA). Due to the conjugated structure, the designed material incorporates the strong blue fluorescence that assists in bio-imaging. In short, the inherent features of hypercrosslinked microporous polymers nanospheres (HMPNs) enabled the high encapsulation of Epirubicin (EPI) and its controlled release in TNBC cell lines (SUM-159 and MDA-MB-231) to inhibit cancer cells proliferation. We anticipate that the further development in functionalization of hypercrosslinked polymers may lead to a breakthrough in biomedical applications. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Safety of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics