Tag: 200-300

Synthesis, biological and insilico studies of some new N-(4-(benzofuran-2-yl)-3-arylthiazol-2-(3H)-ylidene)-aryl amines as potential anticancer agents was written by Marupati, Siddhartha;Gaddam, Rajesh Kumar;Prasanna, B.;Thirupathaiah, A.. And the article was included in Rasayan Journal of Chemistry in 2018.Related Products of 6590-96-1 This article mentions the following:

A series of some new N-(4-(benzofuran-2-yl)-3-arylthiazol-2(3H)-ylidene)-arylamines I (Ar¹ = 4-ClC₆H₄, pyridin-4-yl, 4-H₃COC₆H₄, etc.; Ar² = 4-ClC₆H₄, pyridin-3-yl, 4-O₂NC₆H₄, etc.) has been synthesized from bromination of 2-acylbenzofuran than followed by condensation with aryl/heteroarylamines Ar¹NH₂ and arylthioisocyanates Ar²N=C=S in ethanol. The synthesized compounds I were screened for their antioxidant and anticancer activities. The data revealed that compounds I (Ar¹ = 4-H₃COC₆H₄, pyridin-4-yl, 4-ClC₆H₄, 4-O₂NC₆H₄; Ar² = 4-ClC₆H₄, pyridin-3-yl, 3-F₃CC₆H₄, 4-O₂NC₆H₄) showed higher activity than the standard antioxidant ascorbic acid. The anticancer activity of the synthesized compounds I was also evaluated, compared to the standard drug doxorubicin against A549 and MDAMB-231 (Human Lung and breast cancer cell lines). The data revealed that the compounds I (Ar¹ = Ar² = 4-ClC₆H₄), I (Ar¹ = 4-H₃COC₆H₄; Ar² = 4-ClC₆H₄), I (Ar¹ = pyridin-4-yl; Ar² = pyridin-3-yl), I (Ar¹ = 4-ClC₆H₄; Ar² = 2,4-F₂C₆H₃) andI (Ar¹ = Ar² = 4-O₂NC₆H₄) against A549 have shown significant activity with IC₅₀ = 8.00 ± 1.21 μg/mL, IC₅₀ = 4.12 ± 1.51 μg/mL, IC₅₀ = 6.21 ± 0.37 μg/mL, 7.33 ± 0.54 μg/mL and IC₅₀ = 7.80 ± 0.57 μg/mL resp. Similarly, compoundsI (Ar¹ = 4-H₃CC₆H₄; Ar² = Ph), I (Ar¹ = 4-O₂NC₆H₄; Ar² = 3-ClC₆H₄), I (Ar¹ = pyridin-4-yl; Ar² = pyridin-3-yl), I (Ar¹ = 4-ClC₆H₄; Ar² = 3-F₃CC₆H₄) and I (Ar¹ = Ar² = 4-O₂NC₆H₄) exhibited prominent activity against MDAMB-231 cell line with IC₅₀ = 4.11 ± 0.59 μg/mL, IC₅₀ = 2.43 ± 1.12 μg/mL, IC₅₀ = 3.80 ± 0.52 μg/mL, IC₅₀ = 3.73 ± 0.35 μg/mL and IC₅₀ = 4.90 ± 1.64 μg/mL resp. Compounds I (Ar¹ = pyridin-4-yl, 4-O₂NC₆H₄; Ar² = pyridin-3-yl, 4-O₂NC₆H₄) are promising compounds to sustain at low percentage of IC₅₀ and revealed superior potency than doxorubicin, supported by antioxidant and mol. docking studies as well. Most of the newly synthesized compounds exhibit substantial activity in opposition to tested cell lines, and emerged as prospective drugs for further progress. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Related Products of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pd/Cu-Catalyzed tandem head-to-tail dimerization/cycloisomerization of terminal ynamides for the synthesis of 5-vinyloxazolones was written by Tang, Luning;Huang, Hai;Xi, Yang;He, Guangke;Zhu, Hongjun. And the article was included in Organic & Biomolecular Chemistry in 2017.HPLC of Formula: 18437-66-6 This article mentions the following:

An attractive and novel methodol. involving Pd/Cu-catalyzed tandem head-to-tail dimerization/cycloisomerization of terminal ynamides HCCN(Boc)R (R = Ph, 2-MeC₆H₄, 4-FC₆H₄, 4-MeOC₆H₄CH₂, etc.) for the synthesis of 3,5-disubstituted oxazolones I was developed. Under Pd(PPh₃)₂Cl₂/CuI cooperative catalyzed reaction conditions, the reaction provided efficient access to 5-vinyloxazolones with exceptional functional group tolerance and good chemoselectivity. The control experiments demonstrated that Pd(PPh₃)₂Cl₂ serves a key role in the dimerization of terminal ynamides and shows low catalytic activity in the intramol. cyclization. Moreover, the hetero-Diels-Alder reaction of product 5-vinyloxazolones was also described, which provided polycyclic oxazolones in good yield. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6HPLC of Formula: 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterial agents was written by Chu, Daniel T. W.;Fernandes, Prabhavathi B.;Claiborne, Akiyo K.;Gracey, Eugene H.;Pernet, Andre G.. And the article was included in Journal of Medicinal Chemistry in 1986.Reference of 96568-04-6 This article mentions the following:

The aminonaphthyridinecarboxylic acids I (R = H, 4-F, 2,4-F₂, R¹R²N = piperazino, 3-hydroxypyrrolidino, 3- and 4-methylpiperazino, 3-aminopyrrolidino) were prepared from Et 2,6-dichloro-5-fluoro-3-pyridinecarboxylate via cyclization of the esters II. The in vitro antibacterial activity is greatest for I (R = 4-F, 2,4-F₂; R¹R²N = 3-aminopyrrolidino). In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Reference of 96568-04-6).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 96568-04-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site was written by Hu, Xi;Li, Lu;Zhang, Qiangsheng;Wang, Qianqian;Feng, Zhanzhan;Xu, Ying;Xia, Yong;Yu, Luoting. And the article was included in Bioorganic Chemistry in 2020.Application In Synthesis of 2,6-Dichloro-9-isopropyl-9H-purine This article mentions the following:

A series of 3-(((9H-purin-6-yl)amino)methyl)pyridin-2(1H)-one derivatives were designed, synthesized and confirmed as tubulin polymerization inhibitors. All compounds were evaluated for their anti-proliferative activities on three colorectal carcinoma (CRC) cell lines. Among these compounds, SKLB0565 displayed noteworthy potency against eight CRC cell lines with IC₅₀ values ranging from 0.012μM and 0.081μM. Besides, SKLB0565 inhibited tubulin polymerization, caused G2/M phase cell cycle arrest, depolarized mitochondria and induced cell apoptosis in CRC cells. Furthermore, SKLB0565 suppressed cell migration and disrupted the capillary tube formation of human umbilical vein endothelial cells (HUVECs). In this SKLB0565 is a promising anti-tubulin agent for CRC therapy which is worthy of further evaluation is clarified. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Application In Synthesis of 2,6-Dichloro-9-isopropyl-9H-purine).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2,6-Dichloro-9-isopropyl-9H-purine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wittig Ylide Mediated Decomposition of N-Sulfonylhydrazones to Sulfinates was written by Choudhary, Deepika;Khatri, Vineeta;Basak, Ashok K.. And the article was included in Organic Letters in 2018.HPLC of Formula: 777-44-6 This article mentions the following:

N-Sulfonylhydrazones generate sulfinates selectively when treated with a stabilized Wittig ylide in a polar aprotic solvent at elevated temperature The transition metal and base free decomposition method is applicable to N-sulfonylhydrazones generated from a number of aromatic and heteroaromatic aldehydes and ketones. In the case of N-tosylhydrazones derived from O-allyl and O-propargyl salicylaldehydes, selective formation of sulfinate occurs over intramol. [3+2]-cycloaddition reaction. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6HPLC of Formula: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate was written by Pise, Ashok A.;Ingale, Ajit P.;Dalvi, Navnath R.. And the article was included in Synthetic Communications in 2021.Formula: C11H14ClNO2 This article mentions the following:

The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines RNHR¹ [R = n-Bu, cyclohexyl, Ph, Bn, etc.; R¹ = H, Et; RR¹ = -(CH₂)₂O(CH₂)₂-, -(CH₂)₅-] under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection of various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alc., aminoester, and chiral amines to their N-Boc-protected derivatives RN(R¹)C(O)OC(CH₃)₃ under solvent-free conditions with excellent yields. The protocol has several advantages such as easy catalyst, product isolation, short reaction time, excellent yields, outstanding chemoselectivity, and catalyst recyclability, among others. This makes the process practicable, economical, and environmentally benign. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Formula: C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Radiohalogen-labeled imaging agents. 3. Compounds for measurement of brain blood flow by emission tomography was written by Sargent, Thornton III;Shulgin, Alexander T.;Mathis, Chester A.. And the article was included in Journal of Medicinal Chemistry in 1984.HPLC of Formula: 90064-48-5 This article mentions the following:

3-(4-[¹³¹I]iodo-2,5-dimethoxyphenyl)isopropylamines I (R¹ = alkyl, NH₂, OH, CH₂CN, CH₂CH₂SH, PhCH₂, etc.; R² = H, Me, or Et) were prepared by reductive amination of 3-(4-[¹³¹I]iodo-2,5-dimethoxyphenyl)-2-propanone and evaluated for measurement of brain blood flow by emission tomog. Parameters investigated were the percent of injected dose appearing in the brain or other organs and the ratio of organ/blood radioactivity normalized on a weight basis, and since it is desirable that optimal values be reached within a few 1/2 lives, data were obtained at 5 and 30 min for each compound In rats, 3-(4-[¹³¹I]iodo-2,5-dimethoxyphenyl)-N,N-dimethylisopropylamine (I; R¹ = R² = Me), prepared in a matter of s, with a chem. yield and radioactive purity both >90%, had the highest percent uptake in brain, 3.4%, and the highest value of brain/blood ratio, 9.0. In dog this compound reached maximum activity in the brain at 5 min and decreased to 65% of its maximum value by 30 min. In the experiment, the researchers used many compounds, for example, 4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5HPLC of Formula: 90064-48-5).

4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 90064-48-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Genetic and Histopathological Alterations in Caco-2 and HuH-7 Cells Treated with Secondary Metabolites of Marine fungi was written by Mohamed, Aly Fahmy;Abuamara, Tamer M. M.;Amer, Mohamed E.;EI-Moselhy, Laila E.;Gomah, Tamer Albasyoni;Matar, Emadeldin R.;Shebl, Rania Ibrahim;Desouky, Said E.;Abu-Elghait, Mohammed. And the article was included in Journal of Gastrointestinal Cancer in 2022.Quality Control of 1-Chlorooctadecane This article mentions the following:

The present work aimed to study the activity of naturally derived fungal secondary metabolites as anticancer agents concerning their cytotoxicity, apoptotic, genetic, and histopathol. profile. It was noticed that Aspergillus terreus, Aspergillus flavus, and Aspergillus fumigatus induced variable toxic potential that was cell type, secondary metabolite type, and concentration dependent. Human colonic adenocarcinoma cells (Caco-2) showed less sensitivity than hepatocyte-derived cellular carcinoma cells (HuH-7), and in turn, the half-maximal inhibitory concentration (IC₅₀) was variable. Also, the apoptotic potential of Aspergillus species-derived fungal secondary metabolites was proven via detection of up-regulated pro-apoptotic genes and down-regulation of anti-apoptotic genes. The expression level was cell type dependent. Concurrently, apoptotic profile was accompanied with cellular DNA accumulation at the G2/M phase, as well as an elevation in Pre-G1 phase but not during G0/G1 and S phases. Also, there were characteristic apoptotic features of treated cells presented as abnormal intra-nuclear eosinophilic structures, dead cells with mixed euchromatin and heterochromatin, ruptured cell membranes, apoptotic cells with irregular cellular and nuclear membranes, as well as peripheral chromatin condensation. It can be concluded that Aspergillus secondary metabolites are promising agents that can be used as supplementary agents to the currently applied anti-cancer drug regimen. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Quality Control of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Simple N,N-dimethyl phenylsulfonamides show potent anticonvulsant effect in two standard epilepsy models was written by Tanaka, Tomoyuki;Yajima, Nana;Kiyoshi, Tomoko;Miura, Yoshiki;Iwama, Seiji. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Optimization of the previously reported benzothiazine analog A led to the identification of compound 1, which showed anti-convulsant activity in two golden standard animal models of seizure, the MES and scPTZ models. Structure-activity relationship investigation of compound 1 revealed compounds 2, 6 and 19 as attractive anti-epileptic drug (AED) candidates with potent anticonvulsant effect in both the MES and scPTZ models. As these compounds are structurally different from existing AEDs, determination of their mechanism of actions could provide clues to understanding current therapy-resistant seizures. Moreover, these simple phenylsulfoneamide compounds could be good starting points for searching broad spectrum AEDs by such in vivo screening. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Studies of thermal properties of di(methacryloyloxymethyl)naphthalene-divinylbenzene (DMN-DVB) copolymer and its alkyl-bonded derivatives was written by Gawdzik, Barbara;Rogulska, Magdalena;Grochowicz, Marta;Osypiuk-Tomasik, Joanna. And the article was included in Journal of Thermal Analysis and Calorimetry in 2019.Related Products of 3386-33-2 This article mentions the following:

This paper presents the thermal properties of highly crosslinked di(methacryloyloxymethyl)naphthalene-divinylbenzene (DMN-DVB) copolymeric microspheres containing polar groups in the structure and their alkyl-bonded derivatives C₈ and C₁₈ alkyl chains were introduced into the aromatic rings of the DMN-DVB porous copolymer by means of the Friedel-Crafts reaction. As a source of C₈ and C₁₈ alkyl chains, octyl and octadecyl chlorides were used. It was necessary to check whether the introduction of alkyl chains into the structure of polymeric packing had an impact on its thermal properties. The studies were carried out by thermogravimetry coupled online with FTIR spectroscopy and differential scanning calorimetry in inert atm. (helium). It was stated that the modified materials showed 20 and 50% mass losses at higher temperatures than the non-modified one while 1% mass loss was observed at lower temperatures Moreover, an anal. of volatile decomposition products was performed. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Related Products of 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics