Tag: 200-300

Boiling water-catalyzed neutral and selective N-Boc deprotection was written by Wang, Jia;Liang, Yan-Liang;Qu, Jin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.COA of Formula: C11H14ClNO2 This article mentions the following:

A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6COA of Formula: C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors was written by Almstead, Neil G.;Bradley, Rimma S.;Pikul, Stanislaw;De, Biswanath;Natchus, Michael G.;Taiwo, Yetunde O.;Gu, Fei;Williams, Lisa E.;Hynd, Barbara A.;Janusz, Michael J.;Dunaway, C. Michelle;Mieling, Glen E.. And the article was included in Journal of Medicinal Chemistry in 1999.HPLC of Formula: 1138-56-3 This article mentions the following:

The synthesis and enzyme inhibition data for a series of thiazine- and thiazepine-based matrix metalloproteinase (MMP) inhibitors are described. The thiazine- and thiazepine-based inhibitors were discovered by optimization of hetererocyclic sulfonamide-based inhibitors. The most potent series of inhibitors was obtained by modification of the amino acid D-penicillamine. This amino acid provides a gem-di-Me group on the thiazine or thiazepine ring which has a dramatic effect on the in vitro potency of this series. In particular, the sulfide I [n = 0] and the sulfone I [n = 2] were potent, broad-spectrum inhibitors of the MMPs with IC₅₀‘s against MMP-1 of 0.8 and 1.9 nM, resp. The binding mode of this novel thiazepine-based series of MMP inhibitors was established based on X-ray crystallog. of the complex of stromelysin and I [n = 0]. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3HPLC of Formula: 1138-56-3).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 1138-56-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and identification of a new class of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents was written by Prasanna, D. S.;Kavitha, C. V.;Raghava, B.;Vinaya, K.;Ranganatha, S. R.;Raghavan, Sathees C.;Rangappa, K. S.. And the article was included in Investigational New Drugs in 2010.SDS of cas: 6590-96-1 This article mentions the following:

Benzothiazoles are multitarget agents with broad spectrum of biol. activity. Among the antitumor agents discovered in recent years, the identification of various 2-(4-aminophenyl) benzothiazoles as potent and selective antitumor drugs against different cancer cell lines has stimulated remarkable interest. Some of the benzothiazoles are known to induce cell cycle arrest, activation of caspases and interaction with DNA mol. Based on these interesting properties of benzothiazoles and to obtain new biol. active agents, a series of novel 4,5,6,7-tetrahydrobenzo[d]thiazole derivatives, e.g. I, were synthesized and evaluated for their efficacy as antileukemic agents in human leukemia cells (K562 and Reh). The chem. structures of the synthesized compounds were confirmed by ¹H NMR, LCMS and IR anal. The cytotoxicity of these compounds were determined using trypan blue exclusion, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Results showed that, these compounds mediate a significant cytotoxic response to cancer cell lines tested. It was found that the compounds having electron withdrawing groups at different positions of the Ph ring of the thiourea moiety displayed significant cytotoxic effect with IC₅₀ value less than 60 μM. To rationalize the role of electron withdrawing group in the induction of cytotoxicity, I (IC₅₀ âˆ?5 μM) which is having chloro substitution at ortho and para positions was chosen . Flow cytometric anal. of annexin V-FITC/ propidium iodide (PI) double staining and DNA fragmentation suggest that I can induce apoptosis. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1SDS of cas: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of an accurate and sensitive analytical method for the determination of cadmium at trace levels using dispersive liquid-liquid microextraction based on the solidification of floating organic drops combined with slotted quartz tube flame atomic absorption spectrometry was written by Aydin, Ilgin;Chormey, Dotse Selali;Budak, Tuerkan;Firat, Merve;Turak, Fatma;Bakirdere, Sezgin. And the article was included in Journal of AOAC International in 2018.Synthetic Route of C18H37Cl This article mentions the following:

A dispersive liquid-liquidmicroextraction(DLLME) technique based on a solidification-of-floating-organic-drop (SFOD) procedure was developed for the determinationof trace amountsof cadmium (Cd) by using a flame at.absorption spectrometer (FAAS) fitted with a slotted quartz tube (SQT). The extractionof Cd was achieved by forming a complex with diphenylcarbazone. Parameters affecting the formation of complex and extractionoutputs were carefully optimized to obtain high-absorbance signals to achieve lower LODs. An SQT was fitted on top of the flame burner head to further enhance the absorbance of the signals recorded by the FAAS. Coupling the DLLME-SFOD procedure with SQT-FAAS produced an enhancement factor of about 183. The LOD of the method was 0.23μg/L with an RSD of 3.8%. Matrix-matching was used to overcome any low recovery results obtained with tap water and municipal wastewater. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Synthetic Route of C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Can the NF membrane directly obtained by the interfacial polymerization of MPD and TMC? was written by Li, Lan-Qian;Tang, Yong-Jian;Xu, Zhen-Liang. And the article was included in Journal of Membrane Science in 2022.Synthetic Route of C9H3Cl3O3 This article mentions the following:

In the practical application of nanofiltration (NF) membrane, regular chem. cleaning is necessary to eliminate the membrane fouling and ensure the normal operation of the system. Generally, the com. NF membranes can be divided into MPD-TMC membranes and PIP-TMC membranes of which the permeability and pH resistance cannot be balanced. In this work, the ultra-low concentration monomers of MPD and TMC were used to fabricate the dense polyamide layer of NF membrane through a conventional interfacial polymerization reaction. The newly prepared membrane exhibited a smooth surface with very low roughness. Besides, the pore size distribution and desalination performance including water permeability and salt rejection of our membrane were comparable to the lab-made and com. PIP-TMC membranes. The membrane was also confirmed to have an excellent separation efficiency to SO^2-₄/Cl^– anions and good resistance to extreme pH conditions. Overall, this study presents a new insight for the preparation of high-performance NF membrane with good chem. stability. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Synthetic Route of C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effect of oil blends derived from catalytic pyrolysis of waste cooking oil on diesel engine performance, emissions and combustion characteristics was written by Gad, M. S.;Abu-Elyazeed, O. S.;Mohamed, M. A.;Hashim, A. M.. And the article was included in Energy (Oxford, United Kingdom) in 2021.COA of Formula: C18H37Cl This article mentions the following:

The purpose of this study is to study the effect of pyrolysis oil from economical feedstock waste cooking oil on engine performance, emissions and combustion characteristics. Effect of potassium and sodium hydroxide catalysts concentrations of 0.5, 1, 3, 5, 7 and 10% by weight on the oil yield was investigated. NaOH catalyst achieved the highest oil yield of 70% weight at concentration of 1% weight Pyrolysis oil was mixed with diesel oil in volume percentages of 0, 20, 40, 60, 80 and 100%. Oil blends were tested in a diesel engine at variable loads and rated speed of 1500 rpm. The higher oil blend ratio decreased the thermal efficiency, NOx and CO emissions about diesel oil. Increase of oil percentage in the blends led to the increase of specific fuel consumption, smoke and HC emissions about diesel oil. The oil blend B100 achieved the maximum decreases in thermal efficiency, CO and NOx emission by 29, 45 and 65%, resp. about pure diesel. Also, pure pyrolysis oil B100 showed the maximum increases in specific fuel consumption, HC and smoke emissions by 28.3, 33 and 11%, resp. related to diesel oil. Pyrolysis WCO could be alternative fuels in diesel engines. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structural and Thermodynamic Model for the Activation of Cardiac Troponin was written by Poppe, Leszek;Hartman, James J.;Romero, Antonio;Reagan, Jeffrey D.. And the article was included in Biochemistry in 2022.SDS of cas: 76-83-5 This article mentions the following:

Cardiac troponin is a regulatory protein complex located on the sarcomere that regulates the engagement of myosin on actin filaments. Low-mol. weight modulators of troponin that bind allosterically with the calcium ion have the potential to improve cardiac contractility in patients with reduced cardiac function. Here we propose an approach to the rational design of troponin modulators through the combined use of solution NMR and isothermal titration calorimetry methods. In contrast to traditional approaches limited to calcium and activator-bound troponin structures, here we analyzed the structural and thermodn. impact of an activator in the context of the troponin functional cycle. This led us to propose a rationale for developing an efficacious troponin activator. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5SDS of cas: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antidiabetic activity of N’-[3-(alkyl/aryl substituted)-4-oxo-1,3-thiazolidinylidene]-2-(2-pyrazinyloxy)acetohydrazide was written by Verma, Prabhakar;Kamboj, Vipan. And the article was included in Acta Pharmaceutica Sciencia in 2010.Electric Literature of C7H3Cl2NS This article mentions the following:

2-(2-Pyrazinyloxy)acetic acid 2-(3-alkyl-4-oxo-2-thiazolidinylidene)hydrazide and 2-(2-pyrazinyloxy)acetic acid 2-(3-aryl-4-oxo-2-thiazolidinylidene)hydrazide derivatives were designed for a study of their biol. activity, the synthesis of the target compounds was achieved using 2(1H)-pyrazinone, chloroacetic acid Et ester and isothiocyanates as starting materials and the products thus obtained were confirmed by m.p., TLC, UV, IR, NMR. The title compounds were evaluated in a dexamethasone-induced hyperglycemia model and hyperinsulinemia model and it was discovered that these compounds displayed activity as antidiabetic agents with reduced toxicity in comparison with rosiglitazone. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Electric Literature of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arylsulfonic acid derivatives. XIII. Synthesis and biological activity of mono- and bis-β-chloroethylsulfonamides was written by Grigoryan, L. A.;Kaldrikyan, M. A.;Paronikyan, G. M.;Akopyan, L. G.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1983.Computed Properties of C10H13ClO3S This article mentions the following:

p-ROC₆H₄SO₂Cl (R = Me, Et, Pr, Bu, Me₂CHCH₂) reacted with ethylenimine in MeOH and with (ClCH₂CH₂)₂NH.HCl in refluxing pyridine to give 10 p-ROC₆H₄SO₂NR¹CH₂CH₂Cl [I; R¹ = H (II), CH₂CH₂Cl, resp.] in 65-76% yield. Treating II with CH₂:CHCN in aqueous Et₃N gave 5 I (R¹ = CH₂CH₂CN) in 65-72% yield. II (R = Et) reacted with NaNO₂ in dilute AcOH to give 62.5% I (R = Et, R¹ = NO). II had mutagenic activity, but none of the products had significant antitumor or hypoglycemic activity. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Computed Properties of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel and Selective Calcitonin-Inducing Agents was written by Gilbert, Adam M.;Caltabiano, Stephen;Roberts, Denise;Sum, Sam F. W.;Francisco, Gerardo D.;Lim, Kitae;Asselin, Magda;Ellingboe, John W.;Kharode, Yogendra;Cannistraci, Anna;Francis, Rita;TrailSmith, Mark;Gralnick, David. And the article was included in Journal of Medicinal Chemistry in 2000.Quality Control of 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:

A series of xanthine sulfonamides is presented as a class of calcitonin (CT) inducers – a potentially new method for treating diseases associated with postmenopausal bone loss such as osteoporosis. We have found that certain di-n-butylxanthine sulfonamides upregulate CT transcription in a CT-luciferase reporter gene assay (CT-luci) and increase the production and release of CT in a CT secretion/RIA assay (CTS). In addition, these compounds do not have potent PDE4 inhibitory activity as do the related xanthine methylene ketones such as denbufyllene. One compound in particular (I) shows a transcription activation ratio (TAR) of 2.1 in CT-luci, a CTS increase of 3.6-fold, and a PDE4 (phosphodiesterase type IV) IC₅₀ = 4.1 μM. In addition, this compound showed a statistically significant 47% trabecular bone protection in ovariectomized-induced osteopenia (OVX) rats as determined by assay when administered for 4 wk at 30 mg/kg/day, i.p. by quant. computed tomog. (QCT). When administered p.o., compound I shows 50% trabecular bone protection when administered for 3 wk at 50 mg/kg/day, i.p. This compared with salmon CT which shows 62% trabecular bone protection when administered at 50 IU/kg/day for 4 wk. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Quality Control of 4-Butoxybenzene-1-sulfonyl chloride).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of 4-Butoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics