Tag: 200-300

Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits was written by Liu, Meng-Hua;Zhang, Qi;Zhang, Yuan-He;Lu, Xian-Yuan;Fu, Wei-Ming;He, Jing-Yu. And the article was included in Molecules in 2016.Computed Properties of C18H37Cl This article mentions the following:

Both Rosa roxburghii and R. sterilis, belonging to the Rosaceae, are endemic species in Guizhou Province, China. The fruits of these two species are mixed-used as functional food in the region. Aiming to elucidate the phytochem. characteristics of R. roxburghii and R. sterilis fruits, the essential oils and constituents in a methanol extract have been analyzed and compared by GC-MS and UFLC/Q-TOF-MS, resp. As a result, a total of 135 volatile compounds were identified by GC-MS and 91 components were different between R. roxburghii and R. sterilis fruits; a total of 59 compounds in methanol extracts were identified by UFLC/Q-TOF-MS, including 13 organic acids, 12 flavonoids, 11 triterpenes, nine amino acids, five phenylpropanoid derivatives, four condensed tannins, two stilbenes, two benzaldehyde derivatives and one benzoic acid derivative; and nine characteristic compounds were found between R. roxburghii and R. sterilis fruits. This systematic study plays an important role for R. roxburghii and R. sterilis fruits in the product development. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Computed Properties of C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quinone Reduction by Organo-Osmium Half-Sandwich Transfer Hydrogenation Catalysts was written by Bolitho, Elizabeth M.;Worby, Nathan G.;Coverdale, James P. C.;Wolny, Juliusz A.;Schunemann, Volker;Sadler, Peter J.. And the article was included in Organometallics in 2021.Application of 777-44-6 This article mentions the following:

Organo-osmium(II) 16-electron complexes [Os^II(畏⁶-arene)(R-PhDPEN)] (where 畏⁶-arene = para-cymene or biphenyl) can catalyze the reduction of prochiral ketones to optically pure alcs. in the presence of a hydride source. Such complexes can achieve the conversion of pyruvate to unnatural D-lactate in cancer cells. To improve the catalytic performance of these osmium complexes, we have introduced electron-donor and electron-acceptor substituents (R) into the para (R₁) or meta (R₂) positions of the chiral R-phenyl-sulfonyl-diphenylethylenediamine (R-PhDPEN) ligands and explored the reduction of quinones, potential biol. substrates, which play a major role in cellular electron transfer chains. We show that the series of [Os^II(畏⁶-arene)(R-PhDPEN)] derivatives exhibit high turnover frequencies, enantioselectivities (>92%), and conversions (>93%) for the asym. transfer hydrogenation (ATH) of acetophenone-derived substrates and reduce duroquinone and menadione to their di-alc. derivatives Modeling of the catalysis using d. functional theory (DFT) calculations suggests a mechanism involving formic acid deprotonation assisted by the catalyst amine groups, phenyl-duroquinone stacking, hydride transfer to Os^II, possible CO₂ coordination, and tilting of the 畏⁶-arene ring, followed by hydride transfer to the quinone. These findings not only reveal subtle differences between Ru(II) and Os(II) catalysts, but also introduce potential biol. applications. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites was written by Harmse, Rozanne;Coertzen, Dina;Wong, Ho Ning;Smit, Frans J.;van der Watt, Mariette E.;Reader, Janette;Nondaba, Sindiswe H.;Birkholtz, Lyn-Marie;Haynes, Richard K.;N’Da, David D.. And the article was included in ChemMedChem in 2017.HPLC of Formula: 777-44-6 This article mentions the following:

Dihydroartemisinin (DHA), either used in its own right or as the active drug generated in vivo from the other artemisinins in current clin. use-artemether and artesunate-induces quiescence in ring-stage parasites of Plasmodium falciparum (Pf). This induction of quiescence is linked to artemisinin resistance. Thus, we have turned to structurally disparate artemisinins that are incapable of providing DHA on metabolism Accordingly, 11-azaartemisinin 5 and selected N-sulfonyl derivatives were screened against intraerythrocytic asexual stages of drug-sensitive Pf NF54 and drug-resistant K1 and W2 parasites. Most displayed appreciable activities against all three strains, with IC₅₀ values <10.5 nM. The p-trifluoromethylbenzenesulfonyl-11-azaartemisinin derivative 11 [(4′-trifluoromethyl)benzenesulfonylazaartemisinin] was the most active, with IC₅₀ values between 2 and 3 nM. The compounds were screened against Pf NF54 early and transmissible late intraerythrocytic-stage gametocytes using luciferase and parasite lactate dehydrogenase (pLDH) assays. The 2′-thienylsulfonyl derivative 16 (2′-thiophenesulfonylazaartemisinin) was notably active against late-stage (IV-V) gametocytes with an IC₅₀ value of 8.7 nm. All compounds were relatively nontoxic to human fetal lung WI-38 fibroblasts, showing selectivity indexes of >2000 toward asexual parasites. Overall, the readily accessible 11-azaartemisinin 5 and the sulfonyl derivatives 11 and 16 represent potential candidates for further development, in particular for transmission blocking of artemisinin-resistant parasites. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6HPLC of Formula: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Direct synthesis of thiophosphates by reaction of diphenylphosphine oxide with sulfonyl chlorides was written by He, Wei;Wang, Zhiming;Li, Xinjin;Yu, Qing;Wang, Zhongwei. And the article was included in Tetrahedron in 2016.Electric Literature of C8H9ClO4S This article mentions the following:

A new method for the synthesis of thiophosphates by reductive coupling reaction of diphenylphosphine oxide and sulfonyl chlorides has been developed. The reaction is metal-free and needs no additives, affording various aryl and alkyl substituted thiophosphates in good to excellent yields under mild conditions. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of Fsp³-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening was written by Stotani, Silvia;Lorenz, Christoph;Winkler, Matthias;Medda, Federico;Picazo, Edwige;Ortega Martinez, Raquel;Karawajczyk, Anna;Sanchez-Quesada, Jorge;Giordanetto, Fabrizio. And the article was included in ACS Combinatorial Science in 2016.Electric Literature of C8H9ClO4S This article mentions the following:

The exploration of innovative chem. space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biol. relevant metabolites and show attractive features, such as mol. compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available com. reagents and robust chem. transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor 纬 (ROR纬) Agonists was written by Doebelin, Christelle;Patouret, Remi;Garcia-Ordonez, Ruben D.;Chang, Mi Ra;Dharmarajan, Venkatasubramanian;Kuruvilla, Dana S.;Novick, Scott J.;Lin, Li;Cameron, Michael D.;Griffin, Patrick R.;Kamenecka, Theodore M.. And the article was included in ChemMedChem in 2016.Related Products of 777-44-6 This article mentions the following:

The nuclear retinoic acid receptor-related orphan receptor 纬 (ROR纬; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (T_H17) cell proliferation. As such, synthetic small-mol. repressors (inverse agonists) targeting ROR纬 have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing T_H17 cell proliferation through activation (agonism) of ROR纬 may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein the authors describe the development of N-arylsulfonyl indolines as ROR纬 agonists. Structure-activity studies reveal a critical linker region in these mols. as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) anal. of ROR纬-ligand complexes help rationalize the observed results. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies was written by Chawla, Reena;Van Puyenbroeck, Victor;Pflug, Nicholas C.;Sama, Alekhya;Ali, Rameez;Schols, Dominique;Vermeire, Kurt;Bell, Thomas W.. And the article was included in Journal of Medicinal Chemistry in 2016.Application In Synthesis of 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:

Cyclotriazadisulfonamide prevents HIV entry into cells by down-modulating surface CD4 receptor expression through binding to the CD4 signal peptide. According to a two-site binding model, 28 new unsym. analogs bearing a benzyl tail group and nine bearing a cyclohexylmethyl tail have been designed and synthesized. The most potent new CD4 down-modulator (40 (CK147); IC₅₀ 63 nM) has a 4-dimethylaminobenzenesulfonyl side arm. One of the two side arms was varied with substituents in different positions. This gave a range of CD4 down-modulation potencies that correlated well with anti-HIV-1 activities. The side arms of 21 of the new benzyl-tailed analogs were modeled by means of quantum mech. calculations For CADA analogs with arenesulfonamide side arms, the pIC₅₀ values for CD4 down-modulation correlated with the component of the elec. dipole moment in the aromatic ring, suggesting that an attractive electronic interaction is a major factor determining the stability of the complex between the mol. and its target. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Application In Synthesis of 4-Butoxybenzene-1-sulfonyl chloride).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 4-Butoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains was written by Araujo-Neto, Jose B. de;Silva, Maria M. C. da;Oliveira-Tintino, Cicera D. de M.;Begnini, Ieda M.;Rebelo, Ricardo A.;Silva, Luiz E. da;Mireski, Sandro L.;Nasato, Michele C.;Krautler, Maria I. L.;Ribeiro-Filho, Jaime;Siyadatpanah, Abolghasem;Wilairatana, Polrat;Coutinho, Henrique D. M.;Tintino, Saulo R.. And the article was included in Molecules in 2021.Category: chlorides-buliding-blocks This article mentions the following:

The purpose of this study was to evaluate the antibacterial and antibiotic-modulating activities of 1,8-naphthyridine derivatives against multi-resistant bacterial strains. The broth microdilution method was used to determine the min. inhibitory concentration (MIC) of the following compounds: 7-acetamido-1,8-naphthyridin-4(1H)-one and 3-trifluoromethyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide. The antibiotic-modulating activity was analyzed using subinhibitory concentrations (MIC/8) of these compounds in combination with norfloxacin, ofloxacin, and lomefloxacin. Multi-resistant strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were used in both tests. Although the compounds had no direct antibacterial activity (MIC 鈮?1.024渭g/mL), they decreased the MIC of these fluoroquinolones, indicating synergism was obtained from the association of the compounds These results suggested the existence of a structure-activity relationship in this group of compounds with regard to the modulation of antibiotic activity. Therefore, concluded that 1,8-naphthyridine derivatives potentiate the activity of fluoroquinolone antibiotics against multi-resistant bacterial strains, and thereby interesting candidates for the development of drugs against bacterial infections caused by multidrug resistant strains. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and in vitro cytotoxicity of the first palladium(II) oxalato complexes involving adenine-based ligands was written by Starha, Pavel;Travnicek, Zdenek;Popa, Igor. And the article was included in Journal of Inorganic Biochemistry in 2009.COA of Formula: C8H8Cl2N4 This article mentions the following:

The 1st [Pd(Lⁿ)₂(ox)]xH₂O oxalato (ox) complexes involving 2-chloro-N6-(benzyl)-9-isopropyladenine (L¹; complex 1), 2-chloro-N6-(4-methoxybenzyl)-9-isopropyladenine (L²; 2), 2-chloro-N6-(2,3-dimethoxybenzyl)-9-isopropyladenine (L³; 3), 2-chloro-N6-(2,4-dimethoxybenzyl)-9-isopropyladenine (L⁴; 4), and 2-chloro-N6-(4-methylbenzyl)-9-isopropyladenine (L⁵; 5) were synthesized by the reactions of potassium bis(oxalato)palladate(II) dihydrate, [K₂Pd(ox)₂]路2H₂O, with the mentioned organic compounds (H₂ox = oxalic acid; x = 0 for 1–3 and 5 or 2 for 4). Elemental analyses (C, H, N), FTIR, Raman and NMR (¹H, ¹³C, ¹⁵N) spectroscopies, conductivity measurements and thermal studies (TGA and DTA, TG/DTA) were used to characterize the prepared complexes. The mol. structures of [Pd(L²)₂(ox)] (2) and [Pd(L⁵)₂(ox)]路L⁵路Me₂CO (5路L⁵路Me₂CO) were determined by a single crystal x-ray anal. The geometry of these complexes is slightly distorted square-planar with two appropriate Lⁿ (n = 2 or 5) mols. mutually arranged in the head-to-head (2) or head-to-tail (5) orientation. The Lⁿ ligands are coordinated to the central Pd(II) ion via the N7 atoms. The same conclusions regarding the binding properties of L¹-L⁵ ligands can be made based on multinuclear NMR spectra. In vitro cytotoxicity of the complexes 1–5 was evaluated against human chronic myelogenous leukemia (K562) and human breast adenocarcinoma (MCF7) cancer cell lines. Significant cytotoxicity was determined for the complexes 3 (IC₅₀ = 6.2 渭M) and 5 (IC₅₀ = 6.8 渭M) on the MCF7 cell line, which is even better than that found for the known and widely-used platinum-bearing antineoplastic drugs, i.e. oxaliplatin and cisplatin. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7COA of Formula: C8H8Cl2N4).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H8Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Study of denitrocyclization in synthesis of dibenzoxazepinones and dibenzothioazepinones was written by Sakharov, V. N.;Kalandadze, L. S.;Khristolyubova, T. A.;Smirnov, A. V.;Plakhtinskii, V. V.;Ivashchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2008.Computed Properties of C9H8ClNO4 This article mentions the following:

The anal. of kinetic data of intermol. nucleophilic substitution of the 2′-nitro group in series of the diphenylsulfide- and diphenyloxide-2-carboxyamides with carboxyamide group participation has been carried out. The denitrocyclization reaction has been shown to proceed with Smiles rearrangement and spiro-蟽-complex formation limited the process of the dibenzothio- or dibenzoxazepinones. No data on the formation of dibenzothio- or dibenzoxazepinones are reported. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Computed Properties of C9H8ClNO4).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C9H8ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics