Tag: 200-300

Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core was written by Kroth, Heiko;Oden, Felix;Serra, Andreia Monica;Molette, Jerome;Mueller, Andre;Berndt, Mathias;Capotosti, Francesca;Gabellieri, Emanuele;Schmitt-Willich, Heribert;Hickman, David;Pfeifer, Andrea;Dinkelborg, Ludger;Stephens, Andrew. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Reference of 76-83-5 This article mentions the following:

Tau aggregates represent a critical pathol. in Alzheimers disease (AD) and other forms of dementia. The extent of Tau neurofibrillary tangles across defined brain regions corresponds well to the observed level of cognitive decline in AD. Compound 1 (PI-2620) was recently identified as a promising Tau positron emission tomog. tracer for AD and non-AD tauopathies. To evaluate the impact of the N-atom position with respect to Tau- and off-target binding, tricyclic core analogs of PI-2620 with nitrogen atoms at different positions were prepared Affinity to aggregated Tau was evaluated using human AD brain homogenates, and their off-target binding was evaluated in a monoamine oxidase A (MAO-A) competition assay. The novel tricyclic core derivatives all displayed inferior Tau binding or MAO-A off-target selectivity, indicating PI-2620 to be the optimal design for high affinity binding to Tau and high MAO-A selectivity. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Reference of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Solvent-resistant polyimide aerogel film as ultrapermeable support for thin-film composite and covalent organic framework nanofiltration membranes was written by Hu, Jiahui;Kumar, Sushil;Hardian, Rifan;Yang, Cong;Szekely, Gyorgy. And the article was included in Separation and Purification Technology in 2022.Related Products of 4422-95-1 This article mentions the following:

Organic solvent nanofiltration (OSN) membranes require robust selective layers and support materials. In this study, polyamide and polyester thin-film composites (TFCs) and covalent organic frameworks (COFs) were fabricated as selective layers on a polyimide aerogel support. The ultrapermeable support was stable in various organic solvents including harsh polar aprotic solvents such as N,N-dimethylformamide (DMF), dimethylsulfoxide, N,N-dimethylacetamide, and N-methyl-2-pyrrolidone for more than six months. The support enabled fabricating both amorphous and crystalline selective layers at both room and higher temperatures Moreover, the polyimide aerogel support had 85% porosity, facilitating high solvent flux. The compatibility of the selective layers and support was excellent, and as low mol. weight cutoff values (MWCO) as 356 and as high as 591 g mol^-1 were obtained in methanol at 10 bar for the COFs and polyester TFC membranes, resp. Both exptl. MWCO and permeance values of the COF membrane agreed with those predicted using the pore flow model. The effect of the operating temperature on the OSN performance was examined in DMF at 20 and 100 °C. Both membranes demonstrated constant permeance and rejection for more than nine days of continuous filtration. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Related Products of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Eco-friendly construction of spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas via Fe(III)-catalyzed multi-component domino double [4 + 2] annulations was written by Pan, Zhentao;Shi, Shuaijun;Yang, Xuancheng;Xiao, Xuqiong;Zhang, Wangqin;Wang, Shiliang;Ma, Yongmin. And the article was included in Green Chemistry in 2021.Quality Control of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

An unprecedented eco-friendly multi-component domino approach for the synthesis of novel spiroquinazolin-2-(thi)ones I (X = O, S; R = H, Me; R¹ = Me, Et; R² = n-Pr, 4-fluorophenyl, 4-(ethoxycarbonyl)benzen-1-yl, etc.) and quinolin-(thio)ureas II (R³ = i-Pr, 2,4-dichlorophenyl, naphthalen-1-yl, etc.) is described. The protocol proceeds via domino double [4+2] annulations and features an eco-benign catalyst and solvent, simple starting materials, high atom-economy, H₂O as the sole byproduct and a simple work-up procedure. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Quality Control of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Imidazole assisted molecular-scale regulation of polyamide for preparing reverse osmosis membrane with enhanced water permeance was written by Fei, Zhaohui;Jiang, Chi;Li, Mengxin;Hou, Yingfei. And the article was included in Journal of Environmental Chemical Engineering in 2022.Synthetic Route of C9H3Cl3O3 This article mentions the following:

The development of reverse osmosis (RO) technol. is still hindered by many obstacles, especially the low water permeance of RO membrane. Herein, an interfacial polymerization regulated by N-acyl imidazole chem. was proposed to fabricate high permeance RO membranes. The improvement of membrane performance was achieved by simply adding 2-methylimidazole (Hmim) into aqueous phase. More angstrom-scale free volume elements, which acted as water mol. transport channels, were formed in the polyamide separation layer due to the reaction and hydrolysis of Hmim. As a result, a substantial increase in water permeance was achieved while maintaining high NaCl rejection. In addition, more carboxylic acid groups were formed on the membrane surface due to the hydrolysis of N-acyl imidazole, thereby imparting higher hydrophilicity and anti-fouling properties to the membrane. With the addition of 1.5 weight/weight% Hmim, the water permeance of the prepared RO membrane was improved to 4.4 L m^-2 h^-1 bar^-1, nearly 4.5 times compared to the control group, while maintaining a high NaCl rejection of above 98%, thus successfully overcoming the permeability-selectivity trade-off limit. This work paves a new idea for the development of additives in the preparation of RO membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Synthetic Route of C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA was written by D′Agostino, Ilaria;Ardino, Claudia;Poli, Giulio;Sannio, Filomena;Lucidi, Massimiliano;Poggialini, Federica;Visaggio, Daniela;Rango, Enrico;Filippi, Silvia;Petricci, Elena;Visca, Paolo;Botta, Lorenzo;Docquier, Jean-Denis;Dreassi, Elena. And the article was included in European Journal of Medicinal Chemistry in 2022.Synthetic Route of C19H15Cl This article mentions the following:

The ever-faster rise of antimicrobial resistance (AMR) represents a major global Public Health challenge. New chem. entities with innovative Modes of Action (MoAs) are thus desirable. We recently reported the development of a novel class of broad-spectrum bactericidal agents, the AlkylGuanidino Ureas (AGU). Due to their polycationic structure, they likely target bacterial membranes. In order to better understand their MoA, we synthesized a library of AGU derivatives by structural simplification of selected hit compounds and developed specific assays based on membrane models by means of both anal. and computational techniques. Cell-based assays provided exptl. evidence that AGUs disrupt bacterial membranes without showing hemolytic behavior. Hence, we herein report a thorough chem. and biol. characterization of a new series of AGUs obtained through mol. simplification, allowing the rational design of potent antibacterial compounds active on antibiotic-resistant strains. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Synthetic Route of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

π-Delocalization in phosphaphthalimide and its ambident reactivity (O/P) toward main-group electrophiles was written by Shen, Qi;Xu, Jiashi;Chen, Xiaodan. And the article was included in Dalton Transactions in 2022.Synthetic Route of C19H15Cl This article mentions the following:

The report on phosphaphthalimide (1), the P analog of the phthalimide anion, dates back to forty years ago. However, the presence of π-delocalization between two-coordinated P center and neighboring carbonyl groups in 1 was underestimated. Herein, Na salts of 1 were obtained through a convenient procedure on a relatively large scale with a modified procedure. Reactivity studies demonstrated that 1 is indeed a good electrophile and the essential role of π-delocalization in 1 controlling its ambident properties. NBO anal. revealed the p-π conjugation and p-σ^* hyperconjugation in 1 affecting its bond lengths in opposite ways. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Synthetic Route of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antibacterial activity of novel icariin derivatives was written by Wang, A.;Zhang, Aili;Xu, Y.. And the article was included in Pharmazie in 2019.Synthetic Route of C8H9ClO4S This article mentions the following:

A series of aromatic sulfonyls substituted icariin derivatives I (R = 4-FC₆H₄, 4-F₃CC₆H₄, 2-thienyl, etc.) was synthesized and their antibacterial activities against S. aureus (including drug-sensitive bacteria and drug-resistant bacteria) were evaluated. Among them, compound I (R = 4-F₃CC₆H₄) exhibited high potency against methicillin-sensitive (MSSA) and resistant strains of S. aureus (MRSA) with MIC values of 1-2 mmol/L. Reverse virtual screening and mol. docking anal. indicated that compound I (R = 4-F₃CC₆H₄) might bind the allosteric site of PBP2a that may inhibit cell wall synthesis, with the advantage of activity against multidrug resistant S. aureus. Surface plasmon resonance (SPR) experiment further confirmed the binding affinity. Therefore, aromatic sulfonyls at C-3 position substituted icariin derivatives have been considered to be a novel class of anti-MRSA agents worth of further investigation. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Synthetic Route of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Substituted tetrahydroisoquinolines as microtubule-destabilizing agents in triple negative human breast cancer cells was written by Gangapuram, Madhavi;Jean, Riccardo;Mazzio, Elizabeth;Badisa, Ramesh;Eyunni, Suresh;Goodman, Carl B.;Redda, Kinfe K.;Soliman, Karam F.. And the article was included in Anticancer Research in 2016.COA of Formula: C10H13ClO3S This article mentions the following:

Triple-neg. breast cancer (TNBC) occurs at greater frequency amongst African-Americans, being characterized by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal receptor 2 (HER2). TNBC is often invasive and typically treated with cytostatic agents such as taxanes in combination with anthracyclines or platinum-based drugs. In this study, we synthesized a number of tetrahydroisoquinoline moieties by N-amination of substituted isoquinolines by O-mesytelene sulfonylhydroxylamine followed by ylide formation and reduction, which yielded the desired, substituted tetrahydroisoquinolines (THIQs) in moderate to good yield. Using a differential scatter plot to identify potential selective ER-modulating drugs in ER-pos. control cells (MCF-7) driven by estradiol vs. TNBC (MDA-MB-231) cells, the in vitro data showed an absence of effects on the ER (compared to 4-hydroxytamoxifen and raloxifene). In contrast, two lead compounds halted proliferation (cytostatic) in MDA-MB-231 TNBC cells at a potency level below 2.5 μM concomitant with mitotic arrest, attenuated replicative DNA synthesis, halted microtubule nucleation/stunted tubulin polymerization, abnormal expansive cytoskeletal tubulin and actin morphologies with multinucleation of cells. The most effective cytostatic compounds GM-3-53 and GM-3-121 blocked replicative processes at the G2 growth phase. These findings suggest that specific THIQs work independently of the ER, by holding static the microtubule network thereby preventing mitosis. Future work is required to establish the safety and efficacy of these drugs and their potential adjunct therapeutic gain in the presence of taxanes in TNBC. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3COA of Formula: C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore was written by Shi, Yihui;Park, Jaehyeon;Lagisetti, Chandraiah;Zhou, Wei;Sambucetti, Lidia C.;Webb, Thomas R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Recommanded Product: 203436-45-7 This article mentions the following:

The splicing of pre-mRNA is a critical process in normal cells and is deregulated in cancer. Compounds that modulate this process have recently been shown to target a specific vulnerability in tumors. We have developed a novel cell-based assay that specifically activates luciferase in cells exposed to SF3B1 targeted compounds, such as sudemycin D6. This assay was used to screen a combined collection of approved drugs and bioactive compounds This screening approach identified several active hits, the most potent of which were CGP-74514A and aminopurvalanol A, both have been reported to be cyclin-dependent kinases (CDKs) inhibitors. We found that these compounds, and their analogs, show significant cdc2-like kinase (CLK) inhibition and clear structure-activity relationships (SAR) at CLKs. We prepared a set of analogs and were able to ‘dial out’ the CDK activity and simultaneously developed CLK inhibitors with low nanomolar activity. Thus, we have demonstrated the utility of our exon-skipping assay and identified new mols. that exhibit potency and selectivity for CLK, as well as some structurally related dual CLK/CDK inhibitors. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Recommanded Product: 203436-45-7).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 203436-45-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design of Novel Phosphopantetheine Adenylyltransferase Inhibitors: A Potential New Approach to Tackle Mycobacterium tuberculosis was written by Primi, Marina C.;Tavares, Mauricio T.;Klein, Larry L.;Izard, Tina;R. Sant′Anna, Carlos M.;Franzblau, Scott G.;Ferreira, Elizabeth I.. And the article was included in Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2021.SDS of cas: 777-44-6 This article mentions the following:

Tuberculosis (TB) has been a challenging disease worldwide, especially for the neglected poor populations. Presently, there are approx. 2 billion people infected with TB worldwide and 10 million people in the world fell ill with active TB, leading to 1.5 million deaths. The classic treatment is extensive and the drug- and multi-drug resistance of Mycobacterium tuberculosis has been a threat to the efficacy of the drugs currently used. Therefore, the rational design of new anti-TB candidates is urgently needed. With the aim of contributing to face this challenge, 78 compounds have been proposed based on SBDD (Structure-Based Drug Design) strategies applied to target the M. tuberculosis phosphopantetheine adenylyltransferase (MtPPAT) enzyme. Ligand-Based Drug Design (LBDD) strategies were also used for establishing Structure-Activity Relationships (SAR) and for optimizing the structures. MtPPAT is important for the biosynthesis of CoA (CoA) and it has been studied recently toward the discovery of new inhibitors. After docking simulations and enthalpy calculations, the interaction of selected compounds with MtPPAT was found to be energetically favorable. The most promising compounds were then synthesized and submitted to anti-M. tuberculosis and MtPPAT inhibition assays. One of the compounds synthesized (MCP163), showed the highest activity in both of these assays. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6SDS of cas: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics