Tag: 200-300

Preparation of N-trifluoromethylthiosaccharin: A shelf-stable electrophilic reagent for trifluoromethylthiolation was written by Zhu, Jiansheng;Xu, Chunhui;Xu, Chunfa;Shen, Qilong. And the article was included in Organic Syntheses in 2017.Synthetic Route of C7H4ClNO3S This article mentions the following:

The preparation of N-(trifluoromethylthio)saccharin (I) was reported. Application of I as a trifluromethylthiolation reagent was also discussed. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Synthetic Route of C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, spectral characterization and antimicrobial activity of thiourea/urea derivatives of amlodipine was written by Vedavathi, P.;Sekhar, K. Chandra;Raju, C. Naga. And the article was included in Pharmacia Lettre in 2013.Formula: C7H3Cl2NS This article mentions the following:

Amlodipine is one of the calcium channel blockers having dihydropyridine group, used as an antihypertensive drug. A series of novel ureaandthioureaderivativesofamlodipine(1) were prepared by reacting (1) with various substituted isocyanates/isothiocyanates in the presence of triethylamine in THF at 50 °C. Their structures were established by IR, ¹H, ¹³CNMR, Mass spectral data and C, H, N elemental anal. Their antimicrobial activity was evaluated and the title compounds exhibited moderate antimicrobial activity. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

β-Cyclodextrin based molecular reactors for free radical chemistry in aqueous media was written by Johnson, Anne E.;Perchyonok, V. Tamara. And the article was included in Current Organic Chemistry in 2009.Category: chlorides-buliding-blocks This article mentions the following:

A broad range of fundamental free radical reactions, such as hydrogen and halogen atom transfer, radical deoxygenations, radical cyclization reactions, radical additions to C=C and C=N double bonds, in β-cyclodextrin based mol. reactors at room temperature are investigated. The reactions proceeded smoothly in moderate to excellent yield at ambient temperature In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Category: chlorides-buliding-blocks).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, Antimycobacterial Activity and 3-D QSAR Studies of Some New Derivatives of p-Hydroxybenzohydrazide was written by Bhole, Ritesh. P.;Bhusari, Kishore P.. And the article was included in QSAR & Combinatorial Science in 2009.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Various N’-[3-(4-substituted alkyl/aryl thiaiazolidin-2-ylidene]-4-hydroxy benzohydrazide (4.a-i) and N’-[-(3,4-disubstituted)-1,3-thiazolidin-2-ylidene)]-4-hydroxybenzohydrazide from (5.a-i) to (10.a-i) were synthesized using appropriate synthetic route. The entire test compounds (4.a-i) and compounds from (5.a-i) to (10.a-i) were assayed in vitro against H₃₇Rv strain of M. tuberculosis. The min. inhibitory concentration (MIC) was determined for test compounds and for reference standards The test compounds showed significant antimycobacterial activity against the microbial strains used, when tested in vitro. In general, p-hydroxybenzohydrazide ring and substituted thiazoline ring are essential for antimicrobial activity. Among the compounds tested, compounds 5.i (I), 6.f, 7.d, 8.g and 9.f were found to be most potent. The test compounds were found to be nontoxic up to a dose level of 1000 μg/mL. All compounds were then subjected for 3D-QSAR studies. 3D-QSAR study based on the principal of alignment of pharmacophoric features by Schrodinger PHASE module. The 3D-QSAR study allowed us to confirm the preferential binding mode of p-hydroxybenzohydrazide inside the active site. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of β-Keto Sulfones by Oxy-Sulfonylation of Alkynes in HFIP was written by Chen, Xingyu;Lu, Sixian;Zheng, Yuyan;Wang, Jigang;Yang, Lan;Sun, Peng. And the article was included in Advanced Synthesis & Catalysis in 2022.Recommanded Product: 777-44-6 This article mentions the following:

Herein, authors have established a method for the construction of β-keto sulfones through aerobic oxy-sulfonylation of alkynes with sulfinates. The reaction performed employing air as the oxidant and oxygen source. Moreover, this protocol exhibits low consume of sulfinates, short reaction period, and minimal waste. Mechanism study and d. functional theory (DFT) calculation showed that the solvent played a significant role in the transformation. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Recommanded Product: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Asymmetric Synthesis of Spirooxazolidinone Oxindoles by the Thiourea-Catalyzed Aldol Reaction of 2-Isocyanatomalonate Diesters was written by Chen, Xiao-Pan;Liu, Jin-Xin;Li, Hong-Yan;Xiao, You-Cai;Chen, Fen-Er. And the article was included in Advanced Synthesis & Catalysis in 2022.Product Details of 76-83-5 This article mentions the following:

A tertiary amino-thiourea catalyzed asym. aldol reaction between 2-isocyanatomalonate esters and isatins was achieved. Optical active spirooxazolidinone oxindole derivatives I [R = Me, Bn, trityl, etc.; R¹ = H, 4-Me, 5-i-Pr, etc.; R² = Me, Et, Bn, etc.; X = C, N] were obtained with excellent yields (80%-96%) and enantioselectivities (67%-99% ee) under mild conditions, providing an updated example to apply isatins as the electrophile in the asym. aldol reaction with 2-isocyanatomalonate esters. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Product Details of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper-Catalyzed Alkylarylation of Unactivated Alkenes: Synthesis of 3-Alkyl Indolines from N-Allyl Anilines and Alkanes was written by Liang, Deqiang;Huo, Bojie;Dong, Yongrui;Wang, Yan;Dong, Ying;Wang, Baoling;Ma, Yinhai. And the article was included in Chemistry – An Asian Journal in 2019.Reference of 18437-66-6 This article mentions the following:

A rare example of C(sp³)-H functionalization of simple alkanes with unactivated alkenes was presented. In the presence of a copper salt and di-tert-Bu peroxide (DTBP), N-allyl anilines underwent exo-selective alkylation/cyclization cascade with unactivated alkenic bonds as radical acceptors and simple alkanes as radical precursors, providing a direct access to 3-alkyl indolines I [R = H, 5-Cl, 5-Ph, etc.; R¹ = C(Me)₂CH₂CH₃, cyclopentyl, cyclohexyl, etc.; R² = C(O)Me, Boc, SO₂Et, etc.]. The present protocol featured simple operation, broad substrate scope and great exo selectivity. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Regiocontrolled palladium-catalyzed direct C2-arylations of Methoxalen using benzenesulfonyl chlorides and C2,C3-diarylations using aryl bromides as the aryl sources was written by Li, Haoran;Roisnel, Thierry;Soule, Jean-Francois;Doucet, Henri. And the article was included in Tetrahedron Letters in 2020.Synthetic Route of C7H4ClF3O2S This article mentions the following:

Conditions for the regioselective palladium-catalyzed direct C2-arylation and C2,C3-diarylation of methoxalen were described. The use of benzenesulfonyl chlorides as the coupling partner allowed control of the regioselectivity of the arylation in favor of the C2 carbon of methoxalen. This method tolerated a variety of substituents on the benzenesulfonyl chloride derivatives Notably, 2-, 3- and 4-bromobenzenesulfonyl chlorides and 4-iodobenzenesulfonyl chloride were coupled with methoxalen without cleavage of the C-Br or C-I bonds. Conversely, the use of an excess amount of aryl bromides as the aryl source provided access to C2,C3-diarlyated methoxalenes. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Synthetic Route of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Biomimetic Total Syntheses of (+)-Chloropupukeananin, (-)-Chloropupukeanolide D, and Chloropestolides was written by Suzuki, Takahiro;Watanabe, Soichiro;Ikeda, Wataru;Kobayashi, Susumu;Tanino, Keiji. And the article was included in Journal of Organic Chemistry in 2021.COA of Formula: C9H9ClO3 This article mentions the following:

Chloropupukeananin, chloropupukeanolides, and chloropestolides are a family of structurally complex bioactive natural products that possess highly functionalized tricyclo[4.3.1.03,7]decane or bicyclo[2.2.2]octane skeletons. Biosynthesis of the chloropupukeananin family is triggered by the intermol. heterodimeric Diels-Alder reaction between maldoxin and iso-A82775C; however, the enzymes involved have not yet been identified. Herein report the one-pot biomimetic synthesis of chloropupukeananin and chloropupukeanolide D. Moreover, the effect of the solvent on the intermol. Diels-Alder reaction of siccayne and maldoxin suggested that the biosynthesis of the chloropupukeananin family involves a Diels-Alderase-catalyzed heterodimeric Diels-Alder reaction. In the experiment, the researchers used many compounds, for example, 4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5COA of Formula: C9H9ClO3).

4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: Sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors was written by Majmudar, Jaimeen D.;Hahne, Kalub;Hrycyna, Christine A.;Gibbs, Richard A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Formula: C8H9ClO4S This article mentions the following:

Human isoprenylcysteine carboxyl methyltransferase (hIcmt) is a promising anticancer target as it is important for the post-translational modification of oncogenic Ras proteins. We herein report the synthesis and biochem. activity of 41 farnesyl-cysteine based analogs vs. hIcmt. We have demonstrated that the amide linkage of a hIcmt substrate can be replaced by a sulfonamide bond to achieve hIcmt inhibition. The most potent sulfonamide-modified farnesyl cysteine analog was 6ag with an IC₅₀ of 8.8 ± 0.5 μM for hIcmt. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Formula: C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics