Tag: 200-300

Synthesis of N-phenylsulfonamide derivatives and investigation of some esterase enzymes inhibiting properties was written by Akin Kazancioglu, Elif;Senturk, Murat. And the article was included in Bioorganic Chemistry in 2020.Electric Literature of C7H4ClF3O2S This article mentions the following:

In this study, synthesis of nine N-phenylsulfonamide derivatives I [R = Me, 4-methoxyphenyl, 4-fluorophenyl, 2-thiophenyl, etc.] was designed by starting from aniline, which was the simplest aromatic amine. These compounds I were obtained in yields between 69 and 95%. Inhibitory properties of synthesized compounds I on carbonic anhydrase I (CA I), CA II isoenzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. The compound I [R = 2-naphthyl] for CA I, AChE and BChE, 2 for CA II showed a very active inhibition profile (KI 45.7 ± 0.46 for CA I, 33.5 ± 0.38 nM for CA II, 31.5 ± 0.33 nM for AChE and 24.4 ± 0.29 nM for BChE). The results indicate that these N-phenyl-sulfonamide derivatives I were potent CA and cholinesterases and new potential drugs. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nitroacenaphthene as a New Photocatalyst for the Synthesis of Sulfonyl Amidines was written by Jian, Yong;Chen, Ming;Yang, Chao;Xia, Wujiong. And the article was included in Synthesis in 2019.SDS of cas: 777-44-6 This article mentions the following:

A small mol., namely nitroacenaphthene, is reported for the first time as a recyclable visible-light photocatalyst for the construction of the C=N bond from sulfonyl azides RS(O)₂N₃ (R = Pr, 4-bromophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) and amines R¹N(R²)(R³) (R¹ = H, Me, Et, n-Pr; R² = Et, n-Pr, i-Pr, n-Bu; R³ = Me, Et, n-Pr, i-Pr, n-Bu). This scalable, site-selective protocol provides a convenient way to access various sulfonyl amidines (E/Z)-RS(O)N=CHN(R²)(R³) under mild conditions. Two reaction pathways are proposed according to different transformation patterns. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6SDS of cas: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sulfonyl transfer reactions: solvolysis of arenesulfonyl chlorides in aqueous trifluoroethanol was written by Forbes, Rowena M.;Maskill, H.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1991.Product Details of 63624-28-2 This article mentions the following:

Activation parameters for the solvolysis in aqueous trifluoroethanol of arenesulfonyl chlorides with electron-supplying substituents have been determined; the results are not in accord with earlier proposals that such compounds react by an S_N1 mechanism. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Product Details of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Elucidating dynamic behavior of synthetic supramolecular polymers in water by hydrogen/deuterium exchange mass spectrometry was written by Lou, Xianwen;Schoenmakers, Sandra M. C.;van Dongen, Joost L. J.;Garcia-Iglesias, Miguel;Casellas, Nicolas M.;Fernandez-Castano Romera, Marcos;Sijbesma, Rint P.;Meijer, E. W.;Palmans, Anja R. A.. And the article was included in Journal of Polymer Science (Hoboken, NJ, United States) in 2021.Electric Literature of C19H15Cl This article mentions the following:

A comprehensive understanding of the structure, self-assembly mechanism,and dynamics of one-dimensional supramol. polymers in water is essentialfor their application as biomaterials. Although a plethora of techniques areavailable to study the first two properties, there is a paucity i possibilities to study dynamic exchange of monomers between supramol. polymers in solution We recently introduced hydrogen/deuterium exchange mass spectrometry (HDX-MS) to characterize the dynamic nature of synthetic supramol. polymers with only a minimal perturbation of the chem. structure was introduced. To further expand the application of this powerful technique some essential exptl. aspects was reaffirmed and the technique was applied to a diverse library of assemblies. HDX-MS was widely applicable if there are exchangeable hydrogen atoms protected from direct contact with the solvent and if the monomer concentration was sufficiently high to ensure the presence of supramol. polymers during dilution In addition, it was demonstrated that the kinetic behavior as probed by HDX-MS was influenced by the internal order within the supramol. polymers and by the self-assembly mechanism. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Electric Literature of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanism of oxidation of some active methylene compounds by N-chlorosaccharin in acetic acid-water medium. A kinetic study was written by Khan, M. U.;Nigam, S. K.;Gupta, O. P.;Tiwari, A. K. S.;Parihar, S. S.;Nigam, A.. And the article was included in Oxidation Communications in 1999.Related Products of 14070-51-0 This article mentions the following:

Oxidation of MeCOCH₂CO₂Et and CH₂(CO₂Et)₂ by N-chlorosaccharin in aqueous AcOH was studied. This reaction exhibits 1st-order dependence on both [oxidant] and [substrate]. The reaction is acid catalyzed. The effect of solvent on the reaction kinetics was also examined, as was the effect of ionic strength of the medium. The reaction rate was retarded by the addition of saccharin. The stoichiometry of the oxidation is 1:2, which shows the formation of a transitory complex between the enolic form of the substrate and the oxidant. The effect of temperature on reaction rate was also studied, and the thermodn. parameters were evaluated. Taking into account all the observed kinetic data, a plausible mechanism was described and a suitable rate law was derived. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Related Products of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reinvestigation of chlorination of saccharin. A mild and convenient synthesis of o-cyanophenylsulfonyl chloride was written by Yoon, Yong Jin;Kang, Yoon Se. And the article was included in Bulletin of the Korean Chemical Society in 1985.Formula: C7H4ClNO3S This article mentions the following:

Treating saccharin with PCl₅-ZnCl₂ 15-30 min at 65-70° gave 85-90 % o-NCC₆H₄SO₂Cl. Refluxing saccharin or its Na salt with POCl₃ 2-3 h gave 75% N-chlorosaccharin I. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Formula: C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Inhibition of the Human Proteasome by Imidazoline Scaffolds was written by Azevedo, Lauren M.;Lansdell, Theresa A.;Ludwig, Jacob R.;Mosey, Robert A.;Woloch, Daljinder K.;Cogan, Dillon P.;Patten, Gregory P.;Kuszpit, Michael R.;Fisk, Jason S.;Tepe, Jetze J.. And the article was included in Journal of Medicinal Chemistry in 2013.Electric Literature of C8H9ClO4S This article mentions the following:

The proteasome has emerged as the primary target for the treatment of multiple myeloma. Unfortunately, nearly all patients develop resistance to competitive-type proteasome inhibitors such as bortezomib. Herein, the optimization of noncompetitive proteasome inhibitors to yield derivatives that exhibit nanomolar potency (compound I, IC₅₀ 130 nM) toward proteasome inhibition and overcome bortezomib resistance is described. These studies illustrate the feasibility of the development of noncompetitive proteasome inhibitors as additives and/or alternatives to competitive proteasome inhibitors. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, biological evaluation, and modeling studies of novel conformationally-restricted analogues of sorafenib as selective kinase-inhibitory antiproliferative agents against hepatocellular carcinoma cells was written by Sbenati, Rawan M.;Zaraei, Seyed-Omar;El-Gamal, Mohammed I.;Anbar, Hanan S.;Tarazi, Hamadeh;Zoghbor, Malaka M.;Mohamood, Najma A.;Khakpour, Mahta M.;Zaher, Dana M.;Omar, Hany A.;Alach, Nour N.;Shehata, Mahmoud K.;El-Gamal, Randa. And the article was included in European Journal of Medicinal Chemistry in 2021.COA of Formula: C7H4ClF3O2S This article mentions the following:

Sorafenib is one of the clin. used anticancer agents that inhibits several kinases. In this study, novel indole-based rigid analogs of sorafenib were designed and synthesized in order to enhance kinase selectivity and hence minimize the side effects associated with its use. The target compounds possess different linkers; urea, amide, sulfonamide, or thiourea, in addition to different terminal aryl moieties attached to the linker in order to investigate their impact on biol. activity. They were tested against Hep3B, Huh7, and Hep-G2 hepatocellular carcinoma (HCC) cell lines to study their potency. Among all the tested target derivatives, arylaminocarbonylaminoindolylpicolinamide I exerted superior antiproliferative potency against all the three tested HCC cell lines compared to sorafenib. Based on these preliminary results, I was selected for further biol. and in silico investigations. Up to 30μM, I did not inhibit 50% of the proliferation of WI-38 normal cells, which indicated promising selectivity against HCC cells than normal cells. In addition, I exerted superior kinase selectivity than sorafenib. It is selective for VEGFR2 and VEGFR3 angiogenesis-related kinases, while sorafenib is a multikinase inhibitor. Superior kinase selectivity of I to sorafenib can be attributed to its conformationally-restricted indole nucleus and the bulky N-methylpiperazinyl moiety. Western blotting was carried out and confirmed the ability of I to inhibit VEGFR2 kinase inside Hep-G2 HCC cells in a dose-dependent pattern. I induces apoptosis and necrosis in Hep-G2 cell line, as shown by caspase-3/7 and lactate dehydrogenase (LDH) release assays, resp. Moreover, I did not inhibit hERG. Thus, we could achieve a more selective kinase inhibitor than sorafenib with retained or even better antiproliferative potency against HCC cell lines. Furthermore, mol. docking and dynamic simulation studies were carried out to investigate its binding mode with VEGFR2 kinase. The mol. has a unique orientation upon binding with the kinase. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6COA of Formula: C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Spectra-structure correlations in solid metal saccharinates. II. Ab initio molecular structures and vibrational spectra of N-substituted saccharins at the HF level was written by Naumov, Pance;Jovanovski, Gligor;Ohashi, Yuji. And the article was included in Solid State Sciences in 2002.Recommanded Product: 14070-51-0 This article mentions the following:

Ground-state ab initio mol. geometries and vibrational spectra of 24 N-substituted isolated saccharins with small-size B, Br, C, Cl, F, N, O, P or S-groups and the parent mol. are predicted at RHF/6-31G level to examine the mol. structural changes stemming from N-substitution of saccharin (o-sulfobenzimide). Trends in the mol. geometrical parameters of the sulfimide ring and the carbonyl stretching frequency are discussed in relation to the electronic properties of the substituent and the solid state effects. The results are compared with the crystallog. data for N-substituted saccharins and metal saccharinato salts/complexes retrieved from the Cambridge Structural Database. The ability of several theor. methods to describe the substitution/deprotonation of the conjugated CO-NH-SO₂ structure is summarized. Electronic properties of the substituent affect significantly only the immediate C-N and S-N bonds by as much as ±0.014 Å, while other bonds are relatively less influenced ( ± 0.004 Å). Combined with the effects of the crystal packing and thermal vibrations, they impose flexibility on the intramol. lengths up to ±0.02 Å. High correlation (R = 0.966) between the theor. ν(CO) frequencies and C-O distances is predictable for both of these parameters, but is lowered notably in the crystal by both vibrational and solid-state circumstances. From the structural viewpoint, the N_sac-X bonds (X = B, Br, C, Cl, F, N, O, P, S; sac denotes saccharin) behave similarly to the purely covalent N_sac-metal bonds. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fluorinated pyrido[2,3-c]pyridazines. II. Synthesis and antibacterial activity of 1,7-disubstituted 6-fluoro-4(1H)-oxopyrido[2,3-c]pyridazine-3-carboxylic acids was written by Miyamoto, Teruyuki;Matsumoto, Junichi. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Recommanded Product: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:

Chem. modification of pyridonecarboxylic acid antibacterials with a 1,8-naphthyridine ring, such as enoxacin and tosufloxacin, to their 2-aza derivatives was studied. A new series of 1,7-disubstituted fluorooxopyridopyridazines, e.g. I (R = Et, CH₂CH₂F, C₆H₄F-4, R¹ = H, Me), was prepared by either alkylation of Et 6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido[2,3-c]pyridazine-3-carboxylate or intramol. cyclization of Et 2-(2,6-dichloro-5-fluoronicotinoyl)-2-[2-(p-fluorophenyl)hydrazono]acetate, followed by displacement reaction with cyclic amines at C-7. Antibacterial activities of these compounds were markedly inferior to those of enoxacin and tosufloxacin. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Recommanded Product: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics