Tag: 200-300

Ti-Mediated Efficient Reductive Dehalogenation of Carbon-Halogen Bonds was written by Gonzalez-Delgado, Jose A.;Prieto, Consuelo;Enriquez, Lourdes;Jaraiz, Martin;Lopez-Perez, Jose L.;Barrero, Alejandro F.;Arteaga, Jesus F.. And the article was included in Asian Journal of Organic Chemistry in 2016.Product Details of 3386-33-2 This article mentions the following:

A mild and efficient methodol. for the reductive dehalogenation of carbon-halogen bonds in both activated (allylic or benzylic) and non-activated halides with excess Ti^III was thoroughly described. A detailed computational and exptl. study corroborates that the reaction occurred via the allyl(benzyl) radical and allyl(benzyl)-Ti, which was protonated by a Bronsted acid and proceeds regioselectively in the case of allylic derivatives This synthetic method was compatible with a wide range of functional groups and reaction conditions and thus presented a mild process for reductive dehalogenation in the field of organic synthesis. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Product Details of 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient, continuous N-Boc deprotection of amines using solid acid catalysts was written by Wu, Jing;Zheng, Chunming;Li, Bryan;Hawkins, Joel M.;Scott, Susannah L.. And the article was included in Reaction Chemistry & Engineering in 2021.Related Products of 18437-66-6 This article mentions the following:

The use of simple solid Bronsted acid catalysts to achieve continuous N-Boc deprotection of amines, e.g., tert-Bu 2-oxopiperidine-1-carboxylate without addnl. workup steps has been described. Using THF as the solvent, H-BEA zeolite affords high yields of a variety of aromatic and aliphatic amines, e.g., 2-piperidinone often in residence times of less than a minute at 140°C. The same catalyst/solvent combination is ineffective in batch conditions, due to the much lower temperature of refluxing THF. Boc-protected p-chloroaniline was deprotected with a throughput of 18 mmol p-chloroaniline per h per g_cat, sustained over 9 h. The active sites of the zeolite do not appear to be directly associated with the Al framework substitution in the micropores, since partially ion-exchanged Na/H-BEA shows activity similar to H-BEA. The strong Bronsted acid sites (framework [Si(OH)Al]), are likely poisoned by the amine product. Moderate Bronsted acid sites associated with silanol defects near Al on or near the external surface (and not susceptible to Na+-exchange) are presumably the active sites, since they are not poisoned even by more basic aliphatic amines. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Related Products of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, single-crystal and preliminary antitumor activity of novel arenesulfonylimidazolidin-2-ones was written by Abdel-Aziz, Alaa A.-M.;El-Azab, Adel S.;El-Subbagh, Hussein I.;Al-Obaid, Abdulrahman M.;Alanazi, Amer M.;Al-Omar, Mohamed A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Reference of 63624-28-2 This article mentions the following:

Mono(arylsulfonyl) and bis(arylsulfonyl) dimethoxyimidazolidinones I [R = PhSO₂, 2-naphthylsulfonyl, 4-MeC₆H₄SO₂, 4-MeOC₆H₄SO₂, 4-ClC₆H₄SO₂, 2,4-(MeO)₂C₆H₃SO₂, 2,4-Cl₂C₆H₄SO₂, 2,4,6-Me₃C₆H₂SO₂, 2,4,6-(Me₂CH)₃C₆H₂SO₂; R¹ = H, R] were prepared as cyclic analogs of the antitumor agent sulofenur and tested for their antitumor activity in a variety of human cancer cell lines. Bromination of 1,3-diacetyl-2-imidazolone followed by treatment with DIPEA and methanol gave I (R = H; R¹ = MeCO); sulfonylation followed by cleavage of the remaining acetyl group yielded I [R = PhSO₂, 2-naphthylsulfonyl, 4-MeC₆H₄SO₂, 4-MeOC₆H₄SO₂, 4-ClC₆H₄SO₂, 2,4-(MeO)₂C₆H₃SO₂, 2,4-Cl₂C₆H₄SO₂, 2,4,6-Me₃C₆H₂SO₂, 2,4,6-(Me₂CH)₃C₆H₂SO₂; R¹ = H], while cleavage of the remaining acetyl group followed by disulfonylation gave I [R = R¹ = PhSO₂, 2-naphthylsulfonyl, 4-MeC₆H₄SO₂, 4-MeOC₆H₄SO₂, 4-ClC₆H₄SO₂, 2,4-(MeO)₂C₆H₃SO₂, 2,4-Cl₂C₆H₄SO₂, 2,4,6-Me₃C₆H₂SO₂, 2,4,6-(Me₂CH)₃C₆H₂SO₂]. Bis(arylsulfonyl) dimethoxyimidazolidinones were more active against cancer cells than the corresponding mono(arylsulfonyl) dimethoxyimidazolidinones, with bis(arylsulfonyl) dimethoxyimidazolidinones showing particular activity against lung and kidney cancer cell lines. I (R = R¹ = 4-ClC₆H₄) showed remarkable broad-spectrum antitumor activity. The structure of I [R = 2,4-(MeO)₂C₆H₃SO₂; R¹ = H] was determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationship and hypoglycemic activity of tricyclic matrines with advantage of treating diabetic nephropathy was written by Tang, Sheng;Wang, Can;Li, Ying-Hong;Niu, Tian-Yu;Zhang, Yuan-Hui;Pang, Yu-Dong;Wang, Yan-Xiang;Kong, Wei-Jia;Song, Dan-Qing. And the article was included in European Journal of Medicinal Chemistry in 2020.Electric Literature of C7H4ClF3O2S This article mentions the following:

Forty-three tricyclic matrinic derivatives with a unique scaffold were prepared and evaluated for their stimulation effects on glucose consumption in HepG2 cells. The structure-activity relationship was systematically elucidated for the first time. Among them, compound 17a(I) exhibited the most promising potency, and dose-dependently increased glucose consumption in L6 myotubes. It significantly lowered blood glucose, glucosylated Hb and AGE level, and improved glucose tolerance and insulin resistance in KK-Ay mice as well. More importantly, 17a effectively ameliorated diabetic nephropathy (DN), as indicated by the improvement of renal function and pathol. changes, and decrease of urinary protein. Furthermore, 17a could induce glycolysis but suppressed aerobic oxidation of glucose, in a similar mechanism to Metform. Our results indicated that in addition to hyperglycemia, 17a may be developed to treat diabetic complication such as DN. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics and mechanistic approach of N-chlorosaccharin oxidation of some aliphatic aldehydes was written by Khan, M. U.;Verma, J. K.;Nigam, S. K.;Parihar, S. S.;Dwivedi, H. P.. And the article was included in Oxidation Communications in 1998.Application of 14070-51-0 This article mentions the following:

The kinetic studies of N-chlorosaccharin (NCSA) oxidation of acetaldehyde and propionaldehyde have been reported in aqueous acetic acid medium. The reactions follow identical kinetics, being first order in each NCSA, and 1 to 0 order with respect to substrate and [H⁺]. A pos. effect on the oxidation rate is observed for solvent whereas saccharin exhibited a neg. trend. The ionic strength does not influence the oxidation rate. Various activation parameters have been evaluated. The products of the reactions were identified as the corresponding acids. A suitable scheme of mechanism consistent with the exptl. results has been proposed. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Application of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of Dithioacetal Derivatives Containing Sulfonamide Moiety of Novel Antiviral Agents by TMV Coat Protein as a Potential Target was written by Yang, Yuyuan;Zhang, Jian;Li, Xiangyang;He, Fangcheng;Wu, Rong;Hu, Deyu;Song, Baoan. And the article was included in ACS Omega in 2020.Related Products of 777-44-6 This article mentions the following:

Tobacco mosaic virus coat protein (TMV CP) plays an important role in viral replication, translation, and intracellular and intercellular movements. Thus, TMV CP could be regarded as a potential target for antiviral agents. In this study, in order to find out whether dithioacetal derivatives act on the CP target, a series of dithioacetal derivatives containing sulfonamide moiety was first designed and synthesized. Bioassay results demonstrated that three of the compounds exhibited excellent activities against TMV, with half-maximal effective concentrations (EC₅₀) of the curative, protective, and inactivate activities being 183.0 ± 3.2, 252.3 ± 2.6, and 63.8 ± 1.2μg/mL, 270.6 ± 3.7, 249.7 ± 3.5, and 57.7 ± 1.4μg/mL, and 329.5 ± 1.5, 269.2 ± 3.7, and 48.1 ± 2.0μg/mL, which were higher than those for the control agents ningnanmycin (331.0 ± 2.8, 271.0 ± 2.8, and 77.4 ± 1.3μg/mL, resp.) and d2 (471.5 ± 1.4, 447.2 ± 2.1, and 91.7 ± 1.8μg/mL, resp.). Transmission electron microscopy showed that the particle morphol. of TMV was destroyed by I, and microscale thermophoresis (MST) showed that I bonded to CP with a dissociation constant (K_d) of 9.7 ± 1.7μM. Then, mol. docking and MST further illustrated that I had a weak binding affinity with the TMV mutant protein (K_d = 561.3 ± 83.2μM). Thus, we deduced that the dithioacetal derivative I may inhibit TMV activity by binding TMV CP. This work provides some new insights for the design and optimization of anti-TMV agents. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Stereospecific Cross-Coupling of Secondary Organotrifluoroborates: Potassium 1-(Benzyloxy)alkyltrifluoroborates was written by Molander, Gary A.;Wisniewski, Steven R.. And the article was included in Journal of the American Chemical Society in 2012.Application of 18437-66-6 This article mentions the following:

Potassium 1-(alkoxy/acyloxy)alkyltrifluoroborates have been synthesized through a copper-catalyzed diboration of aldehydes and subsequent conversion of the resulting potassium 1-(hydroxy)alkyltrifluoroborates. The palladium-catalyzed Suzuki-Miyaura reaction employing the potassium 1-(benzyloxy)alkyltrifluoroborates with aryl and heteroaryl chlorides provides access to protected secondary alcs. in high yields. The β-hydride elimination pathway is avoided through use of the benzyl protecting group, which is proposed to stabilize the diorganopalladium intermediate by coordination of the arene to the metal center. This cross-coupling is stereospecific with complete retention of stereochem. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An “on-water” exploration of CuO nanoparticle catalysed synthesis of 2-aminobenzothiazoles was written by Rout, Saroj Kumar;Guin, Srimanta;Nath, Jayashree;Patel, Bhisma K.. And the article was included in Green Chemistry in 2012.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

An “on-water” one-pot process has been engineered for the preparation of 2-aminobenzothiazole from ortho-halo (-F, -Cl, -Br and -I) substituted unsym. thioureas. For ortho -I and -Br substrates the reactions afford 2-aminobenzothiazoles under metal free condition promoted by base. However, the relatively inert ortho -Cl and -F substrates undergo intramol. arylthiolation only in the presence of CuO nanoparticles yielding 2-aminobenzothiazoles. This methodol. provides easy access to aminobenzothiazoles utilizing even the ortho -Cl and -F substrates. The catalyst is recyclable several times without loss of substantial activity. Other remarkable features include the wide range of functional group tolerance, absence of chromatog. purification (for ortho -I and -Br substrates) and providing moderate to excellent yield of the products under mild conditions, thus rendering the methodol. as a highly eco-friendly alternative to the existing methods. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis was written by Richter, Adrian;Narula, Gagandeep;Rudolph, Ines;Seidel, Ruediger W.;Wagner, Christoph;Av-Gay, Yossef;Imming, Peter. And the article was included in ChemMedChem in 2022.Application In Synthesis of 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid This article mentions the following:

8-Nitrobenzothiazinones (BTZs) were a promising class of antimycobacterial agents currently under investigation in clin. trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and was applicable for preparation of a wide variety of BTZ analogs. The synthetic procedure furthermore facilitates the replacement of the sulfur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogs were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay. In the experiment, the researchers used many compounds, for example, 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4Application In Synthesis of 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid).

2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives was written by Cheng, Pi;Zhang, Quan;Ma, Yun-Bao;Jiang, Zhi-Yong;Zhang, Xue-Mei;Zhang, Feng-Xue;Chen, Ji-Jun. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Application of 18437-66-6 This article mentions the following:

A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepines were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. I [R = CH₂CH₂OH] showed IC₅₀ of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, resp., which were 10 times higher than that of its analog I [R = H] and led to better selective index (SI) values (SI = 23.2 and 3.4, resp.). In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics