Tag: 200-300

Mechanism of oxidation of (p-substituted phenylthio)acetic acids with N-chlorosaccharin was written by Alhaji, N. M. I.;Uduman Mohideen, A. M.;Lawrence Mary, S. Sofia. And the article was included in E-Journal of Chemistry in 2011.Safety of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

The kinetics of oxidation of (phenylthio)acetic acid (PTAA) with N-chlorosaccharin (NCSA) have been studied potentiometrically in 80:20 (volume/volume) acetonitrile-water medium at 298 K. The reaction is first-order each with respect to PTAA and NCSA and shows a neg. dependence on [H⁺]. NCSA itself is shown to be the active oxidizing species. Effects of ionic strength variation, added saccharin, added acrylonitrile, added NaCl and solvent composition variation have been studied. Effect of substituents on the reaction rate has been analyzed by employing various (p-sustituted phenylthio)acetic acids. The electron-releasing substituent in the Ph ring of PTAA accelerates the reaction rate while the electron-withdrawing substituent retards the rate. The excellently linear Hammett plot yields a large neg. ρ value, supporting the involvement a chlorosulfonium ion intermediate in the rate-determining step. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Safety of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Monoamine-modified thin film composite nanofiltration membrane for permselective separation of fermentation bioproducts was written by Gonzales, Ralph Rolly;Shintani, Takuji;Sunami, Shunsuke;Sasaki, Yuji;Nakagawa, Keizo;Yoshioka, Tomohisa;Matsuyama, Hideto. And the article was included in Journal of Applied Polymer Science in 2022.Application In Synthesis of Trimesoylchloride This article mentions the following:

One process involved in biorefinery for generation of value-added products is fermentation After fermentation, the downstream bioproduct purification process is conventionally performed by organic solvent extraction, which is environmentally-hazardous and costly. Membrane-based separation is a cost-efficient and environmentally-benign method for bioproduct separation and purification In this study, a thin film composite (TFC) nanofiltration (NF) membrane was prepared and the pore size and charge of the polyamide layer were controlled by introducing iminodiacetic acid (IDA), a charged monoamine monomer, with piperazine (PIP) during interfacial polymerization (IP). The newly-developed NF membrane was found to have a mol. weight cut-off (MWCO) of 500 to 1350 Da, allowing the permeation of the fermentation product, while rejecting other higher mol. weight compounds IDA addition in the aqueous amine solution during IP effectively engineered the MWCO values and pore sizes of TFC NF membranes for specific applications, such as separation of fermentation bioproducts. This study successfully showed that IDA reduced the diffusivity of PIP during IP, which neg. affected the polyamide formation and membrane performance. The optimal PIP:IDA concentration ratio was determined by MWCO and effective pore diameter for effective bioproduct separation and purification, which could not be performed by the current com.-available NF membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application In Synthesis of Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Flavor characteristics of shrimp sauces with different fermentation and storage time was written by Zhu, Wenhui;Luan, Hongwei;Bu, Ying;Li, Xuepeng;Li, Jianrong;Ji, Guangren. And the article was included in LWT–Food Science and Technology in 2019.COA of Formula: C18H37Cl This article mentions the following:

The present study investigated the volatile compounds in nearly three-year shrimp sauces and the effects of different fermentation and storage time on the integral aroma characteristics. The 89 volatile compounds were identified by solid phase microextraction (SPME) and gas chromatog.-mass spectrometry (GC-MS) anal. Compared with the other two samples, the shrimp sauces which fermented and storage for 2 years has the highest umami amino acid content and the better flavor. The results of electronic nose (e-nose) and electronic tongue (e-tongue) detection to distinguish the aroma characteristics of different samples demonstrated good agreement with those obtained by GC-MS anal. These results suggested that proper fermentation and storage time are critical to the flavor quality of shrimp sauces. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, pharmacokinetics, and biological activity of a series of new pyridonecarboxylic acid antibacterial agents bearing a 5-fluoro-2-pyridyl group or a 3-fluoro-4-pyridyl group at N-1 was written by Yoon, Sung June;Chung, Yong Ho;Lee, Chi Woo;Oh, Yoon Seok;Choi, Dong Rack;Kim, Nam Doo;Lim, Jae Kyung;Jin, Yoon Ho;Lee, Dug Keun;Lee, Won Yong. And the article was included in Journal of Heterocyclic Chemistry in 1997.Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:

The 1-(5-fluoro-2-pyridyl) or 1-(3-fluoro-4-pyridyl) group was introduced in the syntheses of new pyridonecarboxylic acid antibacterial agents. 1-(5-Fluoro-2-pyridyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxoquinolone-3-carboxylic acid (DW-116) showed a moderate in vitro antibacterial activity, but it was found to have very excellent pharmacokinetic profiles so that DW-116 showed dramatic increased in vivo efficacy. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of fungicide fluquinconazole was written by Wang, Guang-yu;Zhou, Yue-gen;Wang, Hui;Kong, Fan-lei. And the article was included in Nongyao in 2014.COA of Formula: C7H3Cl2NS This article mentions the following:

This article aims to study the synthetic route of fluquinconazole. Fluquinconazole was obtained from 2-amino-5-fluorobenzoic acid through reactions of condensation and ring-closure by one-pot method, chlorination and nucleophilic substitution. Under the optimal reaction conditions, the total yield of fluquinconazole was 67.1% based on 2-amino-5-fluorobenzoic acid, the purity was 99%. The structure was confirmed by HPLC-MS, ¹H NMR. This method can be used as an effective path to synthesize fluquinconazole in industrial scale for the advantages of mild reaction condition and high yield. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1COA of Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lewis Acid-Catalyzed Asymmetric Selenocyanation of β-Ketoesters with N-Selenocyanatosaccharin was written by Wu, Di;Qiu, Jiashen;Li, Chengqiu;Yuan, Lexia;Yin, Hongquan;Chen, Fu-Xue. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

The first electrophilic asym. selenocyanation has been achieved in the presence of Ni(OTf)₂ and (R,R)-DBFOX/Ph using N-selenocyanatosaccharin as the new selenocyanation reagent. Thus, a series of α-selenocyanato-β-keto esters were synthesized with high yields (up to 99%) and good ee values (up to 92% ee). The readily preparation of the reagent and high enantioselectivity make this methodol. much practical for the synthesis of chiral selenocyanates. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease was written by Swarbrick, Crystall;Zogali, Vasiliki;Chan, Kitti Wing Ki;Kiousis, Dimitrios;Gwee, Chin Piaw;Wang, Sai;Lescar, Julien;Luo, Dahai;von Itzstein, Mark;Matsoukas, Minos-Timotheos;Panagiotakopoulos, George;Vasudevan, Subhash G.;Rassias, Gerasimos. And the article was included in European Journal of Medicinal Chemistry in 2021.Recommanded Product: 63624-28-2 This article mentions the following:

The flavivirus genus of the Flaviviridae family comprises Dengue, Zika and West-Nile viruses which constitute unmet medical needs as neither appropriate antivirals nor safe vaccines are available. The dengue NS2BNS3 protease is one of the most promising validated targets for developing a dengue treatment however reported protease inhibitors suffer from toxicity and cellular inefficacy. Here we report SAR on our previously reported Zika-active carbazole scaffold, culminating in prodrug compound SP-471P (EC₅₀ 1.10μM, CC₅₀ > 100μM) that generates SP-471 (I â†?II); one of the most potent, non-cytotoxic and cell-active protease inhibitors described in the dengue literature. In cell-based assays, SP-471P leads to inhibition of viral RNA replication and complete abolishment of infective viral particle production even when administered 6 h post-infection. Mechanistically, SP-471 appears to inhibit both normal intermol. protease processes and intramol. cleavage events at the NS2BNS3 junction, as well as at NS3 internal sites, all critical for virus replication. These render SP-471 a unique to date multimodal inhibitor of the dengue protease. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Recommanded Product: 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Covalently Immobilizable Tris(Pyridino)-Crown Ether for Separation of Amines Based on Their Degree of Substitution was written by Vezse, Panna;Benda, Bianka;Fekete, Andras;Golcs, Adam;Toth, Tunde;Huszthy, Peter. And the article was included in Molecules in 2022.Synthetic Route of C19H15Cl This article mentions the following:

A great number of biol. active compounds contain at least one amine function. Appropriate selectivity can only be accomplished in a few cases upon the substitution of these groups, thus functionalization of amines generally results in a mixture of them. The separation of these derivatives with very similar characteristics can only be performed on a preparative scale or by applying pre-optimized HPLC methods. A tris(pyridino)-crown ether was designed and synthesized for overcoming these limitations at a mol. level. It is demonstrated, that this selector mol. is able to distinguish protonated primary, secondary and tertiary amines by the formation of reversible complexes with different stabilities. This degree of substitution-specific mol. recognition of amines opens the door to develop separation processes primarily focusing on the purification of biol. active compounds in a nanomolar scale. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Synthetic Route of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of 7,9-Disulfatetrahydroberberine as Novel Lipid-Lowering Agents was written by Li, Dong-Dong;Yu, Pan;Wang, Zhen-Zhong;Xiao, Wei;Zhou, Xin-Hu;Zhao, Lin-Guo. And the article was included in ACS Omega in 2020.Electric Literature of C7H4ClF3O2S This article mentions the following:

Berberine (BBR), a well-known alkaloid, exhibits various pharmacol. activities, especially hypolipidemic activity, which has attracted much interest from medicinal chemists in the past decade. However, little progress was made on the structural modification of BBR for improving lipid-lowering activity, mainly due to its unclear biol. target and low safety. In this study, a new scaffold of 7,9-disulfatetrahydroberberine was discovered unexpectedly, provided with extremely low cytotoxicity. Hence, a novel series of highly safe 7,9-disulfatetrahydroberberines were designed, synthesized, and evaluated for their hypolipidemic activities. In order to investigate the significance of the 9-position substituent, another new series of 7-sulfatetrahydroberberines were designed and synthesized. Lipid-lowering experiments showed that among these compounds, 5f exhibited the best lipid-lowering activity based on two cell models, 3T3-L1 cells and HepG2 cells. Compared with the blank control, the inhibition rate of compound 5f against total cholesterol was over 60%, the inhibition rate against triglyceride was over 70%, the inhibition rate against low-d. lipoprotein cholesterol was approx. 75%, and the inhibition rate against high-d. lipoprotein cholesterol was close to 50%, which were far superior to the pos. control BBR. This result also verified the feasibility of the development of BBR as a lipid-lowering drug via disubstituted modification at the 7- and 9-position. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anisotropic Ferromagnetic Organic Nanoflowers was written by Sasidharan, Sajitha;Ghosh, Sayandeep;Sreedhar, Rishi;Kumari, Kalpana;Thota, Subhash;Ramakrishnan, Vibin. And the article was included in Journal of Physical Chemistry C in 2022.Application In Synthesis of (Chloromethanetriyl)tribenzene This article mentions the following:

We report a weak anisotropic ferromagnetic behavior in a purely organic mol. at room temperature, a property rarely reported in organic nanomaterials. The reported 1,2-bis(tritylthio)ethane, forming plate- and organic-flower-like morphologies at the nanolevel, is the first organic crystal with an inherent magnetic property at 300 and 2 K. However, at low temperatures, the magnetization value [M_max(T) ~116 emu/mol at 2 K] increases drastically at 3 orders higher compared to 300 K. Interestingly, the system exhibits strong anisotropy with an anisotropic constant, K₁ ~3.25 x 10³ erg/cc, and anisotropy field, H_K ~3.25 kOe. Below 10 K, this system displays unusual temperature dependence of the coercive field [H_C(T)] and remanence magnetization [M_R(T)] with a hysteresis-peak anomaly (T* ~10-15 K) due to the enhanced spin-orbit coupling. The maximum H_C and M_R at T* were H_C = 220 Oe and M_R ~12 emu/mol, resp. Beyond T*, H_C(T) and M_R(T) drop continuously and become negligible as the measurement temperature approaches 300 K. Our results demonstrate that the tri-Ph mols. can be further exploited for the design and synthesis of organic magnets for possible applications in spintronics and memory storage devices. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application In Synthesis of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics