Tag: 200-300

Discovery of hydrazone containing thiadiazoles as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors was written by Dogan, Hilal;Dogan, Sengul Dilem;Gunduz, Miyase Gozde;Krishna, Vagolu Siva;Lherbet, Christian;Sriram, Dharmarajan;Sahin, Onur;Saripinar, Emin. And the article was included in European Journal of Medicinal Chemistry in 2020.Related Products of 6590-96-1 This article mentions the following:

The rational design and synthesis of eighteen new thiadiazolylhydrazones I [R¹ = H, Me; R² = H, Cl; R³ = H, Me, NO₂, etc.] which were synthesized by intramol. oxidative N-S bond formation reaction of 2-benzylidene-N-(phenylcarbamothioyl)hydrazine-1-carboximidamide derivatives II by phenyliodine(III) bis(trifluoroacetate) (PIFA) under mild conditions were presented. Furthermore, the proposed structure of compounds I [R¹ = Me, R² = H, R³ = MeO] was resolved by single-crystal X-ray anal. The compounds I were evaluated for their in vitro antitubercular activity against M. tuberculosis H37Rv. Among them, some compounds I exhibited remarkable antimycobacterial activity, MIC = 0.78-6.25渭g/mL, with low cytotoxicity. Addnl., the most active compounds were screened for their biol. activities against M. tuberculosis in nutrient starvation model. Enzyme inhibition assays and mol. docking studies revealed enoyl acyl carrier protein reductase (InhA) as the possible target enzyme of compounds to show their antitubercular activities. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Related Products of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

NHC-Pd(II)-azole complexes catalyzed Suzuki-Miyaura cross-coupling of sterically hindered aryl chlorides with arylboronic acids was written by Zhang, Yingying;Zhang, Rong;Ni, Chang;Zhang, Xue;Li, Yanji;Lu, Qingwen;Zhao, Yuxuan;Han, Fangwai;Zeng, Yongfei;Liu, Guiyan. And the article was included in Tetrahedron Letters in 2020.Recommanded Product: 5-Bromo-2-chloro-m-xylene This article mentions the following:

In order to synthesize hindered biaryls RR¹ [R = 2-MeC₆H₄, 2,6-di-EtC₆H₃, 2-Me-4-FC₆H₃, etc.; R¹ = Ph, 2-MeC₆H₄, 2-FC₆H₄, etc.], a series of NHC-Pd(II)-azole complexes I [R² = H, Me; R³ = H, Me; X = C, N] were synthesized and characterized. The steric environment effect as well as electronic effect of azole ligands had been assessed. All these complexes I were applied in the Suzuki-Miyaura cross-coupling reaction of sterically hindered aryl chlorides with low catalysts loadings (0.1 mol %) under mild conditions in air and good to excellent isolated yields of sterically hindered biaryls were obtained. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-m-xylene (cas: 206559-40-2Recommanded Product: 5-Bromo-2-chloro-m-xylene).

5-Bromo-2-chloro-m-xylene (cas: 206559-40-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 5-Bromo-2-chloro-m-xylene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

9-Sulfonyl-9(H)-Purine Derivatives Inhibit HCV Replication Via their Degradation Species was written by Hu, Rong;Wang, Wan-Li;Xiao, Kun-Jie;Wang, Ning-Yu. And the article was included in Pharmaceutical Chemistry Journal in 2021.Category: chlorides-buliding-blocks This article mentions the following:

Cell-based screening of a privileged small mol. library led to the discovery of 9-sulfonyl-9(H)-purine as new scaffold for hepatitis C virus (HCV) inhibitors. Structure-activity relationship study with respect to the 2-, 6- and 9-positions in the purine core resulted in the identification of several active compounds with moderate potency against the HCV genotype 1b. Subsequent stability studies demonstrated that HCV inhibitors of this type were unstable in Dulbecco’s modified eagle medium (DMEM) and plasma, as well as glutathione-containing water, and their instability was closely related to their HCV inhibitory activity. A preliminary study of the mechanism of action showed that the sulfonamide bond at the 9-position of purine would be the primary degradation site and the resulting sulfonylation degradation species would mediate the anti-HCV activity of 9-sulfonyl-9(H)-purines. Results of this study demonstrated that 9-sulfonyl-9(H)-purine is an unstable scaffold for HCV inhibitors and further detailed anal. of the degradation species is needed to determine the main active components and direct target for this type of mols. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thin-film nanocomposite forward osmosis membrane with polydopamine @ UiO-66-NH₂-modified polypropylene support and its antifouling property was written by Du, Chunhui;Hu, Jintai;Chen, Fen. And the article was included in Journal of Applied Polymer Science in 2022.Synthetic Route of C9H3Cl3O3 This article mentions the following:

Polypropylene (PP) porous flat membrane is ultrathin and has high porosity, which is suitable for the support of forward osmosis (FO) membrane. However, its high hydrophobicity is its Achilles heel. Dopamine and UiO-66-NH₂ were co-deposited onto the surface of PP support, and interfacial polymerization was performed to fabricate a thin-film nanocomposite (TFN) FO membrane. The reaction-generated polydopamine improved the hydrophilicity of PP membrane, and at the same time enhanced the adhering of UiO-66-NH₂ to the support. The UiO-66-NH₂ nanoparticles were anchored evenly on the surface of the support, which improved the H₂O flux of FO membrane from 11.1 LMH (TFC, TFN-0 without UiO-66-NH₂) to 20.7 LMH (TFN-0.1, with 0.1% UiO-66-NH₂) using 1 mol/L NaCl as the draw solution in FO mode. Compared with TFC membrane, TFN-0.1 membrane also exhibited relative lower specific salt flux (鈭?.252) and structural parameter (鈭?79渭m). When separating Na alginate foulant, the normalized H₂O flux recovery ratio of TFN-0.1 was remained 0.89, and most of the fouling was reversible, as for TFC membrane the data decreased to 0.76 after 2 cycles of operation. Probably UiO-66-NH₂ modified FO membrane exhibited good permeation and antifouling property. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Synthetic Route of C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

DOPC-Detergent Conjugates: Fusogenic Carriers for Improved In Vitro and In Vivo Gene Delivery was written by Pierrat, Philippe;Casset, Anne;Kereselidze, Dimitri;Lux, Marie;Pons, Francoise;Lebeau, Luc. And the article was included in Macromolecular Bioscience in 2016.COA of Formula: C18H37Cl This article mentions the following:

Phospholipid-detergent conjugates are proposed as fusogenic carriers for gene delivery. Eleven compounds are prepared and their properties are investigated. The ability of the conjugates to promote fusion with a neg. charged model membrane is determined Their DNA delivery efficiency and cytotoxicity are assessed in vitro. Lipoplexes are administered in the mouse lung, and transgene expression Indeterminate inflammatory activity are measured. The results show that conjugation of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) with C₁₂E₄ produces a carrier that can efficiently deliver DNA to cells, with negligible -associated toxicity. Fusogenicity of the conjugates shows good correlation with in vitro transfection efficiency and crucially depends on the length of the polyether moiety of the detergent. Finally, DOPC-C₁₂E₄ reveals highly potent for in vivo DNA delivery and favorably compares to GL67A, the current golden standard for gene delivery to the airway, opening the way for further promising developments. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fouling-resistant ionic graft-polyamide nanofiltration membrane with improved permeance for lithium separation from MgCl₂/LiCl mixtures was written by Soyekwo, Faizal;Wen, Hui;Liao, Dan;Liu, Changkun. And the article was included in Journal of Membrane Science in 2022.Name: Trimesoylchloride This article mentions the following:

Selective recovery of lithium from Salt Lake brines using environmentally friendly technologies is increasingly demanded to overcome the shortage of lithium. However, satisfying high separation precision is challenging for most polymer nanofiltration membranes. Besides, bestowing high permeance together with improved membrane fouling remains a challenge for the widespread implementation of membrane processes. Herein, a new tri-quaternary ammonium-based ionic liquid (TQAIL) electrolyte monomer is synthesized and utilized for the surface modification of nascent polyamide active layer to fabricate IL-modified polyamide nanofiltration (NF) membrane for Mg²⁺/Li⁺ separation Mol. dynamics simulations confirm that TQAIL modification creates nanoscale structural heterogeneity leading to enhanced surface hydrophilicity and reduces internal resistance through the membrane selective layer. The TQAIL membrane exhibits improved Li⁺/Mg²⁺ selectivity and improved water permeability of 26.11 L m^-2 h^-1 bar^-1, which is fourfold that of unmodified membrane accompanied with a 100-h stable continuous nanofiltration. Moreover, the membrane displays good anti-biofouling behavior with excellent antimicrobial properties. This study offers new insights into how surface functionalization using multication side chains can remarkably improve ion separations by molecularly tuning ion-membrane electrostatic interactions in polymeric membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Name: Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed anti-Michael Reductive Heck Reaction of 伪,尾-Unsaturated Esters was written by Guo, Tao;Ding, Yalan;Zhou, Lili;Xu, Haiyan;Loh, Teck-Peng;Wu, Xiaojin. And the article was included in ACS Catalysis in 2020.HPLC of Formula: 206559-40-2 This article mentions the following:

A general intermol. anti-Michael reductive Heck reaction of 伪,尾-unsaturated esters with organobromides has been developed. Most topical classes of aryl, heteroaryl, and vinyl bromides were found to efficiently react with a variety of internal conjugated alkenes. This protocol set up a platform toward diverse 伪-arylated 1,6-dicarbonyl frameworks found in natural products and drugs, which are still highly challenging targets in traditional 伪-arylation protocols because of competitive selectivity of enolation. A removable directing group, gram-scale reaction, and modification of complex mols. have addnl. demonstrated that the anti-Michael reductive Heck reaction is a powerful complementary strategy to the classical 伪-arylation approaches. Preliminary mechanistic studies are consistent with our proposed mechanistic design. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-m-xylene (cas: 206559-40-2HPLC of Formula: 206559-40-2).

5-Bromo-2-chloro-m-xylene (cas: 206559-40-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 206559-40-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An expedient strategy for the synthesis of tryptamines and other heterocycles was written by Nicolaou, K. C.;Krasovskiy, Arkady;Trepanier, Vincent E.;Chen, David Y.-K.. And the article was included in Angewandte Chemie, International Edition in 2008.COA of Formula: C11H14ClNO2 This article mentions the following:

N-Boc-protected anilines are converted into an array of useful N-heterocycles and tryptamines through an expedient, cascade-based synthetic sequence involving ortho metalation and subsequent coupling with N-Boc-pyrrolidin-3-one. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6COA of Formula: C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anion Chelation via Double Chalcogen Bonding: The Case of a Bis-telluronium Dication and Its Application in Electrophilic Catalysis via Metal-Chloride Bond Activation was written by Zhou, Benyu;Gabbai, Francois P.. And the article was included in Journal of the American Chemical Society in 2021.COA of Formula: C19H15Cl This article mentions the following:

Telluronium cations have long been known to engage their counteranions via secondary interactions. Yet, this property has rarely been exploited for anion binding. Motivated by such an application, we have now synthesized a bis-telluronium dication ([3]²⁺) that was obtained as a tetrafluoroborate salt by reaction of 2,7-di-tert-butyl-9,9-dimethylxanthene-4,5-diboronic acid with phenoxatellurine difluoride and BF₃路OEt₂. As confirmed by the formation of Te-(渭-BF₄)-Te bridges in the structure of [3][BF₄]₂, [3]²⁺ functions as a bidentate Lewis acid toward anions. [3][BF₄]₂ has also been converted into the more exposed [3][BArF₂₄]₂ ([BArF₂₄]^– = [B(3,5-(CF₃)₂C₆H₃)₄]^–). The latter, which readily ionizes Ph₃CCl, displays a chloride anion binding constant that exceeds that of a monofunctional model compound by almost 4 orders of magnitude. The unique properties of this new bis-telluronium dication are further highlighted by its ability to activate Ph₃PAuCl and cis-(Ph₃P)₂PtCl₂, leading to catalytic systems highly active in the cycloisomerization of propargylamide or enyne substrates. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5COA of Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorination of ketones with N-chlorosaccharin was written by Panchatsharam, V. S.;Sundaram, S.;Venkatasubramanian, N.. And the article was included in Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical in 1981.Related Products of 14070-51-0 This article mentions the following:

A Taft LFER for the title reaction gave 蟻^* = -0.49 which is in accordance with an enolization mechanism that involves the development of pos. charge in the transition state. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Related Products of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics