Tag: 200-300

N-[(Trifluoromethyl)thio]saccharin: An Easily Accessible, Shelf-Stable, Broadly Applicable Trifluoromethylthiolating Reagent was written by Xu, Chunfa;Ma, Bingqing;Shen, Qilong. And the article was included in Angewandte Chemie, International Edition in 2014.Recommanded Product: 14070-51-0 This article mentions the following:

A new, electrophilic trifluoromethylthiolaton agent N-[(trifluoromethyl)thio]saccharin, was developed and can be synthesized in two steps from saccharin within 30 min. N-[(trifluoromethyl)thio]saccharin is a powerful trifluoromethylthiolation agent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcs., amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic β-keto esters, and alkynes under mild reaction conditions. The synthesis of the target compounds was achieved using 2-[(trifluoromethyl)thio]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide as a key reactant. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of 3-Quinazolin-4(3H)-on-3-yl-2,N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors was written by Dong, Jiaqiang;Huang, Jingjie;Zhou, Ji;Tan, Ye;Jin, Jing;Tan, Xi;Wang, Bei;Yu, Tao;Wu, Chengde;Chen, Shuhui;Wang, Tie-Lin. And the article was included in ACS Medicinal Chemistry Letters in 2020.Formula: C7H4ClF3O2S This article mentions the following:

Phosphoinositide 3-kinases (PI3Ks) mediate a series of events related to cell growth, proliferation, survival, and differentiation. Overexpression of PI3Ks can lead to the dysregulation of cell homeostasis and cause tumorigenesis. In this study, rationally designed compounds were investigated as PI3Kα-selective inhibitors. Our efforts culminated in the discovery of a series of quinazolin-4(3H)-one derivatives with 2-substituted-N-methylpropanamide substitutions as PI3Kα-selective inhibitors. The best compound, I, has PI3Kα enzymic and cellular IC₅₀ values of 1.8 and 12.1 nM, resp. It exhibits biochem. selectivities for PI3Kα over PI3Kβ/δ/γ of 150/7.72/7.67-fold and cellular selectivities of 115/15.1/>826-fold, resp. Compound I is 59% orally bioavailable with a dose-normalized AUC of 3090 nM. These effects translated into in vivo conditions, as I significantly time- and dose-dependently inhibited phosphorylation of Akt in BT-474 s.c. xenograft mice and inhibited tumor growth. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Formula: C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rhodium-Catalyzed Ring Expansion of Azetidines via Domino Conjugate Addition/N-Directed α-C(sp³)-H Activation was written by Sun, Ling-Zhi;Yang, Xuan;Li, Nan-Nan;Li, Meng;Ouyang, Qin;Xie, Jian-Bo. And the article was included in Organic Letters in 2022.Electric Literature of C19H15Cl This article mentions the following:

A facile synthetic method for 4-aryl-4,5-dihydropyrrole-3-carboxylates was developed, with a rhodium-catalyzed ring expansion strategy from readily available 2-(azetidin-3-ylidene) acetates and aryl boronic acids. Mechanistic investigations suggest a novel domino “conjugate addition/N-directed α-C(sp³)-H activation” process. The asym. catalytic synthesis of the 4-aryl-4,5-dihydropyrrole-3-carboxylate was realized by using QuinoxP* (91-97% ee). The synthetic utility of this protocol was demonstrated by the synthesis of 3,4-disubstituted or 2,3,4-trisubstituted pyrrolidines with excellent diastereoselectivities. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Electric Literature of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Montmorillonite K-10 and montmorillonite KSF as new and reusable catalysts for conversion of amines to N-(tert-butyl carbamates) was written by Chankeshwara, Sunay V.;Chakraborti, Asit K.. And the article was included in Journal of Molecular Catalysis A: Chemical in 2006.SDS of cas: 18437-66-6 This article mentions the following:

Montmorillonite K-10 and montmorillonite KSF were found to be new and reusable catalysts for chemoselective conversion of amines to N-t-Boc derivatives at room temperature under solvent-free conditions without competitive formation of isocyanate, urea and N,N-di-t-Boc. Various aromatic, heteroaromatic and aliphatic amines afforded N-(t-Bu carbamates) in excellent yields on treatment with (Boc)₂O after 5 min-2 h. Chiral amine and esters of α-amino acids afforded optically pure N-t-Boc derivatives in high yields. The catalytic efficiency of montmorillonite KSF was marginally inferior to that of montmorillonite K-10. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6SDS of cas: 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.SDS of cas: 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemical constitution and the dissociation constants of monocarboxylic acids. XV. Steric effects in substituted nitrobenzoic acids was written by Dippy, J. F. J.;Hughes, S. R. C.;Laxton, J. W.. And the article was included in Journal of the Chemical Society in 1956.Recommanded Product: 2-Chloro-6-nitrobenzoic acid This article mentions the following:

The dissociation constants were determined conductimetrically in H₂O at 25° for 2,3-(O₂N)₂C₆H₃CO₂H (I), 2,4-(O₂N)₂C₆H₃CO₂H (II), 2,5-(O₂N)₂C₆H₃CO₂H (III), 2,6-(O₂N)₂C₆H₃CO₂H (IV), 3,4-(O₂N)₂C₆H₃CO₂H (V), 3,5-(O₂N)₂C₆H₃CO₂H (VI), 2,3-Cl(O₂N)C₆H₃CO₂H (VII), 2,4-Cl(O₂N)C₆H₃CO₂H (VIII), 2,5-Cl(O₂N)C₆H₃CO₂H (IX), 2,6-Cl(O₂N)C₆H₃CO₂H (X), 2,6-Br(O₂N)C₆H₃CO₂H (XI), 2,4,6-(O₂N)₃C₆H₂CO₂H (XII), 4,3,5-Me(O₂N)₂C₆H₂CO₂H (XIII), 2-O₂NC₆H₄OH (XIV), 2,6-(O₂N)₂C₆H₃OH (XV), and 2,4,6-(O₂N)₃C₆H₂OH (XVI). The results shed light on the operation of steric effects in the BzOH system. V was prepared from 3,4-(O₂N)₂C₆H₃Me by oxidation with KMnO₄ in 50% H₂SO₄. Refluxing 2,4-(O₂N)₂C₆H₃Me with equal volumes of fuming HNO₃ and AcOH gave II. I and XII were prepared from PhEt and 2,4,6-(O₂N)₃C₆H₂Me, resp. All acids were recrystallized repeatedly from conductivity H₂O to constant m.p. after drying several weeks in desiccators, and equivalents were confirmed by alkalimetry. Measurements were made with an improved bridge network and equipment already described (loc. cit.). Solutions were prepared individually by weight at each concentration The thermodynamic dissociation constants were calculated along the usual lines. A solvent correction was applied in the derivation of K for XIV. Fuoss’s extrapolation method (cf. C.A. 29, 2824⁸), in which measurements of the equivalent conductivity of the aqueous acid are used, were employed for the determination of Λ₀. Dissociation constants × 10³ found were: I, 14.1; II, 37.6; III, 23.9; IV, 72.5; V, 1.52; VI, 1.50; VII, 9.51; VIII, 10.9; IX, 6.80; X, 45.5; XI, 42.4; XII, 222; and XIII, 1.07. For the phenols the dissociation constants were: XIV, 5.9 × 10^-8; XV, 1.97 × 10^-4; and XVI, 1.96 × 10^-1. The values of Λ₀ exhibit none of the regularities usual in related monocarboxylic acids. This is perhaps connected with the fact that in this series anomalies are introduced by large steric factors which are likely to influence variously and anomalously the solvation characteristics of the different anions. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Recommanded Product: 2-Chloro-6-nitrobenzoic acid).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 2-Chloro-6-nitrobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of N-(4-Phenoxyphenyl)benzenesulfonamide Derivatives as Novel Nonsteroidal Progesterone Receptor Antagonists was written by Yamada, Ayumi;Kazui, Yuko;Yoshioka, Hiromasa;Tanatani, Aya;Mori, Shuichi;Kagechika, Hiroyuki;Fujii, Shinya. And the article was included in ACS Medicinal Chemistry Letters in 2016.Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

We report here development of N-(4-phenoxyphenyl)benzenesulfonamide derivatives as a novel class of nonsteroidal progesterone receptor (PR) antagonists. PR plays key roles in various physiol. systems, including the female reproductive system, and PR antagonists are candidates for clin. treatment of multiple diseases, including uterine leiomyoma, endometriosis, breast cancer, and some psychiatric disorders. We found that the benzenesulfonanilide skeleton functions as a novel scaffold for PR antagonists, and we adopted 3-chlorobenzenesulfonyl derivative 20a as a lead compound for structural development. Among the synthesized compounds, 3-trifluoromethyl derivative 32 exhibited the most potent PR-antagonistic activity, with high binding affinity for PR and selectivity over androgen receptor (AR). It is structurally distinct from other nonsteroidal PR antagonists, including cyanopyrrole derivatives, and further modification is expected to afford novel selective PR modulators. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Membrane properties of amacrocyclic tetraether bisphosphatidylcholine lipid: Effect of a single membrane-spanning polymethylene cross-linkage between two head groups of ditetradecylphosphatidylcholine membrane was written by Tsuchida, Naoyuki;Takagi, Toshiyuki;Takahashi, Hiroshi;Yoshihara, Toshitada;Tobita, Seiji;Sonoyama, Masashi. And the article was included in Biochimica et Biophysica Acta, Biomembranes in 2021.Application of 76-83-5 This article mentions the following:

The plasma membranes of archaea are abundant in macrocyclic tetraether lipids that contain a single or double long transmembrane hydrocarbon chains connecting the two glycerol backbones at both ends. In this study, a novel amacrocyclic bisphosphatidylcholine lipid bearing a single membrane-spanning octacosamethylene chain, 1,1′-O-octacosamethylene-2,2′-di-O-tetradecyl-bis-(sn-glycero)-3,3′-diphosphocholine (AC-(di-O-C14PC)2), was synthesized to elucidate effects of the interlayer cross-linkage on membrane properties based on comparison with its corresponding diether phosphatidylcholine, 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine (DTPC), that forms bilayer membrane. Several physicochem. techniques demonstrated that while AC-(di-O-C14PC)2 monolayer, which adopts a particularly high-ordered structure in the gel phase, shows remarkably high thermotropic transition temperature compared to DTPC bilayer, the fluidity of both phospholipids above the transition temperature is comparable. Nonetheless, the fluorescent dye leakage from inside the AC-(di-O-C14PC)2 vesicles in the fluid phase is highly suppressed. The origin of the membrane properties characteristic of AC-(di-O-C14PC)2 monolayer is discussed in terms of the single long transmembrane hydrophobic linkage and the diffusional motion of the lipid mols. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Ni⁰ σ-Borane Complex Bearing a Rigid Bidentate Borane/Phosphine Ligand: Boryl Complex Formation by Oxidative Dehydrochloroborylation and Catalytic Activity for Ethylene Polymerization was written by Seidel, Falk William;Nozaki, Kyoko. And the article was included in Angewandte Chemie, International Edition in 2022.Electric Literature of C19H15Cl This article mentions the following:

While of interest, synthetically feasible access to boryl ligands and complexes remains limited, meaning such complexes remain underexploited in catalysis. For bidentate boryl ligands, oxidative addition of boranes to low-valent Ir^I or Pt⁰ are the only examples yet reported. As part of authors interest in developing improved group 10 ethylene polymerization catalysts, they present here an optimized synthesis of a novel, rigid borane/phosphine ligand and its Ni⁰ σ-borane complex. From the latter, an unprecedented oxidative dehydrochloroborylation, to give a Ni^II boryl complex, was achieved. Furthermore, this new B/P ligand allowed the nickel-catalyzed polymerization of ethylene, which suggests that Ni⁰ σ-hydroborane complexes act as masked Ni^II boryl hydride reagents. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Electric Literature of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

N-halo compounds nitrogen centered radicals, their chemistry and application in the living radical polymerization of MMA was written by Percec, V.;Grigoras, C.. And the article was included in Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) in 2002.Name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

Our research group is elaborating new classes of universal initiators that are suitable for the design and synthesis of complex macromol. architectures. The N-centered radical chem. is not well understood except for some classic reactions. Here we report preliminary results on the use of various N-halogenated derivatives (Scheme 1) as initiators for the living radical polymerization (LRP) of Me methacrylate (MMA). LRP of MMA initiated with this new class of initiators based on N-halo derivatives was achieved with good results in spite of the initial expectation regarding their low reactivity towards electron-poor olefins. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents was written by Yao, Jianwen;Chen, Jing;He, Zuopeng;Sun, Wei;Xu, Wenfang. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Computed Properties of C7H3Cl2NS This article mentions the following:

A novel series of diaryl thiourea containing sorafenib derivatives 9a-t was designed and synthesized. The structures of all the newly synthesized compounds were determined by ¹H NMR, ¹³C NMR and HRMS. Their antiproliferative activities against HCT116 and MDA-MB-231 cell lines, and their inhibitory activities against the phosphorylation of VEGFR were evaluated and described. Some of the compounds showed significant activities against both cell lines and VEGFR. Compounds 9g, 9m, 9o and 9p demonstrated competitive antiproliferative activities to sorafenib, the reference standard, while compounds 9d, 9m, and 9p showed significant inhibitory activities against the phosphorylation of VEGFR. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Computed Properties of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics