Tag: 200-300

The Bis(η⁶-benzene)lithium Cation: A Fundamental Main-Group Organometallic Species was written by Jie, Xiaoming;Li, Jun;Daniliuc, Constantin G.;Wuebker, Anna-Lena;Hansen, Michael Ryan;Eckert, Hellmut;Mueck-Lichtenfeld, Christian;Kehr, Gerald;Erker, Gerhard. And the article was included in Angewandte Chemie, International Edition in 2021.Electric Literature of C19H15Cl This article mentions the following:

The synthesis and characterization of the bis(η⁶-benzene)lithium cation, the benzene metallocene of the lightest metal, is reported. The boron compound FmesBCl₂ [Fmes: 2,4,6-tris(trifluoromethyl)phenyl] reacted with three molar equivalents of the lithio-acetylene reagent Li-CC-Fmxyl [Fmxyl: 3,5-bis(trifluoromethyl)phenyl]. Subsequent crystallization from benzene gave the [bis(η⁶-benzene)Li]⁺ cation with the [{FmesB(-CC-Fmxyl)₃}₂Li]^– anion. This parent [(arene)₂Li]⁺ cation shows an eclipsed arrangement of the pair of benzene ligands at the central lithium cation with uniform carbon-lithium bond lengths. The corresponding [(η⁶-toluene)₂Li]⁺ and [(η⁶-durene)₂Li]⁺ containing salts were similarly prepared The bis(arene)lithium cations were characterized by x-ray diffraction, by solid-state ⁷Li MAS NMR spectroscopy and their bonding features were analyzed by DFT calculations In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Electric Literature of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anti-inflammatory hybrids of secondary amines and amide-sulfamide derivatives was written by Bai, Renren;Sun, Jian;Liang, Zhongxing;Yoon, Younghyoun;Salgado, Eric;Feng, Amber;Oum, Yoonhyeun;Xie, Yuanyuan;Shim, Hyunsuk. And the article was included in European Journal of Medicinal Chemistry in 2018.Reference of 777-44-6 This article mentions the following:

The CXCR4/CXCL12 chemokine axis can chemotactically accumulate inflammatory cells to local tissues and regulate the release of inflammatory factors. Developing novel CXCR4 modulators may provide a desirable strategy to control the development of inflammation. A series of novel hybrids were designed by integrating the key pharmacophores of three CXCR4 modulators. The majority of compounds displayed potent CXCR4 binding affinity. Compound 7a (N-(4-(phenylsulfonamidomethyl)benzyl)-4-((pyrimidin-2-ylamino)methyl)benzamide) exhibited 1000-fold greater affinity than AMD3100 and significantly inhibited invasion of CXCR4-pos. tumor cells. Addnl., compound 7a blocked mice ear inflammation by 67% and suppressed the accumulation of inflammatory cells in an in vivo mouse ear edema evaluation. Western blot analyses revealed that 7a inhibited the CXCR4/CXCL12-mediated phosphorylation of Akt and p44 in a dose-dependent manner. Moreover, compound 7a had no observable cytotoxicity and displayed a favorable plasma stability in the authors’ preliminary pharmacokinetic study. These results confirmed that this is a feasible method to develop CXCR4 modulators for the regulation and reduction of inflammation. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Reference of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of some pyrazoles, pyrazolones and oxadiazoles bearing 2-arylamino-5-mercapto-1,3,4-thiadiazole nuclei as possible antimicrobial agents was written by Nair, Smitha;Garg, S. P.;Sah, Pramilla. And the article was included in Indian Journal of Heterocyclic Chemistry in 2002.Formula: C9H8ClNO4 This article mentions the following:

2-Arylamino-5-mercapto-1,3,4-thiadiazol-(3′-nitrophenyl)-4′-carbohydrazide (IV) was cyclized with pentane-2,4-dione to give the substituted pyrazoles (V). Reaction of IV with Et acetoacetate lead to the formation of 2-arylamino-5-mercapto-1,3,4-thiadiazol-(3′-nitrophenyl)-1”-carbonyl-3”-methyl-5(4H)-pyrazolones (VI). The hydrazide IV was also converted to 2”-(2-arylamino-5-mercapto-1,3,4-thiadiazol)-3′-nitrophenyl-1”,3”,4”-oxadiazolin-5”-thiones (VII) in presence of carbon disulfide and potassium hydroxide. Subsequent reaction of the thiones VII with secondary amines in presence of formaldehyde gave the title compounds All the compounds were evaluated for antibacterial and antifungal activities. Some of them are effective against the microbes. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Formula: C9H8ClNO4).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C9H8ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120) was written by Sparks, Steven M.;Chen, Grace;Collins, Jon L.;Danger, Dana;Dock, Steven T.;Jayawickreme, Channa;Jenkinson, Stephen;Laudeman, Christopher;Leesnitzer, M. Anthony;Liang, Xi;Maloney, Patrick;McCoy, David C.;Moncol, David;Rash, Vincent;Rimele, Thomas;Vulimiri, Padmaja;Way, James M.;Ross, Sean. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Computed Properties of C10H13ClO3S This article mentions the following:

The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Computed Properties of C10H13ClO3S).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C10H13ClO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of oxidation of some amino acids by N-chlorosaccharin in aqueous acetic acid medium was written by Farook, N. A. Mohamed;Prabaharan, R.;Rahini, S.;Kumar, R. Senthil;Rajamahendran, G.;Krishnan, B. Gopala. And the article was included in E-Journal of Chemistry in 2004.Reference of 14070-51-0 This article mentions the following:

The kinetics of oxidation of some amino acids (AA; glycine, alanine, aspartic acid, arginine, and histidine) by N-chlorosaccharin (NCSA) has been studied in aqueous acetic acid medium in the presence of perchloric acid. The observed rate of oxidation is first order in [AA], [NCSA] and of inverse fractional order in [H⁺]. The main product of the oxidation is the corresponding aldehyde. The ionic strength has no significant effect on the reaction rate. The effect of changing the dielec. constant of the medium on the rate indicates the reaction to be of dipole-dipole type. Hypochlorous acid has been postulated as the reactive oxidizing species. Activation parameters are computed with respect to slow step of the mechanism. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Reference of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analysis of chemical compounds in hot melt adhesives from composite packaging by gas chromatography-mass spectrometry combined with retention index was written by Shan, Li-jun;Li, Hui-zhen;Lin, Qin-bao;Song, Huan;Wang, Rong-zhen;Wu, Yu-mei. And the article was included in Fenxi Shiyanshi in 2016.Product Details of 5344-49-0 This article mentions the following:

A gas chromatog.-mass spectrometry (GC-MS) method was used to analyze chem. components in hot melt adhesives from composite packaging. The separated peaks were identified by mass spectral library searching combined with retention index comparison. Sixty-two chem. components were identified from hot melt adhesives, and the chem. compounds were mainly composed of esters, hydrocarbons, acids, aldehydes and ketones. The relative deviation of this method was less than 2.6%. The qual. result of this method was reliable and realizable. This established method can be used for further study of chem. components in hot melt adhesives. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Product Details of 5344-49-0).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 5344-49-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and evaluation of halogenated 12N-sulfonyl matrinic butanes as potential anti-coxsackievirus agents was written by Cheng, Xin-Yue;Li, Yu-Huan;Tang, Sheng;Zhang, Xin;Wang, Yan-Xiang;Wang, Sheng-Gang;Jiang, Jian-Dong;Li, Ying-Hong;Song, Dan-Qing. And the article was included in European Journal of Medicinal Chemistry in 2017.Safety of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Twenty-eight new 12N-benzenesulfonyl matrinic butane and halogenated 12N-sulfonyl matrinic butane/ethane derivatives were designed, synthesized and evaluated for their anti-coxsackievirus activities against CVB3. SAR anal. indicated the introduction of a fluoro atom on the 1′-position might be helpful for keeping potency. Among them, compound I exhibited potential activities against all CVBs with IC₅₀ ranging from 0.69 to 5.14 μM, suggesting a broad-spectrum anti-coxsackievirus B feature. In addition, it also displayed an excellent PK and a good safety profile, indicating a highly druggable nature. Thus, we consider compound I to be a promising drug candidate in the treatment of not only viral myocarditis caused by CVB3 but also various diseases infected with coxsackieviruses B. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Safety of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Co-assembly of soluble metal-organic polyhedrons for high-flux thin-film nanocomposite membranes was written by Xu, Shanshan;Li, Sen;Guo, Xiangyu;Huang, Hongliang;Qiao, Zhihua;Zhong, Chongli. And the article was included in Journal of Colloid and Interface Science in 2022.Application of 4422-95-1 This article mentions the following:

Well-developed pore channels and large effective permeation area are sorely needed in developing highly permeable synthetic membranes for the reduction of energy consumption in separation processes. Herein, water stable, soluble and reactive amino-functionalized metal-organic polyhedron (MOP) ZrT-1-NH2 with intrinsic porosity is co-assembled with lysine (Lys) into a new kind of thin-film nanocomposite (TFN) membranes through in situ interfacial polymerization (IP) with trimesoyl chloride (TMC). Striped structure on the membrane surface is induced by the participation of the amino-MOP in polymerization, which greatly enhances the effective permeation area of the separation layer compared with the membranes feature smooth surface. Meanwhile, the suitable pore aperture of the introduced ZrT-1-NH2 can also benefit the diffusion of water mols. and block the transport of mols. with bulkier mol. volumes The results showed that the formed membrane exhibits significantly improved water permeance (27.3 L m-2 h-1 bar-1, 480% increase) compared with that of the pristine Lys/TMC membrane (4.7 L m-2 h-1 bar-1). The compositing of ZrT-1-NH2 also leads to an increase in the rejection selectivity of dye and salt, rejection selectivity of dye/salt mixture, as well as in antifouling and antibacterial properties, making the ZrT-1-NH2-Lys/TMC composite membrane a potential choice for dye/salt separation Moreover, this work demonstrates the bright prospects of applying soluble and reactive porous cages in the development of high-loading defect-less TFN membranes for efficient mol. separations In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Application of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process was written by Yang, Bin;Chansaenpak, Kantapat;Wu, Hongmiao;Zhu, Lin;Wang, Mengzhe;Li, Zibo;Lu, Hongjian. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Application In Synthesis of tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

The intramol. fluorocyclization of unsaturated carbamates is described here using a hypervalent iodine reagent in the presence of a silver catalyst. Both (hetero)aryl-substituted olefins and acrylamides can be utilized as effective substrates. Preliminary mechanistic investigations suggest that the reaction proceeds via a cyclization/1,2-(hetero)aryl migration/fluorination cascade involving an unusual radical process. Furthermore, starting from no-carrier-added [¹⁸F]TBAF, a simple one-pot, two-step cascade method was developed for the generation of ¹⁸F-labeled heterocycles with high radiochem. purity. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application In Synthesis of tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Biological control of Fusarium tomato-wilt disease by cyanobacteria Nostoc spp. was written by El-Sheekh, Mostafa M.;Deyab, Mohamed A.;Hasan, Reham S. A.;Abu Ahmed, Seham E.;Elsadany, Abdelgawad Y.. And the article was included in Archives of Microbiology in 2022.HPLC of Formula: 3386-33-2 This article mentions the following:

This study investigated the effect of foliar application of extract and culture of Nostoc calcicola and Nostoc linckia on the Fusarium oxysporum f. sp.lycopersici (FOL) that infects tomatoes (Solanum lycopersicum) plant in vitro and in vivo. Cyanobacterial isolates were isolated from saline soils at El-Hamoul and Seidy Salem locations Kafr Elsheikh, Egypt, and identified to be N. calcicola and N. linckia Bioactive compounds of extract were analyzed by Gas chromatog.-mass spectrometry (GC-MS). Dry weight, carotene, chlorophyll content, and total phenolic compounds of isolates were measured. Plant height, dry weight, fruit number, and fruit weight of tomatoes were estimated GC/MS anal. showed 49 and 35 bioactive compounds in extracts of N. calcicola and N. linckia, resp. N. calcicola possesses the highest values of chlorophyll a, carotenoid, and total phenol contents in dry weight compared with N. linckia. After 100 days of tomato growth, the results showed the highest yield of tomato fruits with the application of N. calcicola and N. linckia compared with the untreated plants and the plants which were infected with Fusarium, suggesting that N. calcicola and N. linckia can serve as a new bioagent for biol. control of the soil fungus Fusarium oxysporum f. sp. lycopersici (FOL). In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2HPLC of Formula: 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.HPLC of Formula: 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics